Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb | Cell Signaling Technology 9106 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb

catalog :

9106

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

E10

reactivity :

African green monkey, human, mouse, rat, dogs, chicken, pigs , zebrafish , fruit fly

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section

more info or order :

Cell Signaling Technology product webpage

citations: 208

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 6a	Escasany E, Lanzón B, García Carrasco A, Izquierdo Lahuerta A, Torres L, Corrales P, et al. Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney. Dis Model Mech. 2021;14: pubmed publisher
western blot; human; 1:3000; loading ...; fig 4a	Sánchez Fdez A, Re Louhau M, Rodríguez Núñez P, Ludeña D, Matilla Almazán S, Pandiella A, et al. Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer. NPJ Precis Oncol. 2021;5:78 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 7b	Shang P, Stepicheva N, Teel K, McCauley A, Fitting C, Hose S, et al. βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Commun Biol. 2021;4:850 pubmed publisher
western blot; mouse; 1:500; loading ...; fig s3	Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher
western blot; human; loading ...; fig s4b, s4d	Strazza M, Azoulay Alfaguter I, Peled M, Adam K, Mor A. Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells. Commun Biol. 2021;4:672 pubmed publisher
western blot; human; 1:3000; loading ...; fig 2b	Wang Z, Goto Y, Allevato M, Wu V, Saddawi Konefka R, Gilardi M, et al. Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nat Commun. 2021;12:2383 pubmed publisher
western blot; mouse; 1:1000; loading ...	Maruyama K, Naemura K, Arima Y, Uchijima Y, Nagao H, Yoshihara K, et al. Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery. iScience. 2021;24:102305 pubmed publisher
western blot; human; loading ...; fig 5a	Lu L, Wei R, Prats Ejarque G, Goetz M, Wang G, Torrent M, et al. Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model. Cell Mol Life Sci. 2020;: pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 5i	Yan J, Bengtson C, Buchthal B, Hagenston A, Bading H. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020;370: pubmed publisher
western blot; human; 1:1000; loading ...; fig 7g	Huang Y, Liang C, Ritz D, Coelho R, Septiadi D, Estermann M, et al. Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. elife. 2020;9: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s3-1	Leinonen H, Pham N, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. elife. 2020;9: pubmed publisher
western blot; human; 1:2000; loading ...; fig 5s2a	Rogerson C, Ogden S, Britton E, Ang Y, Sharrocks A. Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma. elife. 2020;9: pubmed publisher
western blot; human; 1:2000; loading ...; fig 10d	Fulgenzi G, Hong Z, Tomassoni Ardori F, Barella L, Becker J, Barrick C, et al. Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun. 2020;11:1950 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3a	Huang C, Lu S, Huang T, Huang B, Sun H, Yang S, et al. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics. 2020;10:2817-2831 pubmed publisher
western blot; mouse; 1:2000; loading ...	Duplaquet L, Leroy C, Vinchent A, Paget S, Lefebvre J, Vanden Abeele F, et al. Control of cell death/survival balance by the MET dependence receptor. elife. 2020;9: pubmed publisher
western blot; mouse; loading ...; fig 5d	Guo X, Kolpakov M, Hooshdaran B, Schappell W, Wang T, Eguchi S, et al. Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload. JACC Basic Transl Sci. 2020;5:69-83 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4c	Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher
western blot; human; loading ...; fig 5a	Weisell J, Ohukainen P, Näpänkangas J, Ohlmeier S, Bergmann U, Peltonen T, et al. Heat shock protein 90 is downregulated in calcific aortic valve disease. BMC Cardiovasc Disord. 2019;19:306 pubmed publisher
western blot; human; 1:1000; loading ...; fig e6d	Amendola C, Mahaffey J, Parker S, Ahearn I, Chen W, Zhou M, et al. KRAS4A directly regulates hexokinase 1. Nature. 2019;576:482-486 pubmed publisher
flow cytometry; mouse; 1:200; loading ...; fig 3b	Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kulhanek K, et al. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science. 2019;366:109-115 pubmed publisher
western blot; rat; loading ...; fig 1b	Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6b western blot; human; 1:1000; loading ...; fig 6a	Tomassoni Ardori F, Fulgenzi G, Becker J, Barrick C, Palko M, Kuhn S, et al. Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels. elife. 2019;8: pubmed publisher
western blot; human; 1:1000; fig 3g	Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, et al. Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nat Commun. 2019;10:2350 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6a	Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, et al. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019;10:2352 pubmed publisher
western blot; human; 1:2000; loading ...; fig 3	Fazi B, Proserpio C, Galardi S, Annesi F, Cola M, Mangiola A, et al. The Expression of the Chemokine CXCL14 Correlates with Several Aggressive Aspects of Glioblastoma and Promotes Key Properties of Glioblastoma Cells. Int J Mol Sci. 2019;20: pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 6a western blot; human; loading ...; fig 2d	Jia Y, Li H, Wang J, Wang Y, Zhang P, Ma N, et al. Phosphorylation of 14-3-3ζ links YAP transcriptional activation to hypoxic glycolysis for tumorigenesis. Oncogenesis. 2019;8:31 pubmed publisher
western blot; mouse; loading ...; fig 1i	Tan Y, Kagan J. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019;: pubmed publisher
western blot; mouse; loading ...; fig 2e	Choi Y, Park S, Sun Y, Yoo J, Pudupakam R, Foo S, et al. Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis. Nat Microbiol. 2019;4:429-437 pubmed publisher
western blot; human; loading ...; fig s2f	Lee C, Moon S, Jeong J, Lee S, Lee M, Yoo S, et al. Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis. Cell Death Dis. 2018;9:401 pubmed publisher
western blot; human; loading ...; fig 1b	Kostas M, Haugsten E, Zhen Y, Sørensen V, Szybowska P, Fiorito E, et al. Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. Mol Cell Proteomics. 2018;17:850-870 pubmed publisher
western blot; human; loading ...; fig 1c	Thaler S, Schmidt M, Roβwag S, Thiede G, Schad A, Sleeman J. Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. Oncotarget. 2017;8:72281-72301 pubmed publisher
western blot; human; loading ...; fig 2c	Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed publisher
western blot; human; loading ...; fig 1e	Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 3a	El Gamal H, Eid A, Munusamy S. Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury. Biomed Res Int. 2017;2017:5903105 pubmed publisher
western blot; mouse; loading ...; fig 2d	Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y, et al. p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. Sci Rep. 2017;7:45964 pubmed publisher
immunohistochemistry; fruit fly ; 1:500; loading ...; fig 3e	Földi I, Anthoney N, Harrison N, Gangloff M, Verstak B, Nallasivan M, et al. Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila. J Cell Biol. 2017;216:1421-1438 pubmed publisher
western blot; human; loading ...; fig 6b	Fischer A, Harrison K, Ramirez Y, Auer D, Chowdhury S, Prusty B, et al. Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense. elife. 2017;6: pubmed publisher
immunocytochemistry; mouse; 1:1000; fig 7c	Laporte M, Chatellard C, Vauchez V, Hemming F, Deloulme J, Vossier F, et al. Alix is required during development for normal growth of the mouse brain. Sci Rep. 2017;7:44767 pubmed publisher
immunocytochemistry; human; loading ...; fig s1	Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 3f	Hwang I, Park C, Harrison K, Kehrl J. Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and GÎ±i2. J Immunol. 2017;198:2721-2734 pubmed publisher
western blot; human; loading ...; fig 5f	Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher
western blot; chicken; fig 8d	Boswell B, Korol A, West Mays J, Musil L. Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017;28:907-921 pubmed publisher
western blot; human; fig 3a	Roy D, Mondal S, Khurana A, Jung D, Hoffmann R, He X, et al. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. Sci Rep. 2017;7:41977 pubmed publisher
western blot; human; loading ...; fig s7e	Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, et al. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Sci Rep. 2017;7:41434 pubmed publisher
western blot; human; loading ...; fig 5e	Xu J, Zhang X, Wang H, Ge S, Gao T, Song L, et al. HCRP1 downregulation promotes hepatocellular carcinoma cell migration and invasion through the induction of EGFR activation and epithelial-mesenchymal transition. Biomed Pharmacother. 2017;88:421-429 pubmed publisher
western blot; human; loading ...; fig 2a	Huang Y, Zhou B, Wernig M, Sudhof T. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion. Cell. 2017;168:427-441.e21 pubmed publisher
western blot; human; loading ...; fig 6a	Nascimbeni A, Fanin M, Angelini C, Sandri M. Autophagy dysregulation in Danon disease. Cell Death Dis. 2017;8:e2565 pubmed publisher
flow cytometry; human; 1:1000; loading ...; fig 3	Ertsås H, Nolan G, Labarge M, Lorens J. Microsphere cytometry to interrogate microenvironment-dependent cell signaling. Integr Biol (Camb). 2017;9:123-134 pubmed publisher
immunocytochemistry; zebrafish ; loading ...; fig 3b	Dieris M, Ahuja G, Krishna V, Korsching S. A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine. Sci Rep. 2017;7:40892 pubmed publisher
western blot; rat; loading ...; fig 7a	Pandini G, Satriano C, Pietropaolo A, Gianì F, Travaglia A, La Mendola D, et al. The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor. Front Neurosci. 2016;10:569 pubmed publisher
western blot; human; fig s7e	Lee S, Rho S, Park H, Park J, Kim J, Lee I, et al. Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017;127:457-471 pubmed publisher
western blot; human; loading ...; fig 2c	Tsai C, Lin Y, Huang C, Shih C, Tsai Y, Tsao N, et al. Thrombomodulin regulates monocye differentiation via PKC? and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421 pubmed publisher
western blot; human; loading ...; fig 2a	Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed publisher
western blot; human; fig 2a, 2b, 2c	Park J, Lee C, Kim H, Kim D, Son J, Ko E, et al. Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling. Oncotarget. 2016;7:83308-83318 pubmed publisher
western blot; human; loading ...	Richter E, Harms M, Ventz K, NÃ¶lker R, Fraunholz M, Mostertz J, et al. Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus. J Proteome Res. 2016;15:4369-4386 pubmed
western blot; human; 1:1000; loading ...	Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher
western blot; human; loading ...; fig 5c	Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, et al. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016;213:2437-2457 pubmed
immunohistochemistry; mouse; loading ...; fig s4b	Thamodaran V, Bruce A. p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development. Open Biol. 2016;6: pubmed publisher
western blot; African green monkey; loading ...; fig 5c	Makita N, Sato T, Yajima Shoji Y, Sato J, Manaka K, Eda Hashimoto M, et al. Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist. J Biol Chem. 2016;291:22460-22471 pubmed
flow cytometry; human; loading ...; fig s18a	Kagoya Y, Nakatsugawa M, Yamashita Y, Ochi T, Guo T, Anczurowski M, et al. BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models. J Clin Invest. 2016;126:3479-94 pubmed publisher
western blot; mouse; 1:2000; fig 5 western blot; human; 1:2000; fig 5	Pourcelot M, Zemirli N, Silva da Costa L, Loyant R, Garcin D, Vitour D, et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. BMC Biol. 2016;14:69 pubmed publisher
western blot; human; fig s9	Gusscott S, Jenkins C, Lam S, Giambra V, Pollak M, Weng A. IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. PLoS ONE. 2016;11:e0161158 pubmed publisher
western blot; human; loading ...; fig 4a	Radke D, Ungefroren H, Helm O, Voigt S, Alp G, Braun H, et al. Negative control of TRAIL-R1 signaling by transforming growth factor ?1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. Cell Signal. 2016;28:1652-62 pubmed publisher
western blot; human; loading ...; fig 4a	Ciaraldi T, Ryan A, Mudaliar S, Henry R. Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes. PLoS ONE. 2016;11:e0158209 pubmed publisher
western blot; mouse; loading ...; fig 5a	Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed publisher
western blot; mouse; loading ...; fig s9	Rackov G, Hernandez Jimenez E, Shokri R, Carmona Rodríguez L, Manes S, Alvarez Mon M, et al. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-?B and IFN-?. J Clin Invest. 2016;126:3089-103 pubmed publisher
western blot; human; 1:750; fig s2	Deblois G, Smith H, Tam I, Gravel S, Caron M, Savage P, et al. ERR? mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016;7:12156 pubmed publisher
western blot; human; fig s1	Tsai S, Huang P, Hsu Y, Peng Y, Lee C, Wang J, et al. Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases. Sci Rep. 2016;6:28612 pubmed publisher
western blot; mouse; fig 7	Petrova L, Gran C, Bjoras M, Doetsch P. Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells. PLoS ONE. 2016;11:e0158581 pubmed publisher
western blot; human; fig 2a	Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed publisher
immunohistochemistry; rat; fig 5g	Fernandez Monreal M, Sánchez Castillo C, Esteban J. APPL1 gates long-term potentiation through its plekstrin homology domain. J Cell Sci. 2016;129:2793-803 pubmed publisher
western blot; mouse; 1:1000; fig 6	Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, et al. A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation. Sci Rep. 2016;6:25955 pubmed publisher
western blot; human; 1:500; fig 4	Fabbri R, Macciocca M, Vicenti R, Paradisi R, Klinger F, Pasquinelli G, et al. Doxorubicin and cisplatin induce apoptosis in ovarian stromal cells obtained from cryopreserved human ovarian tissue. Future Oncol. 2016;12:1699-711 pubmed publisher
western blot; mouse; fig 1	Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
western blot; human; loading ...; fig 2e	Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher
western blot; rat; fig 4	Jang S, Royston S, Lee G, Wang S, Chung H. Seizure-Induced Regulations of Amyloid-?, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity. Neural Plast. 2016;2016:2123748 pubmed publisher
western blot; human; loading ...; fig 4a	Engel B, Bowser J, Broaddus R, Carson D. MUC1 stimulates EGFR expression and function in endometrial cancer. Oncotarget. 2016;7:32796-809 pubmed publisher
western blot; human; fig 4	Xing M, Wang X, Chi Y, Zhou D. Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab. Oncotarget. 2016;7:28262-72 pubmed publisher
western blot; human; fig 2	Fearnley G, Smith G, Abdul Zani I, Yuldasheva N, Mughal N, Homer Vanniasinkam S, et al. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open. 2016;5:571-83 pubmed publisher
western blot; human; 1:1000; fig 3	Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, et al. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS ONE. 2016;11:e0152538 pubmed publisher
western blot; mouse; 1:2000; fig 5b	Prieto J, León M, Ponsoda X, Sendra R, Bort R, Ferrer Lorente R, et al. Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nat Commun. 2016;7:11124 pubmed publisher
western blot; human; 1:1000; fig 4	Patzke C, Acuna C, Giam L, Wernig M, SÃ¼dhof T. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. J Exp Med. 2016;213:499-515 pubmed publisher
western blot; human; fig 1	Meng Y, Zheng L, Yang Y, Wang H, Dong J, Wang C, et al. A monoclonal antibody targeting ErbB2 domain III inhibits ErbB2 signaling and suppresses the growth of ErbB2-overexpressing breast tumors. Oncogenesis. 2016;5:e211 pubmed publisher
western blot; rat; 1:1000; fig 1	Cannavo A, Liccardo D, Eguchi A, Elliott K, Traynham C, Ibetti J, et al. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nat Commun. 2016;7:10877 pubmed publisher
western blot; human; fig 4	Chusri P, Kumthip K, Hong J, Zhu C, Duan X, Jilg N, et al. HCV induces transforming growth factor Î²1 through activation of endoplasmic reticulum stress and the unfolded protein response. Sci Rep. 2016;6:22487 pubmed publisher
western blot; mouse; fig s1	Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher
ELISA; mouse; 1:400; tbl 1	Li M, Corbelli A, Watanabe S, Armelloni S, Ikehata M, Parazzi V, et al. Three-dimensional podocyte-endothelial cell co-cultures: Assembly, validation, and application to drug testing and intercellular signaling studies. Eur J Pharm Sci. 2016;86:1-12 pubmed publisher
immunohistochemistry; mouse; 1:500; loading ...; fig 3d	Abdul Rahman N, Greenwood S, Brett R, Tossell K, Ungless M, Plevin R, et al. Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory. J Neurosci. 2016;36:2348-54 pubmed publisher
western blot; human; 1:1000; fig 1	Klein C, Zwick A, Kissel S, Forster C, Pfeifer D, Follo M, et al. Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. J Exp Med. 2016;213:273-90 pubmed publisher
western blot; human; fig 10	Shang V, O Sullivan S, Kendall D, Roberts R. The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite. Pharmacol Res. 2016;105:152-63 pubmed publisher
western blot; mouse; 1:1000; fig 2	Watari K, Shibata T, Nabeshima H, Shinoda A, Fukunaga Y, Kawahara A, et al. Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice. Sci Rep. 2016;6:19470 pubmed publisher
western blot; human; 1:2000; fig 3	Guan X, Wang N, Cui F, Liu Y, Liu P, Zhao J, et al. Caveolin-1 is essential in the differentiation of human adipose-derived stem cells into hepatocyte-like cells via an MAPK pathway-dependent mechanism. Mol Med Rep. 2016;13:1487-94 pubmed publisher
western blot; human; loading ...; fig 4a	Peng B, Zhu H, Klausen C, Ma L, Wang Y, Leung P. GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression. Mol Hum Reprod. 2016;22:119-29 pubmed publisher
western blot; mouse; fig 4b	Patel A, Yamashita N, Ascano M, Bodmer D, Boehm E, Bodkin Clarke C, et al. RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome. Nat Commun. 2015;6:10119 pubmed publisher
western blot; human; loading ...; fig 3a	Chen J, Chen Y, Yen C, Chen W, Huang W. HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3. Oncotarget. 2016;7:473-89 pubmed publisher
western blot; human; fig 6	Oprea T, Sklar L, Agola J, Guo Y, Silberberg M, Roxby J, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS ONE. 2015;10:e0142182 pubmed publisher
western blot; human; fig 1 western blot; mouse; fig 1	Zhang Z, Wu N, Lu Y, Davidson D, Colonna M, Veillette A. DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015;212:2165-82 pubmed publisher
western blot; human; fig 1	Dumas A, LÃª Bury G, Marie AnaÃ¯s F, Herit F, Mazzolini J, Guilbert T, et al. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J Cell Biol. 2015;211:359-72 pubmed publisher
western blot; human; 1:1000; fig 4a	Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed publisher
western blot; human; 1:2000; fig 4b	MartÃnez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher
western blot; human; fig S2	Reinardy J, Corey D, Golzio C, Mueller S, Katsanis N, Kontos C. Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. PLoS ONE. 2015;10:e0139614 pubmed publisher
western blot; human; 1:2000; loading ...; fig 3	Cecchetti S, Bortolomai I, Ferri R, Mercurio L, Canevari S, Podo F, et al. Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma. PLoS ONE. 2015;10:e0136120 pubmed publisher
western blot; rat; fig 7	Zhu X, Wang K, Zhang K, Tan X, Wu Z, Sun S, et al. Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1Î²-Induced Nitrative/Oxidative Stress. Int J Mol Sci. 2015;16:21775-90 pubmed publisher
western blot; human; fig 4a	Vennin C, Spruyt N, Dahmani F, Julien S, Bertucci F, Finetti P, et al. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. Oncotarget. 2015;6:29209-23 pubmed publisher
western blot; human; fig 3	Ashford A, Dunkley T, Cockerill M, Rowlinson R, Baak L, Gallo R, et al. Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome. Cell Mol Life Sci. 2016;73:883-900 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6	Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in Î²-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed publisher
western blot; mouse; 1:2000; fig 3	Fisher O, Deng H, Liu D, Zhang Y, Wei R, Deng Y, et al. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015;6:7937 pubmed publisher
western blot; human	Picot N, Guerrette R, Beauregard A, Jean S, Michaud P, Harquail J, et al. Mammaglobin 1 promotes breast cancer malignancy and confers sensitivity to anticancer drugs. Mol Carcinog. 2016;55:1150-62 pubmed publisher
western blot; mouse; 1:1000; fig 6	Graham D, Becker C, Doan A, Goel G, Villablanca E, Knights D, et al. Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. Nat Commun. 2015;6:7838 pubmed publisher
western blot; mouse; fig 6	Ito A, Hong C, Rong X, Zhu X, Tarling E, Hedde P, et al. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. elife. 2015;4:e08009 pubmed publisher
western blot; mouse	Andersson L, Scharin TÃ¤ng M, Lundqvist A, Lindbom M, Mardani I, Fogelstrand P, et al. Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia. Cardiovasc Res. 2015;107:478-86 pubmed publisher
western blot; human; 1:500; fig 1	Blancafort A, GirÃ³ Perafita A, Oliveras G, Palomeras S, Turrado C, Campuzano Ã, et al. Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs. PLoS ONE. 2015;10:e0131241 pubmed publisher
western blot; human; 1:1000	Carthy J, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin C, et al. Tamoxifen Inhibits TGF-Î²-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2. J Cell Physiol. 2015;230:3084-92 pubmed publisher
western blot; human; fig 5b	Condelli V, Maddalena F, Sisinni L, Lettini G, Matassa D, Piscazzi A, et al. Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma. Oncotarget. 2015;6:22298-309 pubmed
western blot; rat	Ronchi G, Haastert Talini K, Fornasari B, Perroteau I, Geuna S, Gambarotta G. The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration. Eur J Neurosci. 2016;43:351-64 pubmed publisher
flow cytometry; human; 1:2000	HellesÃ¸y M, Lorens J. Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis. Mol Biol Cell. 2015;26:2698-711 pubmed publisher
western blot; human	Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and Î²TrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher
western blot; human; 1:1000; fig 5c	Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-Î²/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher
western blot; human; 1:1000; fig 5a	Wang Z, Ma B, Ji X, Deng Y, Zhang T, Zhang X, et al. MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF. Cancer Cell Int. 2015;15:40 pubmed publisher
western blot; dogs	Andersen N, Boguslawski E, Kuk C, Chambers C, Duesbery N. Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts. Int J Oncol. 2015;47:71-80 pubmed publisher
western blot; human; fig 6b	Park H, Lee D, Yim M, Choi Y, Park S, Seo S, et al. 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1Î± and NF-ÎºB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions. Int J Mol Med. 2015;36:301-8 pubmed publisher
western blot; mouse; fig 1	Boswell B, Musil L. Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells. Mol Biol Cell. 2015;26:2561-72 pubmed publisher
western blot; rat; fig 5	Bhushan S, Tchatalbachev S, Lu Y, FrÃ¶hlich S, Fijak M, Vijayan V, et al. Differential activation of inflammatory pathways in testicular macrophages provides a rationale for their subdued inflammatory capacity. J Immunol. 2015;194:5455-64 pubmed publisher
western blot; human	Mulens Arias V, Rojas J, PÃ©rez YagÃ¼e S, Morales M, Barber D. Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics. Biomaterials. 2015;52:494-506 pubmed publisher
western blot; human	Richter E, Harms M, Ventz K, Gierok P, Chilukoti R, Hildebrandt J, et al. A multi-omics approach identifies key hubs associated with cell type-specific responses of airway epithelial cells to staphylococcal alpha-toxin. PLoS ONE. 2015;10:e0122089 pubmed publisher
western blot; human; fig 7	Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed publisher
western blot; mouse; 1:1000	Freeman J, Feng Y, Demehri F, Dempsey P, Teitelbaum D. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J. 2015;29:2943-58 pubmed publisher
western blot; human; loading ...; fig 6a	Maione F, Oliaro Bosso S, Meda C, Di Nicolantonio F, Bussolino F, Balliano G, et al. The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination. Sci Rep. 2015;5:9054 pubmed publisher
western blot; human; fig 2	Vogel C, Smit M, Maddalo G, Possik P, Sparidans R, van der Burg S, et al. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell Melanoma Res. 2015;28:307-17 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3a	Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher
western blot; human; 1:2000	Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed publisher
western blot; mouse; loading ...; fig 4a	Liu Y, Zhang Q, Ding Y, Li X, Zhao D, Zhao K, et al. Histone lysine methyltransferase Ezh1 promotes TLR-triggered inflammatory cytokine production by suppressing Tollip. J Immunol. 2015;194:2838-46 pubmed publisher
western blot; human; 1:1000; fig s5	Hakanpaa L, Sipilä T, Leppänen V, Gautam P, Nurmi H, Jacquemet G, et al. Endothelial destabilization by angiopoietin-2 via integrin Î²1 activation. Nat Commun. 2015;6:5962 pubmed publisher
western blot; mouse	Cai K, Wang Y, Smith E, Smedberg J, Yang D, Yang W, et al. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia. 2015;17:89-100 pubmed publisher
western blot; rat; 1:1000	DomÃnguez Alonso A, ValdÃ©s Tovar M, SolÃs ChagoyÃ¡n H, BenÃtez King G. Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex. Int J Mol Sci. 2015;16:1907-27 pubmed publisher
western blot; rat; 1:2000; loading ...; fig 2d	Li X, Wu Y, Li X, Li D, Du J, Hu C, et al. Role of eukaryotic translation initiation factor 3a in bleomycin-induced pulmonary fibrosis. Eur J Pharmacol. 2015;749:89-97 pubmed publisher
western blot; rat; 1:500	Loeuillard E, Bertrand J, Herranen A, Melchior C, GuÃ©rin C, CoÃ«ffier M, et al. 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-Î²1 signaling. World J Gastroenterol. 2014;20:18207-15 pubmed publisher
western blot; human	Kong B, Cho Y, Lee E. G protein-coupled estrogen receptor-1 is involved in the protective effect of protocatechuic aldehyde against endothelial dysfunction. PLoS ONE. 2014;9:e113242 pubmed publisher
western blot; mouse	Strand D, Liang Y, Yang F, Barron D, Ressler S, Schauer I, et al. TGF-Î² induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways. Am J Clin Exp Urol. 2014;2:239-48 pubmed
western blot; human; fig 3	Blair B, Wu X, Zahari M, Mohseni M, Cidado J, Wong H, et al. A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations. Proteomics. 2015;15:318-26 pubmed publisher
western blot; human; loading ...; fig 5d	Niu G, Ye T, Qin L, Bourbon P, Chang C, Zhao S, et al. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin Î²4. FASEB J. 2015;29:131-40 pubmed publisher
western blot; human; fig 3	Gray A, Stephens C, Bigelow R, Coleman D, Cardelli J. The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-Î²-induced myofibroblast phenotypes through RhoA and ERK inhibition. PLoS ONE. 2014;9:e109208 pubmed publisher
western blot; mouse; loading ...; fig 5d	Flinsenberg T, Janssen W, Herczenik E, Boross P, Nederend M, Jongeneel L, et al. A novel FcÎ³RIIa Q27W gene variant is associated with common variable immune deficiency through defective FcÎ³RIIa downstream signaling. Clin Immunol. 2014;155:108-17 pubmed publisher
western blot; mouse	Sackmann Sala L, Chiche A, Mosquera Garrote N, Boutillon F, Cordier C, Pourmir I, et al. Prolactin-induced prostate tumorigenesis links sustained Stat5 signaling with the amplification of basal/stem cells and emergence of putative luminal progenitors. Am J Pathol. 2014;184:3105-19 pubmed publisher
western blot; pigs	Wang H, Leinwand L, Anseth K. Roles of transforming growth factor-?1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation. FASEB J. 2014;28:4551-62 pubmed publisher
western blot; human; 1:200	Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, et al. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049 pubmed publisher
western blot; human; 1:1000	Francis V, Abera A, Matjila M, Millar R, Katz A. Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. PLoS ONE. 2014;9:e99680 pubmed publisher
western blot; rat; 1:2000; fig 3	Pysz M, Hao F, Hizli A, Lum M, Swetzig W, Black A, et al. Differential regulation of cyclin D1 expression by protein kinase C ? and ? signaling in intestinal epithelial cells. J Biol Chem. 2014;289:22268-83 pubmed publisher
western blot; human; loading ...; fig 4a	Benzina S, Harquail J, Jean S, Beauregard A, Colquhoun C, Carroll M, et al. Deoxypodophyllotoxin isolated from Juniperus communis induces apoptosis in breast cancer cells. Anticancer Agents Med Chem. 2015;15:79-88 pubmed
immunohistochemistry - frozen section; mouse; 1:1000; fig 4	Darcy M, Trouche S, Jin S, Feig L. Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus. Hippocampus. 2014;24:1317-29 pubmed publisher
western blot; rat	Menaouar A, Florian M, Wang D, Danalache B, Jankowski M, Gutkowska J. Anti-hypertrophic effects of oxytocin in rat ventricular myocytes. Int J Cardiol. 2014;175:38-49 pubmed publisher
western blot; human; 1:1000; fig 1	Duitman J, Ruela de Sousa R, Shi K, de Boer O, Borensztajn K, Florquin S, et al. Protease activated receptor-1 deficiency diminishes bleomycin-induced skin fibrosis. Mol Med. 2014;20:410-6 pubmed publisher
western blot; human	Asp N, Pust S, Sandvig K. Flotillin depletion affects ErbB protein levels in different human breast cancer cells. Biochim Biophys Acta. 2014;1843:1987-96 pubmed publisher
western blot; rat; 1:200	Patki G, Solanki N, Atrooz F, Ansari A, Allam F, Jannise B, et al. Novel mechanistic insights into treadmill exercise based rescue of social defeat-induced anxiety-like behavior and memory impairment in rats. Physiol Behav. 2014;130:135-44 pubmed publisher
western blot; mouse	Pérez Quintero L, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A. EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C?, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014;211:727-42 pubmed publisher
western blot; human; 1:1000	Pourreyron C, Chen M, McGrath J, Salas Alanis J, South A, Leigh I. High levels of type VII collagen expression in recessive dystrophic epidermolysis bullosa cutaneous squamous cell carcinoma keratinocytes increases PI3K and MAPK signalling, cell migration and invasion. Br J Dermatol. 2014;170:1256-65 pubmed publisher
western blot; human	Cheng J, Fan Y, Xu X, Dou J, Tang Y, Zhong X, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5:e1079 pubmed publisher
western blot; mouse	Tchetchelnitski V, Van Den Eijnden M, Schmidt F, Stoker A. Developmental co-expression and functional redundancy of tyrosine phosphatases with neurotrophin receptors in developing sensory neurons. Int J Dev Neurosci. 2014;34:48-59 pubmed publisher
western blot; human	Yim D, Ghosh S, Guy G, Virshup D. Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene. 2015;34:474-84 pubmed publisher
western blot; mouse; fig 5, 7	Zemljic Harpf A, Godoy J, Platoshyn O, Asfaw E, Busija A, Domenighetti A, et al. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014;127:1104-16 pubmed publisher
western blot; human	Kloog Y, Mor A. Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1. Mol Cell Biol. 2014;34:978-88 pubmed publisher
western blot; human; fig 2	Bist P, Dikshit N, Koh T, Mortellaro A, Tan T, Sukumaran B. The Nod1, Nod2, and Rip2 axis contributes to host immune defense against intracellular Acinetobacter baumannii infection. Infect Immun. 2014;82:1112-22 pubmed publisher
western blot; human	Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, et al. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. 2014;10:257-68 pubmed publisher
western blot; mouse; 1:1000	Nakayama A, Nakayama M, Turner C, Höing S, Lepore J, Adams R. Ephrin-B2 controls PDGFR? internalization and signaling. Genes Dev. 2013;27:2576-89 pubmed publisher
western blot; mouse; fig 6	Wu J, Akkuratov E, Bai Y, Gaskill C, Askari A, Liu L. Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src. Biochemistry. 2013;52:9059-67 pubmed publisher
western blot; human	Wu H, Balsbaugh J, Chandler H, Georgilis A, Zullow H, Shabanowitz J, et al. Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. J Biol Chem. 2013;288:36398-408 pubmed publisher
western blot; mouse; 1:10000	Chen Z, Morris D, Jiang L, Liu Y, Rui L. SH2B1 in ?-cells regulates glucose metabolism by promoting ?-cell survival and islet expansion. Diabetes. 2014;63:585-95 pubmed publisher
western blot; human	Lee J, Park J, Kwon O, Kim H, Fornace A, Cha H. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014;73:125-34 pubmed publisher
western blot; mouse; 1:2000	Evans C, Cook S, Coleman M, Gilley J. MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling. PLoS ONE. 2013;8:e76505 pubmed publisher
western blot; human	Reese C, Dyer S, Perry B, Bonner M, Oates J, Hofbauer A, et al. Differential regulation of cell functions by CSD peptide subdomains. Respir Res. 2013;14:90 pubmed publisher
western blot; mouse; 1:1000	Philip B, Roland C, Daniluk J, Liu Y, Chatterjee D, Gomez S, et al. A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology. 2013;145:1449-58 pubmed publisher
immunohistochemistry - paraffin section; mouse	Chai Z, Dai A, Tu Y, Li J, Wu T, Wang Y, et al. Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury. J Am Soc Nephrol. 2013;24:1782-92 pubmed publisher
western blot; human; loading ...; fig 4b	Yu P, Yan M, Lai H, Huang R, Chou Y, Lin W, et al. Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. Int J Cancer. 2014;134:542-51 pubmed publisher
western blot; human	Zhou X, Wang H, Burg M, Ferraris J. High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol. 2013;305:F362-9 pubmed publisher
western blot; human	Chu I, Lai W, Aprelikova O, El Touny L, Kouros Mehr H, Green J. Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFß. PLoS ONE. 2013;8:e61125 pubmed publisher
western blot; human	Caldarelli A, Muller J, Paskowski Rogacz M, Herrmann K, Bauer R, Koch S, et al. A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling. Leukemia. 2013;27:2301-10 pubmed publisher
western blot; rat	Mehmood T, Schneider A, Pannetier S, Hanauer A. Rsk2 Knockdown in PC12 Cells Results in Sp1 Dependent Increased Expression of the Gria2 Gene, Encoding the AMPA Receptor Subunit GluR2. Int J Mol Sci. 2013;14:3358-75 pubmed publisher
western blot; human	Fan C, Chen C, Chen K, Shen C, Kuo Y, Chen Y, et al. Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo. J Transl Med. 2012;10:254 pubmed publisher
western blot; human	Yang Y, Li J, Pan X, Zhou P, Yu X, Cao H, et al. Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system. Biotechnol Bioeng. 2013;110:958-68 pubmed publisher
immunocytochemistry; mouse; fig 4 western blot; mouse	Turco M, Furia L, Dietze A, Fernandez Diaz L, Ronzoni S, Sciullo A, et al. Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein. Stem Cells. 2012;30:2423-36 pubmed publisher
western blot; mouse	Austenaa L, Barozzi I, Chronowska A, Termanini A, Ostuni R, Prosperini E, et al. The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity. 2012;36:572-85 pubmed publisher
western blot; human; fig 1	Riaz A, Zeller K, Johansson S. Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in ?1 integrin-mediated cell survival. PLoS ONE. 2012;7:e32081 pubmed publisher
western blot; human; fig 2	Ngai J, Inngjerdingen M, Berge T, Tasken K. Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. BMC Immunol. 2009;10:27 pubmed publisher
immunohistochemistry - free floating section; rat; 1:500	Papadeas S, Halloran C, McCown T, Breese G, Blake B. Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. J Comp Neurol. 2008;511:271-85 pubmed publisher
western blot; human	Rieger J, Lemke D, Maurer G, Weiler M, Frank B, Tabatabai G, et al. Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL. J Neurochem. 2008;106:2436-48 pubmed publisher
	Baietti M, Simíček M, Abbasi Asbagh L, Radaelli E, Lievens S, Crowther J, et al. OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. EMBO Mol Med. 2016;8:288-303 pubmed publisher
	Milagre C, Gopinathan G, Everitt G, Thompson R, Kulbe H, Zhong H, et al. Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer. Cancer Res. 2015;75:1255-64 pubmed publisher
	Wang Z, Liu X, Zhang D, Wang X, Zhao F, Shi P, et al. Coâ€‘culture with human fetal epidermal keratinocytes promotes proliferation and migration of human fetal and adult dermal fibroblasts. Mol Med Rep. 2015;11:1105-10 pubmed publisher
	Monti M, Solito R, Puccetti L, Pasotti L, Roggeri R, Monzani E, et al. Protective effects of novel metal-nonoates on the cellular components of the vascular system. J Pharmacol Exp Ther. 2014;351:500-9 pubmed publisher
	Gondo A, Shinotsuka T, Morita A, Abe Y, Yasui M, Nuriya M. Sustained down-regulation of Î²-dystroglycan and associated dysfunctions of astrocytic endfeet in epileptic cerebral cortex. J Biol Chem. 2014;289:30279-88 pubmed publisher
	Vignarajan S, Xie C, Yao M, Sun Y, Simanainen U, Sved P, et al. Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A?? via AKT in prostate cancer cells. Oncotarget. 2014;5:6289-99 pubmed publisher
	Li G, Wang Y, Pan Q, Wang J, Fan J, Sun C. RNAi screening with shRNAs against histone methylation-related genes reveals determinants of sorafenib sensitivity in hepatocellular carcinoma cells. Int J Clin Exp Pathol. 2014;7:1085-92 pubmed
	Gras B, Jacqueroud L, Wierinckx A, Lamblot C, Fauvet F, Lachuer J, et al. Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. PLoS ONE. 2014;9:e92254 pubmed publisher
	Suo D, Park J, Harrington A, Zweifel L, Mihalas S, Deppmann C. Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014;17:36-45 pubmed publisher
	Hua S, Yao M, Vignarajan S, Witting P, Hejazi L, Gong Z, et al. Cytosolic phospholipase A2? sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochim Biophys Acta. 2013;1831:1146-57 pubmed publisher
	Betton B, Gannon P, Koumakpayi I, Diallo J, Mes Masson A, Saad F. Influence of pH on the Cytotoxic Activity of Inositol Hexakisphosphate (IP6) in Prostate Cancer. Front Oncol. 2011;1:40 pubmed publisher
	Odrowaz Z, Sharrocks A. ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8:e1002694 pubmed publisher
	Miron V, Durafourt B, Antel J, Kennedy T. Assessment of sphingosine-1-phosphate receptor expression and associated intracellular signaling cascades in primary cells of the human central nervous system. Methods Mol Biol. 2012;874:141-54 pubmed publisher
	Ramirez I, Pietka G, Jones D, Divecha N, Alia A, Baraban S, et al. Impaired neural development in a zebrafish model for Lowe syndrome. Hum Mol Genet. 2012;21:1744-59 pubmed publisher
	Campbell J, Davidenko N, Caffarel M, Cameron R, Watson C. A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology. PLoS ONE. 2011;6:e25661 pubmed publisher
	Cooper D, Pechkovsky D, Hackett T, Knight D, Granville D. Granzyme K activates protease-activated receptor-1. PLoS ONE. 2011;6:e21484 pubmed publisher
	Fei Z, Bera T, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem. 2011;286:27761-8 pubmed publisher
	Fonseca B, Alain T, Finestone L, Huang B, Rolfe M, Jiang T, et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by p. J Biol Chem. 2011;286:27111-22 pubmed publisher
	Burga L, Hu H, Juvekar A, Tung N, Troyan S, Hofstatter E, et al. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Res. 2011;13:R30 pubmed publisher
	Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010;37:551-66 pubmed publisher
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	Ellson C, Davidson K, Ferguson G, O Connor R, Stephens L, Hawkins P. Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med. 2006;203:1927-37 pubmed
	Sommers C, Lee J, Steiner K, Gurson J, Depersis C, El Khoury D, et al. Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med. 2005;201:1125-34 pubmed

product information

SKU :

9106S

Product-Name :

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb

Size :

200 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, M, R, Hm, Mk, Mi, Dm, Z, B, Pg

Applications :

Flow cytometry

Product-Category :

MAP Kinase Signaling

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

42, 44

Host :

Mouse

Target :

ERK1 (Thr202/Tyr204) phosphate/ERK2 (Thr185/Tyr187) phosphate

more info or order :

Cell Signaling Technology product webpage