product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
IRF-1 (D5E4) XP® Rabbit mAb
catalog :
8478
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
D5E4
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2000; loading ...
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s4
Ehrnström B, Beckwith K, Yurchenko M, Moen S, Kojen J, Lentini G, et al. Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Front Immunol. 2017;8:1243 pubmed publisher
  • western blot; human; loading ...; fig 4a
Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3a
  • western blot; human; loading ...; fig 6c
  • immunocytochemistry; mouse; fig 3b
Gay G, Braun L, Brenier Pinchart M, Vollaire J, Josserand V, Bertini R, et al. Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-?-mediated host defenses. J Exp Med. 2016;213:1779-98 pubmed publisher
  • western blot; human; 1:1000; fig s7
Du L, LI Y, Fakih M, Wiatrek R, Duldulao M, Chen Z, et al. Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Nat Commun. 2016;7:12326 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Xie C, Liu C, Wu B, Lin Y, Ma T, Xiong H, et al. Effects of IRF1 and IFN-? interaction on the M1 polarization of macrophages and its antitumor function. Int J Mol Med. 2016;38:148-60 pubmed publisher
  • western blot; human; 1:1000; fig 3
Ou Yang L, Xiao S, Liu P, Yi S, Zhang X, Ou Yang S, et al. Forkhead box C1 induces epithelial‑mesenchymal transition and is a potential therapeutic target in nasopharyngeal carcinoma. Mol Med Rep. 2015;12:8003-9 pubmed publisher
  • western blot; human
Schmidt T, Schmid Burgk J, Hornung V. Synthesis of an arrayed sgRNA library targeting the human genome. Sci Rep. 2015;5:14987 pubmed publisher
  • western blot; mouse; fig 4
Mould A, Morgan M, Nelson A, Bikoff E, Robertson E. Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation. PLoS Genet. 2015;11:e1005375 pubmed publisher
  • western blot; human; fig 1h
Odendall C, Dixit E, Stavru F, Bierne H, Franz K, Durbin A, et al. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol. 2014;15:717-26 pubmed publisher
  • western blot; human; fig 1d
Bachmann S, Frommel S, Camicia R, Winkler H, Santoro R, Hassa P. DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Mol Cancer. 2014;13:125 pubmed publisher
Kanayama M, Hayano T, Koebis M, Maeda T, Tabe Y, Horie S, et al. Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1. Prostate. 2017;77:1489-1498 pubmed publisher
Bugge M, Bergstrom B, Eide O, Solli H, Kjønstad I, Stenvik J, et al. Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness. J Biol Chem. 2017;292:15408-15425 pubmed publisher
Kim S, Das A, Chai J, Binas B, Choi M, Park K, et al. Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand. Sci Rep. 2016;6:30311 pubmed publisher
Man S, Karki R, Malireddi R, Neale G, Vogel P, Yamamoto M, et al. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nat Immunol. 2015;16:467-75 pubmed publisher
Robertson S, Lubick K, Freedman B, Carmody A, Best S. Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function. J Immunol. 2014;192:2744-55 pubmed publisher
product information
SKU :
8478P
Product-Name :
IRF-1 (D5E4) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, M, R, (Mk)
Applications :
Flow cytometry
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
45-48
Host :
Rabbit
Target :
IRF-1
Primary-Protein :
IRF1
Alt-Names :
IRF-1,IRF1,Interferon regulatory factor 1,MAR
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.