product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PTEN (D4.3) XP® Rabbit mAb
catalog :
9188S
quantity :
100 ul
price :
260 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat, dog
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
citations: 25
Published Application/Species/DilutionReference
  • immunohistochemistry - paraffin section; human; tbl 1
Castillo-Martin M, Thin T, Lorduy A, Cordon-Cardo C. Immunopathologic Assessment of PTEN Expression. Methods Mol Biol. 2016;1388:23-37 pubmed publisher
  • western blot; human; fig 2
Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed publisher
  • western blot; human; fig 2a
Fedorenko I, Abel E, Koomen J, Fang B, Wood E, Chen Y, et al. Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells. Oncogene. 2016;35:1225-35 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/β-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:125; fig 1
  • western blot; mouse; 1:1000; fig 5
Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6
  • western blot; human; 1:1000; fig 6
Egawa H, Jingushi K, Hirono T, Ueda Y, Kitae K, Nakata W, et al. The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN. Sci Rep. 2016;6:20574 pubmed publisher
  • immunohistochemistry; human; tbl 2
Eritja N, Santacana M, Maiques O, Gonzalez-Tallada X, Dolcet X, Matias-Guiu X. Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. Methods. 2015;77:31-40 pubmed publisher
  • western blot; rat; 1:2000
Heinen A, Beyer F, Tzekova N, Hartung H, Küry P. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Exp Neurol. 2015;271:25-35 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Messaoudi S, He Y, Gutsol A, Wight A, Hébert R, Vilmundarson R, et al. Endothelial Gata5 transcription factor regulates blood pressure. Nat Commun. 2015;6:8835 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Gonzalez S, Fernando R, Berthelot J, Perrin-Tricaud C, Sarzi E, Chrast R, et al. In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath. Mitochondrion. 2015;23:32-41 pubmed publisher
  • immunohistochemistry; mouse; 1:50
  • western blot; mouse; 1:5000
Kim S, Ebbert K, Cordeiro M, Romero M, Zhu J, Serna V, et al. Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology. 2015;156:1464-76 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • western blot; human
Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100-4 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250
Danilov C, Steward O. Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice. Exp Neurol. 2015;266:147-60 pubmed publisher
  • immunohistochemistry - paraffin section; human
Morotti A, Panuzzo C, Crivellaro S, Pergolizzi B, Familiari U, Berger A, et al. BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. Leukemia. 2014;28:1326-33 pubmed publisher
  • western blot; human; fig 3
Moriarity B, Rahrmann E, Beckmann D, Conboy C, Watson A, Carlson D, et al. Simple and efficient methods for enrichment and isolation of endonuclease modified cells. PLoS ONE. 2014;9:e96114 pubmed publisher
  • western blot; human
Wang J, Chen J, Miller D, Li W. Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Mol Cancer Ther. 2014;13:16-26 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:400
Haws M, JARAMILLO T, Espinosa F, Widman A, Stuber G, Sparta D, et al. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol. 2014;522:1171-90 pubmed publisher
  • western blot; human; 1:1000
Gao D, Vela I, Sboner A, Iaquinta P, Karthaus W, Gopalan A, et al. Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014;159:176-87 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 6
Giatromanolaki A, Sivridis E, Mitrakas A, Kalamida D, Zois C, Haider S, et al. Autophagy and lysosomal related protein expression patterns in human glioblastoma. Cancer Biol Ther. 2014;15:1468-78 pubmed publisher
  • immunohistochemistry; human; 1:50
Lotan T, Gumuskaya B, Rahimi H, Hicks J, Iwata T, Robinson B, et al. Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia. Mod Pathol. 2013;26:587-603 pubmed publisher
  • western blot; mouse; 1:500
Kim H, Woo H, Ryu J, Bok J, Kim J, Choi S, et al. Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS ONE. 2013;8:e55609 pubmed publisher
  • western blot; mouse; 1:1000
Ma X, Choudhury S, Hua X, Dai Z, Li Y. Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway. Carcinogenesis. 2013;34:1216-23 pubmed publisher
Lewandowski G, Steward O. AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. J Neurosci. 2014;34:9951-62 pubmed publisher
Thomaidis T, Maderer A, Formentini A, Bauer S, Trautmann M, Schwarz M, et al. Proteins of the VEGFR and EGFR pathway as predictive markers for adjuvant treatment in patients with stage II/III colorectal cancer: results of the FOGT-4 trial. J Exp Clin Cancer Res. 2014;33:83 pubmed publisher
Lan R, Geng H, Polichnowski A, Singha P, Saikumar P, McEwen D, et al. PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol. 2012;302:F1210-23 pubmed publisher
product information
SKU :
9188S
Product-Name :
PTEN (D4.3) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M, R, Mk, Dg, (C)
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
PI3K / Akt Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
54
Host :
Rabbit
Target :
PTEN
Primary-Protein :
PTEN
Alt-Names :
10q23del,BZS,DEC,MGC11227,MHAM,MMAC1,MMAC1 phosphatase and tensin homolog deleted on chromosome 10,Mutated in multiple advanced cancers 1,PTEN,PTEN1,Phosphatase and tensin homolog,Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,TEP1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.