product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Stat3 (Tyr705) Antibody
catalog :
9131
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, reverse phase protein lysate microarray
citations: 89
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig s1a
Fearon A, Slabber C, Kuklin A, Bachofner M, Tortola L, Pohlmeier L, et al. Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis. iScience. 2021;24:103143 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5b
Zhang D, Yamaguchi S, Zhang X, Yang B, Kurooka N, Sugawara R, et al. Upregulation of Mir342 in Diet-Induced Obesity Mouse and the Hypothalamic Appetite Control. Front Endocrinol (Lausanne). 2021;12:727915 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
He L, Pratt H, Gao M, Wei F, Weng Z, Struhl K. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. elife. 2021;10: pubmed publisher
  • western blot; rat; 1:250; loading ...; fig s2a
Zavvarian M, Hong J, Khazaei M, Chio J, Wang J, Badner A, et al. The Protein Kinase Inhibitor Midostaurin Improves Functional Neurological Recovery and Attenuates Inflammatory Changes Following Traumatic Cervical Spinal Cord Injury. Biomolecules. 2021;11: pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs J, Wawrzyniak M, et al. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e
Tsoi H, Man E, Chau K, Khoo U. Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6b
  • western blot; mouse; 1:1000; loading ...; fig 5b
Lim C, Or Y, Ong Z, Chung H, Hayashi H, Shrestha S, et al. Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
  • western blot; human; 1:1000; loading ...; fig 5b
Gualandi M, Iorio M, Engeler O, Serra Roma A, Gasparre G, Schulte J, et al. Oncogenic ALK F1174L drives tumorigenesis in cutaneous squamous cell carcinoma. Life Sci Alliance. 2020;3: pubmed publisher
  • western blot; human; 1:1000; fig 4f
Steins A, van Mackelenbergh M, van der Zalm A, Klaassen R, Serrels B, Goris S, et al. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. EMBO Rep. 2020;21:e48780 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3b
Park S, Jang A, Bouret S. Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring. PLoS Biol. 2020;18:e3000296 pubmed publisher
  • western blot; mouse; loading ...; fig 3f
Guo X, Kolpakov M, Hooshdaran B, Schappell W, Wang T, Eguchi S, et al. Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload. JACC Basic Transl Sci. 2020;5:69-83 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Mlyczynska E, Kurowska P, Drwal E, Opydo Chanek M, Tworzydło W, Kotula Balak M, et al. Apelin and apelin receptor in human placenta: Expression, signalling pathway and regulation of trophoblast JEG‑3 and BeWo cells proliferation and cell cycle. Int J Mol Med. 2020;45:691-702 pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 5
Kelley L, Verlezza S, Long H, Loka M, Walker C. Increased Hypothalamic Projections to the Lateral Hypothalamus and Responses to Leptin in Rat Neonates From High Fat Fed Mothers. Front Neurosci. 2019;13:1454 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed publisher
  • western blot; human; loading ...
Debruyne D, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. 2019;572:676-680 pubmed publisher
  • western blot; mouse; fig 5g
Wang D, Zheng X, Fu B, Nian Z, Qian Y, Sun R, et al. Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. EBioMedicine. 2019;46:119-132 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 1d
Pascual García M, Bonfill Teixidor E, Planas Rigol E, Rubio Perez C, Iurlaro R, Arias A, et al. LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy. Nat Commun. 2019;10:2416 pubmed publisher
  • western blot; human; loading ...; fig 4c
Ferraro D, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, et al. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells. BMC Cancer. 2019;19:312 pubmed publisher
  • western blot; human; loading ...; fig s6b
Kennedy S, Han J, Portman N, Nobis M, Hastings J, Murphy K, et al. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Res. 2019;21:43 pubmed publisher
  • western blot; mouse; loading ...; fig e3h
  • western blot; human; loading ...; fig e3g
Garcia Bermudez J, Baudrier L, Bayraktar E, Shen Y, La K, Guarecuco R, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019;567:118-122 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Simonović N, Witalisz Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, et al. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol. 2019;202:1724-1734 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, et al. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Oncogene. 2019;38:2658-2674 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, et al. Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Nat Commun. 2018;9:5300 pubmed publisher
  • western blot; mouse; loading ...; fig s3a
Sutherland L, Ruhe M, Gattegno Ho D, Mann K, Greaves J, Koscielniak M, et al. LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci. 2018;131: pubmed publisher
  • western blot; mouse; fig 1h
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  • western blot; human; loading ...; fig 4f
  • western blot; mouse; loading ...; fig 2a, s8h, s14e, s15f
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
  • western blot; human; loading ...; fig 2e
Tamassia N, Arruda Silva F, Calzetti F, Lonardi S, Gasperini S, Gardiman E, et al. A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It. Front Immunol. 2018;9:795 pubmed publisher
  • western blot; human; fig 1a
Morgan E, Wasson C, Hanson L, Kealy D, Pentland I, McGuire V, et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PLoS Pathog. 2018;14:e1006975 pubmed publisher
  • western blot; human; 1:1000; fig s7b
Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher
  • western blot; human; 1:1000; fig s3f
Frattini V, Pagnotta S, Tala -, Fan J, Russo M, Lee S, et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018;553:222-227 pubmed publisher
  • western blot; mouse; fig 7c
Rajbhandari P, Thomas B, Feng A, Hong C, Wang J, Vergnes L, et al. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018;172:218-233.e17 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d
Sharma D, Malik A, Guy C, Karki R, Vogel P, Kanneganti T. Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis. Gastroenterology. 2018;154:948-964.e8 pubmed publisher
  • western blot; mouse; fig 3d
Wang Y, Kuang Z, Yu X, Ruhn K, Kubo M, Hooper L. The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science. 2017;357:912-916 pubmed publisher
  • western blot; mouse; fig 1a
Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • western blot; human; fig 8c
  • western blot; mouse; loading ...; fig 8a
Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Dong Q, Li J, Wu Q, Zhao N, Qian C, Ding D, et al. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci Rep. 2017;7:42678 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  • western blot; mouse; loading ...; fig 4
Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 3
  • western blot; mouse
Hwang M, Go Y, Park J, Shin S, Song S, Oh B, et al. Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance. Int J Obes (Lond). 2017;41:279-288 pubmed publisher
  • western blot; human; 1:1000; fig s11b
Huang T, Alvarez A, Pangeni R, Horbinski C, Lu S, Kim S, et al. A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Nat Commun. 2016;7:12885 pubmed publisher
  • western blot; human; fig 3
Yuzugullu H, Von T, Thorpe L, Walker S, Roberts T, Frank D, et al. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discov. 2016;2:16030 pubmed publisher
  • western blot; mouse; 1:1000; fig 3d
  • western blot; human; 1:1000; loading ...; fig 3
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
  • western blot; mouse; loading ...; fig 6a, 6c
Janowski A, Colegio O, Hornick E, McNiff J, Martin M, Badovinac V, et al. NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest. 2016;126:3917-3928 pubmed publisher
  • western blot; human; 1:300; fig 4
Li J, Yang Z, Chen Z, Bao Y, Zhang H, Fang X, et al. ATF3 suppresses ESCC via downregulation of ID1. Oncol Lett. 2016;12:1642-1648 pubmed
  • western blot; human; 1:1000; fig 6.a, b
Fiedor E, Gregoraszczuk E. The molecular mechanism of action of superactive human leptin antagonist (SHLA) and quadruple leptin mutein Lan-2 on human ovarian epithelial cell lines. Cancer Chemother Pharmacol. 2016;78:611-22 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 1
Senzacqua M, Severi I, Perugini J, Acciarini S, Cinti S, Giordano A. Action of Administered Ciliary Neurotrophic Factor on the Mouse Dorsal Vagal Complex. Front Neurosci. 2016;10:289 pubmed publisher
  • western blot; human; 1:1000; fig 5e
Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
  • EMSA; human; fig S5
Yang W, Ng F, Chan K, Pu X, Poston R, Ren M, et al. Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. PLoS Genet. 2016;12:e1006127 pubmed publisher
  • western blot; human; 1:1000; fig 3
Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher
  • western blot; human; loading ...; fig 4e
Salvi V, Vermi W, Gianello V, Lonardi S, Gagliostro V, Naldini A, et al. Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors. Oncotarget. 2016;7:39256-39269 pubmed publisher
  • flow cytometry; mouse; fig 6E
  • immunocytochemistry; mouse; 1:100; fig 6D
Kanda M, Nagai T, Takahashi T, Liu M, Kondou N, Naito A, et al. Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction. PLoS ONE. 2016;11:e0156562 pubmed publisher
  • western blot; human; tbl 1
Lombardo G, Dentelli P, Togliatto G, Rosso A, Gili M, Gallo S, et al. Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action. Sci Rep. 2016;6:25689 pubmed publisher
  • western blot; mouse; 1:1000; fig s3
Moshfegh C, Aires L, Kisielow M, Vogel V. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep. 2016;6:25104 pubmed publisher
  • western blot; human; fig 2
Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher
  • western blot; mouse; loading ...; fig 3b
  • western blot; human
Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, et al. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest. 2016;126:2064-76 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Macritchie N, Volpert G, Al Washih M, Watson D, Futerman A, Kennedy S, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016;28:946-55 pubmed publisher
  • western blot; human; loading ...; fig 3a
Slørdahl T, Abdollahi P, Vandsemb E, Rampa C, Misund K, Baranowska K, et al. The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells. Oncotarget. 2016;7:27295-306 pubmed publisher
  • western blot; human; fig 4
Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed publisher
  • western blot; mouse; fig s1
Yu Y, Cui Y, Zhao Y, Liu S, Song G, Jiao P, et al. The binding capability of plasma phospholipid transfer protein, but not HDL pool size, is critical to repress LPS induced inflammation. Sci Rep. 2016;6:20845 pubmed publisher
  • western blot; mouse
Däbritz J, Judd L, Chalinor H, Menheniott T, Giraud A. Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells. Sci Rep. 2016;6:20584 pubmed publisher
  • western blot; human; loading ...; fig 2a
Lu S, Natarajan S, Mott J, Kharbanda K, Harrison Findik D. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway. PLoS ONE. 2016;11:e0147474 pubmed publisher
  • western blot; human; loading ...; fig 5e
Zimmermann M, Arruda Silva F, Bianchetto Aguilera F, Finotti G, Calzetti F, Scapini P, et al. IFNα enhances the production of IL-6 by human neutrophils activated via TLR8. Sci Rep. 2016;6:19674 pubmed publisher
  • western blot; human; fig s5
Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0147344 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Drilon A, Somwar R, Wagner J, Vellore N, Eide C, Zabriskie M, et al. A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer. Clin Cancer Res. 2016;22:2351-8 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; fig 4
  • western blot; mouse; fig 4
Hristova M, Rocha Ferreira E, Fontana X, Thei L, Buckle R, Christou M, et al. Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage. J Neurochem. 2016;136:981-94 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Ye S, Zhang D, Cheng F, Wilson D, Mackay J, He K, et al. Wnt/β-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci. 2016;129:269-76 pubmed publisher
  • western blot; human; 1:100; fig 4j
  • immunohistochemistry; mouse; 1:100; fig 4a
Manda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, et al. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene. 2016;35:3282-92 pubmed publisher
  • western blot; mouse; loading ...; fig s3b
Trierweiler C, Hockenjos B, Zatloukal K, Thimme R, Blum H, Wagner E, et al. The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice. Cell Death Differ. 2016;23:576-82 pubmed publisher
Zhang C, Wang C, Jiang M, Gu C, Xiao J, Chen X, et al. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun. 2018;9:2745 pubmed publisher
Guo G, Gong K, Ali S, Ali N, Shallwani S, Hatanpaa K, et al. A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma. Nat Neurosci. 2017;20:1074-1084 pubmed publisher
Li L, Fan L, Zhou J, Grantham J, Calvet J, Sage J, et al. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest. 2017;127:2751-2764 pubmed publisher
Cho S, Na W, Choi M, Kang S, Lee S, Choi C. Autophagy inhibits cell death induced by the anti-cancer drug morusin. Am J Cancer Res. 2017;7:518-530 pubmed
Bhattacharya S, Srinivasan K, Abdisalaam S, Su F, Raj P, Dozmorov I, et al. RAD51 interconnects between DNA replication, DNA repair and immunity. Nucleic Acids Res. 2017;45:4590-4605 pubmed publisher
Park E, Lee Y, Oh T, Kim B, Lim B, Lim J. Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1? mRNA Expression in Malignant Melanoma Cells. Int J Mol Sci. 2017;18: pubmed publisher
Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher
Beer A, Zenzmaier C, Schreinlechner M, Haas J, Dietrich M, Herz J, et al. Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member. Oncotarget. 2016;7:68721-68733 pubmed publisher
Mathew M, Tan E, Saeui C, Bovonratwet P, Sklar S, Bhattacharya R, et al. Metabolic flux-driven sialylation alters internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells. Oncotarget. 2016;7:66491-66511 pubmed publisher
Kim R, Kaushik N, Suh Y, Yoo K, Cui Y, Kim M, et al. Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer. Oncotarget. 2016;7:53430-53442 pubmed publisher
Phan A, Hua T, Kim M, Vo V, Choi J, Kim H, et al. Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer. Oncotarget. 2016;7:54702-54713 pubmed publisher
Lee H, Keum S, Sheng H, Warner D, Lo D, Marchuk D. Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. J Clin Invest. 2016;126:2827-38 pubmed publisher
Gruber R, Panayiotou R, Nye E, Spencer Dene B, Stamp G, Behrens A. YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. Gastroenterology. 2016;151:526-39 pubmed publisher
Lee S, Min H, Jung H, Park K, Hyun S, Cho J, et al. Essential role of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors. Oncogene. 2016;35:5515-5526 pubmed publisher
Kumar A, Jagadeeshan S, Subramanian A, Chidambaram S, Surabhi R, Singhal M, et al. Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor. J Biol Chem. 2016;291:12310-21 pubmed publisher
McFarland B, Marks M, Rowse A, Fehling S, Gerigk M, Qin H, et al. Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma. Oncotarget. 2016;7:20621-35 pubmed publisher
Woo S, Choi Y, Kim A, Yun Y, Shin Y, Cho S, et al. Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Mol Med Rep. 2016;13:2967-72 pubmed publisher
Saygideğer Kont Y, Minas T, Jones H, Hour S, Çelik H, Temel I, et al. Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small Cell Lung Cancer Cells. Neoplasia. 2016;18:111-20 pubmed publisher
Guo D, Cui H, Zhang Q, Morgan D, Thedens D, Nishimura D, et al. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. PLoS Genet. 2016;12:e1005890 pubmed publisher
product information
SKU :
9131S
Product-Name :
Phospho-Stat3 (Tyr705) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk, (C, B, Dg)
Applications :
Chromatin Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
79, 86
Host :
Rabbit
Target :
STAT3 (Tyr705) phosphate
Primary-Protein :
STAT3
Alt-Names :
APRF,Acute-phase response factor,DNA-binding protein APRF,FLJ20882,HIES,MGC16063,STAT3,Signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 (acute-phase response factor)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.