product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
CREB (86B10) Mouse mAb
catalog :
9104
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
86B10
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
citations: 61
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3c
Wang Z, Zhang X, Tian X, Yang Y, Ma L, Wang J, et al. CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Oncol Rep. 2021;45: pubmed publisher
  • western blot; mouse; 1:1500; loading ...; fig 1k
Xhima K, Markham Coultes K, Nedev H, Heinen S, Saragovi H, Hynynen K, et al. Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease. Sci Adv. 2020;6:eaax6646 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1b
  • immunocytochemistry; human; loading ...; fig 1c
Du H, LE Y, Sun F, Li K, Xu Y. ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells. Anal Cell Pathol (Amst). 2019;2019:1575031 pubmed publisher
  • western blot; human; 1:1000; fig s7b
Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
  • western blot; rat; loading ...; fig 6o
Shi Y, Zhang X, Chen C, Tang M, Wang Z, Liang X, et al. Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways. Brain Behav Immun. 2017;66:244-256 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2b
Dong E, Bachleda A, Xiong Y, Osawa S, Weiss E. Reduced phosphoCREB in Müller glia during retinal degeneration in rd10 mice. Mol Vis. 2017;23:90-102 pubmed
  • western blot; human; loading ...; fig 6h
Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Möllmann J, Kahles F, Lebherz C, Kappel B, Baeck C, Tacke F, et al. The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism. Diabetes Obes Metab. 2017;19:496-508 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f, S10a
Roy A, Kundu M, Jana M, Mishra R, Yung Y, Luan C, et al. Identification and characterization of PPAR? ligands in the hippocampus. Nat Chem Biol. 2016;12:1075-1083 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8f
Eccles R, Czajkowski M, Barth C, Müller P, McShane E, Grunwald S, et al. Bimodal antagonism of PKA signalling by ARHGAP36. Nat Commun. 2016;7:12963 pubmed publisher
  • western blot; human; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4b
Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
  • western blot; mouse; loading ...; fig s2
Inda C, Dos Santos Claro P, Bonfiglio J, Senin S, Maccarrone G, Turck C, et al. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol. 2016;214:181-95 pubmed publisher
  • western blot; human; fig 3d
Vorvis C, Hatziapostolou M, Mahurkar Joshi S, Koutsioumpa M, Williams J, Donahue T, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1124-37 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2d
Natale C, Duperret E, Zhang J, Sadeghi R, Dahal A, O Brien K, et al. Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors. elife. 2016;5: pubmed publisher
  • western blot; human; 1:5000; fig s5
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, et al. ASK1 signalling regulates brown and beige adipocyte function. Nat Commun. 2016;7:11158 pubmed publisher
  • western blot; human; 1:1000; fig 4
Patzke C, Acuna C, Giam L, Wernig M, Südhof T. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. J Exp Med. 2016;213:499-515 pubmed publisher
  • western blot; mouse; fig s7
Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531:53-8 pubmed publisher
  • western blot; rat; loading ...; fig 4a
Li X, Lu F, Li W, Xu J, Sun X, Qin L, et al. Underlying Mechanisms of Memory Deficits Induced by Etomidate Anesthesia in Aged Rat Model: Critical Role of Immediate Early Genes. Chin Med J (Engl). 2016;129:48-53 pubmed publisher
  • western blot; rat; fig 5
Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher
  • western blot; human; 1:1000; fig 3
Woolery K, Mohamed M, Linger R, Dobrinski K, Roman J, Kruk P. BRCA1 185delAG Mutation Enhances Interleukin-1β Expression in Ovarian Surface Epithelial Cells. Biomed Res Int. 2015;2015:652017 pubmed publisher
  • western blot; mouse; 1:1000
Kim H, Kim I, Dong Y, Lee I, Kim J, Kim J, et al. Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci. 2015;16:8772-88 pubmed publisher
Kim S, Wu C, Jia W, Xing Y, Tibbetts R. Roles of constitutive and signal-dependent protein phosphatase 2A docking motifs in burst attenuation of the cyclic AMP response element-binding protein. J Biol Chem. 2021;297:100908 pubmed publisher
Lucia K, Wu Y, Garcia J, Barlier A, Buchfelder M, Saeger W, et al. Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription. Oncogene. 2020;39:3367-3380 pubmed publisher
Baburina Y, Krestinin R, Odinokova I, Sotnikova L, Kruglov A, Krestinina O. Astaxanthin Inhibits Mitochondrial Permeability Transition Pore Opening in Rat Heart Mitochondria. Antioxidants (Basel). 2019;8: pubmed publisher
Coa L, Abreu T, Tashima A, Green J, Pascon R, Vallim M, et al. AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells. Biosci Rep. 2019;39: pubmed publisher
Tsunematsu H, Uyeda A, Yamamoto N, Sugo N. Immunocytochemistry and fluorescence imaging efficiently identify individual neurons with CRISPR/Cas9-mediated gene disruption in primary cortical cultures. BMC Neurosci. 2017;18:55 pubmed publisher
Liu Y, Weng Y, Lin H, Tang S, Chen C, Liang C, et al. Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Sci Rep. 2017;7:41437 pubmed publisher
Ortuño M, Robinson S, Subramanyam P, Paone R, Huang Y, Guo X, et al. Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect. Nat Med. 2016;22:1170-1179 pubmed publisher
Lin D, Chai Y, Izadpanah R, Braun S, Alt E. NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-α. Cell Cycle. 2016;15:2414-9 pubmed publisher
Steven A, Leisz S, Sychra K, Hiebl B, Wickenhauser C, Mougiakakos D, et al. Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization. Oncotarget. 2016;7:52061-52084 pubmed publisher
Moura D, Fernández I, Marín Royo G, López Sánchez I, Martín Doncel E, Vega F, et al. Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Sci Rep. 2016;6:28532 pubmed publisher
Khaperskyy D, Schmaling S, Larkins Ford J, McCormick C, Gaglia M. Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein. PLoS Pathog. 2016;12:e1005427 pubmed publisher
Qian Y, Forssberg H, Diaz Heijtz R. Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents. PLoS ONE. 2015;10:e0140974 pubmed publisher
Gebhardt A, Habjan M, Benda C, Meiler A, Haas D, Hein M, et al. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Nat Commun. 2015;6:8192 pubmed publisher
Gomez A, Altomare D, Sun W, Midde N, Ji H, Shtutman M, et al. Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine. Int J Neuropsychopharmacol. 2015;19: pubmed publisher
Song M, Ryoo I, Choi H, Choi B, Kim S, Heo T, et al. NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages. PLoS ONE. 2015;10:e0134235 pubmed publisher
Zhu J, Midde N, Gomez A, Sun W, Harrod S. Intra-ventral tegmental area HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats. Front Microbiol. 2015;6:540 pubmed publisher
Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, et al. Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo. J Am Heart Assoc. 2015;4: pubmed publisher
Jimenez Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, et al. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nat Chem Biol. 2015;11:347-354 pubmed publisher
Zhao F, Siu M, Jiang L, Tam K, Ngan H, Le X, et al. Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance. PLoS ONE. 2014;9:e113478 pubmed publisher
Nishiyama K, Hirai K. The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 ?-cells. PLoS ONE. 2014;9:e102073 pubmed publisher
Chen K, Hou Y, Wang K, Li J, Xia Y, Yang X, et al. Reexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinoma. Biomed Res Int. 2014;2014:742417 pubmed publisher
Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout Neveu E, Grenier Godard M, et al. Development of a conditionally immortalized human pancreatic ? cell line. J Clin Invest. 2014;124:2087-98 pubmed publisher
Hart L, Rauch A, Carr A, Vermeesch J, O Driscoll M. LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition. Dis Model Mech. 2014;7:535-45 pubmed publisher
Haery L, Lugo Picó J, Henry R, Andrews A, Gilmore T. Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth. Mol Cancer. 2014;13:29 pubmed publisher
Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed publisher
Malaguarnera R, Sacco A, Morcavallo A, Squatrito S, Migliaccio A, Morrione A, et al. Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling. Endocrinology. 2014;155:1207-21 pubmed publisher
Thompson R, Vardinogiannis I, Gilmore T. Identification of an NF-?B p50/p65-responsive site in the human MIR155HG promoter. BMC Mol Biol. 2013;14:24 pubmed publisher
Fukuda A, Shimada M, Nakadai T, Nishimura K, Hisatake K. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. PLoS ONE. 2013;8:e72496 pubmed publisher
Aregger M, Cowling V. Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites. Biochem J. 2013;455:67-73 pubmed publisher
Rice S, Elia A, Jawad Z, Pellatt L, Mason H. Metformin inhibits follicle-stimulating hormone (FSH) action in human granulosa cells: relevance to polycystic ovary syndrome. J Clin Endocrinol Metab. 2013;98:E1491-500 pubmed publisher
Chang Y, Yu Y, Shew J, Lee W, Hwang J, Chen Y, et al. Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO Mol Med. 2013;5:1165-79 pubmed publisher
Dho S, Deverman B, Lapid C, Manson S, Gan L, Riehm J, et al. Control of cellular Bcl-xL levels by deamidation-regulated degradation. PLoS Biol. 2013;11:e1001588 pubmed publisher
Wang J, El Masry N, Talbot I, Tomlinson I, Alison M, El Bahrawy M. Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients. Gastroenterol Res Pract. 2013;2013:107534 pubmed publisher
Gomez A, Midde N, Mactutus C, Booze R, Zhu J. Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. PLoS ONE. 2012;7:e44149 pubmed publisher
Stefan E, Malleshaiah M, Breton B, Ear P, Bachmann V, Beyermann M, et al. PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades. Nat Commun. 2011;2:598 pubmed publisher
van der Watt P, Ngarande E, Leaner V. Overexpression of Kpn?1 and Kpn?2 importin proteins in cancer derives from deregulated E2F activity. PLoS ONE. 2011;6:e27723 pubmed publisher
Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin Martin B, LONGMORE G, et al. Ajuba is required for Rac activation and maintenance of E-cadherin adhesion. J Cell Biol. 2011;195:855-71 pubmed publisher
Dufresne A, Bertucci F, Penel N, Le Cesne A, Bui B, Tubiana Hulin M, et al. Identification of biological factors predictive of response to imatinib mesylate in aggressive fibromatosis. Br J Cancer. 2010;103:482-5 pubmed publisher
Yang L, Zhang Q, Zhou C, Yang F, Zhang Y, Wang R, et al. Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus. PLoS ONE. 2010;5:e9851 pubmed publisher
Hashimoto Y, Loftis D, Adams J. Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells. PLoS ONE. 2009;4:e5130 pubmed publisher
product information
SKU :
9104S
Product-Name :
CREB (86B10) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
Neuroscience
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
43
Host :
Mouse
Target :
CREB
Primary-Protein :
CREB
Alt-Names :
CREB,CREB-1,CREB1,Cyclic AMP-responsive element-binding protein 1,MGC9284,active transcription factor CREB,cAMP responsive element binding protein 1,cAMP-response element-binding protein-1,cAMP-responsive element-binding protein 1,transactivator protein
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.