LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb | Cell Signaling Technology 8975 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb

catalog :

8975

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

D11H6

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation, immunocytochemistry knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; loading ...; fig 6c western blot knockout validation; mouse; loading ...; fig 2i, s3c, 9c	Nakatani T, Tsujimoto K, Park J, Jo T, Kimura T, Hayama Y, et al. The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II. Nat Commun. 2021;12:3333 pubmed publisher
immunocytochemistry knockout validation; mouse; loading ...; fig 1g western blot knockout validation; mouse; 1:2000; loading ...; fig 3d	Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun. 2016;7:13130 pubmed publisher
western blot knockout validation; mouse; loading ...; fig 1a	Ying L, Zhang M, Ma X, Si Y, Li X, Su J, et al. Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure. Front Cell Dev Biol. 2021;9:672032 pubmed publisher
western blot; human; loading ...; fig 7f	Timms R, Zhang Z, Rhee D, Harper J, Koren I, Elledge S. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019;365: pubmed publisher
western blot; human; loading ...; fig s3a	Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4a	Hsu C, Lee E, Gordon K, Paz E, Shen W, Ohnishi K, et al. MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun. 2018;9:942 pubmed publisher
western blot; human; 1:1000; fig s2	Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
western blot; rat; 1:1000	Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher
western blot; human; fig 1	Rebsamen M, Pochini L, Stasyk T, de AraÃºjo M, Galluccio M, Kandasamy R, et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015;519:477-81 pubmed publisher
western blot; human; 1:500	McNulty S, Flint M, Nichol S, Spiropoulou C. Host mTORC1 signaling regulates andes virus replication. J Virol. 2013;87:912-22 pubmed publisher
	Chen Y, Navarrete M, Wang Y, McClintock N, Sakurai R, Wang F, et al. N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells. Sci Rep. 2020;10:11952 pubmed publisher
	Jia J, Abudu Y, Claude Taupin A, Gu Y, Kumar S, Choi S, et al. Galectins Control mTOR in Response to Endomembrane Damage. Mol Cell. 2018;70:120-135.e8 pubmed publisher
	Li X, Gao M, Choi J, Kim B, Zhou M, Chen Z, et al. Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics. 2017;16:594-607 pubmed publisher
	Kissing S, Rudnik S, Damme M, Lüllmann Rauch R, Ichihara A, Kornak U, et al. Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Autophagy. 2017;13:670-685 pubmed publisher
	Nada S, Mori S, Takahashi Y, Okada M. p18/LAMTOR1: a late endosome/lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway. Methods Enzymol. 2014;535:249-63 pubmed publisher

product information

SKU :

8975P

Product-Name :

LAMTOR1/C11orf59 (D11H6) XP® Rabbit mAb

Size :

40 ul

Price-(USD) :

135 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Immunofluorescence (Immunocytochemistry)

Product-Category :

PI3K / Akt Signaling

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

C11orf59

Primary-Protein :

LAMTOR1

Alt-Names :

C11orf59,CK059,FLJ20625,PDRO,Ragulator1,RhoA activator C11orf59,chromosome 11 open reading frame 59,late endosomal/lysosomal adaptor, MAPK and MTOR activator 1,p18,p27Kip1-releasing factor from RhoA,p27RF-Rho

more info or order :

Cell Signaling Technology product webpage