Published Application/Species/Sample/Dilution | Reference |
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- immunocytochemistry; human; 1:200; loading ...; fig 7b
| Bondeson D, Paolella B, Asfaw A, Rothberg M, Skipper T, Langan C, et al. Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nat Cancer. 2022;3:681-695 pubmed publisher
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- western blot; human; 1:1000; fig 4b
| Zhao J, Lu W, Ren Y, Fu Y, Martens Y, Shue F, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathol. 2021;142:807-825 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 4d
| Zhang Y, Chen Y, Li Y, Huang F, Luo B, Yuan Y, et al. The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 6b
| Li Y, Chen L, Li L, Sottas C, Petrillo S, Lazaris A, et al. Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021;24:102457 pubmed publisher
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- immunocytochemistry; human; 1:100; loading ...; fig 5h
| Zhou H, Qin L, Jiang Q, Murray K, Zhang H, Li B, et al. Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nat Commun. 2021;12:504 pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig 4g
| Stojakovic A, Trushin S, Sheu A, Khalili L, Chang S, Li X, et al. Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Commun Biol. 2021;4:61 pubmed publisher
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- immunocytochemistry; human; loading ...
| Tan C, Chang H, Zhou Q, Yu C, Fu N, Sabapathy K, et al. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. EMBO Rep. 2021;:e50854 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 4a
| Zang R, Case J, Yutuc E, Ma X, Shen S, Gomez Castro M, et al. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci U S A. 2020;117:32105-32113 pubmed publisher
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- immunocytochemistry; human; 1:200; fig 1e
| Hall Roberts H, Agarwal D, Obst J, Smith T, Monzón Sandoval J, Di Daniel E, et al. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimers Res Ther. 2020;12:151 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 4b
| Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020;11:3258 pubmed publisher
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- immunocytochemistry; human; 1:1000; loading ...; fig 1b
| Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 1
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- western blot; human; loading ...; fig 6c
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- western blot; human; 1:3000; loading ...; fig 4c
| Riessland M, Kolisnyk B, Kim T, Cheng J, Ni J, Pearson J, et al. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell Stem Cell. 2019;25:514-530.e8 pubmed publisher
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- immunocytochemistry; human; 1:100; loading ...; fig s3h
| Höglinger D, Burgoyne T, Sanchez Heras E, Hartwig P, Colaco A, Newton J, et al. NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress. Nat Commun. 2019;10:4276 pubmed publisher
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- proximity ligation assay; human; 1:200; loading ...; fig 5e
| Atakpa P, Thillaiappan N, Mataragka S, Prole D, Taylor C. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep. 2018;25:3180-3193.e7 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 1d
| Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Nnah I, Wang B, Saqcena C, Weber G, Bonder E, Bagley D, et al. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. Autophagy. 2019;15:151-164 pubmed publisher
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- immunohistochemistry; human; loading ...; fig 3a
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- immunocytochemistry; human; 1:200; loading ...; fig 2d
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- immunocytochemistry; human; 1:200; loading ...; fig 3c
| Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed publisher
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- western blot; human; loading ...; fig s10a
| Suresh S, Chavalmane A, Dj V, Yarreiphang H, Rai S, Paul A, et al. A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity. Autophagy. 2017;13:1221-1234 pubmed publisher
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- immunohistochemistry; human; loading ...; fig 4
| Ghadially H, Brown L, Lloyd C, Lewis L, LEWIS A, Dillon J, et al. MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue. Br J Cancer. 2017;116:1208-1217 pubmed publisher
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- immunocytochemistry; human; 1:200; loading ...; fig 7a
| Sanger A, Yip Y, Randall T, Pernigo S, Steiner R, Dodding M. SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. J Cell Sci. 2017;130:1637-1651 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 4c
| Varadaraj A, JENKINS L, Singh P, Chanda A, Snider J, Lee N, et al. TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism. Mol Biol Cell. 2017;28:1195-1207 pubmed publisher
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- immunocytochemistry; human; loading ...; fig s5a
| Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher
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- flow cytometry; human; loading ...; fig 6a
| Prasad A, Kulkarni R, Jiang S, Groopman J. Cocaine Enhances DC to T-cell HIV-1 Transmission by Activating DC-SIGN/LARG/LSP1 Complex and Facilitating Infectious Synapse Formation. Sci Rep. 2017;7:40648 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 2c
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- immunocytochemistry; human; loading ...; fig 1e
| Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, et al. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature. 2017;541:228-232 pubmed publisher
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- immunocytochemistry; human; 1:200; loading ...; fig 4c
| Song H, Chiang H, Tseng W, Wu P, Chien C, Leu H, et al. Using CRISPR/Cas9-Mediated GLA Gene Knockout as an In Vitro Drug Screening Model for Fabry Disease. Int J Mol Sci. 2016;17: pubmed
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- immunocytochemistry; human; loading ...; fig 5
| Assadi G, Vesterlund L, Bonfiglio F, Mazzurana L, Cordeddu L, Schepis D, et al. Functional Analyses of the Crohn's Disease Risk Gene LACC1. PLoS ONE. 2016;11:e0168276 pubmed publisher
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- immunocytochemistry; human; 1:200; loading ...; fig 3a
- western blot; human; loading ...; fig 1c
| Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1b
| Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed publisher
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- immunocytochemistry; human; fig 2
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- immunocytochemistry; human; fig 4
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- immunocytochemistry; human; fig 3
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- immunocytochemistry; human; fig 2
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- immunohistochemistry; human; 1:1000; loading ...; fig 4a
- western blot; human; 1:2000; loading ...; fig 7b
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- western blot; mouse; fig 6
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- immunocytochemistry; human; loading ...; fig s1a
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- immunocytochemistry; human; 1:400; fig 6
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- western blot; human; fig 2
| Zou M, Zhu W, Wang L, Shi L, Gao R, Ou Y, et al. AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition. Oncotarget. 2016;7:13122-38 pubmed publisher
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- immunocytochemistry; human; fig 4
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- immunocytochemistry; human; loading ...; fig s1a
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- immunocytochemistry; human; fig 6
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- immunocytochemistry; human; 1:1000; fig 3
- western blot; human; 1:1000; fig 3
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- immunocytochemistry; human; 1:100; loading ...
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- immunocytochemistry; human; 1:200; fig 5
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- immunocytochemistry; human; fig 2n
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- immunocytochemistry; human; fig 3
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- immunocytochemistry; human; 1:100
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