product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
4E-BP1 (53H11) Rabbit mAb (Biotinylated)
catalog :
8594
clonality :
monoclonal
host :
rabbit
conjugate :
biotin
clone name :
53H11
reactivity :
human, mouse, rat
application :
western blot
citations: 12
Reference
Hou L, Li Y, Song H, Zhang Z, Sun Y, Zhang X, et al. Protective Macroautophagy Is Involved in Vitamin E Succinate Effects on Human Gastric Carcinoma Cell Line SGC-7901 by Inhibiting mTOR Axis Phosphorylation. PLoS ONE. 2015;10:e0132829 pubmed publisher
Li S, Chen C, Lu H, Huang W, Tien W, Lan Y, et al. Phosphorylated p70S6K expression is an independent prognosticator for patients with esophageal squamous cell carcinoma. Surgery. 2015;157:570-80 pubmed publisher
Gorr T, Vogel J. Western blotting revisited: critical perusal of underappreciated technical issues. Proteomics Clin Appl. 2015;9:396-405 pubmed publisher
Weisberg E, Nonami A, Chen Z, Nelson E, Chen Y, Liu F, et al. Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R. Clin Cancer Res. 2014;20:5483-95 pubmed publisher
Chen Y, Li J, Hu J, Zheng J, Zheng Z, Liu T, et al. Emodin enhances ATRA-induced differentiation and induces apoptosis in acute myeloid leukemia cells. Int J Oncol. 2014;45:2076-84 pubmed publisher
López Rivera E, Jayaraman P, Parikh F, Davies M, Ekmekcioglu S, Izadmehr S, et al. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res. 2014;74:1067-78 pubmed publisher
Komori Y, Yada K, Ohta M, Uchida H, Iwashita Y, Fukuzawa K, et al. Mammalian target of rapamycin signaling activation patterns in pancreatic neuroendocrine tumors. J Hepatobiliary Pancreat Sci. 2014;21:288-95 pubmed publisher
Nakashima A, Tanimura Ito K, Oshiro N, Eguchi S, Miyamoto T, Momonami A, et al. A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A. FEBS Lett. 2013;587:2924-9 pubmed publisher
Dobson T, Chen J, Krushel L. Dysregulating IRES-dependent translation contributes to overexpression of oncogenic Aurora A Kinase. Mol Cancer Res. 2013;11:887-900 pubmed publisher
Trancikova A, Mamais A, Webber P, Stafa K, Tsika E, Glauser L, et al. Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations. PLoS ONE. 2012;7:e47784 pubmed publisher
Murai A, Asa S, Kodama A, Hirata A, Yanai T, Sakai H. Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines. BMC Vet Res. 2012;8:128 pubmed publisher
Tambe Y, Okuyama N, Nakagawa T, Muramoto A, Hasebe M, Chano T, et al. Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway. Cancer Lett. 2012;314:82-91 pubmed publisher
product information
SKU :
8594S
Product-Name :
4E-BP1 (53H11) Rabbit mAb (Biotinylated)
Size :
100 ul
Price-(USD) :
291 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Western blot
Product-Category :
Translational Control
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
15-20
Host :
Rabbit
Target :
4E-BP1
Primary-Protein :
4E-BP1
Alt-Names :
4E-BP1,4EBP1,BP-1,EIF4EBP1,Eukaryotic translation initiation factor 4E-binding protein 1,MGC4316,PHAS-I,Phosphorylated heat- and acid-stable protein regulated by insulin 1,eIF4E-binding protein 1,eukaryotic translation initiation factor 4E binding protein 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.