product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Stat3α (D1A5) XP® Rabbit mAb
catalog :
8768
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D1A5
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 12
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:200; loading ...; fig 1a, s1c
Han J, Kwon S, Kim Y, Choi J, Kim J, Lee Y, et al. Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1d
Viau A, Baaziz M, Aka A, Mazloum M, Nguyen C, Kuehn E, et al. Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2020;31:1035-1049 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1d
Lindner P, Paul S, Eckstein M, Hampel C, Muenzner J, Erlenbach Wuensch K, et al. EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells. Cell Death Dis. 2020;11:147 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, et al. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Oncogene. 2019;38:2658-2674 pubmed publisher
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 2
Harwardt T, Lukas S, Zenger M, Reitberger T, Danzer D, Übner T, et al. Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathog. 2016;12:e1005748 pubmed publisher
  • western blot; mouse; fig 6
  • western blot; human; fig 6
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126:495-508 pubmed
  • western blot; mouse; 1:1000; fig 6
  • western blot; human; 1:1000; fig 7
Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  • western blot; human
Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
Xie Y, Yu D, Wu J, Li L. Protective effects of physiological testosterone on advanced glycation end product?induced injury in human endothelial cells. Mol Med Rep. 2017;15:1165-1171 pubmed publisher
Dasgupta M, Unal H, Willard B, Yang J, Karnik S, Stark G. Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3. J Biol Chem. 2014;289:30763-71 pubmed publisher
Cao Y, Xia D, Qi S, Du J, Ma P, Wang S, et al. Epiregulin can promote proliferation of stem cells from the dental apical papilla via MEK/Erk and JNK signalling pathways. Cell Prolif. 2013;46:447-56 pubmed publisher
Nakdimon I, Walser M, Fröhli E, Hajnal A. PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development. PLoS Genet. 2012;8:e1002881 pubmed publisher
product information
SKU :
8768P
Product-Name :
Stat3α (D1A5) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, (Pg)
Applications :
Chromatin Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
86
Host :
Rabbit
Target :
STAT3
Primary-Protein :
STAT3
Alt-Names :
APRF,Acute-phase response factor,DNA-binding protein APRF,FLJ20882,HIES,MGC16063,STAT3,Signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 (acute-phase response factor)
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.