product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425) (D27F4) Rabbit mAb
catalog :
8828
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
D27F4
reactivity :
human, mouse, rat, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 83
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:2500; loading ...; fig s1e
Kabwe J, Sawada H, Mitani Y, Oshita H, Tsuboya N, Zhang E, et al. CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension. Respir Res. 2022;23:87 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Choi J, Maddala R, Karnam S, Skiba N, Vann R, Challa P, et al. Role of vasorin, an anti-apoptotic, anti-TGF-β and hypoxia-induced glycoprotein in the trabecular meshwork cells and glaucoma. J Cell Mol Med. 2022;26:2063-2075 pubmed publisher
  • western blot; mouse; loading ...; fig s4b
  • western blot; human; loading ...; fig 1a
Tsai H, Wang J, Hsu Y, Chiu Y, Lin C, Lu C, et al. miR-424/322 protects against abdominal aortic aneurysm formation by modulating the Smad2/3/runt-related transcription factor 2 axis. Mol Ther Nucleic Acids. 2022;27:656-669 pubmed publisher
  • western blot; mouse; fig 1a
Eritja N, Navaridas R, Ruiz Mitjana A, Vidal Sabanés M, Egea J, Encinas M, et al. Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Sun W, Byon C, Kim D, Choi H, Park J, Joo S, et al. Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88. Front Pharmacol. 2021;12:708575 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Gyamfi J, Yeo J, Kwon D, Min B, Cha Y, Koo J, et al. Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. NPJ Breast Cancer. 2021;7:129 pubmed publisher
  • western blot; mouse; loading ...; fig 3g, 6c
  • western blot; human; loading ...; fig 2g, 6a
Gu P, Wang D, Zhang J, Wang X, Chen Z, Gu L, et al. Protective function of interleukin-22 in pulmonary fibrosis. Clin Transl Med. 2021;11:e509 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 6b
Escasany E, Lanzón B, García Carrasco A, Izquierdo Lahuerta A, Torres L, Corrales P, et al. Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney. Dis Model Mech. 2021;14: pubmed publisher
  • western blot; mouse; 1:100; loading ...; fig 2b
Li T, Yang X, Xu D, Gao Z, Gao Y, Jin F, et al. OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis. Oxid Med Cell Longev. 2021;2021:4158495 pubmed publisher
  • western blot; mouse; fig 4m
Kim G, Kim W, Lim S, Lee H, Koo J, Nam K, et al. In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse. Adv Sci (Weinh). 2021;8:2004973 pubmed publisher
  • flow cytometry; mouse
Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Bansod S, Saifi M, Godugu C. Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model. Sci Rep. 2021;11:12894 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Nishad R, Mukhi D, Singh A, Motrapu M, Chintala K, Tammineni P, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12:342 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5
Can xe8 S, Van Snick J, Uyttenhove C, Pilotte L, van den Eynde B. TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism. J Immunother Cancer. 2021;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
  • western blot; mouse; 1:1000; loading ...; fig 5a, 5c
Pan Y, Iejima D, Nakayama M, Suga A, Noda T, Kaur I, et al. Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro. J Biol Chem. 2021;296:100456 pubmed publisher
  • western blot; human; 1:1000; fig 3b
Yang D, Shi J, Xia Z, Guo W, Ahmed M, Zhang S. Hepatic connective tissue growth factor expression and regulation differ between non-steatotic and non-alcoholic steatotic livers from brain-dead donor. Sci Rep. 2021;11:3857 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 9d
Tang C, Wu M, Zhao D, Edwards D, McVicar A, Luo Y, et al. Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways. PLoS Genet. 2021;17:e1009233 pubmed publisher
  • chromatin immunoprecipitation; rat; loading ...; fig 5h
  • immunoprecipitation; rat; loading ...; fig 5g
He F, Li L, Li P, Deng Y, Yang Y, Deng Y, et al. Cyclooxygenase-2/sclerostin mediates TGF-β1-induced calcification in vascular smooth muscle cells and rats undergoing renal failure. Aging (Albany NY). 2020;12:21220-21235 pubmed publisher
  • western blot; human; 1:500; fig s3f
Wang H, Wang M, Wen Y, Xu C, Chen X, Wu D, et al. Biphasic Regulation of Mesenchymal Genes Controls Fate Switches During Hematopoietic Differentiation of Human Pluripotent Stem Cells. Adv Sci (Weinh). 2020;7:2001019 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 11c
Suzuki K, Matsumoto M, Katoh Y, Liu L, Ochiai K, Aizawa Y, et al. Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation. PLoS ONE. 2020;15:e0236781 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:1000; loading ...; fig 4a
Williams M, Solnica Krezel L. Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. elife. 2020;9: pubmed publisher
  • immunohistochemistry; zebrafish ; 1:1000; loading ...; fig 2a
Schauer A, Pinheiro D, Hauschild R, Heisenberg C. Zebrafish embryonic explants undergo genetically encoded self-assembly. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Sarić N, Selby M, Ramaswamy V, Kool M, Stockinger B, Hogstrand C, et al. The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma. Sci Rep. 2020;10:148 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Lee J, Hall J, Kroehling L, Wu L, Najar T, Nguyen H, et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020;180:79-91.e16 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7b
Tran B, Yu Y, Chang L, Tan B, Jia W, Xiong Y, et al. A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway. Int J Nanomedicine. 2019;14:10061-10077 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2i, s2b
Kuninty P, Bansal R, de Geus S, Mardhian D, Schnittert J, van Baarlen J, et al. ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. Sci Adv. 2019;5:eaax2770 pubmed publisher
  • western blot; human; loading ...; fig 3b
Hori A, Shimoda M, Naoi Y, Kagara N, Tanei T, Miyake T, et al. Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer. Breast Cancer Res. 2019;21:88 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 12b
Ying W, Li X, Rangarajan S, Feng W, Curtis L, Sanders P. Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. J Clin Invest. 2019;129:2792-2806 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2g
Prajapati DiNubila M, Benito Gonzalez A, Golden E, Zhang S, Doetzlhofer A. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 1s1f
Hamaguchi M, Muramatsu R, Fujimura H, Mochizuki H, Kataoka H, Yamashita T. Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system. elife. 2019;8: pubmed publisher
  • western blot; human; 1:400; loading ...; fig 5e
  • western blot; rat; 1:400; loading ...; fig 7a
Wang M, Xiong L, Jiang L, Lu Y, Liu F, Song L, et al. miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7. EBioMedicine. 2019;41:670-682 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Narayana Y, Gadgil C, Mote R, Rajan R, Subramanyam D. Clathrin-Mediated Endocytosis Regulates a Balance between Opposing Signals to Maintain the Pluripotent State of Embryonic Stem Cells. Stem Cell Reports. 2019;12:152-164 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6d
Wang L, Chai Y, Li C, Liu H, Su W, Liu X, et al. Oxidized phospholipids are ligands for LRP6. Bone Res. 2018;6:22 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6a
Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed publisher
  • western blot; human; 1:1000; fig 2b
Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed publisher
  • immunocytochemistry; human; fig 3a
  • western blot; human; fig 3b
Bermeo S, Al Saedi A, Kassem M, Vidal C, Duque G. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation. J Cell Biochem. 2017;118:4425-4435 pubmed publisher
  • western blot; human; fig 4a
Wu Y, Wang L, Deng D, Zhang Q, Liu W. Renalase Protects against Renal Fibrosis by Inhibiting the Activation of the ERK Signaling Pathways. Int J Mol Sci. 2017;18: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; tbl 2
Singh R, Braga M, Reddy S, Lee S, Parveen M, Grijalva V, et al. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017;158:1217-1230 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Dahan J, Levillayer F, Xia T, Nouet Y, Werts C, Fanton d Andon M, et al. LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor ?1 Expression. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; rat; 1:1000; fig 8a
Shu D, Wojciechowski M, Lovicu F. Bone Morphogenetic Protein-7 Suppresses TGF?2-Induced Epithelial-Mesenchymal Transition in the Lens: Implications for Cataract Prevention. Invest Ophthalmol Vis Sci. 2017;58:781-796 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5c
  • western blot; human; loading ...; fig 5a
Melchionna R, Iapicca P, Di Modugno F, Trono P, Sperduti I, Fassan M, et al. The pattern of hMENA isoforms is regulated by TGF-?1 in pancreatic cancer and may predict patient outcome. Oncoimmunology. 2016;5:e1221556 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s2e
  • western blot; human; loading ...; fig s2d
Sun J, Liu X, Gao H, Zhang L, Ji Q, Wang Z, et al. Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis. Oncotarget. 2017;8:11489-11506 pubmed publisher
  • western blot; mouse; loading ...; fig 8b
Lee H, Khan S, Khaliqdina S, Altintas M, Grahammer F, Zhao J, et al. Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem. 2017;292:732-747 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig e6
Mueller A, van Velthoven C, Fukumoto K, Cheung T, Rando T. Intronic polyadenylation of PDGFR? in resident stem cells attenuates muscle fibrosis. Nature. 2016;540:276-279 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
  • western blot; human; 1:1000; loading ...; fig 4a
Wu X, Wu X, Ma Y, Shao F, Tan Y, Tan T, et al. CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. Nat Commun. 2016;7:13498 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 4
  • western blot; mouse; 1:1000
Liu W, Zhou L, Zhou C, Zhang S, Jing J, Xie L, et al. GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation. Nat Commun. 2016;7:12794 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 5a
Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed publisher
  • immunocytochemistry; human; 1:200; fig s2
Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5a
Xiao X, Senavirathna L, Gou X, Huang C, Liang Y, Liu L. EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis. Physiol Rep. 2016;4: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 3
Liu J, Akanuma N, Liu C, Naji A, Halff G, Washburn W, et al. TGF-?1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Sci Rep. 2016;6:30904 pubmed publisher
  • western blot; mouse; fig 4
Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Tisza M, Zhao W, Fuentes J, Prijic S, Chen X, Levental I, et al. Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts. Oncotarget. 2016;7:51553-51568 pubmed publisher
  • western blot; human; 1:1000; fig 3a
Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016;14:159-64 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 1
Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher
  • western blot; mouse; fig 2
Kral J, Kuttke M, Schrottmaier W, Birnecker B, Warszawska J, Wernig C, et al. Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways. Sci Rep. 2016;6:23034 pubmed publisher
  • western blot; mouse; fig 3
  • western blot; human; fig 2
Liu L, Liu X, Ren X, Tian Y, Chen Z, Xu X, et al. Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification. Sci Rep. 2016;6:21602 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3b
Leiva M, Quintana J, Ligos J, Hidalgo A. Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability. Nat Commun. 2016;7:10222 pubmed publisher
  • western blot; human; 1:1000; fig s4i
Maxfield K, Taus P, Corcoran K, Wooten J, Macion J, Zhou Y, et al. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun. 2015;6:8840 pubmed publisher
  • western blot; human; 1:300; fig 5
Buczek M, Miles A, Green W, Johnson C, Boocock D, Pockley A, et al. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 2016;35:3465-75 pubmed publisher
  • western blot; human; fig 1
Gurung S, Werkmeister J, Gargett C. Inhibition of Transforming Growth Factor-β Receptor signaling promotes culture expansion of undifferentiated human Endometrial Mesenchymal Stem/stromal Cells. Sci Rep. 2015;5:15042 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 4
Schira J, Schulte M, Döbele C, Wallner C, Abraham S, Daigeler A, et al. Human scaphoid non-unions exhibit increased osteoclast activity compared to adjacent cancellous bone. J Cell Mol Med. 2015;19:2842-50 pubmed publisher
  • western blot; human; fig 6
Yan M, Yao C, Chow J, Chang C, Hwang P, Chuang S, et al. Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells. Mar Drugs. 2015;13:6099-116 pubmed publisher
  • western blot; human; 1:500; fig 4
Maris P, Blomme A, Palacios A, Costanza B, Bellahcène A, Bianchi E, et al. Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Med. 2015;12:e1001871 pubmed publisher
  • immunohistochemistry; mouse; 1:300; fig 5
  • western blot; mouse; 1:500; fig 5
Wu C, Jiao H, Lai Y, Zheng W, Chen K, Qu H, et al. Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015;6:7531 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Maachani U, Tandle A, Shankavaram U, Kramp T, Camphausen K. Modulation of miR-21 signaling by MPS1 in human glioblastoma. Oncotarget. 2016;7:52912-52927 pubmed publisher
  • western blot; human; fig 5
Min K, Liggett J, Silva G, Wu W, Wang R, Shen R, et al. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Oncogene. 2016;35:377-88 pubmed publisher
  • western blot; human
Singh K, Lovren F, Pan Y, Quan A, Ramadan A, Matkar P, et al. The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem. 2015;290:2547-59 pubmed publisher
  • western blot; human; 1:800
Sun G, Shi L, Li M, Jiang N, Fu L, Guo J. Lefty inhibits glioma growth by suppressing Nodal-activated Smad and ERK1/2 pathways. J Neurol Sci. 2014;347:137-42 pubmed publisher
  • western blot; human
So J, Lin J, Wahler J, Liby K, Sporn M, Suh N. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS ONE. 2014;9:e107616 pubmed publisher
  • western blot; mouse
Yang X, Han Z, Zhang S, Zhu P, Hao C, Fan T, et al. Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-?1 generation. Cell Death Dis. 2014;5:e1308 pubmed publisher
  • western blot; mouse
Ekman M, Bhattachariya A, Dahan D, Uvelius B, Albinsson S, Swärd K. Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. PLoS ONE. 2013;8:e82308 pubmed publisher
  • western blot; rat; 1:1000
Mitchell K, Shah J, Tsytsikova L, Campbell A, Affram K, Symes A. LPS antagonism of TGF-? signaling results in prolonged survival and activation of rat primary microglia. J Neurochem. 2014;129:155-68 pubmed publisher
Gurrapu S, Franzolin G, Fard D, Accardo M, Medico E, Sarotto I, et al. Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells. Sci Signal. 2019;12: pubmed publisher
Lun X, Szklarczyk D, Gábor A, Dobberstein N, Zanotelli V, Saez Rodriguez J, et al. Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. Mol Cell. 2019;74:1086-1102.e5 pubmed publisher
Qin Y, Garrison B, Ma W, Wang R, Jiang A, Li J, et al. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Cell. 2018;174:156-171.e16 pubmed publisher
Zambrano S, Rodriguez P, Guo J, Möller Hackbarth K, Schwarz A, Patrakka J. FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice. Sci Rep. 2018;8:4712 pubmed publisher
Fang Q, Wang X, Zhao W, Ding S, Shi B, Xia Y, et al. Angiotensin-converting enzyme inhibitor reduces scar formation by inhibiting both canonical and noncanonical TGF-β1 pathways. Sci Rep. 2018;8:3332 pubmed publisher
Chang Z, Lorenzini M, Chen X, Tran U, Bangayan N, Chen Y. Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nat Chem Biol. 2018;14:317-324 pubmed publisher
Ross M, Esser A, Fox G, Schmieder A, Yang X, Hu G, et al. Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases. Cancer Res. 2017;77:6299-6312 pubmed publisher
Oh S, Liu M, Nixon B, Kang D, Toure A, Bivona M, et al. Foxp3-independent mechanism by which TGF-? controls peripheral T cell tolerance. Proc Natl Acad Sci U S A. 2017;114:E7536-E7544 pubmed publisher
Li S, Nie E, Yin Y, Benowitz L, Tung S, Vinters H, et al. GDF10 is a signal for axonal sprouting and functional recovery after stroke. Nat Neurosci. 2015;18:1737-45 pubmed publisher
Dong X, Zhang C, Ma S, Wen H. High concentrations of mast cell chymase facilitate the transduction of the transforming growth factor-β1/Smads signaling pathway in skin fibroblasts. Exp Ther Med. 2015;9:955-960 pubmed
product information
SKU :
8828S
Product-Name :
Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425) (D27F4) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
52, 60
Host :
Rabbit
Target :
Smad2 (Ser465/Ser467) phosphate/Smad3 (Ser423/Ser425) phosphate
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.