product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p44/42 MAPK (Erk1/2) (3A7) Mouse mAb
catalog :
9107
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3A7
reactivity :
least shrew, human, mouse, rat, zebrafish
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
citations: 95
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500-1:1000; loading ...; fig 1a
Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed publisher
  • western blot; human; loading ...; fig 3b
Chen H, Teng Y, Chen X, Liu Z, Geng F, Liu Y, et al. Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase. CNS Neurosci Ther. 2021;27:1300-1312 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Yang S, Qu Y, Chen J, Chen S, Sun L, Zhou Y, et al. Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion. Front Pharmacol. 2021;12:688073 pubmed publisher
  • western blot; human; loading ...; fig s5a
Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, et al. DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021;11:6355-6369 pubmed publisher
  • western blot; human; loading ...; fig s6
Wakashin H, Heymann J, Roshanravan H, Daneshpajouhnejad P, Rosenberg A, Shin M, et al. APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress. BMC Nephrol. 2020;21:371 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s5c
Eyler C, Matsunaga H, Hovestadt V, Vantine S, van Galen P, Bernstein B. Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance. Genome Biol. 2020;21:174 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3s2b
Laboute T, Gandia J, Pellissier L, Corde Y, Rebeillard F, Gallo M, et al. The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...
Hamilton W, Mosesson Y, Monteiro R, Emdal K, Knudsen T, Francavilla C, et al. Dynamic lineage priming is driven via direct enhancer regulation by ERK. Nature. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 5b
MacFarlane E, Parker S, Shin J, Kang B, Ziegler S, Creamer T, et al. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. J Clin Invest. 2019;129:659-675 pubmed publisher
  • western blot; human; loading ...; fig s1d
Ruscetti M, Leibold J, Bott M, Fennell M, Kulick A, Salgado N, et al. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018;362:1416-1422 pubmed publisher
  • western blot; human; loading ...; fig s10b, s10d, s12b
  • western blot; mouse; loading ...; fig 10c
Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, et al. Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science. 2018;362: pubmed publisher
  • western blot; mouse; fig 5b
Albrengues J, Shields M, Ng D, Park C, Ambrico A, Poindexter M, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018;361: pubmed publisher
  • western blot; human; loading ...; fig s1b
Kim S, Knight D, Jones L, Vervoort S, Ng A, Seymour J, et al. JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias. Genes Dev. 2018;32:849-864 pubmed publisher
  • western blot; human; 1:2000; fig 4e
Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018;115:E5746-E5755 pubmed publisher
  • western blot; human; loading ...; fig 3b
Pilling A, Kim J, Estrada Bernal A, Zhou Q, Le A, Singleton K, et al. ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer. Oncotarget. 2018;9:8823-8835 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Coelho M, de Carné Trécesson S, Rana S, Zecchin D, Moore C, Molina Arcas M, et al. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA. Immunity. 2017;47:1083-1099.e6 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d
Ameen G, Mora S. Cbl downregulation increases RBP4 expression in adipocytes of female mice. J Endocrinol. 2018;236:29-41 pubmed publisher
  • western blot; human; loading ...; fig 6f
Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017;36:6850-6862 pubmed publisher
  • western blot; human; loading ...; fig 1a
Vaishnavi A, Schubert L, Rix U, Marek L, Le A, Keysar S, et al. EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases. Cancer Res. 2017;77:3551-3563 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y, et al. p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. Sci Rep. 2017;7:45964 pubmed publisher
  • western blot; mouse; 1:2000; fig 9b
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  • western blot; human; loading ...; fig 6c
Duclos C, Champagne A, Carrier J, Saucier C, Lavoie C, Denault J. Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling. Cell Death Discov. 2017;3:16100 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Gautam J, Nirwane A, Yao Y. Laminin differentially regulates the stemness of type I and type II pericytes. Stem Cell Res Ther. 2017;8:28 pubmed publisher
  • western blot; human; loading ...; fig 3a
Ni Y, Teng T, Li R, Simonyi A, Sun G, Lee J. TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK. PLoS ONE. 2017;12:e0170346 pubmed publisher
  • western blot; human; loading ...; fig 5e
Xu J, Zhang X, Wang H, Ge S, Gao T, Song L, et al. HCRP1 downregulation promotes hepatocellular carcinoma cell migration and invasion through the induction of EGFR activation and epithelial-mesenchymal transition. Biomed Pharmacother. 2017;88:421-429 pubmed publisher
  • western blot; rat; loading ...; fig 7a
Pandini G, Satriano C, Pietropaolo A, Gianì F, Travaglia A, La Mendola D, et al. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor. Front Neurosci. 2016;10:569 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Rahman A, Haugh J. Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation. J Biol Chem. 2017;292:2866-2872 pubmed publisher
  • western blot; human; loading ...; fig 4c
Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Yi J, Huang Y, Kwaczala A, Kuo I, Ehrlich B, Campbell S, et al. Low-dose dasatinib rescues cardiac function in Noonan syndrome. JCI Insight. 2016;1:e90220 pubmed publisher
  • western blot; human; fig 4
Ang Z, Er J, Tan N, Lu J, Liou Y, Grosse J, et al. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci Rep. 2016;6:34145 pubmed publisher
  • western blot; human; loading ...; fig 7
Zhao Y, Zhang B, Lei Y, Sun J, Zhang Y, Yang S, et al. Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma. Tumour Biol. 2016;37:13167-13176 pubmed
  • western blot; human; 1:1000; loading ...; fig 7b
Merry C, McMahon S, Forrest M, Bartels C, Saiakhova A, Bartel C, et al. Transcriptome-wide identification of mRNAs and lincRNAs associated with trastuzumab-resistance in HER2-positive breast cancer. Oncotarget. 2016;7:53230-53244 pubmed publisher
  • western blot; human; fig 3a
Hanson R, Brown R, Steele M, Grandgenett P, Grunkemeyer J, Hollingsworth M. Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis. Oncotarget. 2016;7:39996-40011 pubmed publisher
  • western blot; mouse; fig 1C
  • western blot; human; fig 1D
Thomas J, Chhuy Hy L, Andrykovich K, Moos M. SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR. PLoS ONE. 2016;11:e0154294 pubmed publisher
  • western blot; human; 1:1000; fig 4
Papke B, Murarka S, Vogel H, Martín Gago P, Kovacevic M, Truxius D, et al. Identification of pyrazolopyridazinones as PDE? inhibitors. Nat Commun. 2016;7:11360 pubmed publisher
  • western blot; human; 1:1000; fig 2
Rhee M, Lee S, Kim J, Ham D, Park H, Yang H, et al. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Sci Rep. 2016;6:23960 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; fig s1
Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed publisher
  • western blot; human; loading ...; fig s1b
Saygideğer Kont Y, Minas T, Jones H, Hour S, Çelik H, Temel I, et al. Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small Cell Lung Cancer Cells. Neoplasia. 2016;18:111-20 pubmed publisher
  • western blot; human; fig 3
Baietti M, Simíček M, Abbasi Asbagh L, Radaelli E, Lievens S, Crowther J, et al. OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. EMBO Mol Med. 2016;8:288-303 pubmed publisher
  • western blot; mouse; 1:2500; fig 4
White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, et al. KRAS insertion mutations are oncogenic and exhibit distinct functional properties. Nat Commun. 2016;7:10647 pubmed publisher
  • western blot; rat; 1:10,000; fig 12
Bean L, Kumar A, Rani A, Guidi M, Rosario A, Cruz P, et al. Re-Opening the Critical Window for Estrogen Therapy. J Neurosci. 2015;35:16077-93 pubmed publisher
  • western blot; human; fig 6
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, et al. Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. Oncotarget. 2016;7:1717-31 pubmed publisher
  • western blot; human; 1:1000; fig 6
Verbrugge S, Al M, Assaraf Y, Kammerer S, Chandrupatla D, Honeywell R, et al. Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. Oncotarget. 2016;7:5240-57 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 9f
Cohen M, Johnson W, Pilat J, Kiselar J, DeFrancesco Lisowitz A, Zigmond R, et al. Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons. Mol Cell Biol. 2015;35:4238-52 pubmed publisher
  • western blot; human; fig 6
Gong Y, Qiu W, Ning X, Yang X, Liu L, Wang Z, et al. CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration. Oncotarget. 2015;6:25856-67 pubmed publisher
  • western blot; human
Picot N, Guerrette R, Beauregard A, Jean S, Michaud P, Harquail J, et al. Mammaglobin 1 promotes breast cancer malignancy and confers sensitivity to anticancer drugs. Mol Carcinog. 2016;55:1150-62 pubmed publisher
  • western blot; rat; fig 6e
Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, et al. An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development. J Immunol. 2015;195:1608-16 pubmed publisher
  • western blot; human; fig 1a
Johlfs M, Gorjala P, Urasaki Y, Le T, Fiscus R. Capillary Isoelectric Focusing Immunoassay for Fat Cell Differentiation Proteomics. PLoS ONE. 2015;10:e0132105 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, et al. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015;21:820-6 pubmed publisher
  • western blot; human; 1:1000
Carthy J, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin C, et al. Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2. J Cell Physiol. 2015;230:3084-92 pubmed publisher
  • western blot; human; fig 3
Hensel J, Duex J, Owens C, Dancik G, Edwards M, Frierson H, et al. Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors. Mol Cancer Res. 2015;13:1306-15 pubmed publisher
  • western blot; mouse; 1:2000; fig 3
Najm F, Madhavan M, Zaremba A, Shick E, Karl R, Factor D, et al. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 2015;522:216-20 pubmed publisher
  • immunocytochemistry; human; 1:250
Hayashi Y, Bardsley M, Toyomasu Y, Milosavljevic S, Gajdos G, Choi K, et al. Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. Gastroenterology. 2015;149:420-32.e16 pubmed publisher
  • western blot; human; fig 7
Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed publisher
  • western blot; zebrafish ; fig 4a
Jeffery J, Neyt C, Moore W, Paterson S, Bower N, Chenevix Trench G, et al. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. FASEB J. 2015;29:1999-2009 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2d
Li X, Wu Y, Li X, Li D, Du J, Hu C, et al. Role of eukaryotic translation initiation factor 3a in bleomycin-induced pulmonary fibrosis. Eur J Pharmacol. 2015;749:89-97 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
  • western blot; human; loading ...; fig 2g
Yoda A, Adelmant G, Tamburini J, Chapuy B, Shindoh N, Yoda Y, et al. Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med. 2015;21:71-5 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Flinsenberg T, Janssen W, Herczenik E, Boross P, Nederend M, Jongeneel L, et al. A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling. Clin Immunol. 2014;155:108-17 pubmed publisher
  • western blot; human; 1:1000; fig 4
Lin C, Chen P, Hsu L, Kuo D, Chu S, Hsieh Y. Inhibition of the invasion and migration of renal carcinoma 786‑o‑si3 cells in vitro and in vivo by Koelreuteria formosana extract. Mol Med Rep. 2014;10:3334-42 pubmed publisher
  • western blot; mouse; 1:1000
Niu F, Yao H, Zhang W, Sutliff R, Buch S. Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci. 2014;34:11812-25 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Moorwood C, Philippou A, Spinazzola J, Keyser B, Macarak E, Barton E. Absence of ?-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle. Skelet Muscle. 2014;4:13 pubmed publisher
  • western blot; human; loading ...; fig 4a
Benzina S, Harquail J, Jean S, Beauregard A, Colquhoun C, Carroll M, et al. Deoxypodophyllotoxin isolated from Juniperus communis induces apoptosis in breast cancer cells. Anticancer Agents Med Chem. 2015;15:79-88 pubmed
  • western blot; rat; 1:1000
Patki G, Solanki N, Atrooz F, Ansari A, Allam F, Jannise B, et al. Novel mechanistic insights into treadmill exercise based rescue of social defeat-induced anxiety-like behavior and memory impairment in rats. Physiol Behav. 2014;130:135-44 pubmed publisher
  • western blot; human; 1:1000
Pourreyron C, Chen M, McGrath J, Salas Alanis J, South A, Leigh I. High levels of type VII collagen expression in recessive dystrophic epidermolysis bullosa cutaneous squamous cell carcinoma keratinocytes increases PI3K and MAPK signalling, cell migration and invasion. Br J Dermatol. 2014;170:1256-65 pubmed publisher
  • western blot; least shrew
Alkam T, Chebolu S, Darmani N. Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva). Eur J Pharmacol. 2014;722:156-64 pubmed
  • western blot; mouse; fig 5
Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 2013;23:994-1006 pubmed publisher
  • western blot; human
Abbonante V, Gruppi C, Rubel D, Gross O, Moratti R, Balduini A. Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions. J Biol Chem. 2013;288:16738-46 pubmed publisher
  • western blot; human
Yang Y, Li J, Pan X, Zhou P, Yu X, Cao H, et al. Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system. Biotechnol Bioeng. 2013;110:958-68 pubmed publisher
Batool T, Fang J, Barash U, Moustakas A, Vlodavsky I, Li J. Overexpression of heparanase attenuated TGF-?-stimulated signaling in tumor cells. FEBS Open Bio. 2017;7:405-413 pubmed publisher
Dyshlovoy S, Tabakmakher K, Hauschild J, Shchekaleva R, Otte K, Guzii A, et al. Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro. Mar Drugs. 2016;14: pubmed publisher
Gao Y, Mutter Rottmayer E, Greenwalt A, Goldfarb D, Yan F, Yang Y, et al. A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis. Nat Commun. 2016;7:12105 pubmed publisher
Singhal G, Fisher F, Chee M, Tan T, El Ouaamari A, Adams A, et al. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS ONE. 2016;11:e0148252 pubmed publisher
Pereira M, Martynhak B, Andreatini R, Svenningsson P. 5-HT6 receptor agonism facilitates emotional learning. Front Pharmacol. 2015;6:200 pubmed publisher
Wostradowski T, Gudi V, Pul R, Gingele S, Lindquist J, Stangel M, et al. Effect of interferon-β1b on CXCR4-dependent chemotaxis in T cells from multiple sclerosis patients. Clin Exp Immunol. 2015;182:162-72 pubmed publisher
De Marco C, Malanga D, Rinaldo N, De Vita F, Scrima M, Lovisa S, et al. Mutant AKT1-E17K is oncogenic in lung epithelial cells. Oncotarget. 2015;6:39634-50 pubmed publisher
Tang J, Cui W, Song F, Zhai C, Hu H, Zuo Q, et al. Effects of mesenchymal stem cells on interleukin-1β-treated chondrocytes and cartilage in a rat osteoarthritic model. Mol Med Rep. 2015;12:1753-60 pubmed publisher
Didonna A, Venturini A, Hartman K, Vranac T, ÄŒurin Å erbec V, Legname G. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). Peerj. 2015;3:e811 pubmed publisher
Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, et al. Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell. 2014;158:1254-1269 pubmed publisher
Zhong W, Hutchinson T, Chebolu S, Darmani N. Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva). PLoS ONE. 2014;9:e104718 pubmed publisher
Vasiliauskas J, Nashu M, Pathrose P, Starnes S, Waltz S. Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model. Oncotarget. 2014;5:5547-58 pubmed
Giri S, Rattan R, Deshpande M, Maguire J, Johnson Z, Graham R, et al. Preclinical therapeutic potential of a nitrosylating agent in the treatment of ovarian cancer. PLoS ONE. 2014;9:e97897 pubmed publisher
Wang Y, Zhu G, Briz V, Hsu Y, Bi X, Baudry M. A molecular brake controls the magnitude of long-term potentiation. Nat Commun. 2014;5:3051 pubmed publisher
Davies K, Mahale S, Astling D, Aisner D, Le A, Hinz T, et al. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE. 2013;8:e82236 pubmed publisher
Ekman M, Bhattachariya A, Dahan D, Uvelius B, Albinsson S, Swärd K. Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. PLoS ONE. 2013;8:e82308 pubmed publisher
Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher
de Souza W, Fortunato Miranda N, Robbs B, de Araujo W, de Freitas Junior J, Bastos L, et al. Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling. PLoS ONE. 2013;8:e74994 pubmed publisher
Zhang Z, Chu W, Song B, Gooz M, Zhang J, Yu C, et al. TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells. PLoS ONE. 2013;8:e73424 pubmed publisher
Cebula M, Ochel A, Hillebrand U, Pils M, Schirmbeck R, Hauser H, et al. An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells. PLoS ONE. 2013;8:e68720 pubmed publisher
Newbold A, Vervoort S, Martin B, Bots M, Johnstone R. Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors. Cell Death Dis. 2012;3:e387 pubmed publisher
Schmidt J, Riechers A, Stoll R, Amann T, Fink F, Spruss T, et al. Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition. PLoS ONE. 2012;7:e37941 pubmed publisher
Bhargavan B, Fatma N, Chhunchha B, Singh V, Kubo E, Singh D. LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway. Cell Death Dis. 2012;3:e316 pubmed publisher
Tsai W, Wang P, Lin S, Wu I, Ko Y, Chen Y, et al. Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites. Front Microbiol. 2012;3:60 pubmed publisher
Lal A, Thomas M, Altschuler G, Navarro F, O Day E, Li X, et al. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011;7:e1002363 pubmed publisher
Fonseca B, Alain T, Finestone L, Huang B, Rolfe M, Jiang T, et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by p. J Biol Chem. 2011;286:27111-22 pubmed publisher
Marchini C, Montani M, Konstantinidou G, Orrù R, Mannucci S, Ramadori G, et al. Mesenchymal/stromal gene expression signature relates to basal-like breast cancers, identifies bone metastasis and predicts resistance to therapies. PLoS ONE. 2010;5:e14131 pubmed publisher
product information
SKU :
9107S
Product-Name :
p44/42 MAPK (Erk1/2) (3A7) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Mi, Z, B, Pg
Applications :
Western blot
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
42, 44
Host :
Mouse
Target :
ERK1/ERK2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.