product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-EGF Receptor (Tyr1068) (D7A5) XP® Rabbit mAb (Biotinylated)
catalog :
8543
clonality :
monoclonal
host :
rabbit
conjugate :
biotin
antigen modification :
phosphorylated
clone name :
D7A5
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Cell Signaling Technology product webpage
citations: 12
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1
Li W, Qiu Y, Zhang H, Tian X, Fang W. P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. PLoS ONE. 2015;10:e0133165 pubmed publisher
Milagre C, Gopinathan G, Everitt G, Thompson R, Kulbe H, Zhong H, et al. Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer. Cancer Res. 2015;75:1255-64 pubmed publisher
Carlino M, Fung C, Shahheydari H, Todd J, Boyd S, Irvine M, et al. Preexisting MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients. Clin Cancer Res. 2015;21:98-105 pubmed publisher
Katsila T, Juliachs M, Gregori J, Macarulla T, Villarreal L, Bardelli A, et al. Circulating pEGFR is a candidate response biomarker of cetuximab therapy in colorectal cancer. Clin Cancer Res. 2014;20:6346-56 pubmed publisher
Moreno Càceres J, Caja L, Mainez J, Mayoral R, Martin Sanz P, Moreno Vicente R, et al. Caveolin-1 is required for TGF-?-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17. Cell Death Dis. 2014;5:e1326 pubmed publisher
Fong J, Jacobs R, Moravec D, Uppada S, Botting G, Nlend M, et al. Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer. PLoS ONE. 2013;8:e78398 pubmed publisher
Asano R, Hagiwara Y, Koyama N, Masakari Y, Orimo R, Arai K, et al. Multimerization of anti-(epidermal growth factor receptor) IgG fragments induces an antitumor effect: the case for humanized 528 scFv multimers. FEBS J. 2013;280:4816-26 pubmed publisher
Paulson A, Linklater E, Berghuis B, App C, Oostendorp L, Paulson J, et al. MET and ERBB2 are coexpressed in ERBB2+ breast cancer and contribute to innate resistance. Mol Cancer Res. 2013;11:1112-21 pubmed publisher
Hall K, Hill D, Otero M, Plumb D, Froemel D, Dragomir C, et al. ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Mol Cell Biol. 2013;33:3077-90 pubmed publisher
Kuo H, Chen Y, Chang H, Jeng J, Lin E, Pan C, et al. The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancer. Carcinogenesis. 2013;34:1708-16 pubmed publisher
Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng S, et al. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2012;303:L89-96 pubmed publisher
Degen M, Natarajan E, Barron P, Widlund H, Rheinwald J. MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin ?2 expression in oral dysplasia and squamous cell carcinoma. Am J Pathol. 2012;180:2462-78 pubmed publisher
product information
SKU :
8543S
Product-Name :
Phospho-EGF Receptor (Tyr1068) (D7A5) XP® Rabbit mAb (Biotinylated)
Size :
100 ul
Price-(USD) :
321 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Western blot
Product-Category :
RTK
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
175
Host :
Rabbit
Target :
EGFR (Tyr1092) phosphate
Primary-Protein :
EGFR
Alt-Names :
EGFR,ERBB,ERBB1,Epidermal growth factor receptor,HER1,PIG61,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian),mENA
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.