product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Stat3 (Tyr705) (3E2) Mouse mAb
catalog :
9138
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
3E2
reactivity :
human, mouse, rat, cow, rabbit
application :
western blot, immunoprecipitation, flow cytometry
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2a
Prado C, Gaiazzi M, Gonzalez H, Ugalde V, Figueroa A, Osorio Barrios F, et al. Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:571 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
Maachani U, Shankavaram U, Kramp T, Tofilon P, Camphausen K, Tandle A. FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells. Oncotarget. 2016;7:77365-77377 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; fig 10b
Liu L, Phua Y, Lee R, Ma X, Jenkins Y, Novy K, et al. Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases. J Biol Chem. 2016;291:21571-21583 pubmed
  • western blot; human; 1:1000; fig 4
Jahani Asl A, Yin H, Soleimani V, Haque T, Luchman H, Chang N, et al. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nat Neurosci. 2016;19:798-806 pubmed publisher
  • western blot; mouse; fig 1
  • western blot; human; fig 1
M L, P P, T K, M P, E S, J P, et al. Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Mol Oncol. 2016;10:735-750 pubmed publisher
  • western blot; human; fig 5e
Chakedis J, French R, Babicky M, Jaquish D, Howard H, Mose E, et al. A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. Oncogene. 2016;35:3249-59 pubmed publisher
  • western blot; mouse; fig 5
Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed publisher
  • western blot; human; fig 3
Wu L, Guo L, Liang Y, Liu X, Jiang L, Wang L. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncol Rep. 2015;34:3311-7 pubmed publisher
  • western blot; rat; 1:1000; fig 3
  • western blot; human; 1:1000; fig 6
Alkhateeb A, Buckett P, Gardeck A, Kim J, Byrne S, Fraenkel P, et al. The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro. Am J Physiol Gastrointest Liver Physiol. 2015;308:G1019-26 pubmed publisher
  • western blot; mouse
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher
  • western blot; mouse; fig 4
Cheng F, Lienlaf M, Wang H, Perez Villarroel P, Lee C, Woan K, et al. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. J Immunol. 2014;193:2850-62 pubmed publisher
  • western blot; mouse
Cansby E, Nerstedt A, Amrutkar M, Durán E, Smith U, Mahlapuu M. Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained. Mol Cell Endocrinol. 2014;393:143-51 pubmed publisher
  • western blot; human
de Graaf E, Kaplon J, Zhou H, Heck A, Peeper D, Altelaar A. Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence. Mol Cell Proteomics. 2014;13:2089-100 pubmed publisher
  • western blot; rabbit; 1:1,000
Jiang Y, Kou Z, Wu T, An W, Zhou R, Wang H, et al. Xist deficiency and disorders of X-inactivation in rabbit embryonic stem cells can be rescued by transcription-factor-mediated conversion. Stem Cells Dev. 2014;23:2283-96 pubmed publisher
  • western blot; mouse
Smith G, Kumar A, Saba J. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013;3:351-368 pubmed
  • western blot; human
Waitkus M, Chandrasekharan U, Willard B, Tee T, Hsieh J, Przybycin C, et al. Signal integration and gene induction by a functionally distinct STAT3 phosphoform. Mol Cell Biol. 2014;34:1800-11 pubmed publisher
  • western blot; mouse
Carlson T, Pellerin A, Djuretic I, Trivigno C, Koralov S, Rao A, et al. Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation. J Immunol. 2014;192:2167-76 pubmed publisher
  • western blot; human; fig 6E
Bohonowych J, Hance M, Nolan K, DEFEE M, Parsons C, Isaacs J. Extracellular Hsp90 mediates an NF-?B dependent inflammatory stromal program: implications for the prostate tumor microenvironment. Prostate. 2014;74:395-407 pubmed publisher
  • western blot; mouse
Biensø R, Knudsen J, Brandt N, Pedersen P, Pilegaard H. Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle. Pflugers Arch. 2014;466:1647-57 pubmed publisher
Noor A, Umelo I, Kronenberger P, Giron P, De Vlieghere E, De Wever O, et al. Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer. Oncotarget. 2018;9:28731-28744 pubmed publisher
Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M. PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. Oncotarget. 2018;9:14939-14958 pubmed publisher
Gudiksen A, Schwartz C, Bertholdt L, Joensen E, Knudsen J, Pilegaard H. Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise. PLoS ONE. 2016;11:e0156460 pubmed publisher
Chen L, Brar M, Leung F, Hsiao W. Triterpenoid herbal saponins enhance beneficial bacteria, decrease sulfate-reducing bacteria, modulate inflammatory intestinal microenvironment and exert cancer preventive effects in ApcMin/+ mice. Oncotarget. 2016;7:31226-42 pubmed publisher
Villa A, Rizzi N, Vegeto E, Ciana P, Maggi A. Estrogen accelerates the resolution of inflammation in macrophagic cells. Sci Rep. 2015;5:15224 pubmed publisher
White A, LaBarge S, McCurdy C, Schenk S. Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab. 2015;4:569-75 pubmed publisher
Park S, Kim J, Oh C, Choi S, Jeon J, Lee I. Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells. Exp Mol Med. 2015;47:e145 pubmed publisher
Abubaker K, Luwor R, Escalona R, McNally O, Quinn M, Thompson E, et al. Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden. Front Oncol. 2014;4:75 pubmed publisher
Arai Y, Totoki Y, Takahashi H, Nakamura H, Hama N, Kohno T, et al. Mouse model for ROS1-rearranged lung cancer. PLoS ONE. 2013;8:e56010 pubmed publisher
Park J, Kim Y, Ha Y, Kwon H, Lee Y. High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression. BMB Rep. 2012;45:299-304 pubmed
product information
SKU :
9138S
Product-Name :
Phospho-Stat3 (Tyr705) (3E2) Mouse mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, (B)
Applications :
Flow cytometry
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
79, 86
Host :
Mouse
Target :
STAT3 (Tyr705) phosphate
Primary-Protein :
STAT3
Alt-Names :
APRF,Acute-phase response factor,DNA-binding protein APRF,FLJ20882,HIES,MGC16063,STAT3,Signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 (acute-phase response factor)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.