product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
CYLD (D1A10) Rabbit mAb
catalog :
8462S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat, dog, cow
application :
western blot, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 5
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig Meanwhile, silencing XIAP (another E3 ligase degraded upon TRAIL treatment (52)) or CYLD (a deubiquitinase known to be targeted by active caspase-8 (53)) had no effect on basal CAS expression or TRAIL-induced CAS up-regulation, respectively (data not shown).
Monian P, Jiang X. The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. J Biol Chem. 2016;291:2379-88 pubmed publisher
  • western blot; human; fig 5
Wagner S, Satpathy S, Beli P, Choudhary C. SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016;: pubmed
  • western blot; human; fig 3, 4, 5
Kobayashi T, Masoumi K, Massoumi R. Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells. Oncogene. 2015;34:2251-60 pubmed publisher
  • western blot; human; 1:1000; fig 2b
Liang Q, Dexheimer T, Zhang P, Rosenthal A, Villamil M, You C, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014;10:298-304 pubmed publisher
Wu X, Fukushima H, North B, Nagaoka Y, Nagashima K, Deng F, et al. SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination. Oncotarget. 2014;5:4211-21 pubmed
product information
SKU :
8462S
Product-Name :
CYLD (D1A10) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, (Hm, B, Dg, GP, Hr)
Applications :
Immunoprecipitation
Product-Category :
Ubiquitin and Ubiquitin-like proteins
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
108
Host :
Rabbit
Target :
CYLD
Primary-Protein :
CYLD
Alt-Names :
CDMT,CYLD,CYLD1,CYLDI,Deubiquitinating enzyme CYLD,EAC,FLJ20180,FLJ31664,FLJ78684,HSPC057,KIAA0849,MFT,MFT1,Probable ubiquitin carboxyl-terminal hydrolase CYLD,SBS,TEM,USPL2,Ubiquitin thioesterase CYLD,Ubiquitin-specific-processing protease CYLD,cylindromatosis (turban tumor syndrome),ubiquitin specific peptidase like 2,ubiquitin thiolesterase CYLD
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.