product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb
catalog :
9145
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
D3A7
reactivity :
human, mouse, rat, bovine, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 530
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 2f
Svinka J, Pflügler S, Mair M, Marschall H, Hengstler J, Stiedl P, et al. Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis. J Mol Med (Berl). 2017;95:109-117 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
de Lartigue G, Ronveaux C, Raybould H. Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab. 2014;3:595-607 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Zheng Z, Chen J, Lyu H, Lam S, Lu G, Chan W, et al. Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage. Stroke Vasc Neurol. 2021;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Correia de Sousa M, Calo N, Sobolewski C, Gjorgjieva M, Clement S, Maeder C, et al. Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Passman A, Strauss R, McSpadden S, Finch Edmondson M, Andrewartha N, Woo K, et al. Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; 1:500; fig 7c
Lo Cascio C, McNamara J, Melendez E, Lewis E, Dufault M, Sanai N, et al. Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells. JCI Insight. 2021;6: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2e
  • western blot; mouse; 1:1000; loading ...; fig 2b
De Velasco M, Kura Y, Ando N, Sako N, Banno E, Fujita K, et al. Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 2a
Liu Y, Lin J, Chen Y, Li Z, Zhou J, Lu X, et al. Omega‑3 polyunsaturated fatty acids inhibit IL‑11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity. Int J Mol Med. 2021;48: pubmed publisher
  • western blot; human; loading ...; fig 2c
Moon S, Lee H, Kim S, Hong J, Chun S, Lee H, et al. Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells. BMC Cancer. 2021;21:931 pubmed publisher
  • western blot; human; loading ...; fig 5d
Wang Y, Liu X, Hu G, Hu C, Gao Y, Huo M, et al. EGFR-IL-6 Signaling Axis Mediated the Inhibitory Effect of Methylseleninic Acid on Esophageal Squamous Cell Carcinoma. Front Pharmacol. 2021;12:719785 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6a
Berger C, Heyne H, Heiland T, Dommel S, Höfling C, Guiu Jurado E, et al. A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice. J Lipid Res. 2021;62:100105 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 5h
  • western blot; human; loading ...; fig 4a, 4b
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 8f
  • western blot; mouse; loading ...; fig 4g, 8e
Chen X, Miao M, Zhou M, Chen J, Li D, Zhang L, et al. Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell Death Dis. 2021;12:761 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7d
De Groof T, Bergkamp N, Heukers R, Giap T, Bebelman M, Goeij de Haas R, et al. Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies. Nat Commun. 2021;12:4357 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7a
Xia Y, Wang G, Jiang M, Liu X, Zhao Y, Song Y, et al. A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway. Onco Targets Ther. 2021;14:4047-4060 pubmed publisher
  • immunohistochemistry; rat; 1:100; loading ...; fig 7c
  • western blot; rat; loading ...; fig 7a
Li H, Yang Q, Wang W, Tian X, Feng F, Zhang S, et al. Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3. J Neuroinflammation. 2021;18:150 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Kwan Y, Teo M, Lim J, Tan M, Rosellinny G, Wahli W, et al. LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; loading ...; fig 6d
Cheng X, Wang J, Liu C, Jiang T, Yang N, Liu D, et al. Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway. J Exp Clin Cancer Res. 2021;40:199 pubmed publisher
  • western blot; human; loading ...; fig 1a,
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3h
Jiang H, Deng W, Zhu K, Zeng Z, Hu B, Zhou Z, et al. LINC00467 Promotes Prostate Cancer Progression via M2 Macrophage Polarization and the miR-494-3p/STAT3 Axis. Front Oncol. 2021;11:661431 pubmed publisher
  • western blot; human; loading ...; fig 6g, s11b
Liu Z, Li C, Zhang R, Wei D, Shang Y, Yong Y, et al. EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling. Mol Cancer. 2021;20:79 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s7a
Liu M, Rao H, Liu J, Li X, Feng W, Gui L, et al. The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol. 2021;43:102004 pubmed publisher
  • western blot; rat; loading ...; fig 2a
Li T, Zhao X, Duan J, Cui S, Zhu K, Wan Y, et al. Targeted inhibition of STAT3 in neural stem cells promotes neuronal differentiation and functional recovery in rats with spinal cord injury. Exp Ther Med. 2021;22:711 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7c
Shang L, Ren H, Wang S, Liu H, Hu A, Gou P, et al. SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization. Oxid Med Cell Longev. 2021;2021:6662156 pubmed publisher
  • western blot; mouse; loading ...
Gruber T, Pan C, Contreras R, Wiedemann T, Morgan D, Skowronski A, et al. Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metab. 2021;33:1155-1170.e10 pubmed publisher
  • western blot; human; loading ...; fig 2d
Dahou H, Minati M, Jacquemin P, Assi M. Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8d
Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021;12:2281 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, et al. Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cell Mol Gastroenterol Hepatol. 2021;12:633-651 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1d
  • western blot; mouse; loading ...; fig 1b
Hunter S, McIntosh B, Shi Y, Sperberg R, Funatogawa C, Labanieh L, et al. An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy. Commun Biol. 2021;4:452 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Huo S, Shi W, Ma H, Yan D, Luo P, Guo J, et al. Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene. Oxid Med Cell Longev. 2021;2021:6699054 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Melin N, Sánchez Taltavull D, Fahrner R, Keogh A, Dosch M, Büchi I, et al. Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Cell Death Dis. 2021;12:366 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Peng W, Chang M, Wu Y, Zhu W, Tong L, Zhang G, et al. Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway. Stem Cell Res Ther. 2021;12:216 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2b
Xiong Y, Liu D, Shen R, Xiong Y. A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells. Aging (Albany NY). 2021;13:5185-5196 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2a
Faber C, Deem J, Phan B, Doan T, Ogimoto K, Mirzadeh Z, et al. Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2a
Vogel A, Kanevsky I, Che Y, Swanson K, Muik A, Vormehr M, et al. BNT162b vaccines protect rhesus macaques from SARS-CoV-2. Nature. 2021;592:283-289 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2a
Marinić M, Mika K, Chigurupati S, Lynch V. Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s9a
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 9c
  • western blot; human; 1:500; loading ...; fig 3c
Tyagi A, Sharma S, Wu K, Wu S, Xing F, Liu Y, et al. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun. 2021;12:474 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s3-1a
Han J, Kwon S, Kim Y, Choi J, Kim J, Lee Y, et al. Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network. elife. 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5g
Lopušná K, Nowialis P, Opavska J, Abraham A, Riva A, Opavsky R. Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling. EBioMedicine. 2021;63:103191 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1i
Drori A, Gammal A, Azar S, Hinden L, Hadar R, Wesley D, et al. CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5l
Lian B, Pei Y, Jiang Y, Xue M, Li D, Li X, et al. Truncated HDAC9 identified by integrated genome-wide screen as the key modulator for paclitaxel resistance in triple-negative breast cancer. Theranostics. 2020;10:11092-11109 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5c
  • western blot; mouse; 1:2000; loading ...; fig 5a
Gawriluk T, Simkin J, Hacker C, Kimani J, Kiama S, Ezenwa V, et al. Complex Tissue Regeneration in Mammals Is Associated With Reduced Inflammatory Cytokines and an Influx of T Cells. Front Immunol. 2020;11:1695 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Yeo S, Zhu X, Okamoto T, Hao M, Wang C, Lu P, et al. Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6b
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, et al. Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis. Front Immunol. 2020;11:1598 pubmed publisher
  • immunohistochemistry; mouse; loading ...
  • western blot; mouse; fig 6i
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 3b
  • western blot; human; 1:2000; loading ...; fig 3a
Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, et al. Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels. PLoS ONE. 2020;15:e0235573 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Zhao X, Guo W, Zou L, Hu B. FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells. Cancer Cell Int. 2020;20:245 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5c
Pattwell S, Arora S, Cimino P, Ozawa T, Szulzewsky F, Hoellerbauer P, et al. A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nat Commun. 2020;11:2977 pubmed publisher
  • western blot; human; loading ...; fig 6e
Liao T, Lin C, Jiang J, Yang S, Teng H, Yang M. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Theranostics. 2020;10:6095-6112 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 4c
Jiang H, Gallet S, Klemm P, Scholl P, Folz Donahue K, Altmuller J, et al. MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020;107:306-319.e9 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1e
  • western blot; human; loading ...; fig s2a
Dmitrieva N, Walts A, Nguyen D, Grubb A, Zhang X, Wang X, et al. Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome. J Clin Invest. 2020;130:4167-4181 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5g
Gualandi M, Iorio M, Engeler O, Serra Roma A, Gasparre G, Schulte J, et al. Oncogenic ALK F1174L drives tumorigenesis in cutaneous squamous cell carcinoma. Life Sci Alliance. 2020;3: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1a
  • western blot; mouse; 1:1000; loading ...; fig 2a
Viau A, Baaziz M, Aka A, Mazloum M, Nguyen C, Kuehn E, et al. Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2020;31:1035-1049 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Gallo S, Spilinga M, Albano R, Ferrauto G, Di Gregorio E, Casanova E, et al. Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro. Br J Pharmacol. 2020;177:3107-3122 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3
Ahmed C, ILDEFONSO C, Johnson H, Lewin A. A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis. PLoS ONE. 2020;15:e0227524 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2d
  • western blot; mouse; 1:1000; loading ...; fig 2a
Lindner P, Paul S, Eckstein M, Hampel C, Muenzner J, Erlenbach Wuensch K, et al. EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells. Cell Death Dis. 2020;11:147 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 4h
  • western blot; mouse; 1:1000; loading ...; fig 4g
Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, Komori M, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Eneuro. 2020;7: pubmed publisher
  • western blot; human; loading ...; fig 1f
Hindupur S, Schmid S, Koch J, Youssef A, Baur E, Wang D, et al. STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy. Int J Mol Sci. 2020;21: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4
  • western blot; mouse; 1:1000; loading ...; fig 5b
Markotic A, Flegar D, Grcevic D, Sućur A, Lalić H, Turcić P, et al. LPS-induced inflammation desensitizes hepatocytes to Fas-induced apoptosis through Stat3 activation-The effect can be reversed by ruxolitinib. J Cell Mol Med. 2020;24:2981-2992 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 5b
  • western blot; rat; 1:800; loading ...; fig 4ba
Wang T, Sun X, Cui H, Liu K, Zhao J. The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway. Mol Med Rep. 2020;21:1097-1106 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Meng X, Zhao Y, Han B, Zha C, Zhang Y, Li Z, et al. Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways. Nat Commun. 2020;11:594 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s4a
Boudewijns S, Bloemendal M, de Haas N, Westdorp H, Bol K, Schreibelt G, et al. Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial. Cancer Immunol Immunother. 2020;69:477-488 pubmed publisher
  • western blot; human; loading ...; fig 5a
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1b
Zhang L, Wang Y, Wu G, Rao L, Wei Y, Yue H, et al. Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation. Cell Prolif. 2020;53:e12742 pubmed publisher
  • western blot; human; 1:750; loading ...; fig 6f
Orgaz J, Crosas Molist E, Sadok A, Perdrix Rosell A, Maiques O, Rodriguez Hernandez I, et al. Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance. Cancer Cell. 2020;37:85-103.e9 pubmed publisher
  • western blot; human; 1:400; loading ...; fig 5a
Hong Z, Wang Z, Zhou B, Wang J, Tong H, Liao Y, et al. Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells. Int J Oncol. 2020;56:783-793 pubmed publisher
  • western blot; human; loading ...; fig 3c
Dai E, Han L, Liu J, Xie Y, Kroemer G, Klionsky D, et al. Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein. Autophagy. 2020;:1-15 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5d
Zhang L, Pan J, Mamtilahun M, Zhu Y, Wang L, Venkatesh A, et al. Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion. Theranostics. 2020;10:74-90 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher
  • western blot; human; loading ...; fig 5b
Li W, Zhang X, Wu F, Zhou Y, Bao Z, Li H, et al. Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer. Cell Death Dis. 2019;10:918 pubmed publisher
  • western blot; mouse; loading ...; fig e6j
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher
  • western blot; human; loading ...; fig 4b
Linnebacher A, Mayer P, Marnet N, Bergmann F, Herpel E, Revia S, et al. Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer. Cells. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 4c
Liu H, Feng X, Yang B, Tong R, Lu Y, Chen D, et al. Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway. Am J Transl Res. 2019;11:4713-4725 pubmed
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 8i, 9a
  • western blot; human; 1:1000; loading ...; fig 7f, 8a, s14a
Sang Y, Li Y, Zhang Y, Alvarez A, Yu B, Zhang W, et al. CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. Nat Commun. 2019;10:4013 pubmed publisher
  • western blot; human; loading ...; fig 1b
Niu J, Sun Y, Chen B, Zheng B, Jarugumilli G, Walker S, et al. Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature. 2019;573:139-143 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2h
Xiao W, Wang L, Howard J, Kolhe R, Rojiani A, Rojiani M. TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC. Cancers (Basel). 2019;11: pubmed publisher
  • western blot; human; 1:1000; fig 3s1e
Park M, Kim A, Manandhar S, Oh S, Jang G, Kang L, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4g
Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
Wang D, Zheng X, Fu B, Nian Z, Qian Y, Sun R, et al. Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. EBioMedicine. 2019;46:119-132 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2a
Torres D, Pitts M, Hashimoto A, Berry M. Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. Nutrients. 2019;11: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Wang S, Yao F, Lu X, Li Q, Su Z, Lee J, et al. Temozolomide promotes immune escape of GBM cells via upregulating PD-L1. Am J Cancer Res. 2019;9:1161-1171 pubmed
  • western blot; mouse; loading ...; fig 2b
Cai Y, Xue F, Qin H, Chen X, Liu N, Fleming C, et al. Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation. Cell Rep. 2019;27:3034-3048.e5 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, et al. PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:204 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Cheng Z, Lei Z, Yang P, Si A, Xiang D, Tang X, et al. Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways. Mol Carcinog. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig e2j
  • western blot; human; 1:1000; loading ...; fig 1f, e2a
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig e2i
  • western blot; mouse; 1:1000; loading ...; fig e2h
Shi Y, Gao W, Lytle N, Huang P, Yuan X, Dann A, et al. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019;569:131-135 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d
Udden S, Kwak Y, Godfrey V, Khan M, Khan S, Loof N, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5j
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed publisher
  • western blot; human; loading ...; fig 5d
Chen Z, Wang H, Wang S, Fan L, Feng S, Cai X, et al. USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells. J Clin Invest. 2019;130:2043-2055 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Wang E, Dai Z, Ferrante A, Drake C, Christiano A. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019;: pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2c
Souriant S, Balboa L, Dupont M, Pingris K, Kviatcovsky D, Cougoule C, et al. Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages. Cell Rep. 2019;26:3586-3599.e7 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 2b
  • western blot; human; 1:100; loading ...; fig 2b
Matozaki M, Saito Y, Yasutake R, Munira S, Kaibori Y, Yukawa A, et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance. Exp Cell Res. 2019;: pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3g
Cho J, Xu Z, Parthasarathy U, Drashansky T, Helm E, Zuniga A, et al. Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat Commun. 2019;10:701 pubmed publisher
  • western blot; mouse; 1:3000; loading ...
  • western blot; human; 1:3000; loading ...; fig 3b
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 1h
Stivala S, Codilupi T, Brkic S, Baerenwaldt A, Ghosh N, Hao Shen H, et al. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019;130:1596-1611 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1d
Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, et al. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. EMBO Mol Med. 2019;11: pubmed publisher
  • western blot; human; loading ...; fig 6a
Song J, Zhang X, Liao Z, Liang H, Chu L, Dong W, et al. 14-3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling. J Exp Clin Cancer Res. 2019;38:3 pubmed publisher
  • western blot; human; loading ...; fig 1c
Zhang J, Wang D, Wang L, Wang S, Roden A, Zhao H, et al. Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2019;316:L487-L497 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  • western blot; human; loading ...; fig 5a
Lee E, Ouzounova M, Piranlioglu R, Ma M, Guzel M, Marasco D, et al. The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20. Oncogene. 2019;38:469-482 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 6c
Maseda D, Banerjee A, Johnson E, Washington M, Kim H, Lau K, et al. mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation. Front Immunol. 2018;9:2954 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7c
Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4g, 7l
  • western blot; mouse; loading ...; fig 1c, 4f, s7d
  • western blot; human; loading ...; fig 1d
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2g
Goldie S, Cottle D, Tan F, Roslan S, Srivastava S, Brady R, et al. Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis. Cell Death Dis. 2018;9:1072 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 2d
Chuang H, Tsai C, Hsueh C, Tan T. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Chorzalska A, Morgan J, Ahsan N, Treaba D, Olszewski A, Petersen M, et al. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018;: pubmed publisher
  • immunohistochemistry; human; fig 5a
Song T, Nairismägi M, Laurensia Y, Lim J, Tan J, Li Z, et al. Oncogenic activation of STAT3 pathway drives PD-L1 expression in natural killer/T cell lymphoma. Blood. 2018;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4c
Poffenberger M, Metcalfe Roach A, Aguilar E, Chen J, Hsu B, Wong A, et al. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science. 2018;361:406-411 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
Xie H, Wang Y, Zhang H, Fan Q, Dai D, Zhuang L, et al. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. J Cell Mol Med. 2018;22:4985-4996 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Li R, Serrano J, Xing H, Lee T, Azizgolshani H, Zaman M, et al. Interstitial flow promotes macrophage polarization toward an M2 phenotype. Mol Biol Cell. 2018;29:1927-1940 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunohistochemistry; human
Lin J, Izar B, Wang S, Yapp C, Mei S, Shah P, et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. elife. 2018;7: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 6a
  • western blot; human; fig 5c
Song J, Zhang X, Ge Q, Yuan C, Chu L, Liang H, et al. CRISPR/Cas9-mediated knockout of HBsAg inhibits proliferation and tumorigenicity of HBV-positive hepatocellular carcinoma cells. J Cell Biochem. 2018;119:8419-8431 pubmed publisher
  • western blot; human; loading ...; fig 2a
Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s6h, s14f, s15g
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig s17b
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1d
Ng S, Yoshida N, Christie A, Ghandi M, Dharia N, Dempster J, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018;9:2024 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s5a
Park J, Kim I, Choi J, Lim H, Shin J, Kim Y, et al. AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development. Mol Cancer Res. 2018;16:1287-1298 pubmed publisher
  • western blot; human; fig 7a
Toosi B, El Zawily A, Truitt L, Shannon M, Allonby O, Babu M, et al. EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours. Oncogene. 2018;37:4073-4093 pubmed publisher
  • western blot; mouse; fig 3a
Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk U, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018;9:1352 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • immunocytochemistry; mouse; 1:120; loading ...; fig 6b
  • western blot; mouse; 1:2000; loading ...; fig 6a
Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, et al. Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proc Natl Acad Sci U S A. 2018;115:E2801-E2810 pubmed publisher
  • western blot; human; loading ...; fig 2c
Kulling P, Olson K, Hamele C, Toro M, Tan S, Feith D, et al. Dysregulation of the IFN-?-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLoS ONE. 2018;13:e0193429 pubmed publisher
  • immunocytochemistry; mouse; 1 ug/ml; loading ...; fig s2g
Campana L, Starkey Lewis P, Pellicoro A, Aucott R, Man J, O Duibhir E, et al. The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury. J Immunol. 2018;200:1169-1187 pubmed publisher
  • western blot; mouse; loading ...; fig 4d
He P, Yang J, Yang V, Bialkowska A. Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. Gastroenterology. 2018;154:1494-1508.e13 pubmed publisher
  • western blot; mouse; 1:1000; fig 4c
Xu S, Zhou Z, Li H, Liu Z, Pan X, Wang F, et al. BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis. J Cell Sci. 2018;131: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4c
Oldrini B, Hsieh W, Erdjument Bromage H, Codega P, Carro M, Curiel García A, et al. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017;8:2035 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Kim M, Morales L, Baek M, Slaga T, DiGiovanni J, Kim D. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3? axis inhibits keratinocyte survival and proliferation. Oncotarget. 2017;8:90674-90692 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig s1
Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa T. Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes. Mol Biol Cell. 2018;29:209-219 pubmed publisher
  • western blot; mouse; loading ...; fig s10c
Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
  • western blot; human; loading ...; fig 4b
Penafuerte C, Feldhammer M, Mills J, Vinette V, Pike K, Hall A, et al. Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFN? signaling. Oncoimmunology. 2017;6:e1321185 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 6a
Laviolette L, Mermoud J, Calvo I, Olson N, Boukhali M, Steinlein O, et al. Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein. Nat Commun. 2017;8:15866 pubmed publisher
  • western blot; mouse; loading ...; fig s17c
Ip W, Hoshi N, Shouval D, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356:513-519 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s6c
Ge Y, Gomez N, Adam R, Nikolova M, Yang H, Verma A, et al. Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. Cell. 2017;169:636-650.e14 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 7f
  • western blot; mouse; fig 1f
Lee H, Kim M, Baek M, Morales L, Jang I, Slaga T, et al. Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development. Sci Rep. 2017;7:45077 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 1c
  • western blot; human; 1:1000; loading ...; fig 4c
Ram R, Brasch H, Dunne J, Davis P, Tan S, Itinteang T. The Identification of Three Cancer Stem Cell Subpopulations within Moderately Differentiated Lip Squamous Cell Carcinoma. Front Surg. 2017;4:12 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s6a
Kerins M, Vashisht A, Liang B, Duckworth S, Praslicka B, WOHLSCHLEGEL J, et al. Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig 7A
Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS ONE. 2017;12:e0173661 pubmed publisher
  • western blot; mouse; 1:2000; fig 9b
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1d
Ma J, Sanchez B, Hall D, Tremblay A, Di Marco S, Gallouzi I. STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner. EMBO Mol Med. 2017;9:622-637 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 3a
Basu R, Wu S, Kopchick J. Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways. Oncotarget. 2017;8:21579-21598 pubmed publisher
  • western blot; mouse; loading ...; fig 8b
Conaway E, de Oliveira D, McInnis C, Snapper S, Horwitz B. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017;198:2906-2915 pubmed publisher
  • western blot; human; loading ...; fig 5a
Radder J, Zhang Y, Gregory A, Yu S, Kelly N, Leader J, et al. Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med. 2017;196:159-171 pubmed publisher
  • western blot; human; loading ...; fig s9d
He Y, Wang X, Zhang J, Liu Z, Pan W, Shen Y, et al. Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs. Arterioscler Thromb Vasc Biol. 2017;37:717-729 pubmed publisher
  • western blot; human; loading ...; fig s7b
Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, et al. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Sci Rep. 2017;7:41434 pubmed publisher
  • western blot; human; loading ...; fig s8a
  • western blot; mouse; fig s8a
Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, et al. Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia. 2017;31:1502-1512 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 7b
  • western blot; mouse; 1:1000; loading ...; fig 7a
Cho K, Yoon D, Qiu S, Danziger Z, Grill W, Wetsel W, et al. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Dis Model Mech. 2017;10:559-579 pubmed publisher
  • western blot; mouse; 1:2000; fig s7a
Kechele D, Blue R, Zwarycz B, Espenschied S, Mah A, Siegel M, et al. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017;127:593-607 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig st2
Liu W, Liu J, Xia J, Xue X, Wang H, Qi Z, et al. Leptin receptor knockout-induced depression-like behaviors and attenuated antidepressant effects of exercise are associated with STAT3/SOCS3 signaling. Brain Behav Immun. 2017;61:297-305 pubmed publisher
  • western blot; mouse; 1:400; loading ...; fig 3c
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed publisher
  • western blot; human; loading ...; fig 3b
Wang M, Li G, Yang Z, Wang L, Zhang L, Wang T, et al. Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer. Oncotarget. 2017;8:8083-8094 pubmed publisher
  • western blot; human; loading ...; fig 2a
Zhu F, Hwang B, Miyamoto S, Rui L. Nuclear Import of JAK1 Is Mediated by a Classical NLS and Is Required for Survival of Diffuse Large B-cell Lymphoma. Mol Cancer Res. 2017;15:348-357 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
  • western blot; mouse; 1:1000; loading ...; fig 3a
Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 3
Koh S, On N, Brasch H, Chibnall A, Armstrong J, Davis P, et al. Embryonic Stem Cell-like Population in Dupuytren's Disease. Plast Reconstr Surg Glob Open. 2016;4:e1064 pubmed
  • flow cytometry; human
  • western blot; human; loading ...; fig 5j
  • immunohistochemistry - paraffin section; mouse; fig 3c
  • western blot; mouse; loading ...; fig 6e
Ganta V, Choi M, Kutateladze A, Annex B. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circ Res. 2017;120:282-295 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6a
Jayakumar A, Curtis K, Panickar K, Shamaladevi N, Norenberg M. Decreased STAT3 Phosphorylation Mediates Cell Swelling in Ammonia-Treated Astrocyte Cultures. Biology (Basel). 2016;5: pubmed
  • western blot; human; 1:1000; loading ...; fig s4
Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget. 2017;8:1304-1320 pubmed publisher
  • western blot; human; fig 5a
Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, et al. The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network. Oncogene. 2017;36:2655-2666 pubmed publisher
  • western blot; human; loading ...; fig 1a
Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2c
Mosteiro L, Pantoja C, Alcazar N, Marion R, Chondronasiou D, Rovira M, et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science. 2016;354: pubmed
  • western blot; mouse; loading ...; fig 6d
Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Wang R, Zhang Y, Xu L, Lin Y, Yang X, Bai L, et al. Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice. Sci Rep. 2016;6:36790 pubmed publisher
  • western blot; human; 1:1000; fig 5a
Pandey R, Mehrotra S, Sharma S, Gudde R, Sundar S, Shaha C. Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite Survival. Front Immunol. 2016;7:456 pubmed
  • western blot; human; loading ...; fig 5a
Sikander M, Hafeez B, Malik S, Alsayari A, Halaweish F, Yallapu M, et al. Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer. Sci Rep. 2016;6:36594 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 8i
  • western blot; human; loading ...; fig 6j
Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello Grand M, et al. MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. J Clin Invest. 2016;126:4585-4602 pubmed publisher
  • western blot; human; loading ...; fig 2b
Berthenet K, Bokhari A, Lagrange A, Marcion G, Boudesco C, Causse S, et al. HSP110 promotes colorectal cancer growth through STAT3 activation. Oncogene. 2017;36:2328-2336 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 9a
He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  • immunohistochemistry - paraffin section; human
Southworth T, Plumb J, Gupta V, Pearson J, Ramis I, Lehner M, et al. Anti-inflammatory potential of PI3K? and JAK inhibitors in asthma patients. Respir Res. 2016;17:124 pubmed
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 7a
Willi M, Yoo K, Wang C, Trajanoski Z, Hennighausen L. Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation. Nucleic Acids Res. 2016;44:10277-10291 pubmed
  • western blot; mouse; loading ...; fig 6a
Svoronos N, Perales Puchalt A, Allegrezza M, Rutkowski M, Payne K, Tesone A, et al. Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer Discov. 2017;7:72-85 pubmed publisher
  • western blot; human; loading ...; fig 4
Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher
  • western blot; mouse; fig 2
Sakamoto K, Wehde B, Rädler P, Triplett A, Wagner K. Generation of Janus kinase 1 (JAK1) conditional knockout mice. Genesis. 2016;54:582-588 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig s2a
Garfield A, Shah B, Burgess C, Li M, Li C, Steger J, et al. Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci. 2016;19:1628-1635 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 8a
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1b
BRADSHAW A, Wickremesekera A, Brasch H, Chibnall A, Davis P, Tan S, et al. Cancer Stem Cells in Glioblastoma Multiforme. Front Surg. 2016;3:48 pubmed publisher
  • western blot; human; loading ...; fig 6d
Deng Y, Cheng J, Fu B, Liu W, Chen G, Zhang Q, et al. Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells. Oncogene. 2017;36:1090-1101 pubmed publisher
  • western blot; human
Agatheeswaran S, Pattnayak N, Chakraborty S. Identification and functional characterization of the miRNA-gene regulatory network in chronic myeloid leukemia lineage negative cells. Sci Rep. 2016;6:32493 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s8
  • western blot; mouse; fig 3
Vikram A, Kim Y, Kumar S, Li Q, Kassan M, JACOBS J, et al. Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Nat Commun. 2016;7:12565 pubmed publisher
  • western blot; human; loading ...; fig 4b
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed publisher
  • western blot; mouse; loading ...; fig 7h
Ratsimandresy R, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol. 2017;14:127-142 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6
  • western blot; human; 1:500; fig 5
  • western blot; mouse; 1:500; fig 4
Peda J, Salah S, Wallace D, Fields P, Grantham C, Fields T, et al. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 2016;9:1051-61 pubmed publisher
  • immunohistochemistry; mouse; fig s1
Ashizawa T, Iizuka A, Nonomura C, Kondou R, Maeda C, Miyata H, et al. Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse. Clin Cancer Res. 2017;23:149-158 pubmed publisher
  • western blot; human; 1:1000; fig 3
Jiang S, Gao Y, Hou W, Liu R, Qi X, Xu X, et al. Sinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway. Oncol Lett. 2016;12:1380-1386 pubmed
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5a
  • western blot; human; 1:1000
Metz H, Kargl J, Busch S, Kim K, Kurland B, Abberbock S, et al. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proc Natl Acad Sci U S A. 2016;113:8795-800 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; human; fig 3
Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, et al. Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Sci Rep. 2016;6:29588 pubmed publisher
  • western blot; human; fig 2
Harwardt T, Lukas S, Zenger M, Reitberger T, Danzer D, Übner T, et al. Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathog. 2016;12:e1005748 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 8
  • western blot; mouse; 1:500; fig 7D
Liu S, Li Q, Zhang M, Mao Ying Q, Hu L, Wu G, et al. Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. Sci Rep. 2016;6:28956 pubmed publisher
  • immunohistochemistry; mouse; 1:100; tbl 1
Park K, Luo X, Mooney S, Yungher B, Belin S, Wang C, et al. Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats. J Comp Neurol. 2017;525:380-388 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • western blot; human; loading ...; fig 6d
Zheng X, Xu M, Yao B, Wang C, Jia Y, Liu Q. IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment. Cell Signal. 2016;28:1314-24 pubmed publisher
  • western blot; mouse; fig 5
Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher
  • western blot; human; 1:1000; fig 5d
Beck D, Zobel J, Barber R, Evans S, Lezina L, Allchin R, et al. Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. J Biol Chem. 2016;291:16686-98 pubmed publisher
  • western blot; human; fig 1c
Hendrayani S, Al Harbi B, Al Ansari M, Silva G, Aboussekhra A. The inflammatory/cancer-related IL-6/STAT3/NF-?B positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts. Oncotarget. 2016;7:41974-41985 pubmed publisher
  • western blot; mouse; fig 7
Park J, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, et al. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids. PLoS ONE. 2016;11:e0156334 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 7a
Yang X, Lin Y, Shi Y, Li B, Liu W, Yin W, et al. FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. Cancer Res. 2016;76:4124-35 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100; loading ...
Wang L, Hou S, Han Y. Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci. 2016;19:888-96 pubmed publisher
  • western blot; human; loading ...; fig 5c
  • western blot; mouse; loading ...; fig s6
Sun F, Zhang Z, Tan E, Lim Z, Li Y, Wang X, et al. Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice. Carcinogenesis. 2016;37:701-711 pubmed publisher
  • western blot; mouse; fig 5
Krausgruber T, Schiering C, Adelmann K, Harrison O, Chomka A, Pearson C, et al. T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine. Nat Commun. 2016;7:11627 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Cant Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed publisher
  • western blot; pigs ; 1:1000; fig 2
  • western blot; mouse; 1:1000; fig 2
  • western blot; human; 1:1000; fig 2
Hou D, Jin Y, Nie X, Zhang M, Ta N, Zhao L, et al. Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos. Sci Rep. 2016;6:25838 pubmed publisher
  • western blot; human; fig 6
Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, et al. Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer. Sci Rep. 2016;6:25447 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Li X, Zhou Z, Zhang Y, Yang H. IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse. PLoS ONE. 2016;11:e0154677 pubmed publisher
  • western blot; human; loading ...; fig 4a
Wang W, Zhan M, Li Q, Chen W, Chu H, Huang Q, et al. FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. Oncotarget. 2016;7:34617-29 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Peng J, Wang Q, Liu H, Ye M, Wu X, Guo L. EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway. Tumour Biol. 2016;37:11959-11971 pubmed
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1g
Baillie R, Itinteang T, Yu H, Brasch H, Davis P, Tan S. Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma. J Clin Pathol. 2016;69:742-4 pubmed publisher
  • western blot; mouse; 1:200; fig 3
Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  • western blot; mouse; fig 3
Nagashima H, Okuyama Y, Hayashi T, Ishii N, So T. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. J Immunol. 2016;196:4082-9 pubmed publisher
  • western blot; mouse; 1:1000; fig 9
Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, et al. FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Nat Commun. 2016;7:11314 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 4a
  • western blot; human; fig 2a
Lin A, Wang G, Zhao H, Zhang Y, Han Q, Zhang C, et al. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. Oncoimmunology. 2016;5:e1074376 pubmed
  • immunohistochemistry - frozen section; mouse; fig 3
Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed publisher
  • western blot; human; loading ...; fig 7
Rorsman C, Tsioumpekou M, Heldin C, Lennartsson J. The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem. 2016;291:11608-18 pubmed publisher
  • flow cytometry; mouse; fig 2a
Taylor P, Roy S, Meszaros E, Sun Y, Howell S, Malemud C, et al. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. J Leukoc Biol. 2016;100:213-22 pubmed publisher
  • western blot; mouse; fig 5
Yadav P, Selvaraj B, Bender F, Behringer M, Moradi M, Sivadasan R, et al. Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling. Acta Neuropathol. 2016;132:93-110 pubmed publisher
  • western blot; human; fig 5
Huang J, Yao C, Chuang S, Yeh C, Lee L, Chen R, et al. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction. BMC Cancer. 2016;16:245 pubmed publisher
  • western blot; human; fig 4
Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne P, Kim E, et al. Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma. Oncotarget. 2016;7:24018-26 pubmed publisher
  • western blot; human; fig 6
Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig s7
Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, et al. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Sci Rep. 2016;6:22996 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:25; fig s1
Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed publisher
  • western blot; human; loading ...; fig 3f
Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Antony A, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, et al. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun. 2016;7:10955 pubmed publisher
  • western blot; mouse; 1:1000; fig s8
Wang W, Jossin Y, Chai G, Lien W, Tissir F, Goffinet A. Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling. Nat Commun. 2016;7:10936 pubmed publisher
  • western blot; mouse; fig s3
Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531:53-8 pubmed publisher
  • western blot; mouse; 1:2000; fig 7
Nikolakopoulou A, Koeppen J, Garcia M, Leish J, Obenaus A, Ethell I. Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury. ASN Neuro. 2016;8:1-18 pubmed publisher
  • western blot; human; loading ...; fig 3g
Lee D, Wang Y, Kalaitzidis D, Ramachandran J, Eda H, Sykes D, et al. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016;126:1300-10 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5
  • western blot; mouse; 1:500; fig 1
Kabra D, Pfuhlmann K, García Cáceres C, Schriever S, Casquero García V, Kebede A, et al. Hypothalamic leptin action is mediated by histone deacetylase 5. Nat Commun. 2016;7:10782 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5c
  • western blot; human; loading ...; fig 3c, 5a
Eichten A, Su J, Adler A, Zhang L, Ioffe E, Parveen A, et al. Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade. Cancer Res. 2016;76:2327-39 pubmed publisher
  • western blot; mouse; 1:2000; tbl 2
Carbognin E, Betto R, Soriano M, Smith A, Martello G. Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency. EMBO J. 2016;35:618-34 pubmed publisher
  • western blot; human; fig 1
Kulbe H, Iorio F, Chakravarty P, Milagre C, Moore R, Thompson R, et al. Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells. Oncotarget. 2016;7:15648-61 pubmed publisher
  • western blot; mouse; fig s5
Krause C, Popp O, Thirunarayanan N, Dittmar G, Lipp M, Müller G. MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR. Oncotarget. 2016;7:10414-32 pubmed publisher
  • western blot; human; loading ...; fig 5a
Derangère V, Fumet J, Boidot R, Bengrine L, Limagne E, Chevriaux A, et al. Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?. Oncotarget. 2016;7:9309-21 pubmed publisher
  • western blot; bovine; 1:1000; fig 3
Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3b
  • western blot; mouse; 1:2000; loading ...; fig 4d
Hackett A, Lee D, Dawood A, Rodriguez M, Funk L, Tsoulfas P, et al. STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. Neurobiol Dis. 2016;89:10-22 pubmed publisher
  • western blot; rat; fig 8
Iorga A, Li J, Sharma S, Umar S, Bopassa J, Nadadur R, et al. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. J Am Heart Assoc. 2016;5: pubmed publisher
  • immunohistochemistry; human; 1:50; tbl 2
Menter T, Dickenmann M, Juskevicius D, Steiger J, Dirnhofer S, Tzankov A. Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling. Hematol Oncol. 2017;35:187-197 pubmed publisher
  • western blot; human; fig 2
Ikeda S, Kitadate A, Ito M, Abe F, Nara M, Watanabe A, et al. Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma. Oncotarget. 2016;7:13563-74 pubmed publisher
  • western blot; mouse; fig 1
Cherepkova M, Sineva G, Pospelov V. Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway. Cell Death Dis. 2016;7:e2050 pubmed publisher
  • immunohistochemistry; human; 1:25; fig e5
Shu S, Lin C, He H, Witwicki R, Tabassum D, Roberts J, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016;529:413-417 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Hammoud A, Kirstein N, Mournetas V, Darracq A, Broc S, Blanchard C, et al. Murine Embryonic Stem Cell Plasticity Is Regulated through Klf5 and Maintained by Metalloproteinase MMP1 and Hypoxia. PLoS ONE. 2016;11:e0146281 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7b
Yue X, Zhao Y, Zhang C, Li J, Liu Z, Liu J, et al. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. Oncotarget. 2016;7:3777-90 pubmed publisher
  • western blot; human; fig 6
  • western blot; mouse; fig 6
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126:495-508 pubmed
  • western blot; human; fig 1c
  • flow cytometry; mouse
  • immunoprecipitation; mouse; fig 2a
  • western blot; mouse; fig 1a
Ulaganathan V, Sperl B, Rapp U, Ullrich A. Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site. Nature. 2015;528:570-4 pubmed publisher
  • western blot; human; fig s5
Dorosz S, Ginolhac A, Kähne T, Naumann M, Sauter T, Salsmann A, et al. Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells. Mediators Inflamm. 2015;2015:737310 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 4
Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama Y, et al. Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. Cancer Sci. 2016;107:123-32 pubmed publisher
  • western blot; mouse; fig 4a
Dinh C, Szabo A, Yu Y, Camer D, Wang H, Huang X. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352 pubmed publisher
  • western blot; mouse; fig 3
Diersch S, Wirth M, Schneeweis C, Jörs S, Geisler F, Siveke J, et al. Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene. 2016;35:3880-6 pubmed publisher
  • western blot; mouse; fig 1
Wen Q, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider R, et al. Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nat Med. 2015;21:1473-80 pubmed publisher
  • western blot; human; fig s2
Chinyengetere F, Sekula D, Lu Y, Giustini A, Sanglikar A, Kawakami M, et al. Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas. BMC Cancer. 2015;15:886 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Chen S, Chen Y, Chen B, Cai Y, Zou Z, Wang J, et al. Plumbagin Ameliorates CCl 4 -Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:645727 pubmed publisher
  • western blot; human; 1:1000; fig 4d
Jia D, Tan Y, Liu H, Ooi S, Li L, Wright K, et al. Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo. Oncotarget. 2016;7:771-85 pubmed publisher
  • western blot; human; fig 6g
Rohnalter V, Roth K, Finkernagel F, Adhikary T, Obert J, Dorzweiler K, et al. A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype. Oncotarget. 2015;6:40005-25 pubmed publisher
  • western blot; rat; fig 4
Asano S, Arvapalli R, Manne N, Maheshwari M, Ma B, Rice K, et al. Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction. Int J Nanomedicine. 2015;10:6215-25 pubmed publisher
  • western blot; human; fig 3
Mehner C, Oberg A, Kalli K, Nassar A, Hockla A, Pendlebury D, et al. Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers. Oncotarget. 2015;6:35737-54 pubmed publisher
  • western blot; human; fig 2
Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, et al. Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget. 2015;6:33165-77 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:300
Moravcová S, Červená K, Pačesová D, Bendová Z. Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide. J Neurosci Res. 2016;94:99-108 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
Aparicio Domingo P, Romera Hernandez M, Karrich J, Cornelissen F, Papazian N, Lindenbergh Kortleve D, et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. J Exp Med. 2015;212:1783-91 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig s10a
  • western blot; mouse; 1:1000; fig s6b
  • immunohistochemistry - paraffin section; human; 1:500; fig s11h
Mazur P, Herner A, Mello S, Wirth M, Hausmann S, Sánchez Rivera F, et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015;21:1163-71 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 7
  • immunocytochemistry; mouse; 1:200; fig 5
  • immunohistochemistry; mouse; 1:200; fig 4
Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  • western blot; human
He D, Chen H, Muramatsu H, Lasek A. Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. J Neurochem. 2015;135:508-21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:80; fig 1a
Pencik J, Schlederer M, Gruber W, Unger C, Walker S, Chalaris A, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 2015;6:7736 pubmed publisher
  • western blot; mouse; 1:1000; fig 7a
He C, Medley S, Hu T, Hinsdale M, Lupu F, Virmani R, et al. PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun. 2015;6:7770 pubmed publisher
  • western blot; human; fig 8
Pitari M, Rossi M, Amodio N, Botta C, Morelli E, Federico C, et al. Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts. Oncotarget. 2015;6:27343-58 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Binder Gallimidi A, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein A, et al. Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6:22613-23 pubmed
  • immunohistochemistry; human; 1:50; loading ...; fig 1c
Choi E, Byeon S, Kim S, Lee H, Kwon H, Ahn H, et al. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PLoS ONE. 2015;10:e0130839 pubmed publisher
  • western blot; human; fig 4
Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 5
  • western blot; mouse; fig 5
Castillo Lluva S, Hontecillas Prieto L, Blanco Gómez A, Del Mar Sáez Freire M, García Cenador B, García Criado J, et al. A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development. Oncogene. 2015;34:4777-90 pubmed publisher
  • western blot; human; fig 1
Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed
  • western blot; mouse; 1:1000
Gopinathan G, Milagre C, Pearce O, Reynolds L, Hodivala Dilke K, Leinster D, et al. Interleukin-6 Stimulates Defective Angiogenesis. Cancer Res. 2015;75:3098-107 pubmed publisher
  • immunohistochemistry; human; 1:50; tbl 3
Tzankov A, Leu N, Muenst S, Juskevicius D, Klingbiel D, Mamot C, et al. Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study. J Hematol Oncol. 2015;8:70 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400
Andreasen S, Therkildsen M, Grauslund M, Friis Hansen L, Wessel I, Homøe P. Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gland. APMIS. 2015;123:706-15 pubmed publisher
  • western blot; human; 1:250
Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 3
  • western blot; human; 1:1000; fig 3
Zucha M, Wu A, Lee W, Wang L, Lin W, Yuan C, et al. Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer. Oncotarget. 2015;6:13255-68 pubmed
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse; 1:200; fig 2
Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, et al. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS ONE. 2015;10:e0127942 pubmed publisher
  • immunohistochemistry; human; fig 2
Eriksson P, Aine M, Veerla S, Liedberg F, Sjödahl G, Höglund M. Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems. BMC Med Genomics. 2015;8:25 pubmed publisher
  • flow cytometry; mouse
Palla A, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez López G, et al. The pluripotency factor NANOG promotes the formation of squamous cell carcinomas. Sci Rep. 2015;5:10205 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
Pan D, Jiang C, Ma Z, Blonska M, You M, Lin X. MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression. Oncogene. 2016;35:919-28 pubmed publisher
  • western blot; human; 1:2000; fig 4
Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE. 2015;10:e0126159 pubmed publisher
  • western blot; human; 1:1000; fig 3
  • western blot; mouse; 1:1000; fig 5
Mendonsa A, Chalfant M, Gorden L, VanSaun M. Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells. PLoS ONE. 2015;10:e0126686 pubmed publisher
  • western blot; rat; fig s4
Bhushan S, Tchatalbachev S, Lu Y, Fröhlich S, Fijak M, Vijayan V, et al. Differential activation of inflammatory pathways in testicular macrophages provides a rationale for their subdued inflammatory capacity. J Immunol. 2015;194:5455-64 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; fig 3
He Q, Yi H, Yi H, Xiao T, Qu J, Yuan L, et al. Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling. Oncotarget. 2015;6:16422-36 pubmed
  • western blot; human; 1:1000; fig 4
Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey M, et al. The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Front Microbiol. 2015;6:280 pubmed publisher
  • western blot; human; fig 6
Gupta J, Igea A, Papaioannou M, López Casas P, Llonch E, Hidalgo M, et al. Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget. 2015;6:8539-51 pubmed
  • western blot; human; 1:1000; fig 4e; 4g
  • western blot; mouse; 1:1000; fig 1c
Minter M, Main B, Brody K, Zhang M, Taylor J, Crack P. Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro. J Neuroinflammation. 2015;12:71 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1b
Hansen M, Greibe E, Skovbjerg S, Rohde S, Kristensen A, Jensen T, et al. Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha. Cell Signal. 2015;27:1356-68 pubmed publisher
  • immunocytochemistry; human; 1:200
Fallahi Sichani M, Moerke N, Niepel M, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015;11:797 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig S4d
Lee D, Jeong J, Chun S, Chua S, Jo Y. Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons. Nat Commun. 2015;6:6618 pubmed publisher
  • flow cytometry; human; 1:200; loading ...; fig 6a
  • western blot; human; 1:2000; loading ...; fig S5a
Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher
  • western blot; human; 1:1000; fig 1
Hutchins A, Takahashi Y, Miranda Saavedra D. Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses. Sci Rep. 2015;5:9100 pubmed publisher
  • western blot; human; loading ...; fig 3a
Kong E, Sucic S, Monje F, Savalli G, Diao W, Khan D, et al. STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior. Sci Rep. 2015;5:9009 pubmed publisher
  • ELISA; rat; loading ...; fig 2c
  • western blot; rat; loading ...; fig 3a
  • ELISA; mouse; loading ...; fig 2d
  • western blot; mouse; loading ...; fig 3c
Valapala M, Edwards M, Hose S, Hu J, Wawrousek E, Lutty G, et al. βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes. Sci Rep. 2015;5:8755 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s2b
  • western blot; human; loading ...; fig s4d
  • immunohistochemistry; mouse; 1:100; loading ...; fig s1a
Grabner B, Schramek D, Mueller K, Moll H, Svinka J, Hoffmann T, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 2015;6:6285 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
Coorey N, Shen W, Zhu L, Gillies M. Differential Expression of IL-6/gp130 Cytokines, Jak-STAT Signaling and Neuroprotection After Müller Cell Ablation in a Transgenic Mouse Model. Invest Ophthalmol Vis Sci. 2015;56:2151-61 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4
Kodigepalli K, Nanjundan M. Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells. PLoS ONE. 2015;10:e0117464 pubmed publisher
  • western blot; human; fig 2a
Lu K, Fang X, Feng L, Jiang Y, Zhou X, Liu X, et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer Lett. 2015;359:250-8 pubmed publisher
  • western blot; mouse; 1:1000
Chandler R, Damrauer J, Raab J, Schisler J, Wilkerson M, Didion J, et al. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun. 2015;6:6118 pubmed publisher
  • western blot; human
Maliqueo M, Sundström Poromaa I, Vanky E, Fornes R, Benrick A, Åkerud H, et al. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692-700 pubmed publisher
  • western blot; human
Fiallos E, Judkins J, Matlaf L, Prichard M, DITTMER D, Cobbs C, et al. Human cytomegalovirus gene expression in long-term infected glioma stem cells. PLoS ONE. 2014;9:e116178 pubmed publisher
  • immunohistochemistry; mouse; fig 5
  • western blot; mouse; fig 5
Nikolaou K, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, et al. Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 2015;34:430-47 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Kong L, Wei J, Haider A, Liebelt B, Ling X, Conrad C, et al. Therapeutic targets in subependymoma. J Neuroimmunol. 2014;277:168-75 pubmed publisher
  • immunohistochemistry; rat
  • western blot; rat
Harris R, Apolzan J. Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. Physiol Behav. 2015;138:208-18 pubmed publisher
  • western blot; human; fig 3
Heynen G, Fonfara A, Bernards R. Resistance to targeted cancer drugs through hepatocyte growth factor signaling. Cell Cycle. 2014;13:3808-17 pubmed publisher
  • immunohistochemistry; mouse; 1:800
Dabydeen S, Kang K, Díaz Cruz E, Alamri A, Axelrod M, Bouker K, et al. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis. 2015;36:122-32 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 6
Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, et al. Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. Gastric Cancer. 2015;18:774-83 pubmed publisher
  • western blot; human
Guerrouahen B, Pasquier J, Kaoud N, Maleki M, Beauchamp M, Yasmeen A, et al. Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer. Mol Cancer Ther. 2014;13:3123-36 pubmed publisher
  • immunocytochemistry; human; 1:100
Itou J, Tanaka S, Sato F, Akiyama R, Kawakami Y, Toi M. An optical labeling-based proliferation assay system reveals the paracrine effect of interleukin-6 in breast cancer. Biochim Biophys Acta. 2015;1853:27-40 pubmed publisher
  • western blot; mouse; fig 3
Das L, Rosenjack J, Au L, Galle P, Hansen M, Cathcart M, et al. Hyper-inflammation and skin destruction mediated by rosiglitazone activation of macrophages in IL-6 deficiency. J Invest Dermatol. 2015;135:389-399 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50
  • western blot; mouse; 1:200
Bless E, Reddy T, Acharya K, Beltz B, Tetel M. Oestradiol and diet modulate energy homeostasis and hypothalamic neurogenesis in the adult female mouse. J Neuroendocrinol. 2014;26:805-16 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Kanagavelu S, Flores C, Termini J, Riveron R, Romero L, Chung K, et al. TIR-domain-containing adapter-inducing interferon-? (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Mucosal Immunol. 2015;8:296-306 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig 3
  • western blot; mouse; 1:1000; fig 1
Tyzack G, Sitnikov S, Barson D, Adams Carr K, Lau N, Kwok J, et al. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun. 2014;5:4294 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:80
Schlederer M, Mueller K, Haybaeck J, Heider S, Huttary N, Rosner M, et al. Reliable quantification of protein expression and cellular localization in histological sections. PLoS ONE. 2014;9:e100822 pubmed publisher
  • western blot; human; loading ...; fig 1e
Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, et al. Interferon-? acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J Biol Chem. 2014;289:23786-95 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 5
Stodden G, Lindberg M, King M, Paquet M, MacLean J, Mann J, et al. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015;34:2471-82 pubmed publisher
  • western blot; rat
Kopaliani I, Martin M, Zatschler B, Bortlik K, Müller B, Deussen A. Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta. Basic Res Cardiol. 2014;109:419 pubmed publisher
  • chromatin immunoprecipitation; mouse
  • western blot; mouse
Chong H, Chan J, Goh C, Gounko N, Luo B, Wang X, et al. Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice. Mol Ther. 2014;22:1593-604 pubmed publisher
  • western blot; mouse; 1:2000
Chucair Elliott A, Conrady C, Zheng M, Kroll C, Lane T, Carr D. Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells. Glia. 2014;62:1418-34 pubmed publisher
  • western blot; mouse
Assi H, Espinosa J, Suprise S, SOFRONIEW M, Doherty R, Zamler D, et al. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PLoS ONE. 2014;9:e96318 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000
Briggs D, Lockie S, Benzler J, Wu Q, Stark R, Reichenbach A, et al. Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice. Endocrinology. 2014;155:2411-22 pubmed publisher
  • western blot; human
Liu B, Cao Y, Huizinga T, Hafler D, Toes R. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014;44:2121-9 pubmed publisher
  • western blot; human
Waitkus M, Chandrasekharan U, Willard B, Tee T, Hsieh J, Przybycin C, et al. Signal integration and gene induction by a functionally distinct STAT3 phosphoform. Mol Cell Biol. 2014;34:1800-11 pubmed publisher
  • immunohistochemistry; mouse
Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, et al. Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-? in gastric tissue. Cancer Res. 2014;74:2642-51 pubmed publisher
  • western blot; human; 1:1,000
Gu L, Talati P, Vogiatzi P, Romero Weaver A, Abdulghani J, Liao Z, et al. Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation. Mol Cancer Ther. 2014;13:1246-58 pubmed publisher
  • western blot; human
Chang P, Wang T, Chang Y, Chu C, Lee C, Hsu H, et al. Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells. PLoS ONE. 2014;9:e88556 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • western blot; mouse
Delgado O, Batten K, Richardson J, Xie X, Gazdar A, Kaisani A, et al. Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clin Cancer Res. 2014;20:1610-22 pubmed publisher
  • western blot; human; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 5a
Bravard A, Vial G, Chauvin M, Rouille Y, Bailleul B, Vidal H, et al. FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell Commun Signal. 2014;12:4 pubmed publisher
  • flow cytometry; mouse
McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-? response and ROR?t localization. Eur J Immunol. 2014;44:1137-42 pubmed publisher
  • western blot; mouse; 1:1000
Taylor J, Minter M, Newman A, Zhang M, Adlard P, Crack P. Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease. Neurobiol Aging. 2014;35:1012-23 pubmed publisher
  • western blot; human
Koganti S, de la Paz A, Freeman A, Bhaduri McIntosh S. B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation. J Virol. 2014;88:516-24 pubmed publisher
  • western blot; mouse
Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • immunohistochemistry - paraffin section; human
Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, et al. Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ER?(+) tumorigenesis. Cell Death Differ. 2014;21:234-46 pubmed publisher
  • western blot; rat; 1:2000
Bloomer S, Kregel K, Brown K. Heat stress stimulates hepcidin mRNA expression and C/EBP? protein expression in aged rodent liver. Arch Gerontol Geriatr. 2014;58:145-52 pubmed publisher
  • western blot; human
Paugh B, Zhu X, Qu C, Endersby R, Diaz A, Zhang J, et al. Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res. 2013;73:6219-29 pubmed publisher
  • immunocytochemistry; human; fig 2
Zhao Y, Park S, Bagchi M, Taylor R, Katzenellenbogen B. The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization. Endocrinology. 2013;154:1349-60 pubmed publisher
  • western blot; human; fig 1a
Li Y, Deuring J, Peppelenbosch M, Kuipers E, de Haar C, van der Woude C. STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis. Mol Med. 2012;18:1412-9 pubmed publisher
  • immunohistochemistry; mouse
Syu L, El Zaatari M, Eaton K, Liu Z, Tetarbe M, Keeley T, et al. Transgenic expression of interferon-? in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol. 2012;181:2114-25 pubmed publisher
  • western blot; mouse
Freudenberg J, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, et al. Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity. Nucleic Acids Res. 2012;40:3364-77 pubmed publisher
  • immunohistochemistry; mouse
  • western blot; mouse
Sutherland J, Keightley R, Nixon B, Roman S, Robker R, Russell D, et al. Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation. J Cell Physiol. 2012;227:1188-98 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Caron E, Sachot C, Prevot V, Bouret S. Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J Comp Neurol. 2010;518:459-76 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100
Tripathi R, McTigue D. Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats. J Comp Neurol. 2008;510:129-44 pubmed publisher
Weber C, Zhou Y, Lee J, Looger L, Qian G, Ge C, et al. Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b. Science. 2020;368:303-306 pubmed publisher
Lu H, Kim S, Steelman A, Tracy K, Zhou B, Michaud D, et al. STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination. Proc Natl Acad Sci U S A. 2020;117:5430-5441 pubmed publisher
Lim R, Li L, Yong E, Chew N. STAT-3 regulation of CXCR4 is necessary for the prenylflavonoid Icaritin to enhance mesenchymal stem cell proliferation, migration and osteogenic differentiation. Biochim Biophys Acta Gen Subj. 2018;1862:1680-1692 pubmed publisher
Kim G, Shi G, Somlo D, Haataja L, Song S, Long Q, et al. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest. 2018;128:1125-1140 pubmed publisher
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein J, et al. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat Commun. 2018;9:299 pubmed publisher
Ollila S, Domènech Moreno E, Laajanen K, Wong I, Tripathi S, Pentinmikko N, et al. Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. J Clin Invest. 2018;128:402-414 pubmed publisher
Hummel T, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, et al. Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation. Mol Cell Biol. 2017;37: pubmed publisher
Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed publisher
Ma B, Zhu J, Tan J, Mao Y, Tang L, Shen C, et al. Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway. Am J Cancer Res. 2017;7:433-447 pubmed
Vanlandingham P, Nuno D, Quiambao A, Phelps E, Wassel R, Ma J, et al. Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017;58:2095-2105 pubmed publisher
LeBlanc M, Wang W, Chen X, Caberoy N, Guo F, Shen C, et al. Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy. J Exp Med. 2017;214:1029-1047 pubmed publisher
Coomans de Brachène A, Dif N, de Rocca Serra A, Bonnineau C, Velghe A, Larondelle Y, et al. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. FEBS Open Bio. 2017;7:414-423 pubmed publisher
Peng C, Zhang S, Lei L, Zhang X, Jia X, Luo Z, et al. Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis. Sci Rep. 2017;7:44172 pubmed publisher
Zhang X, Li J, Qin J, Cheng W, Zhu X, Gong F, et al. Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. J Lipid Res. 2017;58:895-906 pubmed publisher
Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, et al. IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting. Nat Commun. 2017;8:14607 pubmed publisher
Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
Kong F, Saldarriaga O, Spratt H, Osorio E, Travi B, Luxon B, et al. Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype. PLoS Pathog. 2017;13:e1006165 pubmed publisher
Han Y, Yue L, Wei M, Ren X, Shao Z, Zhang L, et al. Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis. PLoS ONE. 2017;12:e0166014 pubmed publisher
Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, et al. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. Oncogenesis. 2017;6:e294 pubmed publisher
Taniguchi K, Moroishi T, de Jong P, Krawczyk M, Grebbin B, Luo H, et al. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:1643-1648 pubmed publisher
Jahny E, Yang H, Liu B, Jahnke B, Lademann F, Knösel T, et al. The G Protein-Coupled Receptor RAI3 Is an Independent Prognostic Factor for Pancreatic Cancer Survival and Regulates Proliferation via STAT3 Phosphorylation. PLoS ONE. 2017;12:e0170390 pubmed publisher
Xie Y, Yu D, Wu J, Li L. Protective effects of physiological testosterone on advanced glycation end product?induced injury in human endothelial cells. Mol Med Rep. 2017;15:1165-1171 pubmed publisher
Smigiel J, Parameswaran N, Jackson M. Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer. Mol Cancer Res. 2017;15:478-488 pubmed publisher
Leidgens V, Proske J, Rauer L, Moeckel S, Renner K, Bogdahn U, et al. Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Oncotarget. 2017;8:8250-8263 pubmed publisher
Mateo F, Arenas E, Aguilar H, Serra Musach J, de Garibay G, Boni J, et al. Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Oncogene. 2017;36:2737-2749 pubmed publisher
Gan J, Ke X, Jiang J, Dong H, Yao Z, Lin Y, et al. Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signaling. Proc Natl Acad Sci U S A. 2016;113:14745-14750 pubmed publisher
Pratheeshkumar P, Son Y, Divya S, Wang L, Zhang Z, Shi X. Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism. Sci Rep. 2016;6:37227 pubmed publisher
Nakamura H, Nagasaka K, Kawana K, Taguchi A, Uehara Y, Yoshida M, et al. Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer. BMC Cancer. 2016;16:897 pubmed
Lindberg O, McKinney A, Engler J, Koshkakaryan G, Gong H, Robinson A, et al. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016;7:79101-79116 pubmed publisher
Jhan J, Andrechek E. Stat3 accelerates Myc induced tumor formation while reducing growth rate in a mouse model of breast cancer. Oncotarget. 2016;7:65797-65807 pubmed publisher
Ushiki T, Huntington N, Glaser S, Kiu H, Georgiou A, Zhang J, et al. Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells. PLoS ONE. 2016;11:e0162111 pubmed publisher
Martin Martin N, Piva M, Urosevic J, Aldaz P, Sutherland J, Fernandez Ruiz S, et al. Stratification and therapeutic potential of PML in metastatic breast cancer. Nat Commun. 2016;7:12595 pubmed publisher
Pan Y, Wang S, Su B, Zhou F, Xu T, Zhang R, et al. Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. Oncogene. 2017;36:1069-1079 pubmed publisher
Bucher F, Walz J, Bühler A, Aguilar E, Lange C, Diaz Aguilar S, et al. CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2016;57:4017-26 pubmed publisher
Bottos A, Gotthardt D, Gill J, Gattelli A, Frei A, Tzankov A, et al. Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nat Commun. 2016;7:12258 pubmed publisher
Minter M, Moore Z, Zhang M, Brody K, Jones N, Shultz S, et al. Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype. Acta Neuropathol Commun. 2016;4:72 pubmed publisher
Zhang M, Yin H, Wang W, Li J, Wang X. Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest. Acta Pharmacol Sin. 2016;37:1190-8 pubmed publisher
Mirzamohammadi F, Papaioannou G, Inloes J, Rankin E, Xie H, Schipani E, et al. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nat Commun. 2016;7:12047 pubmed publisher
Pratheeshkumar P, Son Y, Divya S, Turcios L, Roy R, Hitron J, et al. Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling. Oncotarget. 2016;7:51193-51210 pubmed publisher
Borges B, García Galiano D, Rorato R, Elias L, Elias C. PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia. Mol Metab. 2016;5:379-391 pubmed publisher
Gao L, Hong X, Guo X, Cao D, Gao X, DeLaney T, et al. Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis. Oncotarget. 2016;7:43557-43569 pubmed publisher
Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, et al. The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. Oncotarget. 2016;7:51096-51106 pubmed publisher
Xu D, Zhou P, Wang Y, Zhang L, Fu W, Ruan B, et al. Reciprocal activation between STAT3 and miR-181b regulates the proliferation of esophageal cancer stem-like cells via the CYLD pathway. Mol Cancer. 2016;15:40 pubmed publisher
Turpin J, Ling C, Crosby E, Hartman Z, Simond A, Chodosh L, et al. The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment. Oncogene. 2016;35:6053-6064 pubmed publisher
Wu P, Wu D, Zhao L, Huang L, Shen G, Huang J, et al. Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis. Oncotarget. 2016;7:19863-83 pubmed publisher
Ding X, Chaiteerakij R, Moser C, Shaleh H, Boakye J, Chen G, et al. Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells. Oncotarget. 2016;7:20080-92 pubmed publisher
Bachstetter A, Zhou Z, Rowe R, Xing B, Goulding D, Conley A, et al. MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses. PLoS ONE. 2016;11:e0149451 pubmed publisher
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product information
SKU :
9145S
Product-Name :
Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
301 USD
Species-x-Reactivity :
H, M, R, Mk, (Hm, B, Pg, Hr)
Applications :
Chromatin Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
79, 86
Host :
Rabbit
Target :
STAT3 (Tyr705) phosphate
Primary-Protein :
STAT3
Alt-Names :
APRF,Acute-phase response factor,DNA-binding protein APRF,FLJ20882,HIES,MGC16063,STAT3,Signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 (acute-phase response factor)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.