product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
ALK (D5F3) XP® Rabbit mAb (PE Conjugate)
catalog :
8868
clonality :
monoclonal
host :
rabbit
conjugate :
PE
clone name :
D5F3
reactivity :
human
application :
flow cytometry
citations: 26
Reference
Iacono D, Chiari R, Metro G, Bennati C, Bellezza G, Cenci M, et al. Future options for ALK-positive non-small cell lung cancer. Lung Cancer. 2015;87:211-9 pubmed publisher
Kotoula V, Bobos M, Vassilakopoulou M, Tsolaki E, Chrisafi S, Psyrri A, et al. Intact or broken-apart RNA: an alternative concept for ALK fusion screening in non-small cell lung cancer (NSCLC). Appl Immunohistochem Mol Morphol. 2015;23:60-70 pubmed publisher
Doble B, Tan M, Harris A, Lorgelly P. Modeling companion diagnostics in economic evaluations of targeted oncology therapies: systematic review and methodological checklist. Expert Rev Mol Diagn. 2015;15:235-54 pubmed publisher
Zhang K, Deng H, Cagle P. Utility of immunohistochemistry in the diagnosis of pleuropulmonary and mediastinal cancers: a review and update. Arch Pathol Lab Med. 2014;138:1611-28 pubmed publisher
Marchetti A, Barberis M, Papotti M, Rossi G, Franco R, Malatesta S, et al. ALK rearrangement testing by FISH analysis in non-small-cell lung cancer patients: results of the first italian external quality assurance scheme. J Thorac Oncol. 2014;9:1470-6 pubmed publisher
Cha Y, Lee J, Kim H, Lim S, Cho B, Lee C, et al. Screening of ROS1 rearrangements in lung adenocarcinoma by immunohistochemistry and comparison with ALK rearrangements. PLoS ONE. 2014;9:e103333 pubmed publisher
Yang L, Li G, Zhao L, Pan F, Qiang J, Han S. Blocking the PI3K pathway enhances the efficacy of ALK-targeted therapy in EML4-ALK-positive nonsmall-cell lung cancer. Tumour Biol. 2014;35:9759-67 pubmed publisher
Berghoff A, Birner P, Streubel B, Kenner L, Preusser M. ALK gene aberrations and the JUN/JUNB/PDGFR axis in metastatic NSCLC. APMIS. 2014;122:867-72 pubmed publisher
Minca E, Lanigan C, Reynolds J, Wang Z, Ma P, Cicenia J, et al. ALK status testing in non-small-cell lung carcinoma by FISH on ThinPrep slides with cytology material. J Thorac Oncol. 2014;9:464-8 pubmed publisher
Feng Y, Minca E, Lanigan C, Liu A, Zhang W, Yin L, et al. High MET receptor expression but not gene amplification in ALK 2p23 rearrangement positive non-small-cell lung cancer. J Thorac Oncol. 2014;9:646-53 pubmed publisher
Yang J, Zhang X, Su J, Xu C, Zhou Q, Tian H, et al. Lung cancers with concomitant EGFR mutations and ALK rearrangements: diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation. Clin Cancer Res. 2014;20:1383-92 pubmed publisher
Shan L, Lian F, Guo L, Yang X, Ying J, Lin D. Combination of conventional immunohistochemistry and qRT-PCR to detect ALK rearrangement. Diagn Pathol. 2014;9:3 pubmed publisher
Han X, Zhang N, Ma L, Lin D, Hao X, Liu Y, et al. Immunohistochemistry reliably detects ALK rearrangements in patients with advanced non-small-cell lung cancer. Virchows Arch. 2013;463:583-91 pubmed publisher
Li Y, Pan Y, Wang R, Sun Y, Hu H, Shen X, et al. ALK-rearranged lung cancer in Chinese: a comprehensive assessment of clinicopathology, IHC, FISH and RT-PCR. PLoS ONE. 2013;8:e69016 pubmed publisher
Ying J, Guo L, Qiu T, Shan L, Ling Y, Liu X, et al. Diagnostic value of a novel fully automated immunochemistry assay for detection of ALK rearrangement in primary lung adenocarcinoma. Ann Oncol. 2013;24:2589-93 pubmed publisher
Niu H, Zhou Q, Wang F, Shao Q, Guan Y, Wen X, et al. Identification of anaplastic lymphoma kinase break points and oncogenic mutation profiles in acral/mucosal melanomas. Pigment Cell Melanoma Res. 2013;26:646-53 pubmed publisher
Selinger C, Rogers T, Russell P, O Toole S, Yip P, Wright G, et al. Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization. Mod Pathol. 2013;26:1545-53 pubmed publisher
Zhang Y, Jin M, Li L, Zhao H, Zeng X, Jiang L, et al. Evaluation of ALK rearrangement in Chinese non-small cell lung cancer using FISH, immunohistochemistry, and real-time quantitative RT- PCR on paraffin-embedded tissues. PLoS ONE. 2013;8:e64821 pubmed publisher
Roberts P. Clinical use of crizotinib for the treatment of non-small cell lung cancer. Biologics. 2013;7:91-101 pubmed publisher
Nakamura H, Tsuta K, Yoshida A, Shibata T, Wakai S, Asamura H, et al. Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma. J Clin Pathol. 2013;66:705-7 pubmed publisher
Filtenborg Barnkob B, Bzorek M. Expression of anaplastic lymphoma kinase in Merkel cell carcinomas. Hum Pathol. 2013;44:1656-64 pubmed publisher
Minca E, Portier B, Wang Z, Lanigan C, Farver C, Feng Y, et al. ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn. 2013;15:341-6 pubmed publisher
Preusser M, Berghoff A, Ilhan Mutlu A, Magerle M, Dinhof C, Widhalm G, et al. ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer. Lung Cancer. 2013;80:278-83 pubmed publisher
Conklin C, Craddock K, Have C, Laskin J, Couture C, Ionescu D. Immunohistochemistry is a reliable screening tool for identification of ALK rearrangement in non-small-cell lung carcinoma and is antibody dependent. J Thorac Oncol. 2013;8:45-51 pubmed publisher
Wang Z, Zhang X, Bai H, Zhao J, Zhuo M, An T, et al. EML4-ALK rearrangement and its clinical significance in Chinese patients with advanced non-small cell lung cancer. Oncology. 2012;83:248-56 pubmed publisher
Rimkunas V, Crosby K, Li D, Hu Y, Kelly M, Gu T, et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res. 2012;18:4449-57 pubmed publisher
product information
SKU :
8868S
Product-Name :
ALK (D5F3) XP® Rabbit mAb (PE Conjugate)
Size :
100 ul
Price-(USD) :
321 USD
Species-x-Reactivity :
H
Applications :
Flow cytometry
Product-Category :
RTK
Shipping-Temp :
COLD
Storage-Temp :
4°C
Product-Type :
Monoclonal Antibody
Host :
Rabbit
Target :
ALK
Primary-Protein :
ALK
Alt-Names :
ALK,ALK tyrosine kinase receptor,Anaplastic lymphoma kinase,CD246,CD246 antigen,NBLST3,TFG/ALK,anaplastic lymphoma receptor tyrosine kinase
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.