product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Ikaros (D10E5) Rabbit mAb
catalog :
9034
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D10E5
reactivity :
human, mouse
application :
western blot, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3a
Zhou N, Gutierrez Uzquiza A, Zheng X, Chang R, Vogl D, Garfall A, et al. RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation. Leukemia. 2019;: pubmed publisher
  • chromatin immunoprecipitation; mouse; fig s3
Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher
Lundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed publisher
Tan J, Fourrière L, Wang J, Perez F, Boncompain G, Gleeson P. Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production. Mol Biol Cell. 2020;31:27-44 pubmed publisher
Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher
Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al. Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ. Alzheimers Res Ther. 2019;11:97 pubmed publisher
Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher
Boscher E, Husson T, Quenez O, Laquerriere A, Marguet F, Cassinari K, et al. Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer's Disease. J Alzheimers Dis. 2019;68:1243-1255 pubmed publisher
Voytyuk I, Mueller S, Herber J, Snellinx A, Moechars D, Van Loo G, et al. BACE2 distribution in major brain cell types and identification of novel substrates. Life Sci Alliance. 2018;1:e201800026 pubmed publisher
Sadleir K, Popovic J, Vassar R. ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease. J Biol Chem. 2018;293:18434-18443 pubmed publisher
Chatila Z, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram M, et al. BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice. Eneuro. 2018;5: pubmed publisher
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, et al. BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS ONE. 2018;13:e0200344 pubmed publisher
Rao C, Farooqui M, Zhang Y, Asch A, Yamada H. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018;:e12797 pubmed publisher
van Nieuwenhove E, Garcia Perez J, Helsen C, Rodriguez P, van Schouwenburg P, Dooley J, et al. A kindred with Mutant IKAROS and autoimmunity. J Allergy Clin Immunol. 2018;: pubmed publisher
Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, et al. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018;8:1329 pubmed publisher
Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, et al. BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology. Acta Neuropathol. 2018;135:695-710 pubmed publisher
Sun M, Zhang H. Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiol Aging. 2017;60:129-140 pubmed publisher
Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher
Tan J, Li Q, Ciccotosto G, Crouch P, Culvenor J, White A, et al. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein. PLoS ONE. 2013;8:e61246 pubmed publisher
Walker K, Kang E, Whalen M, Shen Y, Tesco G. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 2012;32:10423-37 pubmed publisher
product information
SKU :
9034S
Product-Name :
Ikaros (D10E5) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H
Applications :
Flow cytometry
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
50-70
Host :
Rabbit
Target :
Ikaros
Primary-Protein :
Ikaros
Alt-Names :
CLL-associated antigen KW-6,DNA-binding protein Ikaros,Hs.54452,IK1,IKAROS,IKAROS family zinc finger 1 (Ikaros),IKZF1,Ikaros (zinc finger protein),Ikaros family zinc finger protein 1,LYF1,Lymphoid transcription factor LyF-1,PRO0758,ZNFN1A1,hIk-1,zinc finger protein, subfamily 1A, 1 (Ikaros)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.