product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Stat3 (124H6) Mouse mAb
catalog :
9139
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
124H6
reactivity :
human, mouse, rat, bovine, pigs , domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - free floating section, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 283
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; loading ...; fig 1c
  • western blot knockout validation; mouse; 1:200; loading ...; fig 7a, 1b
Huang Z, Feng J, Feng X, Chan L, Lu J, Lei L, et al. Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitro. Cell Biosci. 2021;11:172 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Bahn M, Yu D, Lee M, Jo S, Lee J, Kim H, et al. Central role of Prominin-1 in lipid rafts during liver regeneration. Nat Commun. 2022;13:6219 pubmed publisher
  • western blot; mouse; loading ...; fig 9a
Song M, Cui X, Zhang J, Li Y, Li J, Zang Y, et al. Shenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155. Pharm Biol. 2022;60:2011-2024 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a, 2b
Ploeger C, Schreck J, Huth T, Fraas A, Albrecht T, Charbel A, et al. STAT1 and STAT3 Exhibit a Crosstalk and Are Associated with Increased Inflammation in Hepatocellular Carcinoma. Cancers (Basel). 2022;14: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s6b
Nataraj N, Noronha A, Lee J, Ghosh S, Mohan Raju H, Sekar A, et al. Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Cell Rep. 2022;38:110418 pubmed publisher
  • western blot; human; 1:1000; fig s7b
  • western blot; mouse; 1:1000; fig s2a
Araujo A, Abaurrea A, Azcoaga P, L xf3 pez Velazco J, Manzano S, Rodriguez J, et al. Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment. J Clin Invest. 2022;132: pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Zhang Y, Yuan P, Ma X, Deng Q, Gao J, Yang J, et al. Deletion of Smooth Muscle Lethal Giant Larvae 1 Promotes Neointimal Hyperplasia in Mice. Front Pharmacol. 2022;13:834296 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 1e
  • western blot; mouse; 1:1000; fig 1f
  • western blot; pigs ; 1:1000; loading ...; fig 10a
Liu N, Lin Y, Li L, Lu J, Geng D, Zhang J, et al. gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes. Commun Biol. 2022;5:64 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a, 5b
  • western blot; rat; 1:1000; loading ...; fig 5a
Liu Z, Qi M, Tian S, Yang Q, Liu J, Wang S, et al. Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway. Front Cell Dev Biol. 2021;9:806850 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Passman A, Strauss R, McSpadden S, Finch Edmondson M, Andrewartha N, Woo K, et al. Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; loading ...; fig 3a
Hsu H, Chen H, Tsai C, Liao P, Chan Y, Lee Y, et al. Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Gyamfi J, Yeo J, Kwon D, Min B, Cha Y, Koo J, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7:129 pubmed publisher
  • western blot; rat; fig 7a
Shi Y, Hu Y, Wang Y, Ma X, Tang L, Tao M, et al. Blockade of Autophagy Prevents the Development and Progression of Peritoneal Fibrosis. Front Pharmacol. 2021;12:724141 pubmed publisher
  • immunohistochemistry - free floating section; human; 1:500; fig 7g
  • immunocytochemistry; human; 1:100; fig 7e
  • western blot; human; 1:1000; fig 7c
Lo Cascio C, McNamara J, Melendez E, Lewis E, Dufault M, Sanai N, et al. Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells. JCI Insight. 2021;6: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 5a
  • western blot; mouse; 1:1000; loading ...; fig 5b
Peron M, Dinarello A, Meneghetti G, Martorano L, Betto R, Facchinello N, et al. Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation. Development. 2021;148: pubmed publisher
  • western blot; rat; 1:250; loading ...; fig s2a
Zavvarian M, Hong J, Khazaei M, Chio J, Wang J, Badner A, et al. The Protein Kinase Inhibitor Midostaurin Improves Functional Neurological Recovery and Attenuates Inflammatory Changes Following Traumatic Cervical Spinal Cord Injury. Biomolecules. 2021;11: pubmed publisher
  • western blot; mouse; loading ...; fig 4g
  • western blot; human; loading ...; fig 4c, 4d
Chen X, Miao M, Zhou M, Chen J, Li D, Zhang L, et al. Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell Death Dis. 2021;12:761 pubmed publisher
  • western blot; mouse; loading ...; fig 5k, s1l
Wei Y, Chen J, Xu X, Li F, Wu K, Jiang Y, et al. Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity-Related Properties. Adv Sci (Weinh). 2021;8:2004319 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs J, Wawrzyniak M, et al. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Yang S, He X, Zhao J, Wang D, Guo S, Gao T, et al. Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer. Cancer Commun (Lond). 2021;41:695-714 pubmed publisher
  • western blot; human; loading ...; fig 1a, 1i
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12:3651 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3h
Jiang H, Deng W, Zhu K, Zeng Z, Hu B, Zhou Z, et al. LINC00467 Promotes Prostate Cancer Progression via M2 Macrophage Polarization and the miR-494-3p/STAT3 Axis. Front Oncol. 2021;11:661431 pubmed publisher
  • western blot; mouse; loading ...; fig s2a
Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed publisher
  • western blot; human; loading ...; fig 6g, s11b
Liu Z, Li C, Zhang R, Wei D, Shang Y, Yong Y, et al. EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling. Mol Cancer. 2021;20:79 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s7a
Liu M, Rao H, Liu J, Li X, Feng W, Gui L, et al. The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol. 2021;43:102004 pubmed publisher
  • western blot; mouse; loading ...; fig 5s
Filppu P, Tanjore Ramanathan J, Granberg K, Gucciardo E, Haapasalo H, Lehti K, et al. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6: pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Geng G, Liu J, Xu C, Pei Y, Chen L, Mu C, et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. elife. 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, et al. Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cell Mol Gastroenterol Hepatol. 2021;12:633-651 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Melin N, Sánchez Taltavull D, Fahrner R, Keogh A, Dosch M, Büchi I, et al. Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Cell Death Dis. 2021;12:366 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e
Tsoi H, Man E, Chau K, Khoo U. Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Peng W, Chang M, Wu Y, Zhu W, Tong L, Zhang G, et al. Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway. Stem Cell Res Ther. 2021;12:216 pubmed publisher
  • western blot; mouse; loading ...; fig 7j
  • western blot; human; loading ...; fig 7p
Shen T, Liu J, Wang C, Rixiati Y, Li S, Cai L, et al. Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer. Signal Transduct Target Ther. 2021;6:115 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Zheng Z, Yang P, Luo W, Yu S, Xu H, Huang Y, et al. STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d, 4i
Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, et al. RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming. Nat Commun. 2021;12:1394 pubmed publisher
  • western blot; mouse; loading ...; fig 6a, 6b
Wang X, Zhao Y, Zhou D, Tian Y, Feng G, Lu Z. Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice. Cell Death Dis. 2021;12:212 pubmed publisher
  • western blot; human; loading ...; fig 6a
Wang H, Hou W, Perera A, Bettler C, Beach J, Ding X, et al. Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Cell Rep. 2021;34:108765 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Zhang W, Wang L, Sun X, Liu X, Xiao Y, Zhang J, et al. Toll-like receptor 5-mediated signaling enhances liver regeneration in mice. Mil Med Res. 2021;8:16 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s7
Jing C, Duan Y, Zhou M, Yue K, Zhuo S, Li X, et al. Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness. Theranostics. 2021;11:2655-2669 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 7b
Blanc V, Riordan J, Soleymanjahi S, Nadeau J, Nalbantoglu I, Xie Y, et al. Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer. J Clin Invest. 2021;131: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7a, 7c
Zhang K, Wang D, Cai H, Cao M, Zhang Y, Zhuang P, et al. IL‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer. Oncol Rep. 2021;45:1105-1117 pubmed publisher
  • western blot; human; loading ...; fig 4e
Chen H, Bian A, Yang L, Yin X, Wang J, Ti C, et al. Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. Oncogene. 2021;40:1440-1457 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Zhao J, Liu X, Chen Y, Zhang L, Zhang Y, Ji D, et al. STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway. Infect Immun. 2021;89: pubmed publisher
  • western blot; human; loading ...; fig 7a
Zhang G, Jiao Q, Shen C, Song H, Zhang H, Qiu Z, et al. Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer. Cancer Sci. 2021;112:997-1010 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Yue R, Wei X, Zhao J, Zhou Z, Zhong W. Essential Role of IFN-γ in Regulating Gut Antimicrobial Peptides and Microbiota to Protect Against Alcohol-Induced Bacterial Translocation and Hepatic Inflammation in Mice. Front Physiol. 2020;11:629141 pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig 1i
Drori A, Gammal A, Azar S, Hinden L, Hadar R, Wesley D, et al. CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance. elife. 2020;9: pubmed publisher
  • western blot; human; fig 4a
Talwar D, Messens J, Dick T. A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex. Nat Commun. 2020;11:4512 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Yeo S, Zhu X, Okamoto T, Hao M, Wang C, Lu P, et al. Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer. elife. 2020;9: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2c
  • western blot; mouse; 1:4000; loading ...; fig 2a, e1a, e1b, e1c
Reilly S, Hung C, Ahmadian M, Zhao P, Keinan O, Gomez A, et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020;2:620-634 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Zhao X, Guo W, Zou L, Hu B. FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells. Cancer Cell Int. 2020;20:245 pubmed publisher
  • western blot; human; loading ...; fig 6e
Liao T, Lin C, Jiang J, Yang S, Teng H, Yang M. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Theranostics. 2020;10:6095-6112 pubmed publisher
  • western blot; mouse; 1:400; loading ...; fig 4a
Walker E, Truong K, McGregor N, Poulton I, Isojima T, Gooi J, et al. Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1e
  • chromatin immunoprecipitation; human; loading ...; fig s5d
  • western blot; human; loading ...; fig s2a
Dmitrieva N, Walts A, Nguyen D, Grubb A, Zhang X, Wang X, et al. Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome. J Clin Invest. 2020;130:4167-4181 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Gallo S, Spilinga M, Albano R, Ferrauto G, Di Gregorio E, Casanova E, et al. Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro. Br J Pharmacol. 2020;177:3107-3122 pubmed publisher
  • western blot; human; loading ...; fig 1f
Hindupur S, Schmid S, Koch J, Youssef A, Baur E, Wang D, et al. STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy. Int J Mol Sci. 2020;21: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Meng X, Zhao Y, Han B, Zha C, Zhang Y, Li Z, et al. Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways. Nat Commun. 2020;11:594 pubmed publisher
  • western blot; human; loading ...; fig 3c
Dai E, Han L, Liu J, Xie Y, Kroemer G, Klionsky D, et al. Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein. Autophagy. 2020;:1-15 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5s1c
Martínez Fábregas J, Wilmes S, Wang L, Hafer M, Pohler E, Lokau J, et al. Kinetics of cytokine receptor trafficking determine signaling and functional selectivity. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7f, 8a, s14a
Sang Y, Li Y, Zhang Y, Alvarez A, Yu B, Zhang W, et al. CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. Nat Commun. 2019;10:4013 pubmed publisher
  • western blot; human; loading ...; fig 1b
Niu J, Sun Y, Chen B, Zheng B, Jarugumilli G, Walker S, et al. Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature. 2019;573:139-143 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2h
Xiao W, Wang L, Howard J, Kolhe R, Rojiani A, Rojiani M. TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC. Cancers (Basel). 2019;11: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4g
Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed publisher
  • western blot; mouse; fig 5g
Wang D, Zheng X, Fu B, Nian Z, Qian Y, Sun R, et al. Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. EBioMedicine. 2019;46:119-132 pubmed publisher
  • western blot; rat; loading ...; fig 1a
Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Wang S, Yao F, Lu X, Li Q, Su Z, Lee J, et al. Temozolomide promotes immune escape of GBM cells via upregulating PD-L1. Am J Cancer Res. 2019;9:1161-1171 pubmed
  • western blot; human; 1:1000; loading ...; fig s4
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, et al. PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:204 pubmed publisher
  • western blot; human; loading ...; fig 2a
Gao X, Liu X, Lu Y, Wang Y, Cao W, Liu X, et al. PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation. Breast Cancer. 2019;: pubmed publisher
  • western blot; human; loading ...; fig s1i
Nakanishi M, Mitchell R, Benoit Y, Orlando L, Reid J, Shimada K, et al. Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Cell. 2019;177:910-924.e22 pubmed publisher
  • western blot; human; loading ...; fig 5d
Chen Z, Wang H, Wang S, Fan L, Feng S, Cai X, et al. USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells. J Clin Invest. 2019;130:2043-2055 pubmed publisher
  • western blot; human; loading ...; fig s6b
Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6b
Derkach K, Zakharova I, Zorina I, Bakhtyukov A, Romanova I, Bayunova L, et al. The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect. PLoS ONE. 2019;14:e0213779 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
  • western blot; human; loading ...; fig 1c, 4b
Neel D, Allegakoen D, Olivas V, Mayekar M, Hemmati G, Chatterjee N, et al. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019;79:546-556 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7c
Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed publisher
  • western blot; human; loading ...; fig 1d
  • western blot; mouse; loading ...; fig 1c, 4f, s7d
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4e
Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
Xie H, Wang Y, Zhang H, Fan Q, Dai D, Zhuang L, et al. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. J Cell Mol Med. 2018;22:4985-4996 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Li R, Serrano J, Xing H, Lee T, Azizgolshani H, Zaman M, et al. Interstitial flow promotes macrophage polarization toward an M2 phenotype. Mol Biol Cell. 2018;29:1927-1940 pubmed publisher
  • western blot; human; loading ...; fig 3a
Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher
  • western blot; mouse; loading ...; fig 2a, s8h, s14e, s15f
  • western blot; human; loading ...; fig 4f
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s8e
  • western blot; human; loading ...; fig s8d
Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley L, et al. Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol. 2018;19:594-605 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 4b
Zhang Y, Cao Y, Zhang L, Feng C, Zhou G, Wen G. Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aR. Biosci Rep. 2018;38: pubmed publisher
  • western blot; human; loading ...; fig 5b
Kulling P, Olson K, Hamele C, Toro M, Tan S, Feith D, et al. Dysregulation of the IFN-?-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLoS ONE. 2018;13:e0193429 pubmed publisher
  • western blot; mouse; loading ...; fig s10c
Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
  • western blot; human; loading ...; fig 4b
Penafuerte C, Feldhammer M, Mills J, Vinette V, Pike K, Hall A, et al. Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFN? signaling. Oncoimmunology. 2017;6:e1321185 pubmed publisher
  • western blot; mouse; fig 1a
Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
  • western blot; mouse; fig 1f
Lee H, Kim M, Baek M, Morales L, Jang I, Slaga T, et al. Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development. Sci Rep. 2017;7:45077 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s6a
Kerins M, Vashisht A, Liang B, Duckworth S, Praslicka B, WOHLSCHLEGEL J, et al. Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; mouse; 1:2000; fig 9b
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  • western blot; mouse; 1:1500; loading ...; fig 4d
Ma J, Sanchez B, Hall D, Tremblay A, Di Marco S, Gallouzi I. STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner. EMBO Mol Med. 2017;9:622-637 pubmed publisher
  • western blot; mouse; loading ...; fig 2e
Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed publisher
  • western blot; human; loading ...; fig s8a
  • western blot; mouse; fig s8a
Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, et al. Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia. 2017;31:1502-1512 pubmed publisher
  • western blot; mouse; 1:1000; fig s7a
Kechele D, Blue R, Zwarycz B, Espenschied S, Mah A, Siegel M, et al. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017;127:593-607 pubmed publisher
  • western blot; mouse; loading ...; fig 9e
Fitter S, Matthews M, Martin S, Xie J, Ooi S, Walkley C, et al. mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 3b
Wang M, Li G, Yang Z, Wang L, Zhang L, Wang T, et al. Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer. Oncotarget. 2017;8:8083-8094 pubmed publisher
  • western blot; human; loading ...; fig 2a
Zhu F, Hwang B, Miyamoto S, Rui L. Nuclear Import of JAK1 Is Mediated by a Classical NLS and Is Required for Survival of Diffuse Large B-cell Lymphoma. Mol Cancer Res. 2017;15:348-357 pubmed publisher
  • western blot; human; loading ...; fig 3d
van Andel H, Ren Z, Koopmans I, Joosten S, Kocemba K, de Lau W, et al. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proc Natl Acad Sci U S A. 2017;114:376-381 pubmed publisher
  • western blot; rat; loading ...; fig 5a
Park S, Yoon S, Kang M, Lee Y, Jung S, Han J. Hippocalcin Promotes Neuronal Differentiation and Inhibits Astrocytic Differentiation in Neural Stem Cells. Stem Cell Reports. 2017;8:95-111 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 3d
  • western blot; human; 1:1000; loading ...; fig 3b
  • western blot; mouse; 1:1000; loading ...; fig 3a
Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget. 2017;8:1304-1320 pubmed publisher
  • western blot; human; fig 5a
Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, et al. The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network. Oncogene. 2017;36:2655-2666 pubmed publisher
  • western blot; human; loading ...; fig 1a
Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 8i
  • immunohistochemistry; human; loading ...; fig s11e
  • western blot; human; loading ...; fig 6j
Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello Grand M, et al. MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. J Clin Invest. 2016;126:4585-4602 pubmed publisher
  • western blot; human; loading ...; fig 2b
Berthenet K, Bokhari A, Lagrange A, Marcion G, Boudesco C, Causse S, et al. HSP110 promotes colorectal cancer growth through STAT3 activation. Oncogene. 2017;36:2328-2336 pubmed publisher
  • western blot; human; loading ...; fig 2a, 8a
Wang Z, Fan P, Zhao Y, Zhang S, Lu J, Xie W, et al. NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription. Cell Mol Life Sci. 2017;74:1117-1131 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2b
Garg N, Bakhshinyan D, Venugopal C, Mahendram S, Rosa D, Vijayakumar T, et al. CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence. Oncogene. 2017;36:606-617 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
Maachani U, Shankavaram U, Kramp T, Tofilon P, Camphausen K, Tandle A. FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells. Oncotarget. 2016;7:77365-77377 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 9a
He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  • western blot; mouse; loading ...; fig 6a
Svoronos N, Perales Puchalt A, Allegrezza M, Rutkowski M, Payne K, Tesone A, et al. Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer Discov. 2017;7:72-85 pubmed publisher
  • western blot; human; loading ...; fig 4
Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher
  • immunoprecipitation; mouse; fig 2
  • western blot; mouse; fig 2
Sakamoto K, Wehde B, Rädler P, Triplett A, Wagner K. Generation of Janus kinase 1 (JAK1) conditional knockout mice. Genesis. 2016;54:582-588 pubmed publisher
  • immunocytochemistry; human; fig 4e
  • western blot; human; fig 2a
  • western blot; mouse; fig 5f
Kim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisher
  • western blot; mouse; 1:1000; fig 3d
  • western blot; human; 1:1000; loading ...; fig 3
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
  • western blot; human
Agatheeswaran S, Pattnayak N, Chakraborty S. Identification and functional characterization of the miRNA-gene regulatory network in chronic myeloid leukemia lineage negative cells. Sci Rep. 2016;6:32493 pubmed publisher
  • western blot; human; loading ...; fig 4b
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed publisher
  • western blot; human; fig 10b
Liu L, Phua Y, Lee R, Ma X, Jenkins Y, Novy K, et al. Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases. J Biol Chem. 2016;291:21571-21583 pubmed
  • western blot; mouse; 1:1000; fig 4
  • western blot; human; 1:1000; fig 5
Peda J, Salah S, Wallace D, Fields P, Grantham C, Fields T, et al. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 2016;9:1051-61 pubmed publisher
  • western blot; human; 1:1000; fig 5e
Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
  • western blot; human; loading ...; fig 6d
Zheng X, Xu M, Yao B, Wang C, Jia Y, Liu Q. IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment. Cell Signal. 2016;28:1314-24 pubmed publisher
  • western blot; human; loading ...; fig 5c
  • western blot; mouse; loading ...; fig s6
Sun F, Zhang Z, Tan E, Lim Z, Li Y, Wang X, et al. Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice. Carcinogenesis. 2016;37:701-711 pubmed publisher
  • western blot; mouse; 1:1000; fig s3
Moshfegh C, Aires L, Kisielow M, Vogel V. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep. 2016;6:25104 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Li X, Zhou Z, Zhang Y, Yang H. IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse. PLoS ONE. 2016;11:e0154677 pubmed publisher
  • western blot; mouse; 1:2000; fig 4
Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  • western blot; human; fig 6
  • western blot; mouse; fig 3
Nagashima H, Okuyama Y, Hayashi T, Ishii N, So T. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. J Immunol. 2016;196:4082-9 pubmed publisher
  • western blot; human; fig 2a
Lin A, Wang G, Zhao H, Zhang Y, Han Q, Zhang C, et al. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. Oncoimmunology. 2016;5:e1074376 pubmed
  • immunocytochemistry; mouse; fig 7
  • western blot; mouse; fig 5
Yadav P, Selvaraj B, Bender F, Behringer M, Moradi M, Sivadasan R, et al. Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling. Acta Neuropathol. 2016;132:93-110 pubmed publisher
  • western blot; human; fig 6
Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher
  • western blot; mouse; fig s3
Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531:53-8 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 4
  • western blot; mouse; 1:2000; fig 1
Kabra D, Pfuhlmann K, García Cáceres C, Schriever S, Casquero García V, Kebede A, et al. Hypothalamic leptin action is mediated by histone deacetylase 5. Nat Commun. 2016;7:10782 pubmed publisher
  • western blot; human; loading ...; fig 3c, 5a
Eichten A, Su J, Adler A, Zhang L, Ioffe E, Parveen A, et al. Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade. Cancer Res. 2016;76:2327-39 pubmed publisher
  • western blot; human; fig 4
Cui J, Xia T, Xie D, Gao Y, Jia Z, Wei D, et al. HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes. Oncogene. 2016;35:4708-18 pubmed publisher
  • western blot; human; 1:1000; fig 3
Long C, Guo W, Zhou H, Wang J, Wang H, Sun X. Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi's sarcoma-associated and herpesvirus-related primary effusion lymphoma cells. Int J Oncol. 2016;48:1519-30 pubmed publisher
  • western blot; bovine; fig 1
Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
  • western blot; rat; fig 8
Iorga A, Li J, Sharma S, Umar S, Bopassa J, Nadadur R, et al. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 1b
Zheng M, Turton K, Zhu F, Li Y, Grindle K, Annis D, et al. A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture. Oncogenesis. 2016;4:e184 pubmed publisher
  • western blot; mouse
Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, et al. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep. 2015;5:18588 pubmed publisher
  • western blot; human; fig 1
Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. 2016;35:4388-98 pubmed publisher
  • western blot; human; 1:1000; fig 4d
Jia D, Tan Y, Liu H, Ooi S, Li L, Wright K, et al. Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo. Oncotarget. 2016;7:771-85 pubmed publisher
  • western blot; human; fig 6g
Rohnalter V, Roth K, Finkernagel F, Adhikary T, Obert J, Dorzweiler K, et al. A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype. Oncotarget. 2015;6:40005-25 pubmed publisher
  • western blot; human; fig 2
Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, et al. Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget. 2015;6:33165-77 pubmed publisher
  • western blot; mouse; fig 2c
Görtz D, Braun G, Maruta Y, Djudjaj S, van Roeyen C, Martin I, et al. Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery. Sci Rep. 2015;5:14685 pubmed publisher
  • western blot; human; 1:1000; fig 5a
Leve F, Peres Moreira R, Binato R, Abdelhay E, Morgado Díaz J. LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PLoS ONE. 2015;10:e0139094 pubmed publisher
  • western blot; human; fig 3a
Singh P, Sharma P, Sahakyan K, Davison D, Sert Kuniyoshi F, Romero Corral A, et al. Differential effects of leptin on adiponectin expression with weight gain versus obesity. Int J Obes (Lond). 2016;40:266-74 pubmed publisher
  • western blot; human; fig 2h
Yao X, Tang Z, Fu X, Yin J, Liang Y, Li C, et al. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015;34:2885-902 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6
Wang W, Yen M, Liu K, Hsu P, Lin M, Chen P, et al. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports. 2015;5:392-404 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  • western blot; human
Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  • western blot; human; fig 5
Masotti A, Donninelli G, Da Sacco L, Varano B, Del Cornò M, Gessani S. HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation. BMC Genomics. 2015;16:480 pubmed publisher
  • western blot; mouse; fig 4
Seto D, Kandarian S, Jackman R. A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. J Biol Chem. 2015;290:19976-86 pubmed publisher
  • immunohistochemistry; human; fig 2
Eriksson P, Aine M, Veerla S, Liedberg F, Sjödahl G, Höglund M. Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems. BMC Med Genomics. 2015;8:25 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
Pan D, Jiang C, Ma Z, Blonska M, You M, Lin X. MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression. Oncogene. 2016;35:919-28 pubmed publisher
  • western blot; human; loading ...; fig 3a
Kong E, Sucic S, Monje F, Savalli G, Diao W, Khan D, et al. STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior. Sci Rep. 2015;5:9009 pubmed publisher
  • ELISA; rat; loading ...; fig 2a
  • western blot; rat; loading ...; fig 3a
  • ELISA; mouse; loading ...; fig 2b
  • western blot; mouse; loading ...; fig 3c
Valapala M, Edwards M, Hose S, Hu J, Wawrousek E, Lutty G, et al. βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes. Sci Rep. 2015;5:8755 pubmed publisher
  • western blot; mouse; loading ...; fig s4h
  • immunoprecipitation; human; loading ...; fig 5d
  • western blot; human; loading ...; fig s2a
Grabner B, Schramek D, Mueller K, Moll H, Svinka J, Hoffmann T, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 2015;6:6285 pubmed publisher
  • western blot; human; 1:1000; fig 1f
Zimmermann M, Aguilera F, Castellucci M, Rossato M, Costa S, Lunardi C, et al. Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils. Nat Commun. 2015;6:6061 pubmed publisher
  • western blot; mouse
Wiesauer I, Gaumannmüller C, Steinparzer I, Strobl B, Kovarik P. Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription. Mol Cell Biol. 2015;35:716-27 pubmed publisher
  • western blot; human; 1:1000; fig 2
Sobotta M, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, et al. Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol. 2015;11:64-70 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 6
Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, et al. Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. Gastric Cancer. 2015;18:774-83 pubmed publisher
  • immunocytochemistry; mouse; 1:25; fig s2
Cheng F, Lienlaf M, Wang H, Perez Villarroel P, Lee C, Woan K, et al. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. J Immunol. 2014;193:2850-62 pubmed publisher
  • western blot; human; fig s3
Vartoukian S, Tilakaratne W, Seoudi N, Bombardieri M, Bergmeier L, Tappuni A, et al. Dysregulation of the suppressor of cytokine signalling 3-signal transducer and activator of transcription-3 pathway in the aetiopathogenesis of Sjögren's syndrome. Clin Exp Immunol. 2014;177:618-29 pubmed publisher
  • western blot; human; loading ...; fig 2b
Shaiken T, Opekun A. Dissecting the cell to nucleus, perinucleus and cytosol. Sci Rep. 2014;4:4923 pubmed publisher
  • western blot; domestic rabbit; 1:1,000
Jiang Y, Kou Z, Wu T, An W, Zhou R, Wang H, et al. Xist deficiency and disorders of X-inactivation in rabbit embryonic stem cells can be rescued by transcription-factor-mediated conversion. Stem Cells Dev. 2014;23:2283-96 pubmed publisher
  • western blot; human
Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed publisher
  • western blot; human; 1:1000; fig s1
Ng Y, Lee J, Supko K, Khan A, Torres S, Berwick M, et al. Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment. Melanoma Res. 2014;24:207-18 pubmed publisher
  • western blot; mouse
Smith G, Kumar A, Saba J. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013;3:351-368 pubmed
  • western blot; human
Waitkus M, Chandrasekharan U, Willard B, Tee T, Hsieh J, Przybycin C, et al. Signal integration and gene induction by a functionally distinct STAT3 phosphoform. Mol Cell Biol. 2014;34:1800-11 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Chatterjee S, Bacopulos S, Yang W, Amemiya Y, SPYROPOULOS D, Raouf A, et al. Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland. PLoS ONE. 2014;9:e87858 pubmed publisher
Okholm T, Kamstrup A, Nielsen M, Hollensen A, Graversgaard M, Kristensen L, et al. circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. bioRxiv. 2023;: pubmed publisher
Liu S, Hur Y, Cai X, Cong Q, Yang Y, Xu C, et al. A tissue injury sensing and repair pathway distinct from host pathogen defense. Cell. 2023;186:2127-2143.e22 pubmed publisher
Mo X, Kazmi H, Preston Alp S, Zhou B, Zaidi M. Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase. Pigment Cell Melanoma Res. 2022;35:342-355 pubmed publisher
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova Lamperti E, et al. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Nat Immunol. 2022;23:62-74 pubmed publisher
Li C, Zhao Z, Luo Y, Ning T, LIU P, Chen Q, et al. Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke. Adv Sci (Weinh). 2021;8:e2101526 pubmed publisher
Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, et al. The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 2021;54:308-323.e6 pubmed publisher
Weber C, Zhou Y, Lee J, Looger L, Qian G, Ge C, et al. Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b. Science. 2020;368:303-306 pubmed publisher
Yoon C, Chang M, Kim D, Kim W, Koo B, Yun S, et al. Epstein-Barr virus-encoded miR-BART5-5p upregulates PD-L1 through PIAS3/pSTAT3 modulation, worsening clinical outcomes of PD-L1-positive gastric carcinomas. Gastric Cancer. 2020;23:780-795 pubmed publisher
Noce V, Battistelli C, Cozzolino A, Consalvi V, Cicchini C, Strippoli R, et al. YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation. Cell Death Dis. 2019;10:768 pubmed publisher
Forero A, Ozarkar S, Li H, Lee C, Hemann E, Nadjsombati M, et al. Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Immunity. 2019;51:451-464.e6 pubmed publisher
Haque M, Li J, Huang Y, Almowaled M, Barger C, Karpf A, et al. NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma. Cancers (Basel). 2019;11: pubmed publisher
Wei L, Wang Z, Xia Y, Liu B. The mechanism and tumor inhibitory study of Lagopsis supine ethanol extract on colorectal cancer in nude mice. BMC Complement Altern Med. 2019;19:173 pubmed publisher
Morgan E, Macdonald A. Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NFκB-IL-6 signalling axis. PLoS Pathog. 2019;15:e1007835 pubmed publisher
Liang F, Emeriaud G, Rassier D, Shang D, Gusev E, Hussain S, et al. Mechanical ventilation causes diaphragm dysfunction in newborn lambs. Crit Care. 2019;23:123 pubmed publisher
Cho J, Xu Z, Parthasarathy U, Drashansky T, Helm E, Zuniga A, et al. Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat Commun. 2019;10:701 pubmed publisher
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher
Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, et al. Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol. 2018;9:2858 pubmed publisher
Martínez Fábregas J, Prescott A, van Kasteren S, Pedrioli D, McLean I, Moles A, et al. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nat Commun. 2018;9:5343 pubmed publisher
Parlato M, Charbit Henrion F, Nader E, Begue B, Guegan N, Bruneau J, et al. Efficacy of Ruxolitinib Therapy in a Patient with Severe Enterocolitis Associated with a STAT3 Gain of Function Mutation. Gastroenterology. 2018;: pubmed publisher
Wan D, Morgan S, Spencley A, Mariano N, Chang E, Shankar G, et al. Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Nat Commun. 2018;9:5078 pubmed publisher
Menotti M, Ambrogio C, Cheong T, Pighi C, Mota I, Cassel S, et al. Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma. Nat Med. 2019;25:130-140 pubmed publisher
Wu C, Jiang X, Wang X, Liu X, Li X, Yang B, et al. Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. J Virol. 2018;92: pubmed publisher
Ishii Y, Shibata W, Sugimori M, Kaneta Y, Kanno M, Sato T, et al. Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation. Gastroenterol Res Pract. 2018;2018:9050715 pubmed publisher
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product information
SKU :
9139S
Product-Name :
Stat3 (124H6) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Chromatin Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
79, 86
Host :
Mouse
Target :
STAT3
Primary-Protein :
STAT3
Alt-Names :
APRF,Acute-phase response factor,DNA-binding protein APRF,FLJ20882,HIES,MGC16063,STAT3,Signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 (acute-phase response factor)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.