| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry knockout validation; mouse; 1:200; loading ...; fig E1
- western blot knockout validation; mouse; 1:1000; loading ...; fig 5E
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1A
| Grove M, Kim H, Santerre M, Krupka A, Han S, Zhai J, et al. YAP/TAZ initiate and maintain Schwann cell myelination. elife. 2017;6: pubmed publisher |
- western blot knockout validation; mouse; 1:1000; loading ...; fig 8a
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1a
| Grove M, Lee H, Zhao H, Son Y. Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury. elife. 2020;9: pubmed publisher |
- western blot knockout validation; human; 1:1000; loading ...; fig 4a
| Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed publisher |
- immunocytochemistry knockout validation; mouse; 1:200; loading ...; fig 2a
| Huang Z, Hu J, Pan J, Wang Y, Hu G, Zhou J, et al. YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation. Development. 2016;143:2398-409 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6b
| Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, et al. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin. elife. 2020;9: pubmed publisher |
- western blot; human; 1:200; loading ...; fig 6b
| Xiao Z, Wei Z, Deng D, Zheng Z, Zhao Y, Jiang S, et al. Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation. Cancer Cell Int. 2020;20:50 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 5b
- western blot; human; 1:1000; loading ...; fig 5d
| Sivaraj K, Dharmalingam B, Mohanakrishnan V, Jeong H, Kato K, Schröder S, et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. elife. 2020;9: pubmed publisher |
- western blot; human; loading ...; fig 6a
| Escoll M, Lastra D, Pajares M, Robledinos Antón N, Rojo A, Fernández Ginés R, et al. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Redox Biol. 2020;30:101425 pubmed publisher |
- immunohistochemistry; zebrafish ; 1:200; loading ...; fig 6b
| Cayuso J, Xu Q, Addison M, Wilkinson D. Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3b, 3j
| Park M, Kim A, Manandhar S, Oh S, Jang G, Kang L, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. elife. 2019;8: pubmed publisher |
- immunocytochemistry; zebrafish ; fig 2a
- immunohistochemistry; zebrafish ; loading ...; fig s2a
| Xia P, Gütl D, Zheden V, Heisenberg C. Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity. Cell. 2019;176:1379-1392.e14 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 1a
| Hwang J, Kim A, Kim K, Il Park J, Oh H, Moon S, et al. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun. 2019;10:421 pubmed publisher |
- western blot; human; 1:1000; fig 4a
| Ho L, Skiba N, Ullmer C, Rao P. Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2018;59:1969-1984 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 6e
| Toloczko A, Guo F, Yuen H, Wen Q, Wood S, Ong Y, et al. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017;77:4921-4933 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Dieffenbach P, Haeger C, Coronata A, Choi K, Varelas X, Tschumperlin D, et al. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017;313:L628-L647 pubmed publisher |
- western blot; human; loading ...; fig 8h
- western blot; mouse; loading ...; fig 7e
| Kapil S, Sharma B, Patil M, Elattar S, Yuan J, Hou S, et al. The cell polarity protein Scrib functions as a tumor suppressor in liver cancer. Oncotarget. 2017;8:26515-26531 pubmed publisher |
- western blot; human; fig 4c
| Noguchi S, Saito A, Mikami Y, Urushiyama H, Horie M, Matsuzaki H, et al. TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts. Sci Rep. 2017;7:42595 pubmed publisher |
- immunohistochemistry; mouse; 1:50; loading ...; fig s5e
| Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s2b
| Wang L, Luo J, Li B, Tian X, Chen L, Huang Y, et al. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 2016;540:579-582 pubmed publisher |
- western blot; mouse; fig 1a
| Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher |
- western blot; human; loading ...; fig 4
| Galoian K, Luo S, Qureshi A, Patel P, Price R, Morse A, et al. Effect of cytostatic proline rich polypeptide-1 on tumor suppressors of inflammation pathway signaling in chondrosarcoma. Mol Clin Oncol. 2016;5:618-624 pubmed |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 2e
| Chen Y, Xu J, Skanderup A, Dong Y, Brannon A, Wang L, et al. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nat Commun. 2016;7:13131 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 1, t3
| Bouvier C, Macagno N, Nguyen Q, Loundou A, Jiguet Jiglaire C, Gentet J, et al. Prognostic value of the Hippo pathway transcriptional coactivators YAP/TAZ and β1-integrin in conventional osteosarcoma. Oncotarget. 2016;7:64702-64710 pubmed publisher |
- immunocytochemistry; human; 1:500; fig 3
- western blot; human; fig 2
- immunocytochemistry; mouse; 1:500; fig 3
- western blot; mouse; fig 2
| Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed publisher |
- immunohistochemistry; mouse; 1:150; fig 5
| Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher |
- western blot; chicken; 1:1000; fig 7
| McKey J, Martire D, de Santa Barbara P, Faure S. LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors. BMC Biol. 2016;14:34 pubmed publisher |
- immunocytochemistry; human; fig 5
| Liu X, Li H, Rajurkar M, Li Q, Cotton J, Ou J, et al. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016;14:1169-1180 pubmed publisher |
- immunoprecipitation; human; 1:50; fig 3b
- western blot; human; fig 3c
| Brusgard J, Choe M, Chumsri S, Renoud K, MacKerell A, Sudol M, et al. RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget. 2015;6:28132-50 pubmed publisher |
- immunocytochemistry; mouse; 1:200; fig 3
- immunohistochemistry; mouse; 1:200; fig 6
| Tsuneki M, Hardee S, Michaud M, Morotti R, Lavik E, Madri J. A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Lab Invest. 2015;95:765-80 pubmed publisher |
- western blot; human; loading ...; fig s4a
| Lin L, Sabnis A, Chan E, Olivas V, Cade L, Pazarentzos E, et al. The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet. 2015;47:250-6 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Serinagaoglu Y, Paré J, Giovannini M, Cao X. Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol. 2015;398:97-109 pubmed publisher |
- western blot; human; fig 4
- western blot; mouse; fig 4
| Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher |
- immunocytochemistry; mouse; 1:200
- western blot; mouse; 1:1000
| Tsuneki M, Madri J. CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression. J Biol Chem. 2014;289:5357-70 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig s1
| Reginensi A, Scott R, Gregorieff A, Bagherie Lachidan M, Chung C, Lim D, et al. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013;9:e1003380 pubmed publisher |
| Choi S, Bae H, Jeong S, Park I, Cho H, Hong S, et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020;11:519 pubmed publisher |
| Malouf G, Flippot R, Dong Y, DiNatale R, Chen Y, Su X, et al. Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers. Sci Rep. 2020;10:701 pubmed publisher |
| Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Sci Rep. 2019;9:19704 pubmed publisher |
| Hoj J, Mayro B, Pendergast A. A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Cell Rep. 2019;29:3421-3434.e8 pubmed publisher |
| di Martino E, Alder O, Hurst C, Knowles M. ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer. Sci Rep. 2019;9:5740 pubmed publisher |
| Komatsu N, Kajiya M, Motoike S, Takewaki M, Horikoshi S, Iwata T, et al. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. Stem Cell Res Ther. 2018;9:342 pubmed publisher |
| Lavado A, Park J, Pare J, Finkelstein D, Pan H, Xu B, et al. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018;47:576-591.e8 pubmed publisher |
| Gill M, Christova T, Zhang Y, Gregorieff A, Zhang L, Narimatsu M, et al. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nat Commun. 2018;9:3510 pubmed publisher |
| Gui Y, Li J, Lu Q, Feng Y, Wang M, He W, et al. Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis. J Biol Chem. 2018;293:16364-16375 pubmed publisher |
| Er E, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018;20:966-978 pubmed publisher |
| Pan J, Xiong L, Zhao K, Zeng P, Wang B, Tang F, et al. YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling. Bone Res. 2018;6:18 pubmed publisher |
| Lai J, Collins M, Uribe V, Jiménez Amilburu V, Günther S, Maischein H, et al. The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish. Development. 2018;145: pubmed publisher |
| Han S, Pang M, Nelson C. Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1. J Cell Sci. 2018;131: pubmed publisher |
| Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates C, et al. Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 2018;128:157-174 pubmed publisher |
| Toyama T, Looney A, Baker B, Stawski L, Haines P, Simms R, et al. Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis. J Invest Dermatol. 2018;138:78-88 pubmed publisher |
| Shanzer M, Adler J, Ricardo Lax I, Reuven N, Shaul Y. The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation. Proc Natl Acad Sci U S A. 2017;114:1678-1683 pubmed publisher |
| Mori S, Takeuchi T, Ishii Y, Yugawa T, Kiyono T, Nishina H, et al. Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J Virol. 2017;91: pubmed publisher |
| Andl T, Le Bras G, Richards N, Allison G, Loomans H, Washington M, et al. Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. Carcinogenesis. 2014;35:2602-10 pubmed publisher |
| Bartucci M, Dattilo R, Moriconi C, Pagliuca A, Mottolese M, Federici G, et al. TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells. Oncogene. 2015;34:681-90 pubmed publisher |
