product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p44/42 MAPK (Erk1/2) Antibody
catalog :
9102
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
hamsters, human, mouse, rat, dogs, pigs , zebrafish , rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, proximity ligation assay
more info or order :
Cell Signaling Technology product webpage
citations: 454
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; fig 7g
  • western blot; human; 1:1000; loading ...; fig 2a, 2c
Mukherjee B, Tiwari A, Palo A, Pattnaik N, Samantara S, Dixit M. Reduced expression of FRG1 facilitates breast cancer progression via GM-CSF/MEK-ERK axis by abating FRG1 mediated transcriptional repression of GM-CSF. Cell Death Discov. 2022;8:442 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s4a
Pan R, Yu Y, Zhu H, Zhang W, Qin Y, Ye L, et al. RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation. iScience. 2022;25:105184 pubmed publisher
  • western blot; mouse; loading ...; fig s7e
Dufour C, Xia H, B chir W, Perry M, Kuzmanov U, Gainullina A, et al. Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency. Commun Biol. 2022;5:955 pubmed publisher
  • western blot; human; loading ...; fig 3c, s3d
Huang J, Wang X, Li B, Shen S, Wang R, Tao H, et al. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression. J Immunother Cancer. 2022;10: pubmed publisher
  • western blot; mouse; 1:2000; fig 5h
Shi H, Wu D, Chen R, Li N, Zhu L. Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine. Theranostics. 2022;12:3656-3675 pubmed publisher
  • western blot; rat; fig 5b
Lan T, Wu Y, Zhang Y, Li S, Zhu Z, Wang L, et al. Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway. J Neuroinflammation. 2022;19:117 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, et al. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022;3:100597 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Bassi G, Mishra S. Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis. iScience. 2022;25:104165 pubmed publisher
  • western blot; mouse; 1:1000; fig 6f
Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, et al. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
  • western blot; human; loading ...; fig 5g
Wang M, Zhang C, Zheng Q, Ma Z, Qi M, Di G, et al. RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways. Int J Biol Sci. 2022;18:942-955 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s3d
D Addio F, Maestroni A, Assi E, Ben Nasr M, Amabile G, Usuelli V, et al. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nat Commun. 2022;13:684 pubmed publisher
  • western blot; human; loading ...; fig 7c
Hsiao Y, Chi J, Li C, Chen L, Chen Y, Liang H, et al. Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple-negative breast cancers. Clin Transl Med. 2022;12:e724 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Grinat J, Kosel F, Goveas N, Kranz A, Alexopoulou D, Rajewsky K, et al. Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells. Life Sci Alliance. 2022;5: pubmed publisher
  • western blot; mouse; fig 1b
Rock S, Jiang K, Wu Y, Liu Y, Li J, Weiss H, et al. Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner. Cell Mol Gastroenterol Hepatol. 2022;13:501-516 pubmed publisher
  • western blot; zebrafish ; 1:1000; loading ...; fig 7a
Song Y, Chen W, Zhu B, Ge W. Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Front Cell Dev Biol. 2021;9:750888 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Correia de Sousa M, Calo N, Sobolewski C, Gjorgjieva M, Clement S, Maeder C, et al. Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Schünke H, Göbel U, Dikic I, Pasparakis M. OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun. 2021;12:5912 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Gyamfi J, Yeo J, Kwon D, Min B, Cha Y, Koo J, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7:129 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Liu Y, Li Y, Huang S, Li Y, Xia J, Jia J, et al. Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways. Aging (Albany NY). 2021;13:21155-21190 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
De Velasco M, Kura Y, Ando N, Sako N, Banno E, Fujita K, et al. Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; loading ...; fig s8c
Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed publisher
  • western blot; human; loading ...; fig 5a
Kareddula A, Medina D, Petrosky W, Dolfi S, Tereshchenko I, Walton K, et al. The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype. Ther Adv Urol. 2021;13:17562872211022462 pubmed publisher
  • western blot; human; loading ...; fig 2b
Moon S, Lee H, Kim S, Hong J, Chun S, Lee H, et al. Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells. BMC Cancer. 2021;21:931 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 6b
Berger C, Heyne H, Heiland T, Dommel S, Höfling C, Guiu Jurado E, et al. A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice. J Lipid Res. 2021;62:100105 pubmed publisher
  • western blot; human; fig 4e
Clark A, Kugathasan U, Baskozos G, Priestman D, Fugger N, Lone M, et al. An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions. Cell Rep Med. 2021;2:100345 pubmed publisher
  • western blot; mouse; 1:1000; fig 6c
Coudert L, Osseni A, Gangloff Y, Schaeffer L, Leblanc P. The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways. BMC Biol. 2021;19:153 pubmed publisher
  • western blot; human; loading ...; fig 2h
Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Shang P, Stepicheva N, Teel K, McCauley A, Fitting C, Hose S, et al. βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells. Commun Biol. 2021;4:850 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Hering L, Katkeviciute E, Schwarzfischer M, Niechcial A, Riggs J, Wawrzyniak M, et al. Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3c
Ibarra B, Machen C, ATIT R. Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development. J Dev Biol. 2021;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4e
Pham Q, Taniyama D, Sekino Y, Akabane S, Babasaki T, Kobayashi G, et al. Clinicopathologic features of TDO2 overexpression in renal cell carcinoma. BMC Cancer. 2021;21:737 pubmed publisher
  • western blot; human; loading ...; fig s7
Bayoumi A, Elsayed A, Han S, Petta S, Adams L, Aller R, et al. Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus. Adv Sci (Weinh). 2021;8:2004168 pubmed publisher
  • western blot; rat; loading ...; fig 7f
Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, et al. HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression. Circulation. 2021;144:638-654 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 14g
Hsieh Y, Lee K, Lei H, Lan K, Huo T, Lin Y, et al. (Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway. Cell Mol Gastroenterol Hepatol. 2021;12:813-838 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7i
López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; loading ...; fig 7e
Kim C, Park S, Lee S, Kim Y, Jang S, Woo S, et al. NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development. Nucleic Acids Res. 2021;49:5760-5778 pubmed publisher
  • western blot; human; 1:700; loading ...; fig 6
Lee J, Hsu Y, Li Y, Cheng S. Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells. Int J Endocrinol. 2021;2021:5583491 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  • western blot; rat; loading ...; fig 5f
Chang B, Guan H, Wang X, Chen Z, Zhu W, Wei X, et al. Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells. Front Mol Biosci. 2021;8:660072 pubmed publisher
  • western blot; pigs ; loading ...
Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, et al. The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response. Nucleic Acids Res. 2021;49:5537-5552 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 10a, 10c
Yan C, Zeng T, Lee K, Nobis M, Loh K, Gou L, et al. Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity. Nat Commun. 2021;12:2622 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Tien J, Chugh S, Goodrum A, Cheng Y, Mannan R, Zhang Y, et al. AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • western blot; zebrafish ; 1:2000; loading ...; fig 3d, 5e
Jamadagni P, Breuer M, Schmeisser K, Cardinal T, Kassa B, Parker J, et al. Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression. EMBO Rep. 2021;22:e50958 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Luckett K, Cracchiolo J, Krishnamoorthy G, Leandro García L, Nagarajah J, Saqcena M, et al. Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers. Endocr Relat Cancer. 2021;28:391-402 pubmed publisher
  • western blot; human; fig s9c
Fang W, Sofia Acevedo D, Smart C, Zinda B, Alissa N, Warren K, et al. Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression. Sci Rep. 2021;11:8708 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8d
Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021;12:2281 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Brea R, Valdecantos P, Rada P, Alen R, García Monzón C, Bosca L, et al. Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. Aging (Albany NY). 2021;13:7800-7827 pubmed publisher
  • western blot; human; loading ...; fig 4h
Wang J, Zhao H, Zheng L, Zhou Y, Wu L, Xu Y, et al. FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells. Theranostics. 2021;11:5045-5060 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3j
Ryu Y, Lee D, Shim J, Park J, Kim Y, Choi S, et al. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021;178:2533-2546 pubmed publisher
  • western blot; human; 1:200; loading ...
Rippe C, Morén B, Liu L, Stenkula K, Mustaniemi J, Wennström M, et al. NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells. Sci Rep. 2021;11:5955 pubmed publisher
  • western blot; mouse; loading ...; fig 7e
Jacques S, Arjomand A, Per xe9 e H, Collins P, Mayer A, Lavergne A, et al. Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma. Sci Rep. 2021;11:5817 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6m
Fang Y, Jiang Q, Li S, Zhu H, Xu R, Song N, et al. Opposing functions of β-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3. Cell Death Differ. 2021;28:1822-1836 pubmed publisher
  • western blot; human; fig 6b
Nagamura Y, Miyazaki M, Nagano Y, Yuki M, Fukami K, Yanagihara K, et al. PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification. Oncogenesis. 2021;10:25 pubmed publisher
  • western blot; mouse; 1:1000; fig 6a
Ischenko I, D Amico S, Rao M, Li J, Hayman M, Powers S, et al. KRAS drives immune evasion in a genetic model of pancreatic cancer. Nat Commun. 2021;12:1482 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Varshney R, Ranjit R, Chiao Y, Kinter M, Ahn B. Myocardial Hypertrophy and Compensatory Increase in Systolic Function in a Mouse Model of Oxidative Stress. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; loading ...; fig 6d
Chu C, Lee Y, Hsieh C, Yeh C, Chao T, Chen P, et al. Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy. Theranostics. 2021;11:3624-3641 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Frison M, Faccenda D, Abeti R, Rigon M, Strobbe D, England Rendon B, et al. The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity. Mol Psychiatry. 2021;: pubmed publisher
  • western blot; human; loading ...; fig 3i
Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, et al. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021;7: pubmed publisher
  • western blot; mouse; loading ...; fig 6a, 6b
Wang X, Zhao Y, Zhou D, Tian Y, Feng G, Lu Z. Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice. Cell Death Dis. 2021;12:212 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Yoo H, Yang S, Kim J, Yang E, Park H, Lee S, et al. Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior. Sci Rep. 2021;11:3700 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5h
Dufeys C, Daskalopoulos E, Castanares Zapatero D, Conway S, Ginion A, Bouzin C, et al. AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism. Basic Res Cardiol. 2021;116:10 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, et al. Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator. Cancer Sci. 2021;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Zhang S, Sousa A, Lin M, Iwano A, Jain R, Ma B, et al. Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease. Cells. 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Huang S, You S, Qian J, Dai C, Shen S, Wang J, et al. Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. Aging (Albany NY). 2021;13:4409-4427 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Tyagi A, Sharma S, Wu K, Wu S, Xing F, Liu Y, et al. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun. 2021;12:474 pubmed publisher
  • western blot; mouse; loading ...; fig 3a, s3a
Okawa E, Gupta M, Kahraman S, Goli P, Sakaguchi M, Hu J, et al. Essential roles of insulin and IGF-1 receptors during embryonic lineage development. Mol Metab. 2021;47:101164 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Hu X, Villodre E, Larson R, Rahal O, Wang X, Gong Y, et al. Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Commun Biol. 2021;4:72 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d, s2g, s3e
Wang Y, Mohseni M, Grauel A, Diez J, Guan W, Liang S, et al. SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms. Sci Rep. 2021;11:1399 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Li S, Zhu Z, Xue M, Pan X, Tong G, Yi X, et al. The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice. Redox Biol. 2021;40:101859 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s6-2a
Dilshat R, Fock V, Kenny C, Gerritsen I, Lasseur R, Travnickova J, et al. MITF reprograms the extracellular matrix and focal adhesion in melanoma. elife. 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig ev1i
Bae M, Roh J, Kim Y, Kim S, Han H, Yang E, et al. SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Mol Med. 2021;13:e12632 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1h
Lei H, Xu H, Shan H, Liu M, Lu Y, Fang Z, et al. Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nat Commun. 2021;12:51 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 1a
Jiang S, Sweat S, Dahlke S, Loane K, Drossel G, Xu W, et al. Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway. J Neurosci. 2021;41:711-725 pubmed publisher
  • western blot; mouse; 1:1000; fig 1a
Kumar V, Ali Shariati M, Mesentier Louro L, Jinsook Oh A, Russano K, Goldberg J, et al. Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy. Curr Eye Res. 2021;46:710-718 pubmed publisher
  • western blot; mouse; fig 2d
Kasuga A, Semba T, Sato R, Nobusue H, Sugihara E, Takaishi H, et al. Oncogenic KRAS-expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice. Cancer Sci. 2021;112:1822-1838 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 6e
  • western blot; human; 1:1000; loading ...; fig 6a, 6f, s1
Guo X, Liu L, Zhang Q, Yang W, Zhang Y. E2F7 Transcriptionally Inhibits MicroRNA-199b Expression to Promote USP47, Thereby Enhancing Colon Cancer Tumor Stem Cell Activity and Promoting the Occurrence of Colon Cancer. Front Oncol. 2020;10:565449 pubmed publisher
  • western blot; human; fig 6c
Royer Pokora B, Busch M, Tenbusch S, Schmidt M, Beier M, Woods A, et al. Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations. Cancers (Basel). 2020;13: pubmed publisher
  • western blot; mouse; loading ...; fig s3
Zhang X, Gou Y, Zhang Y, Li J, Han K, Xu Y, et al. Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Discov. 2020;6:113 pubmed publisher
  • western blot; human; loading ...; fig s3
Alijaj N, Moutel S, Gouveia Z, Gray M, Roveri M, Dzhumashev D, et al. Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma. Cancers (Basel). 2020;12: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5i
Yan J, Bengtson C, Buchthal B, Hagenston A, Bading H. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020;370: pubmed publisher
  • western blot; human; loading ...; fig 6c
Shaaya M, Fauser J, Zhurikhina A, Conage Pough J, Huyot V, Brennan M, et al. Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f
Pati S, Saba K, Salvi S, Tiwari P, Chaudhari P, Verma V, et al. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Kumar A, Xie L, Ta C, Hinton A, Gunasekar S, Minerath R, et al. SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...
Lee T, Yeh C, Lee Y, Shih Y, Chen Y, Hung C, et al. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization. Nat Commun. 2020;11:4254 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Teramura Y, Tanaka M, Yamazaki Y, Yamashita K, Takazawa Y, Ae K, et al. Identification of Novel Fusion Genes in Bone and Soft Tissue Sarcoma and Their Implication in the Generation of a Mouse Model. Cancers (Basel). 2020;12: pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4f
Bhaskar A, Kumar S, Khan M, Singh A, Dwivedi V, Nandicoori V. Host sirtuin 2 as an immunotherapeutic target against tuberculosis. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Chabloz A, Schaefer J, Kozieradzki I, Cronin S, Strebinger D, Macaluso F, et al. Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Commun Biol. 2020;3:342 pubmed publisher
  • western blot; human; 1:1000; fig 4a
Sato T, Verma S, Andrade C, Omeara M, Campbell N, Wang J, et al. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Nat Commun. 2020;11:3282 pubmed publisher
  • western blot; human; loading ...; fig 4g
Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 6a
Wang T, Cao Z, Shen Z, Yang J, Chen X, Yang Z, et al. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2f
Lechertier T, Reynolds L, Kim H, Pedrosa A, Gómez Escudero J, Muñoz Félix J, et al. Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nat Commun. 2020;11:2810 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 2h
  • western blot; rat; 1:2000; loading ...; fig s2g
Bi H, Zhang X, Zhang Y, Xie X, Xia Y, Du J, et al. The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. Sci Adv. 2020;6:eaax4826 pubmed publisher
  • western blot; human; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4e
Feng Y, Mischler W, Gurung A, Kavanagh T, Androsov G, Sadow P, et al. Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis. Cancer Res. 2020;80:2751-2763 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 10d
Fulgenzi G, Hong Z, Tomassoni Ardori F, Barella L, Becker J, Barrick C, et al. Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun. 2020;11:1950 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2j, 4s4a
Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, et al. ERK3/MAPK6 controls IL-8 production and chemotaxis. elife. 2020;9: pubmed publisher
  • western blot; human; 1:2500; fig 1a
Wu P, Hong S, Starenki D, Oshima K, Shao H, Gestwicki J, et al. Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. Oncogene. 2020;39:4257-4270 pubmed publisher
  • western blot; human; 1:50; loading ...; fig 7
Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
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  • western blot; dogs; 1:2000; loading ...; fig 3c
Wu Q, Li G, Wen C, Zeng T, Fan Y, Liu C, et al. Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis. Sci Adv. 2020;6:eaay9819 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1k
Xhima K, Markham Coultes K, Nedev H, Heinen S, Saragovi H, Hynynen K, et al. Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease. Sci Adv. 2020;6:eaax6646 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Veith C, Neghabian D, Luitel H, Wilhelm J, Egemnazarov B, Muntanjohl C, et al. FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction. Basic Res Cardiol. 2020;115:17 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig ev1c
Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, et al. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020;12:e11021 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1b
Mus L, Lambertz I, Claeys S, Kumps C, Van Loocke W, Van Neste C, et al. The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness. Sci Rep. 2020;10:218 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Mlyczynska E, Kurowska P, Drwal E, Opydo Chanek M, Tworzydło W, Kotula Balak M, et al. Apelin and apelin receptor in human placenta: Expression, signalling pathway and regulation of trophoblast JEG‑3 and BeWo cells proliferation and cell cycle. Int J Mol Med. 2020;45:691-702 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
Chen M, Zhao Z, Meng Q, Liang P, Su Z, Wu Y, et al. TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy. Adv Sci (Weinh). 2020;7:1901261 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Li Y, Xu S, Xu Q, Chen Y. Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-κB signalling pathway. Artif Cells Nanomed Biotechnol. 2020;48:452-462 pubmed publisher
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Kim K, Kim J, Kim I, Seong S, Kim N. Rev-erbα Negatively Regulates Osteoclast and Osteoblast Differentiation through p38 MAPK Signaling Pathway. Mol Cells. 2020;43:34-47 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Kim D, Choi J, Jo I, Kim M, Lee H, Hong S, et al. Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑κB pathway. Mol Med Rep. 2020;21:258-266 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher
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Liu T, Han S, Dai Q, Zheng J, Liu C, Li S, et al. IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway. Front Immunol. 2019;10:2952 pubmed publisher
  • western blot; human; loading ...; fig 5a
Weisell J, Ohukainen P, Näpänkangas J, Ohlmeier S, Bergmann U, Peltonen T, et al. Heat shock protein 90 is downregulated in calcific aortic valve disease. BMC Cardiovasc Disord. 2019;19:306 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4a
Wu Y, Chen K, Xing G, Li L, Ma B, Hu Z, et al. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Sci Adv. 2019;5:eaax7525 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Yuan M, Xie F, Xia X, Zhong K, Lian L, Zhang S, et al. UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. Int J Oncol. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 6b
Yang X, Jiang J, Zhang C, Li Y. Baicalein restrains proliferation, migration, and invasion of human malignant melanoma cells by down-regulating colon cancer associated transcript-1. Braz J Med Biol Res. 2019;52:e8934 pubmed publisher
  • western blot; mouse; loading ...; fig s13h
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 2a, 3f, 3k
Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 3a, 3c
Thirugnanam K, Cossette S, Lu Q, Chowdhury S, Harmann L, Gupta A, et al. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. J Am Heart Assoc. 2019;8:e012792 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5a
Liu P, Tee A, Milazzo G, Hannan K, Maag J, Mondal S, et al. The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. Nat Commun. 2019;10:5026 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig e2b
Canon J, Rex K, Saiki A, Mohr C, Cooke K, Bagal D, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575:217-223 pubmed publisher
  • western blot; human; loading ...; fig 3b
Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019;36:402-417.e13 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 4f
Wang H, Wei Y, Pu Y, Jiang D, Jiang X, Zhang Y, et al. Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity. Sci Signal. 2019;12: pubmed publisher
  • western blot; human; loading ...; fig 4a
Linnebacher A, Mayer P, Marnet N, Bergmann F, Herpel E, Revia S, et al. Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer. Cells. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, et al. Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Zhao J, Peng W, Ran Y, Ge H, Zhang C, Zou H, et al. Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia. J Physiol Biochem. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 2f
Sanghvi V, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, et al. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell. 2019;178:807-819.e21 pubmed publisher
  • western blot; rat; loading ...; fig 5c
Eftekharzadeh B, Banduseela V, Chiesa G, Martínez Cristóbal P, Rauch J, Nath S, et al. Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nat Commun. 2019;10:3562 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Gao C, Chen G, Zhang D, Zhang J, Kuan S, Hu W, et al. PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654. Cell Mol Gastroenterol Hepatol. 2019;8:561-578 pubmed publisher
  • western blot; human; loading ...; fig 4a
Masson N, Keeley T, Giuntoli B, White M, Puerta M, Perata P, et al. Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. Science. 2019;365:65-69 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Petersen C, Mahmood B, Badsted C, Dahlby T, Rasmussen H, Hansen M, et al. Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia. BMC Cancer. 2019;19:643 pubmed publisher
  • western blot; human; loading ...; fig 1e
Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, et al. CXCR4 regulates Plasmodium development in mouse and human hepatocytes. J Exp Med. 2019;: pubmed publisher
  • western blot; human; 1:1000; fig 3g
Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, et al. Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nat Commun. 2019;10:2350 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Pietila M, Sahgal P, Peuhu E, Jäntti N, Paatero I, Närvä E, et al. SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nat Commun. 2019;10:2340 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Frischknecht L, Britschgi C, Galliker P, Christinat Y, Vichalkovski A, Gstaiger M, et al. BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly. Sci Rep. 2019;9:7779 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1s2b
Jewell J, Fu V, Hong A, Yu F, Meng D, Melick C, et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. elife. 2019;8: pubmed publisher
  • western blot; rat; loading ...; fig 2e
Xie X, Bi H, Lai S, Zhang Y, Li N, Cao H, et al. The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation. Sci Adv. 2019;5:eaau0495 pubmed publisher
  • western blot; human; loading ...; fig 2b, 2d
Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, et al. Time-resolved protein activation by proximal decaging in living systems. Nature. 2019;569:509-513 pubmed publisher
  • western blot; mouse; loading ...; fig s5a
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher
  • western blot; human; loading ...; fig 7b
Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Wang S, Ni H, Chao X, Wang H, Bridges B, Kumer S, et al. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy. 2019;15:1954-1969 pubmed publisher
  • western blot; mouse; 1:25,000; loading ...; fig 1e
Castel P, Cheng A, Cuevas Navarro A, Everman D, Papageorge A, Simanshu D, et al. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019;363:1226-1230 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s1a
  • immunohistochemistry - paraffin section; rat; 1:2000; loading ...; fig s2i
Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed publisher
  • western blot; human; loading ...; fig 2b
Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed publisher
  • western blot; hamsters; 1:1000; loading ...; fig 8a
Vrijens P, Noppen S, Boogaerts T, Vanstreels E, Ronca R, Chiodelli P, et al. Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway. J Gen Virol. 2019;100:583-601 pubmed publisher
  • western blot; rhesus macaque; loading ...; fig 1d
Hayashi H, Mamun A, Takeyama M, Yamamura A, Zako M, Yagasaki R, et al. Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization. Sci Rep. 2019;9:1560 pubmed publisher
  • western blot; human; loading ...; fig 1d, s1b
  • western blot; mouse; loading ...; fig 4f
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed publisher
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Jia Y, Qi Y, Wang Y, Ma X, Xu Y, Wang J, et al. Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway. Cancer Cell Int. 2019;19:9 pubmed publisher
  • western blot; human; loading ...; fig 3a
Turowec J, Lau E, Wang X, Brown K, Fellouse F, Jawanda K, et al. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. J Biol Chem. 2019;294:1396-1409 pubmed publisher
  • western blot; mouse; loading ...; fig 1g
Chen X, Chanda A, Ikeuchi Y, Zhang X, Goodman J, Reddy N, et al. The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain. J Neurosci. 2019;39:44-62 pubmed publisher
  • proximity ligation assay; human; 1:100; loading ...; fig 1b
Karchugina S, Chernoff J. Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay. J Vis Exp. 2018;: pubmed publisher
  • western blot; human; loading ...; fig 4b
Ablain J, Xu M, Rothschild H, JORDAN R, Mito J, Daniels B, et al. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018;362:1055-1060 pubmed publisher
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Mu L, Tu Z, Miao L, Ruan H, Kang N, Hei Y, et al. A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing. Nat Commun. 2018;9:4259 pubmed publisher
  • western blot; human; loading ...; fig 7c
Song K, Kim J, Lee Y, Bae H, Lee H, Woo S, et al. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance. J Clin Invest. 2018;128:4098-4114 pubmed publisher
  • western blot; mouse; loading ...; fig s3a
Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher
  • western blot; human; loading ...; fig 2e
Jung I, Kim Y, Yu H, Lee M, Kim S, Lee J. CRISPR/Cas9-Mediated Knockout of DGK Improves Antitumor Activities of Human T Cells. Cancer Res. 2018;78:4692-4703 pubmed publisher
  • flow cytometry; mouse; 1:100-1:200; loading ...; fig s5e
  • flow cytometry; human; 1:100-1:200; loading ...; fig s5f
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Wang X, Du C, He X, Deng X, He Y, Zhou X. MiR-4463 inhibits the migration of human aortic smooth muscle cells by AMOT. Biosci Rep. 2018;38: pubmed publisher
  • western blot; human; loading ...; fig 1a
  • immunocytochemistry; mouse; loading ...; fig 4c
Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, et al. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cell Mol Immunol. 2018;: pubmed publisher
  • western blot; mouse; loading ...; fig s3a
zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, et al. Protein kinase N1 critically regulates cerebellar development and long-term function. J Clin Invest. 2018;128:2076-2088 pubmed publisher
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Summers M, Vasiljevski E, Mikulec K, Peacock L, Little D, Schindeler A. Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse. Mol Genet Metab. 2018;123:518-525 pubmed publisher
  • western blot; mouse; fig 6c
Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher
  • western blot; mouse; fig s2d
Shen Q, Zhang Q, Shi Y, Shi Q, Jiang Y, Gu Y, et al. Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation. Nature. 2018;554:123-127 pubmed publisher
  • western blot; human; 1:1000; fig s3f
Frattini V, Pagnotta S, Tala -, Fan J, Russo M, Lee S, et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018;553:222-227 pubmed publisher
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Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed publisher
  • western blot; human; loading ...; fig 5a
Arrizabalaga O, Moreno Cugnon L, Auzmendi Iriarte J, Aldaz P, Ibanez de Caceres I, Garros Regulez L, et al. High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response. Oncogenesis. 2017;6:401 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed publisher
  • western blot; human; loading ...; fig 7a
Wu J, Xiang S, Zhang M, Fang B, Huang H, Kwon O, et al. Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. J Biol Chem. 2018;293:1976-1993 pubmed publisher
  • western blot; human; loading ...; fig s2a
  • western blot; mouse; loading ...; fig 4a
Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Urbanska M, Gozdz A, Macias M, Cymerman I, Liszewska E, Kondratiuk I, et al. GSK3β Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol. 2018;55:6050-6062 pubmed publisher
  • western blot; rat; loading ...; fig 10a
Gasparotto J, Girardi C, Somensi N, Ribeiro C, Moreira J, Michels M, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018;293:226-244 pubmed publisher
  • western blot; mouse; loading ...; fig s10c
Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
  • western blot; human; loading ...; fig 13e
Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
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Urbschat A, Baer P, Zacharowski K, Sprunck V, Scheller B, Raimann F, et al. Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney. Basic Clin Pharmacol Toxicol. 2018;122:223-232 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6b, 6c
Chong I, Aronson L, Bryant H, Gulati A, Campbell J, Elliott R, et al. Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer. Gut. 2018;67:1780-1792 pubmed publisher
  • western blot; human; fig 3b
Walter K, Goodman M, Singhal H, Hall J, Li T, Holloran S, et al. Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer. Mol Cancer Res. 2017;15:1331-1340 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3
Mamo T, Wittern A, Kleppa M, Bohnenpoll T, Weiss A, Kispert A. BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017;26:3553-3563 pubmed publisher
  • western blot; mouse; loading ...; fig s4f
Matsumoto Y, La Rose J, Lim M, Adissu H, Law N, Mao X, et al. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. J Clin Invest. 2017;127:2612-2625 pubmed publisher
  • western blot; human; loading ...; fig 1e
Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher
  • western blot; human; fig s1b
Hu L, Liang S, Chen H, Lv T, Wu J, Chen D, et al. ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis. Proc Natl Acad Sci U S A. 2017;114:E3964-E3973 pubmed publisher
  • western blot; human; 1:5000; fig s5f
Tian H, Ketova T, Hardy D, Xu X, Gao X, Zijlstra A, et al. Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. Arterioscler Thromb Vasc Biol. 2017;37:1115-1126 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Zhou X, Packialakshmi B, Xiao Y, Nurmukhambetova S, Lees J. Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet. Cell Immunol. 2017;317:18-25 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Kim D, Ko H, Park G, Hur D, Kim Y, Yang J. Vandetanib and ADAM inhibitors synergistically attenuate the pathological migration of EBV-infected retinal pigment epithelial cells by regulating the VEGF-mediated MAPK pathway. Exp Ther Med. 2017;13:1415-1425 pubmed publisher
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Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, et al. Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk. Sci Rep. 2017;7:46064 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3a
El Gamal H, Eid A, Munusamy S. Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury. Biomed Res Int. 2017;2017:5903105 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4A
Chen S, Sun J, Zhao G, Guo A, Chen Y, Fu R, et al. Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice. Neurochem Res. 2017;42:2326-2335 pubmed publisher
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Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed publisher
  • western blot; human; loading ...; fig 3a
Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  • western blot; human; loading ...; fig 2d
Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher
  • western blot; mouse; fig 3c
  • western blot; human; loading ...; fig 4a
CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5d
Reynolds L, D Amico G, Lechertier T, Papachristodoulou A, Muñoz Félix J, De Arcangelis A, et al. Dual role of pericyte ?6?1-integrin in tumour blood vessels. J Cell Sci. 2017;130:1583-1595 pubmed publisher
  • western blot; mouse; loading ...; fig EV4a
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
  • western blot; human; loading ...; fig 1f
Li L, Baxter S, Gu N, Ji M, Zhan X. Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci. 2017;130:1475-1485 pubmed publisher
  • western blot; human; loading ...; fig 1f
Li K, Mo C, Gong D, Chen Y, Huang Z, Li Y, et al. DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin. Cancer Lett. 2017;400:194-202 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
  • western blot; human; fig 4a
Obeid S, Wankell M, Charrez B, Sternberg J, Kreuter R, Esmaili S, et al. Adiponectin confers protection from acute colitis and restricts a B cell immune response. J Biol Chem. 2017;292:6569-6582 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3f
Hwang I, Park C, Harrison K, Kehrl J. Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and Gαi2. J Immunol. 2017;198:2721-2734 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 5c
Kumari P, Srivastava A, Ghosh E, Ranjan R, Dogra S, Yadav P, et al. Core engagement with ?-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation. Mol Biol Cell. 2017;28:1003-1010 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 3a
Basu R, Wu S, Kopchick J. Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways. Oncotarget. 2017;8:21579-21598 pubmed publisher
  • western blot; human; loading ...; fig 5f
Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig S6o
Vallejo A, Perurena N, Guruceaga E, Mazur P, Martínez Canarias S, Zandueta C, et al. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8:14294 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Sethna F, Feng W, Ding Q, ROBISON A, Feng Y, Wang H. Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model. Nat Commun. 2017;8:14359 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Steinberg S, Shabaneh T, Zhang P, Martyanov V, Li Z, Malik B, et al. Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors. Cancer Res. 2017;77:1599-1610 pubmed publisher
  • western blot; human; loading ...; fig s9a
He Y, Wang X, Zhang J, Liu Z, Pan W, Shen Y, et al. Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs. Arterioscler Thromb Vasc Biol. 2017;37:717-729 pubmed publisher
  • western blot; human; loading ...; fig 4d
Umstead M, Xiong J, Qi Q, Du Y, Fu H. Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling. Oncotarget. 2017;8:28359-28372 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s7a
Lee J, Hsu C, Michael M, Nanda A, Liu L, McMillan J, et al. Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23. Am J Hum Genet. 2017;100:364-370 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s3
Lim E, Nakanishi S, Hoghooghi V, Eaton S, Palmer A, Frederick A, et al. AlphaB-crystallin regulates remyelination after peripheral nerve injury. Proc Natl Acad Sci U S A. 2017;114:E1707-E1716 pubmed publisher
  • western blot; human; loading ...; fig 3d
Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4b
Barcus C, O Leary K, Brockman J, Rugowski D, Liu Y, Garcia N, et al. Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells. Breast Cancer Res. 2017;19:9 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2e
  • western blot; mouse; 1:1000; fig 2f
Xia L, Plachynta M, Liu T, Xiao X, Song J, Li X, et al. Pro-inflammatory effect of a traditional Chinese medicine formula with potent anti-cancer activity in vitro impedes tumor inhibitory potential in vivo. Mol Clin Oncol. 2016;5:717-723 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5a
Yoo S, Latifkar A, Cerione R, Antonyak M. Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. J Biol Chem. 2017;292:3947-3957 pubmed publisher
  • western blot; human; loading ...; fig s5e
Lee H, Diaz M, Price K, Ozuna J, Zhang S, Sevick Muraca E, et al. Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun. 2017;8:14122 pubmed publisher
  • western blot; mouse; 1:1000; fig 7c
Kechele D, Blue R, Zwarycz B, Espenschied S, Mah A, Siegel M, et al. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017;127:593-607 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Halbrook C, Wen H, Ruggeri J, Takeuchi K, Zhang Y, di Magliano M, et al. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis. Cell Mol Gastroenterol Hepatol. 2017;3:99-118 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3c
Hirai M, Arita Y, McGlade C, Lee K, Chen J, Evans S. Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017;127:569-582 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Clotet S, Soler M, Riera M, Pascual J, Fang F, Zhou J, et al. Stable Isotope Labeling with Amino Acids (SILAC)-Based Proteomics of Primary Human Kidney Cells Reveals a Novel Link between Male Sex Hormones and Impaired Energy Metabolism in Diabetic Kidney Disease. Mol Cell Proteomics. 2017;16:368-385 pubmed publisher
  • western blot; human; loading ...; fig 1A; 1B
Cheng L, Li K, Yi N, Li X, Wang F, Xue B, et al. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. Oncotarget. 2017;8:13186-13194 pubmed publisher
  • western blot; rat; 1:1000; fig 1b
Grossi M, Bhattachariya A, Nordström I, Turczynska K, Svensson D, Albinsson S, et al. Pyk2 inhibition promotes contractile differentiation in arterial smooth muscle. J Cell Physiol. 2017;232:3088-3102 pubmed publisher
  • western blot; mouse; loading ...; fig 6e
Hammers D, Sleeper M, Forbes S, Coker C, Jirousek M, Zimmer M, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016;1:e90341 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Ye Y, Zhao Z, Xu H, Zhang X, Su X, Yang Y, et al. Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway. Neural Plast. 2016;2016:8072156 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
  • western blot; human; 1:1000; loading ...
Su C, Gao X, Yang W, Zhao Y, Fu X, Cui X, et al. Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules. Biochim Biophys Acta Mol Cell Res. 2017;1864:562-571 pubmed publisher
  • western blot; human; loading ...; fig 5
Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, et al. Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway. Sci Rep. 2016;6:39557 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
  • western blot; mouse; 1:1000; loading ...; fig 3a
Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6a
Wymant J, Hiscox S, Westwell A, Urbé S, Clague M, Jones A. The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. J Cancer. 2016;7:2388-2407 pubmed
  • western blot; human; fig s7e
Lee S, Rho S, Park H, Park J, Kim J, Lee I, et al. Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017;127:457-471 pubmed publisher
  • western blot; mouse; loading ...
Ganta V, Choi M, Kutateladze A, Annex B. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circ Res. 2017;120:282-295 pubmed publisher
  • western blot; zebrafish ; 1:200; loading ...
Mayrhofer M, Gourain V, Reischl M, Affaticati P, Jenett A, Joly J, et al. A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. Dis Model Mech. 2017;10:15-28 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 12
Nagahara Y, Shimazawa M, Ohuchi K, Ito J, Takahashi H, Tsuruma K, et al. GPNMB ameliorates mutant TDP-43-induced motor neuron cell death. J Neurosci Res. 2017;95:1647-1665 pubmed publisher
  • western blot; human; loading ...; fig 7e
Santo Domingo J, Chareyron I, Dayon L, Núñez Galindo A, Cominetti O, Pilar Giner Giménez M, et al. Coordinated activation of mitochondrial respiration and exocytosis mediated by PKC signaling in pancreatic ? cells. FASEB J. 2017;31:1028-1045 pubmed publisher
  • western blot; human; loading ...; fig 2c
Tsai C, Lin Y, Huang C, Shih C, Tsai Y, Tsao N, et al. Thrombomodulin regulates monocye differentiation via PKC? and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421 pubmed publisher
  • western blot; human; loading ...; fig 3a
Battram A, Durrant T, Agbani E, Heesom K, Paul D, Piatt R, et al. The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling. J Biol Chem. 2017;292:1691-1704 pubmed publisher
  • western blot; human; loading ...; fig 2a
Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Park J, Kim S, Yoo J, Jang J, Lee A, Oh J, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017;54:7706-7721 pubmed publisher
  • western blot; human; loading ...; fig 6a
Chou H, Fong Y, Lin H, Tsai E, Chen J, Chang W, et al. An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation. Oxid Med Cell Longev. 2016;2016:9128102 pubmed
  • western blot; human; 1:1000; loading ...; fig 2b
  • western blot; rat; 1:1000; loading ...; fig 3a
Flütsch A, Henry K, Mantuano E, Lam M, Shibayama M, Takahashi K, et al. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016;27:1305-1311 pubmed
  • western blot; human; loading ...; fig 2a
Spencer Smith R, Koide A, Zhou Y, Eguchi R, Sha F, Gajwani P, et al. Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017;13:62-68 pubmed publisher
  • western blot; mouse; fig 4G
Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, et al. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016;126:4497-4515 pubmed publisher
  • western blot; mouse; loading ...; fig s3h, s4a
Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Kunzler A, Zeidán Chuliá F, Gasparotto J, Girardi C, Klafke K, Petiz L, et al. Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress. Mol Neurobiol. 2017;54:6903-6916 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig s4b
Zhang Q, Zhang Y, Parsels J, Lohse I, Lawrence T, Pasca di Magliano M, et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia. 2016;18:666-673 pubmed publisher
  • western blot; dogs; loading ...; tbl 1
Bulldan A, Shihan M, Goericke Pesch S, Scheiner Bobis G. Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines. Mol Reprod Dev. 2016;83:1092-1101 pubmed publisher
  • western blot; human; loading ...
Richter E, Harms M, Ventz K, Nölker R, Fraunholz M, Mostertz J, et al. Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus. J Proteome Res. 2016;15:4369-4386 pubmed
  • western blot; human; 1:2000; loading ...; fig 5e
Zimmermann M, Arachchige Don A, Donaldson M, Patriarchi T, Horne M. Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival. Cell Cycle. 2016;15:3278-3295 pubmed
  • western blot; human; 1:1000; fig s3
Tseng H, Vong C, Kwan Y, Lee S, Hoi M. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 2016;6:35016 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 1a
Kotsantis P, Silva L, Irmscher S, Jones R, Folkes L, Gromak N, et al. Increased global transcription activity as a mechanism of replication stress in cancer. Nat Commun. 2016;7:13087 pubmed publisher
  • western blot; human; 1:800; loading ...; fig 7a
Visuttijai K, Pettersson J, Mehrbani Azar Y, van den Bout I, Orndal C, Marcickiewicz J, et al. Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT. PLoS ONE. 2016;11:e0164063 pubmed publisher
  • western blot; human; loading ...; fig 5c
Zhao Y, Fan D, Ru B, Cheng K, Hu S, Zhang J, et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. Eur J Cancer. 2016;68:38-50 pubmed publisher
  • western blot; human; loading ...; fig 4a
Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed
  • western blot; human; loading ...; fig 1c
Wu J, Sun Y, Zhang P, Qian M, Zhang H, Chen X, et al. The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. Cell Death Dis. 2016;7:e2384 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, et al. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016;7:12756 pubmed publisher
  • western blot; human; 1:1000; loading ...
Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1d
Krepler C, Xiao M, Samanta M, Vultur A, Chen H, Brafford P, et al. Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget. 2016;7:71211-71222 pubmed publisher
  • western blot; human; loading ...; fig 5c
Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, et al. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016;213:2437-2457 pubmed
  • western blot; human; 1:1000; loading ...; fig s7e
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 1a, 6f
Olianas M, Dedoni S, Onali P. LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells. J Pharmacol Exp Ther. 2016;359:340-353 pubmed
  • western blot; human; 1:5000; fig 3h
Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, et al. A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment. Oncotarget. 2016;7:74931-74946 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Hong J, Shin M, Douglas I, Chung K, Kim E, Jung J, et al. Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury. Clin Sci (Lond). 2016;130:1993-2003 pubmed
  • western blot; human; loading ...; fig 2c
Gómez Puerto M, Verhagen L, Braat A, Lam E, Coffer P, Lorenowicz M. Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation. Autophagy. 2016;12:1804-1816 pubmed
  • western blot; mouse; 1:1000; fig 1d
Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 5c
Siljamäki E, Abankwa D. SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling. Mol Cell Biol. 2016;36:2612-25 pubmed publisher
  • western blot; rat; loading ...; fig s2
Ogasawara R, Fujita S, Hornberger T, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8
  • western blot; mouse; 1:1000; loading ...; fig 6c
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher
  • western blot; mouse; fig 4c
Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Lie E, Ko J, Choi S, Roh J, Cho Y, Noh R, et al. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion. Nat Commun. 2016;7:12328 pubmed publisher
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Fiedor E, Gregoraszczuk E. The molecular mechanism of action of superactive human leptin antagonist (SHLA) and quadruple leptin mutein Lan-2 on human ovarian epithelial cell lines. Cancer Chemother Pharmacol. 2016;78:611-22 pubmed publisher
  • western blot; human; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4b
Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
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Fecková B, Kimáková P, Ilkovičová L, Szentpéteriová E, Debeljak N, Solárová Z, et al. Far-western blotting as a solution to the non-specificity of the anti-erythropoietin receptor antibody. Oncol Lett. 2016;12:1575-1580 pubmed
  • western blot; human; 1:1000; tbl 1
Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, et al. The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas. Br J Cancer. 2016;115:454-64 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5d
Kreger B, Dougherty A, Greene K, Cerione R, Antonyak M. Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation. J Biol Chem. 2016;291:19774-85 pubmed publisher
  • western blot; mouse; 1:1000; fig s6c
Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536:86-90 pubmed
  • western blot; mouse; 1:1000; fig 6
Raguz J, Jerić I, Niault T, Nowacka J, Kuzet S, Rupp C, et al. Epidermal RAF prevents allergic skin disease. elife. 2016;5: pubmed publisher
  • western blot; rat; loading ...; fig 4a
Babica P, Zurabian R, Kumar E, Chopra R, Mianecki M, Park J, et al. Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells. Toxicol Sci. 2016;153:174-85 pubmed publisher
  • western blot; human; loading ...; fig s1
  • western blot; mouse; loading ...; fig 1b
Inda C, Dos Santos Claro P, Bonfiglio J, Senin S, Maccarrone G, Turck C, et al. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol. 2016;214:181-95 pubmed publisher
  • western blot; human; loading ...; fig 2a
Wang C, Guo S, Wang J, Yan X, Farrelly M, Zhang Y, et al. Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. Oncotarget. 2016;7:49597-49610 pubmed publisher
  • western blot; human; fig 6
Huang C, Lee C, Lin H, Chang J. Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Sci Rep. 2016;6:29256 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Lukjanenko L, Jung M, Hegde N, Perruisseau Carrier C, Migliavacca E, Rozo M, et al. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med. 2016;22:897-905 pubmed publisher
  • western blot; mouse; fig 7
Petrova L, Gran C, Bjoras M, Doetsch P. Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells. PLoS ONE. 2016;11:e0158581 pubmed publisher
  • western blot; human; loading ...; fig 6b
Madureira P, Bharadwaj A, Bydoun M, Garant K, O Connell P, Lee P, et al. Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Oncotarget. 2016;7:47720-47737 pubmed publisher
  • western blot; human; loading ...; fig 2d
Barcus C, Keely P, Eliceiri K, Schuler L. Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells. Oncotarget. 2016;7:48093-48106 pubmed publisher
  • western blot; human; loading ...; fig 3d
Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, et al. Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget. 2016;7:45959-45975 pubmed publisher
  • western blot; human; fig 3a
Khan S, Sikander M, Ebeling M, Ganju A, Kumari S, Yallapu M, et al. MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression. Oncogene. 2017;36:491-500 pubmed publisher
  • western blot; human; fig 2a
Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed publisher
  • western blot; mouse; 1:2000; fig 2
Burger D, Turner M, Munkonda M, Touyz R. Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function. Oxid Med Cell Longev. 2016;2016:5047954 pubmed publisher
  • western blot; human; 1:800; fig 7A
Zhou X, Wei Y, Qiu S, Xu Y, Zhang T, Zhang S. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0157590 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1a,s6
Desrochers L, Bordeleau F, Reinhart King C, Cerione R, Antonyak M. Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation. Nat Commun. 2016;7:11958 pubmed publisher
  • western blot; mouse; fig s4
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
  • western blot; human; loading ...; fig 4c
Han S, Ma X, Zhao Y, Zhao H, Batista A, Zhou S, et al. Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer. Oncotarget. 2016;7:44406-44416 pubmed publisher
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Zhou B, Ritt D, Morrison D, Der C, Cox A. Protein Kinase CK2? Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2? Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. J Biol Chem. 2016;291:17804-15 pubmed publisher
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Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed publisher
  • western blot; human; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 5b
Stein S, Mack E, Rome K, Pajcini K, Ohtani T, Xu L, et al. Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PLoS ONE. 2016;11:e0155408 pubmed publisher
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Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, et al. A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation. Sci Rep. 2016;6:25955 pubmed publisher
  • western blot; human; loading ...; fig 4b
Lee Y, Kim S, Song S, Hong H, Lee Y, Oh B, et al. Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways. Oncotarget. 2016;7:36842-36853 pubmed publisher
  • western blot; rat; loading ...; fig 1a
Bulldan A, Dietze R, Shihan M, Scheiner Bobis G. Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells. Cell Signal. 2016;28:1075-85 pubmed publisher
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Hudson C, McArdle C, López Bernal A. Steroid receptor co-activator interacting protein (SIP) mediates EGF-stimulated expression of the prostaglandin synthase COX2 and prostaglandin release in human myometrium. Mol Hum Reprod. 2016;22:512-25 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10b
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, et al. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun. 2016;7:11471 pubmed publisher
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Lock R, Ingraham R, Maertens O, Miller A, Weledji N, Legius E, et al. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest. 2016;126:2181-90 pubmed publisher
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Illich D, Zhang M, Ursu A, Osorno R, Kim K, Yoon J, et al. Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs. Cell Rep. 2016;15:787-800 pubmed publisher
  • western blot; human; loading ...
Afonina I, Van Nuffel E, Baudelet G, Driege Y, Kreike M, Staal J, et al. The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes. EMBO Rep. 2016;17:914-27 pubmed publisher
  • western blot; human; fig 2
Cross A, Wilson A, Guerrero M, Thomas K, Bachir A, Kubow K, et al. Breast cancer antiestrogen resistance 3-p130Cas interactions promote adhesion disassembly and invasion in breast cancer cells. Oncogene. 2016;35:5850-5859 pubmed publisher
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Thompson A, Stephens J, Bain S, Kanamarlapudi V. Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation. PLoS ONE. 2016;11:e0154229 pubmed publisher
  • western blot; human; fig 4
Xing M, Wang X, Chi Y, Zhou D. Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab. Oncotarget. 2016;7:28262-72 pubmed publisher
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Damle S, Martin R, Cross J, Conrad D. Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis. Mucosal Immunol. 2017;10:205-214 pubmed publisher
  • western blot; human; fig 2
Fearnley G, Smith G, Abdul Zani I, Yuldasheva N, Mughal N, Homer Vanniasinkam S, et al. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open. 2016;5:571-83 pubmed publisher
  • western blot; human; fig 5
Papadakis E, Barker C, Syed H, Reeves T, Schwaiger S, Stuppner H, et al. The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ. Oncogenesis. 2016;5:e215 pubmed publisher
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Prieto J, León M, Ponsoda X, Sendra R, Bort R, Ferrer Lorente R, et al. Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nat Commun. 2016;7:11124 pubmed publisher
  • western blot; human; fig s2
Riggle K, Riehle K, Kenerson H, Turnham R, Homma M, Kazami M, et al. Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma. Pediatr Res. 2016;80:110-8 pubmed publisher
  • western blot; human; fig 7
Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed publisher
  • western blot; human; fig 3
Wen Y, Li H, Zeng Y, Wen W, Pendleton K, Lui V, et al. MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin. Oncotarget. 2016;7:23300-11 pubmed publisher
  • western blot; human; fig 6
Scott D, Tolbert C, Burridge K. Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF. Mol Biol Cell. 2016;27:1420-30 pubmed publisher
  • western blot; human; loading ...; fig 3a
Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Sekine I, Tada Y, et al. Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. Int J Oncol. 2016;48:1825-36 pubmed publisher
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Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher
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Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed publisher
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Cannavo A, Liccardo D, Eguchi A, Elliott K, Traynham C, Ibetti J, et al. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nat Commun. 2016;7:10877 pubmed publisher
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Woo J, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016;113:2762-7 pubmed publisher
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Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher
  • ELISA; mouse; 1:200; tbl 1
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  • western blot; mouse; 1:5000; tbl 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Yufune S, Satoh Y, Akai R, Yoshinaga Y, Kobayashi Y, Endo S, et al. Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain. Sci Rep. 2016;6:21859 pubmed publisher
  • western blot; human; fig s11
Sancho Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, et al. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016;7:10743 pubmed publisher
  • western blot; human; fig 3
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  • western blot; human; fig 4
Cui J, Xia T, Xie D, Gao Y, Jia Z, Wei D, et al. HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes. Oncogene. 2016;35:4708-18 pubmed publisher
  • western blot; human; loading ...; fig 7a
Chang C, Hale S, Cox C, Blair A, Kronsteiner B, Grabowska R, et al. Junctional Adhesion Molecule-A Is Highly Expressed on Human Hematopoietic Repopulating Cells and Associates with the Key Hematopoietic Chemokine Receptor CXCR4. Stem Cells. 2016;34:1664-78 pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Liu Y, Takahashi Y, Desai N, Zhang J, Serfass J, Shi Y, et al. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep. 2016;6:20453 pubmed publisher
  • western blot; mouse
Däbritz J, Judd L, Chalinor H, Menheniott T, Giraud A. Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells. Sci Rep. 2016;6:20584 pubmed publisher
  • western blot; human; fig 2a
Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed publisher
  • western blot; human; loading ...; fig 5a
Derangère V, Fumet J, Boidot R, Bengrine L, Limagne E, Chevriaux A, et al. Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?. Oncotarget. 2016;7:9309-21 pubmed publisher
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Johnson D, Estrada M, Salgado R, Sanchez V, Doxie D, Opalenik S, et al. Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy. Nat Commun. 2016;7:10582 pubmed publisher
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Theodosiou M, Widmaier M, Böttcher R, Rognoni E, Veelders M, Bharadwaj M, et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. elife. 2016;5:e10130 pubmed publisher
  • western blot; human; fig 10
Shang V, O Sullivan S, Kendall D, Roberts R. The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite. Pharmacol Res. 2016;105:152-63 pubmed publisher
  • western blot; human; fig 1
Chung S, Moon H, Ju H, Kim D, Cho K, Ribback S, et al. Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget. 2016;7:7354-66 pubmed publisher
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Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0147344 pubmed publisher
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Zheng F, Yue C, Li G, He B, Cheng W, Wang X, et al. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016;7:10180 pubmed publisher
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Watari K, Shibata T, Nabeshima H, Shinoda A, Fukunaga Y, Kawahara A, et al. Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice. Sci Rep. 2016;6:19470 pubmed publisher
  • western blot; mouse; fig s7
Gu K, Zhang Q, Yan Y, Li T, Duan F, Hao J, et al. Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency. Cell Res. 2016;26:350-66 pubmed publisher
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Yang S, Krug S, Heitmann J, Hu L, Reinhold A, Sauer S, et al. Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier. Biomaterials. 2016;82:20-33 pubmed publisher
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Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed publisher
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Guan X, Wang N, Cui F, Liu Y, Liu P, Zhao J, et al. Caveolin-1 is essential in the differentiation of human adipose-derived stem cells into hepatocyte-like cells via an MAPK pathway-dependent mechanism. Mol Med Rep. 2016;13:1487-94 pubmed publisher
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Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed publisher
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Edmonds M, Boyd K, Moyo T, Mitra R, Duszynski R, Arrate M, et al. MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest. 2016;126:349-64 pubmed publisher
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Chen J, Chen Y, Yen C, Chen W, Huang W. HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3. Oncotarget. 2016;7:473-89 pubmed publisher
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Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
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Awad K, Elinoff J, Wang S, Gairhe S, Ferreyra G, Cai R, et al. Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L187-201 pubmed publisher
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Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Shankaraiah R, Seano G, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. J Natl Cancer Inst. 2016;108: pubmed publisher
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Pai P, Rachagani S, Lakshmanan I, Macha M, Sheinin Y, Smith L, et al. The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Mol Oncol. 2016;10:224-39 pubmed publisher
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Ko T, Chin H, Chuah C, Huang J, Ng K, Khaw S, et al. The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia. Oncotarget. 2016;7:2721-33 pubmed publisher
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Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, et al. Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 2016;107:84-94 pubmed publisher
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Park Y, Kim S, Kwon T, Kim J, Song I, Shin H, et al. Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. Oncogene. 2016;35:3503-13 pubmed publisher
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Chakedis J, French R, Babicky M, Jaquish D, Howard H, Mose E, et al. A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. Oncogene. 2016;35:3249-59 pubmed publisher
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Smith C, D Mello S. Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Mol Neurobiol. 2016;53:5628-39 pubmed publisher
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Thijssen R, Ter Burg J, van Bochove G, de Rooij M, Kuil A, Jansen M, et al. The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells. Leukemia. 2016;30:337-45 pubmed publisher
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Zarpelon A, Rodrigues F, Lopes A, Souza G, Carvalho T, Pinto L, et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB J. 2016;30:54-65 pubmed publisher
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product information
SKU :
9102L
Product-Name :
p44/42 MAPK (Erk1/2) Antibody
Size :
600 ul
Price-(USD) :
574 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Mi, Z, B, Pg, Sc
Applications :
Flow cytometry
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
42, 44
Host :
Rabbit
Target :
ERK1/ERK2
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.