product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
β-Amyloid (D54D2) XP® Rabbit mAb
catalog :
8243
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D54D2
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
citations: 24
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4c
Nies S, Takahashi H, Herber C, Huttner A, Chase A, Strittmatter S. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. J Biol Chem. 2021;297:101159 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:400; loading ...; fig 4e
Dá Mesquita S, Herz J, Wall M, Dykstra T, de Lima K, Norris G, et al. Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology. Sci Adv. 2021;7: pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Huang Z, Zhao J, Wang W, Zhou J, Zhang J. Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer's Disease. Front Cell Neurosci. 2020;14:28 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000; loading ...; fig s7b
Gate D, Saligrama N, Leventhal O, Yang A, Unger M, Middeldorp J, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. 2020;577:399-404 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
Grimaldi A, Pediconi N, Oieni F, Pizzarelli R, Rosito M, Giubettini M, et al. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Front Neurosci. 2019;13:925 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...
Mathys H, Davila Velderrain J, Peng Z, Gao F, Mohammadi S, Young J, et al. Single-cell transcriptomic analysis of Alzheimer's disease. Nature. 2019;570:332-337 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig 3c
Martorell A, Paulson A, Suk H, Abdurrob F, Drummond G, Guan W, et al. Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Cell. 2019;177:256-271.e22 pubmed publisher
  • immunocytochemistry; mouse; 1:250
Brai E, Alina Raio N, Alberi L. Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease. Acta Neuropathol Commun. 2016;4:64 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 4
  • western blot; mouse; 1:4000; fig 4
  • western blot; human; 1:4000; fig 4
Beck S, Guo L, Phensy A, Tian J, Wang L, Tandon N, et al. Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nat Commun. 2016;7:11483 pubmed publisher
  • western blot; mouse; 1:1000
Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher
  • western blot; human; 1:200; fig 7
Zhao Z, Sagare A, Ma Q, Halliday M, Kong P, Kisler K, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015;18:978-87 pubmed publisher
  • western blot; human; 1:1000
Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R, et al. Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells. Neurosci Res. 2015;94:1-9 pubmed publisher
Piccialli I, Tedeschi V, Caputo L, Amato G, De Martino L, De Feo V, et al. The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ1-42 Oligomers in Primary Cortical Neurons. Antioxidants (Basel). 2021;10: pubmed publisher
Wu Y, Wu H, Zeng J, Pluimer B, Dong S, Xie X, et al. Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice. Acta Neuropathol Commun. 2021;9:74 pubmed publisher
Su Q, Li T, He P, Lu X, Yu Q, Gao Q, et al. Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice. Alzheimers Res Ther. 2021;13:7 pubmed publisher
Rao C, Asch A, Carr D, Yamada H. "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease. Aging Cell. 2020;19:e13109 pubmed publisher
Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
Dá Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison R, Kingsmore K, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature. 2018;560:185-191 pubmed publisher
Rao C, Farooqui M, Zhang Y, Asch A, Yamada H. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018;:e12797 pubmed publisher
Lin Y, Seo J, Gao F, Feldman H, Wen H, Penney J, et al. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018;98:1141-1154.e7 pubmed publisher
Dai C, Hu W, Tung Y, Liu F, Gong C, Iqbal K. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimers Res Ther. 2018;10:13 pubmed publisher
Salazar S, Gallardo C, Kaufman A, Herber C, Haas L, Robinson S, et al. Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease. J Neurosci. 2017;37:9207-9221 pubmed publisher
Lu L, Guo L, Gauba E, Tian J, Wang L, Tandon N, et al. Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice. PLoS ONE. 2015;10:e0144068 pubmed publisher
Kim J, Yun H, Jin P, Lee H, Han J, Udumula V, et al. Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells. Neuropharmacology. 2014;79:476-87 pubmed publisher
product information
SKU :
8243S
Product-Name :
β-Amyloid (D54D2) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M
Applications :
Immunofluorescence (Paraffin)
Product-Category :
Neuroscience
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
5
Host :
Rabbit
Target :
APP
Primary-Protein :
APP
Alt-Names :
A4,AAA,ABETA,ABPP,AD1,AICD-50,AICD-57,AICD-59,AID(50),AID(57),AID(59),APP,APPI,Alzheimer disease amyloid protein,Amyloid beta A4 protein,Amyloid intracellular domain 50,Amyloid intracellular domain 57,Amyloid intracellular domain 59,Beta-APP40,Beta-APP42,Beta-amyloid protein 40,Beta-amyloid protein 42,C31,C80,C83,C99,CTFgamma,CVAP,Cerebral vascular amyloid peptide,Gamma-CTF(50),Gamma-CTF(57),Gamma-CTF(59),Gamma-secretase C-terminal fragment 50,Gamma-secretase C-terminal fragment 57,Gamma-secretase C-terminal fragment 59,N-APP,P3(40),P3(42),PN-II,PN2,PreA4,Protease nexin-II,S-APP-alpha,S-APP-beta,Soluble APP-alpha,Soluble APP-beta,amyloid beta (A4) precursor protein,beta-amyloid peptide,peptidase nexin-II
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.