| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 1c
| Lee S, Jung J, Lee Y, Kim S, Kim J, Kim B, et al. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers (Basel). 2021;13: pubmed publisher |
- western blot; rat; loading ...; fig 7f
| Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, et al. HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression. Circulation. 2021;144:638-654 pubmed publisher |
- western blot; human; loading ...; fig 6c
| Shaaya M, Fauser J, Zhurikhina A, Conage Pough J, Huyot V, Brennan M, et al. Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity. elife. 2020;9: pubmed publisher |
- western blot; human; loading ...; fig 4g
| Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher |
- western blot; human; 1:2500; fig 1a
| Wu P, Hong S, Starenki D, Oshima K, Shao H, Gestwicki J, et al. Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. Oncogene. 2020;39:4257-4270 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig e6d
| Amendola C, Mahaffey J, Parker S, Ahearn I, Chen W, Zhou M, et al. KRAS4A directly regulates hexokinase 1. Nature. 2019;576:482-486 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig e2b
| Canon J, Rex K, Saiki A, Mohr C, Cooke K, Bagal D, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575:217-223 pubmed publisher |
- western blot; human; loading ...; fig 3i
| Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kulhanek K, et al. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science. 2019;366:109-115 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4g
| Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3
| Frischknecht L, Britschgi C, Galliker P, Christinat Y, Vichalkovski A, Gstaiger M, et al. BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly. Sci Rep. 2019;9:7779 pubmed publisher |
- western blot; human; loading ...; fig 1d, s1b
| Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed publisher |
- western blot; human; loading ...; fig 5d
| Neel D, Allegakoen D, Olivas V, Mayekar M, Hemmati G, Chatterjee N, et al. Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Cancer Res. 2019;79:546-556 pubmed publisher |
- western blot; human; loading ...; fig s10b, s10d
- western blot; mouse; loading ...; fig s10c
| Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, et al. Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science. 2018;362: pubmed publisher |
- flow cytometry; mouse; 1:100-1:200; loading ...; fig s4c
| Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher |
- western blot; mouse; loading ...; fig s11a
| Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher |
- western blot; mouse; loading ...; fig s3b
| Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed publisher |
- western blot; human; loading ...; fig 7a
| Liang Z, Yang Y, He Y, Yang P, Wang X, He G, et al. SUMOylation of IQGAP1 promotes the development of colorectal cancer. Cancer Lett. 2017;411:90-99 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6b
| Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens P, Neel B. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun. 2017;8:466 pubmed publisher |
- western blot; human; loading ...; fig s1c
| Shaffer S, Dunagin M, Torborg S, Torre E, Emert B, Krepler C, et al. Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance. Nature. 2017;546:431-435 pubmed publisher |
- western blot; human; loading ...; fig 1b
| Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed publisher |
- western blot; mouse; 1:50; fig 5b
| Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann B, et al. Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol. 2017;216:1567-1577 pubmed publisher |
- western blot; human; fig 2c
| Babagana M, Johnson S, Slabodkin H, Bshara W, Morrison C, Kandel E. P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells. Mol Carcinog. 2017;56:1515-1525 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...
| Jung J, Jung H, Neupane S, Kim K, Kim J, Yamamoto H, et al. Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation. Acta Histochem. 2017;119:92-98 pubmed publisher |
- western blot; human; loading ...; fig 6d
| Spencer Smith R, Koide A, Zhou Y, Eguchi R, Sha F, Gajwani P, et al. Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017;13:62-68 pubmed publisher |
- western blot; human; 1:3000; loading ...; fig 5f
| Zimmermann M, Arachchige Don A, Donaldson M, Patriarchi T, Horne M. Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival. Cell Cycle. 2016;15:3278-3295 pubmed |
- western blot; human; 1:1000; loading ...; fig 5a
| Chen B, Zeng X, He Y, Wang X, Liang Z, Liu J, et al. STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. Oncotarget. 2016;7:71400-71416 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Anta B, Pérez RodrÃguez A, Castro J, GarcÃa DomÃnguez C, Ibiza S, MartÃnez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Wang C, Guo S, Wang J, Yan X, Farrelly M, Zhang Y, et al. Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. Oncotarget. 2016;7:49597-49610 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5
| Sun S, Gu X, Gao X, Li Y, Yu H, Xiong W, et al. Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation. Oncotarget. 2016;7:48050-48058 pubmed publisher |
- western blot; human; fig 6
| An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher |
- western blot; human; 1:500; fig 5
| Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher |
- western blot; human; 1:1000; tbl 2
| Bhargava A, Pelech S, Woodard B, Kerwin J, Maherali N. Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. elife. 2016;5: pubmed publisher |
- western blot; human; 1:1000; fig 4
| Roßner F, Gieseler C, Morkel M, Royer H, Rivera M, Bläker H, et al. Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer. Oncogenesis. 2016;5:e187 pubmed publisher |
- western blot; human; fig 3
| Kiel C, Benisty H, Lloréns Rico V, Serrano L. The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF. elife. 2016;5:e12814 pubmed publisher |
| Dhawan N, Scopton A, Dar A. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016;537:112-116 pubmed publisher |
| Thomas J, Chhuy Hy L, Andrykovich K, Moos M. SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR. PLoS ONE. 2016;11:e0154294 pubmed publisher |
