| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig s3a
| Bose R, Karthaus W, Armenia J, Abida W, Iaquinta P, Zhang Z, et al. ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Nature. 2017;546:671-675 pubmed publisher |
- immunocytochemistry knockout validation; mouse; 1:300; fig s1a
- western blot; mouse; 1:2000; fig 1c
| Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1s1a
| McMahon M, Contreras A, Holm M, Uechi T, Forester C, Pang X, et al. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. elife. 2019;8: pubmed publisher |
- immunohistochemistry; mouse; 1:1000; loading ...; fig ex4j
| Adams E, Karthaus W, Hoover E, Liu D, Gruet A, Zhang Z, et al. FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature. 2019;571:408-412 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s2b
| Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, et al. Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun. 2019;10:1665 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s18a
| Shen T, Li H, Song Y, Li L, Lin J, Wei G, et al. Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. Aging (Albany NY). 2019;11:1356-1388 pubmed publisher |
- western blot; mouse; loading ...; fig 3b
- immunocytochemistry; human; loading ...; fig s3a
- western blot; human; loading ...; fig 3b
| Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019;129:1129-1151 pubmed publisher |
- western blot; human; loading ...; fig 3c
| Wang W, Shen T, Dong B, Creighton C, Meng Y, Zhou W, et al. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. J Clin Invest. 2019;: pubmed publisher |
- immunoprecipitation; rat; loading ...; fig 7c
- western blot; rat; loading ...; fig 7c
- immunoprecipitation; mouse; loading ...; fig 4e
- western blot; mouse; loading ...; fig 4a
| Chen C, Zou L, Lin Q, Yan X, Bi H, Xie X, et al. Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload. Redox Biol. 2019;20:390-401 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhang M, Suarez E, Vasquez J, Nathanson L, Peterson L, Rajapakshe K, et al. Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity. Oncogene. 2019;38:1121-1135 pubmed publisher |
- western blot; mouse; loading ...; fig s3a
| Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 2d
| Li H, Zhang P, Zhang Q, Li C, Zou W, Chang Z, et al. WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice. J Biol Chem. 2018;293:8886-8899 pubmed publisher |
- western blot; mouse; fig 6d
| Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk U, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018;9:1352 pubmed publisher |
- western blot; human; 1:1000; fig 1d
| Zhang S, Zhang M, Jing Y, Yin X, Ma P, Zhang Z, et al. Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors. Nat Commun. 2018;9:215 pubmed publisher |
- western blot; human; loading ...; fig 7c
| Kapil S, Sharma B, Patil M, Elattar S, Yuan J, Hou S, et al. The cell polarity protein Scrib functions as a tumor suppressor in liver cancer. Oncotarget. 2017;8:26515-26531 pubmed publisher |
- immunohistochemistry; human; fig s2p
- western blot; human; loading ...; fig s2e
| Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017;542:484-488 pubmed publisher |
- immunocytochemistry; mouse; 1:100; loading ...; fig 3a
- western blot; mouse; 1:2000; loading ...; fig 2d
- western blot; human; 1:2000; loading ...; fig 2d
| Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3f
| Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017;292:2411-2421 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 5b
| Mustachio L, Kawakami M, Lu Y, Rodriguez Canales J, Mino B, Behrens C, et al. The ISG15-specific protease USP18 regulates stability of PTEN. Oncotarget. 2017;8:3-14 pubmed publisher |
- immunocytochemistry; mouse; 1:1000; loading ...; fig 1c
| Goebbels S, Wieser G, Pieper A, Spitzer S, Weege B, Yan K, et al. A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 2017;20:10-15 pubmed publisher |
- immunocytochemistry; human; fig s4b
- western blot; human; fig 4c
| Vidimar V, Gius D, Chakravarti D, Bulun S, Wei J, Kim J. Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2016;2:e1601132 pubmed |
- western blot; human; 1:1000; loading ...; tbl 1
| Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed |
- western blot; human; fig 2
| Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| Krepler C, Xiao M, Samanta M, Vultur A, Chen H, Brafford P, et al. Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget. 2016;7:71211-71222 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Rittig N, Bach E, Thomsen H, Pedersen S, Nielsen T, Jørgensen J, et al. Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial. PLoS ONE. 2016;11:e0162167 pubmed publisher |
- western blot; human; loading ...; fig 6n
| Bi P, Yue F, Karki A, Castro B, Wirbisky S, Wang C, et al. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med. 2016;213:2019-37 pubmed publisher |
- western blot; human; loading ...; fig s3c
| Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, et al. Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2016;2:15044 pubmed publisher |
- western blot; human; fig 4e
| Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, et al. SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Cancer Sci. 2016;107:1270-80 pubmed publisher |
- western blot; human; fig 6a
| Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/?-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed publisher |
- immunohistochemistry - paraffin section; human; tbl 1
| Castillo Martin M, Thin T, Collazo Lorduy A, Cordon Cardo C. Immunopathologic Assessment of PTEN Expression. Methods Mol Biol. 2016;1388:23-37 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:125; fig 1
- western blot; mouse; 1:1000; fig 5
| Dhar S, Kumar A, Zhang L, Rimando A, Lage J, Lewin J, et al. Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer. Oncotarget. 2016;7:18469-84 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 6
- western blot; human; 1:1000; fig 6
| Egawa H, Jingushi K, Hirono T, Ueda Y, Kitae K, Nakata W, et al. The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN. Sci Rep. 2016;6:20574 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4b
| Ho N, Morrison J, Silva A, Coomber B. The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. Biosci Rep. 2016;36:e00299 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
| Messaoudi S, He Y, Gutsol A, Wight A, Hébert R, Vilmundarson R, et al. Endothelial Gata5 transcription factor regulates blood pressure. Nat Commun. 2015;6:8835 pubmed publisher |
- western blot; human; loading ...; fig 8b
| Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, et al. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Nat Commun. 2015;6:8899 pubmed publisher |
- immunohistochemistry - paraffin section; human
- western blot; human
| Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100-104 pubmed publisher |
- western blot; mouse; 1:1000; fig s7d
| Herranz D, Ambesi Impiombato A, Sudderth J, Sánchez MartÃn M, Belver L, Tosello V, et al. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med. 2015;21:1182-9 pubmed publisher |
- immunohistochemistry; human; 1:50; loading ...; fig 2a
| Haffner M, Weier C, Xu M, Vaghasia A, Gürel B, Gümüşkaya B, et al. Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization. J Pathol. 2016;238:31-41 pubmed publisher |
- western blot; human; fig 2a
| Fedorenko I, Abel E, Koomen J, Fang B, Wood E, Chen Y, et al. Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells. Oncogene. 2016;35:1225-35 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Gonzalez S, Fernando R, Berthelot J, Perrin Tricaud C, Sarzi E, Chrast R, et al. In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath. Mitochondrion. 2015;23:32-41 pubmed publisher |
- western blot; rat; 1:2000
| Heinen A, Beyer F, Tzekova N, Hartung H, Küry P. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Exp Neurol. 2015;271:25-35 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:250
| Danilov C, Steward O. Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice. Exp Neurol. 2015;266:147-60 pubmed publisher |
- immunohistochemistry; mouse; 1:50
- western blot; mouse; 1:5000
| Kim S, Ebbert K, Cordeiro M, Romero M, Zhu J, Serna V, et al. Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology. 2015;156:1464-76 pubmed publisher |
- western blot; human; fig 1
| Blanchard Z, Paul B, Craft B, ElShamy W. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. Breast Cancer Res. 2015;17:5 pubmed publisher |
- immunohistochemistry; human; fig 1a
| Mahadevan D, Theiss N, Morales C, Stejskal A, Cooke L, Zhu M, et al. Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST). Oncotarget. 2015;6:1954-66 pubmed |
- immunohistochemistry - paraffin section; human; 1:100; fig 6
| Giatromanolaki A, Sivridis E, Mitrakas A, Kalamida D, Zois C, Haider S, et al. Autophagy and lysosomal related protein expression patterns in human glioblastoma. Cancer Biol Ther. 2014;15:1468-78 pubmed publisher |
- immunohistochemistry; human; tbl 2
| Eritja N, Santacana M, Maiques O, González Tallada X, Dolcet X, Matias Guiu X. Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. Methods. 2015;77-78:31-40 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2b
| Kappler C, Guest S, Irish J, Garrett Mayer E, Kratche Z, Wilson R, et al. Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. Mol Oncol. 2015;9:527-43 pubmed publisher |
- western blot; human; 1:1000
| Gao D, Vela I, Sboner A, Iaquinta P, Karthaus W, Gopalan A, et al. Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014;159:176-187 pubmed publisher |
- western blot; human; fig 3
| Moriarity B, Rahrmann E, Beckmann D, Conboy C, Watson A, Carlson D, et al. Simple and efficient methods for enrichment and isolation of endonuclease modified cells. PLoS ONE. 2014;9:e96114 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Morotti A, Panuzzo C, Crivellaro S, Pergolizzi B, Familiari U, Berger A, et al. BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. Leukemia. 2014;28:1326-33 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:400
| Haws M, JARAMILLO T, Espinosa F, Widman A, Stuber G, Sparta D, et al. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol. 2014;522:1171-90 pubmed publisher |
| Wang J, Chen J, Miller D, Li W. Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Mol Cancer Ther. 2014;13:16-26 pubmed publisher |
- western blot; mouse; 1:500
| Kim H, Woo H, Ryu J, Bok J, Kim J, Choi S, et al. Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS ONE. 2013;8:e55609 pubmed publisher |
- western blot; mouse; 1:1000
| Ma X, Choudhury S, Hua X, Dai Z, Li Y. Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway. Carcinogenesis. 2013;34:1216-23 pubmed publisher |
- immunohistochemistry; human; 1:50
| Lotan T, Gumuskaya B, Rahimi H, Hicks J, Iwata T, Robinson B, et al. Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia. Mod Pathol. 2013;26:587-603 pubmed publisher |
| Palam L, Mali R, Ramdas B, Srivatsan S, Visconte V, Tiu R, et al. Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway. JCI Insight. 2018;3: pubmed publisher |
| Montero Conde C, Leandro García L, Chen X, Oler G, Ruiz Llorente S, Ryder M, et al. Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene. Proc Natl Acad Sci U S A. 2017;114:E4951-E4960 pubmed publisher |
| Vieira N, Spinazzola J, Alexander M, Moreira Y, Kawahara G, Gibbs D, et al. Repression of phosphatidylinositol transfer protein ? ameliorates the pathology of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017;114:6080-6085 pubmed publisher |
| Guo J, Dou L, Meng X, Chen Z, Yang W, Fang W, et al. Hepatic MiR-291b-3p Mediated Glucose Metabolism by Directly Targeting p65 to Upregulate PTEN Expression. Sci Rep. 2017;7:39899 pubmed publisher |
| Gao D, Zhan Y, Di W, Moore A, Sher J, Guan Y, et al. A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PLoS ONE. 2016;11:e0161084 pubmed publisher |
| Zuckermann A, La Ragione R, Baines D, Williams R. Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model. Br J Pharmacol. 2015;172:5306-17 pubmed publisher |
| Chen Z, Yuan Y, Wang Y, Liu Z, Chan H, Chen S. Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2015;152:29-39 pubmed publisher |
| Unno K, Ono M, Winder A, Maniar K, Paintal A, Yu Y, et al. Establishment of human patient-derived endometrial cancer xenografts in NOD scid gamma mice for the study of invasion and metastasis. PLoS ONE. 2014;9:e116064 pubmed publisher |
| Wang Z, Xu D, Ding H, Kim J, Zhang J, Hai T, et al. Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model. Oncogene. 2015;34:4975-84 pubmed publisher |
| Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, et al. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2015;45:1192-205 pubmed publisher |
| Thomaidis T, Maderer A, Formentini A, Bauer S, Trautmann M, Schwarz M, et al. Proteins of the VEGFR and EGFR pathway as predictive markers for adjuvant treatment in patients with stage II/III colorectal cancer: results of the FOGT-4 trial. J Exp Clin Cancer Res. 2014;33:83 pubmed publisher |
| Imura Y, Yasui H, Outani H, Wakamatsu T, Hamada K, Nakai T, et al. Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma. Mol Cancer. 2014;13:185 pubmed publisher |
| Lewandowski G, Steward O. AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. J Neurosci. 2014;34:9951-62 pubmed publisher |
| Wang H, Chen P, Liu X, Zhao W, Shi L, Gu X, et al. Prognostic impact of gastrointestinal bleeding and expression of PTEN and Ki-67 on primary gastrointestinal stromal tumors. World J Surg Oncol. 2014;12:89 pubmed publisher |
| Zhang S, Chung W, Wu G, Egan S, Xu K. Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia. 2014;16:158-67 pubmed publisher |
| Le Floc h A, Tanaka Y, Bantilan N, Voisinne G, Altan Bonnet G, Fukui Y, et al. Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. J Exp Med. 2013;210:2721-37 pubmed publisher |
| Sawitzky M, Zeissler A, Langhammer M, Bielohuby M, Stock P, Hammon H, et al. Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. PLoS ONE. 2012;7:e39711 pubmed publisher |
| He Z, Gao Y, Deng Y, Li W, Chen Y, Xing S, et al. Lipopolysaccharide induces lung fibroblast proliferation through Toll-like receptor 4 signaling and the phosphoinositide3-kinase-Akt pathway. PLoS ONE. 2012;7:e35926 pubmed publisher |
| Lan R, Geng H, Polichnowski A, Singha P, Saikumar P, McEwen D, et al. PTEN loss defines a TGF-?-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol. 2012;302:F1210-23 pubmed publisher |
