product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
RUNX2 (D1H7) Rabbit mAb
catalog :
8486
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D1H7
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 16
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:250; loading ...; fig 3a
  • western blot; human; 1:2000; loading ...; fig 2e
Shen J, Sun Y, Liu X, Zhu Y, Bao B, Gao T, et al. EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/β-catenin signaling. Stem Cell Res Ther. 2021;12:415 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 3g
  • western blot; mouse; 1:1000; loading ...; fig 7a
Yen Y, Chien M, Wu P, Hung S. PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021;4:658 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s1b
Iwayama T, Okada T, Ueda T, Tomita K, Matsumoto S, Takedachi M, et al. Osteoblastic lysosome plays a central role in mineralization. Sci Adv. 2019;5:eaax0672 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Li J, Wang P, Xie Z, Wang S, Cen S, Li M, et al. TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2. Cell Death Differ. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Yang R, Yu T, Kou X, Gao X, Chen C, Liu D, et al. Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter. Nat Commun. 2018;9:2143 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Fujita S, Mukai T, Mito T, Kodama S, Nagasu A, Kittaka M, et al. Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis. Bone. 2018;106:156-166 pubmed publisher
  • western blot; mouse; loading ...; fig 9e
Fitter S, Matthews M, Martin S, Xie J, Ooi S, Walkley C, et al. mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; 1:1000; fig 6
Fan C, Jia L, Zheng Y, Jin C, Liu Y, Liu H, et al. MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network. Stem Cell Reports. 2016;7:236-48 pubmed publisher
  • western blot; human; fig 1
  • western blot; mouse; fig 2
Shin M, He Y, Marrogi E, Piperdi S, Ren L, Khanna C, et al. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. PLoS Genet. 2016;12:e1005884 pubmed publisher
  • western blot; rat; 1:1000; fig 11
Wang Y, Zhu G, Wang J, Chen J. Irradiation alters the differentiation potential of bone marrow mesenchymal stem cells. Mol Med Rep. 2016;13:213-23 pubmed publisher
Lim R, Li L, Yong E, Chew N. STAT-3 regulation of CXCR4 is necessary for the prenylflavonoid Icaritin to enhance mesenchymal stem cell proliferation, migration and osteogenic differentiation. Biochim Biophys Acta Gen Subj. 2018;1862:1680-1692 pubmed publisher
Shen X, Geng Y, Liu P, Huang X, Li S, Liu C, et al. Magnitude-dependent response of osteoblasts regulated by compressive stress. Sci Rep. 2017;7:44925 pubmed publisher
Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, et al. CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer. Oncotarget. 2016;7:47637-47649 pubmed publisher
Roos A, Satterfield L, Zhao S, Fuja D, Shuck R, Hicks M, et al. Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis. Br J Cancer. 2015;113:1289-97 pubmed publisher
Chang C, Fan T, Yu J, Liao G, Lin Y, Shih A, et al. The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer. J Transl Med. 2014;12:257 pubmed publisher
Lee Y, Nimura K, Lo W, Saga K, Kaneda Y. Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes. PLoS ONE. 2014;9:e106661 pubmed publisher
product information
SKU :
8486S
Product-Name :
RUNX2 (D1H7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Chromatin Immunoprecipitation
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
55-62
Host :
Rabbit
Target :
AML3
Primary-Protein :
AML3
Alt-Names :
AML3,Acute myeloid leukemia 3 protein,CBF-alpha 1,CBF-alpha-1,CBFA1,CCD,CCD1,Core-binding factor subunit alpha-1,MGC120022,MGC120023,OSF-2,OSF2,Oncogene AML-3,Osteoblast-specific transcription factor 2,PEA2-alpha A,PEA2aA,PEBP2-alpha A,PEBP2A,PEBP2A1,PEBP2A2,PEBP2aA,PEBP2aA1,Polyomavirus enhancer-binding protein 2 alpha A subunit,RUNX2,Runt-related transcription factor 2,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit,core-binding factor, runt domain, alpha subunit 1,polyomavirus enhancer binding protein 2 alpha A subunit
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.