| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; fig 1
| Ah Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin Blank N, et al. Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cells. J Cell Mol Med. 2016;20:1956-65 pubmed publisher |
- western blot; mouse; 1:1000; fig 3h
- western blot; human; 1:1000; loading ...; fig 3g, 3i
| Xu P, Xiong W, Lin Y, Fan L, Pan H, Li Y. Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression. Cell Death Dis. 2021;12:779 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 3b
- immunocytochemistry; human; loading ...; fig 1j
| Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep. 2021;36:109412 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs J, Wawrzyniak M, et al. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s5a
| Atcha H, Jairaman A, Holt J, Meli V, Nagalla R, Veerasubramanian P, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021;12:3256 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 7a
| Shang L, Ren H, Wang S, Liu H, Hu A, Gou P, et al. SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization. Oxid Med Cell Longev. 2021;2021:6662156 pubmed publisher |
- immunohistochemistry; mouse; 1:500; loading ...; fig 5d
| McElrath C, Espinosa V, Lin J, Peng J, Sridhar R, Dutta O, et al. Critical role of interferons in gastrointestinal injury repair. Nat Commun. 2021;12:2624 pubmed publisher |
- western blot; mouse; fig 6d
| Gangoso E, Southgate B, Bradley L, Rus S, Gálvez Cancino F, McGivern N, et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell. 2021;184:2454-2470.e26 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s3d
| Shang M, Yang H, Yang R, Chen T, Fu Y, Li Y, et al. The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. Nat Commun. 2021;12:1940 pubmed publisher |
- western blot; mouse; fig 4g
| Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; fig 5g
- western blot; mouse; 0.2 ug/ml; loading ...; fig 4h
| Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed publisher |
- western blot; human; loading ...
| Liao T, Lin C, Jiang J, Yang S, Teng H, Yang M. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Theranostics. 2020;10:6095-6112 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed publisher |
- western blot; mouse; loading ...; fig 4b
| Wang Bishop L, Wehbe M, Shae D, James J, Hacker B, Garland K, et al. Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. J Immunother Cancer. 2020;8: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2h
| Weindel C, Bell S, Vail K, West K, Patrick K, Watson R. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. elife. 2020;9: pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 4d
- western blot; mouse; loading ...; fig 4b
| Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a
- western blot; human; 1:1000; loading ...; fig 8a
| Mosaheb M, Dobrikova E, Brown M, Yang Y, Cable J, Okada H, et al. Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. Nat Commun. 2020;11:524 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Lohard S, Bourgeois N, Maillet L, Gautier F, Fétiveau A, Lasla H, et al. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nat Commun. 2020;11:259 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s6c
| Kim J, Gupta R, Blanco L, Yang S, Shteinfer Kuzmine A, Wang K, et al. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science. 2019;366:1531-1536 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt M, Hermanns H, et al. IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression. J Exp Clin Cancer Res. 2019;38:397 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Pech M, Fong L, Villalta J, Chan L, Kharbanda S, O Brien J, et al. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. elife. 2019;8: pubmed publisher |
- western blot; mouse; loading ...; fig s4f
| Liu Y, You Y, Lu Z, Yang J, Li P, Liu L, et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019;365:1171-1176 pubmed publisher |
- western blot; human; 1:1000; fig 3s1e
| Park M, Kim A, Manandhar S, Oh S, Jang G, Kang L, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. elife. 2019;8: pubmed publisher |
- western blot; human; loading ...; fig s3b
| Joyce M, Berry Wynne K, Dos Santos T, Addison W, McFarlane N, Hobman T, et al. HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response. PLoS Pathog. 2019;15:e1007949 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5d
| Reisländer T, Lombardi E, Groelly F, Miar A, Porru M, Di Vito S, et al. BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. Nat Commun. 2019;10:3143 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 4f
| von Gamm M, Schaub A, Jones A, Wolf C, Behrens G, Lichti J, et al. Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019;: pubmed publisher |
- mass cytometry; human; loading ...; fig s1
| Fernandez I, Baxter R, Garcia Perez J, Vendrame E, Ranganath T, Kong D, et al. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019;216:1255-1267 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig s1a
- western blot; mouse; loading ...; fig 1b
| Wang E, Dai Z, Ferrante A, Drake C, Christiano A. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019;: pubmed publisher |
- western blot; human; loading ...; fig 4c
| Sakahara M, Okamoto T, Oyanagi J, Takano H, Natsume Y, Yamanaka H, et al. IFN/STAT signaling controls tumorigenesis and the drug response in colorectal cancer. Cancer Sci. 2019;110:1293-1305 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4a
| Martin V, Chiriaco C, Modica C, Acquadro A, Cortese M, Galimi F, et al. Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours. Br J Cancer. 2019;120:527-536 pubmed publisher |
- western blot; mouse; loading ...; fig 3e
| Mastroianni J, Stickel N, Andrlova H, Hanke K, Melchinger W, Duquesne S, et al. miR-146a Controls Immune Response in the Melanoma Microenvironment. Cancer Res. 2019;79:183-195 pubmed publisher |
- western blot; mouse; loading ...; fig 3d
| Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Lee E, Ouzounova M, Piranlioglu R, Ma M, Guzel M, Marasco D, et al. The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20. Oncogene. 2019;38:469-482 pubmed publisher |
- western blot; mouse; loading ...; fig s5c
| Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, et al. Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Nat Commun. 2018;9:5300 pubmed publisher |
- western blot; human; 1:1000; fig 4a
| Qin L, Min W, Xin S. AIP1 suppresses transplant arteriosclerosis through inhibition of vascular smooth muscle cell inflammatory response to IFNγ. Anat Rec (Hoboken). 2018;: pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 4g
- western blot; mouse; loading ...; fig 1c, 4f
- western blot; human; loading ...; fig 1d
| Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1d
- western blot; human; loading ...; fig 4a
| Sarkar M, Hile G, Tsoi L, Xing X, Liu J, Liang Y, et al. Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Ann Rheum Dis. 2018;77:1653-1664 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s1g
| Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed publisher |
- western blot; mouse; loading ...; fig s11a
| Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher |
- western blot; mouse; loading ...; fig 6d
| Xi J, Huang Q, Wang L, Ma X, Deng Q, Kumar M, et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018;37:3151-3165 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Taylor J, Cash M, Santostefano K, Nakanishi M, Terada N, Wallet M. CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. J Leukoc Biol. 2018;: pubmed publisher |
- western blot; human; 1:1000; fig s7a
| Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4b
| Chiang C, Pauli E, Biryukov J, Feister K, Meng M, White E, et al. The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling. J Virol. 2018;92: pubmed publisher |
- western blot; mouse; loading ...; fig 6a
- immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 1a
- western blot; human; loading ...; fig s8k
| Wang W, Wang Y, Qu C, Wang S, Zhou J, Cao W, et al. The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response. Hepatology. 2018;67:2096-2112 pubmed publisher |
- western blot; human; loading ...; fig 4d
| Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed publisher |
- western blot; human; loading ...; fig 5d
| Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed publisher |
- western blot; mouse; loading ...; fig 3b
| Xue N, Zhou Q, Ji M, Jin J, Lai F, Chen J, et al. Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype. Sci Rep. 2017;7:39011 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5a
| Eletto D, Burns S, Angulo I, Plagnol V, Gilmour K, Henriquez F, et al. Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection. Nat Commun. 2016;7:13992 pubmed publisher |
- western blot; human; loading ...; fig 5d
| Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed |
- western blot; human; fig 5a
| Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, et al. The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network. Oncogene. 2017;36:2655-2666 pubmed publisher |
- western blot; mouse; loading ...; fig s9a
| Han J, Bae J, Choi C, Choi S, Kang H, Jo E, et al. Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Autophagy. 2016;12:2326-2343 pubmed |
- western blot; mouse; loading ...; fig s3b
| Günther C, He G, Kremer A, Murphy J, Petrie E, Amann K, et al. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest. 2016;126:4346-4360 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Southworth T, Plumb J, Gupta V, Pearson J, Ramis I, Lehner M, et al. Anti-inflammatory potential of PI3K? and JAK inhibitors in asthma patients. Respir Res. 2016;17:124 pubmed |
- western blot; mouse; loading ...; fig 3j
| Huai W, Song H, Yu Z, Wang W, Han L, Sakamoto T, et al. Mint3 potentiates TLR3/4- and RIG-I-induced IFN-? expression and antiviral immune responses. Proc Natl Acad Sci U S A. 2016;113:11925-11930 pubmed |
- western blot; mouse; fig 6c
| Textor A, Schmidt K, Kloetzel P, Weißbrich B, Perez C, Charo J, et al. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2016;213:2333-2348 pubmed |
- western blot; human; loading ...; fig 4
| Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher |
- western blot; human; 1:200; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; mouse; fig 4c
| Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher |
- immunohistochemistry; mouse; 1:1000; fig 1
| Senzacqua M, Severi I, Perugini J, Acciarini S, Cinti S, Giordano A. Action of Administered Ciliary Neurotrophic Factor on the Mouse Dorsal Vagal Complex. Front Neurosci. 2016;10:289 pubmed publisher |
- immunoprecipitation; human; fig 2
- western blot; human; 1:1000; fig 2
| Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, et al. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. PLoS Pathog. 2016;12:e1005764 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Sharma N, Kumawat K, Rastogi M, Basu A, Singh S. Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5. Sci Rep. 2016;6:27685 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher |
- western blot; mouse; loading ...; fig 1e
| Cant Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed publisher |
- western blot; mouse; loading ...; fig 1d
| Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, et al. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016;352:1232-6 pubmed publisher |
- western blot; mouse; fig 1a
| Anghelina D, Lam E, Falck Pedersen E. Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. J Virol. 2016;90:5915-27 pubmed publisher |
- western blot; human; fig s1c
| Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin F. Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System. J Immunol. 2016;196:4322-30 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Slørdahl T, Abdollahi P, Vandsemb E, Rampa C, Misund K, Baranowska K, et al. The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells. Oncotarget. 2016;7:27295-306 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 5c
| Li J, Chen K, Li S, Liu T, Wang F, Xia Y, et al. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS ONE. 2016;11:e0152570 pubmed publisher |
- immunohistochemistry; human; 1:50; tbl 2
| Menter T, Dickenmann M, Juskevicius D, Steiger J, Dirnhofer S, Tzankov A. Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling. Hematol Oncol. 2017;35:187-197 pubmed publisher |
- western blot; mouse; fig 5
| Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed publisher |
- western blot; mouse; fig 8
| Kraut B, Maier H, Kókai E, Fiedler K, Boettger T, Illing A, et al. Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. PLoS ONE. 2015;10:e0141591 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 9e
| Herz J, Johnson K, McGavern D. Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells. J Exp Med. 2015;212:1153-69 pubmed publisher |
- western blot; human; loading ...; fig 5
| Wang S, Zheng G, Zhao L, Xu F, Qian J. Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-α-induced Jak/Stat1 pathway. J Cell Mol Med. 2015;19:2432-40 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE. 2015;10:e0126159 pubmed publisher |
- chromatin immunoprecipitation; human; 1:80; loading ...; fig 8a
- flow cytometry; human; 1:200; loading ...; fig 6a
- western blot; human; 1:1000; loading ...; fig 6b
| Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher |
- western blot; mouse; fig 4
| Radhakrishnan V, Kojs P, Ramalingam R, Midura Kiela M, Angeli P, Kiela P, et al. Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules. J Biol Chem. 2015;290:8964-74 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Jay J, Hammer A, Nestor Kalinoski A, Diakonova M. JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein. Mol Cell Biol. 2015;35:111-31 pubmed publisher |
| Liu Y, Zhang Z, Zhao X, Yu R, Zhang X, Wu S, et al. Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression. Viral Immunol. 2014;27:267-76 pubmed publisher |
| Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 5a
- flow cytometry; human; loading ...; fig 2b
| Le Saout C, Hasley R, Imamichi H, Tcheung L, Hu Z, Luckey M, et al. Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathog. 2014;10:e1003976 pubmed publisher |
| McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-? response and ROR?t localization. Eur J Immunol. 2014;44:1137-42 pubmed publisher |
- western blot; mouse; 1:3000
| Lam E, Stein S, Falck Pedersen E. Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol. 2014;88:974-81 pubmed publisher |
| Kearney S, Delgado C, Eshleman E, Hill K, O Connor B, Lenz L. Type I IFNs downregulate myeloid cell IFN-? receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. J Immunol. 2013;191:3384-92 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:400
- western blot; human; fig 1a
| Li Y, Deuring J, Peppelenbosch M, Kuipers E, de Haar C, van der Woude C. STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis. Mol Med. 2012;18:1412-9 pubmed publisher |
- western blot; human; 1:2000
| Chen Y, Wu K, Chen C. Methamphetamine reduces human influenza A virus replication. PLoS ONE. 2012;7:e48335 pubmed publisher |
- immunohistochemistry; mouse
| Syu L, El Zaatari M, Eaton K, Liu Z, Tetarbe M, Keeley T, et al. Transgenic expression of interferon-? in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol. 2012;181:2114-25 pubmed publisher |
| Nitulescu I, Meyer S, Wen Q, Crispino J, Lemieux M, Levine R, et al. Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation. EBioMedicine. 2017;26:112-125 pubmed publisher |
| Zhang X, Li J, Qin J, Cheng W, Zhu X, Gong F, et al. Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. J Lipid Res. 2017;58:895-906 pubmed publisher |
| Huang Q, Duan L, Qian X, Fan J, Lv Z, Zhang X, et al. IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma. Sci Rep. 2016;6:36551 pubmed publisher |
| Lee D, Wang Y, Kalaitzidis D, Ramachandran J, Eda H, Sykes D, et al. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016;126:1300-10 pubmed publisher |
| Carbotti G, Barisione G, Airoldi I, Mezzanzanica D, Bagnoli M, Ferrero S, et al. IL-27 induces the expression of IDO and PD-L1 in human cancer cells. Oncotarget. 2015;6:43267-80 pubmed publisher |
| Murray C, Griffin Ã, O Loughlin E, Lyons A, Sherwin E, Ahmed S, et al. Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C. Brain Behav Immun. 2015;48:274-86 pubmed publisher |
| Riebeling T, Staab J, Herrmann Lingen C, Meyer T. DNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers. BMC Biochem. 2014;15:28 pubmed publisher |
| Cheng Z, Li Sha G, Jing Lin Z, Wen Wu Z, Xue Si C, Xing Xing C, et al. Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis. PLoS ONE. 2014;9:e112719 pubmed publisher |
| Vlková V, Stepanek I, Hruskova V, Senigl F, Mayerova V, Srámek M, et al. Epigenetic regulations in the IFN? signalling pathway: IFN?-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes. Oncotarget. 2014;5:6923-35 pubmed |
| Lange C, Gouttenoire J, Duong F, Morikawa K, Heim M, Moradpour D. Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-?. J Immunol. 2014;192:6037-44 pubmed publisher |
| Nishizawa K, Oguma A, Kawata M, Sakasegawa Y, Teruya K, Doh ura K. Efficacy and mechanism of a glycoside compound inhibiting abnormal prion protein formation in prion-infected cells: implications of interferon and phosphodiesterase 4D-interacting protein. J Virol. 2014;88:4083-99 pubmed publisher |
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