product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
NF-κB p65 (D14E12) XP® Rabbit mAb
catalog :
8242
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D14E12
reactivity :
African green monkey, human, mouse, rat, dogs, chicken, bovine, pigs , domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, ChIP-Seq, other, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 416
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:2000; fig 4b
Kim K, Kabra A, Kim D, Xue Y, Huang Y, Hou P, et al. KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Sci Adv. 2022;8:eabl4618 pubmed publisher
  • western blot knockout validation; human; loading ...; fig e5b
  • western blot; mouse; loading ...; fig 2b
Liu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisher
  • western blot knockout validation; mouse; 1:1000; fig s4e
  • immunocytochemistry; mouse; 1:400; fig 3a
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s3e
Geng X, Wang C, Gao X, Chowdhury P, Weiss J, Villegas J, et al. GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms. Blood Cancer J. 2022;12:149 pubmed publisher
  • western blot; mouse; loading ...; fig 4g
Zang N, Cui C, Guo X, Song J, Hu H, Yang M, et al. cGAS-STING activation contributes to podocyte injury in diabetic kidney disease. iScience. 2022;25:105145 pubmed publisher
  • western blot; human; 1:1000; fig 1f
Feng K, Meng P, Zhang M, Zou X, Li S, Huang C, et al. IL-24 Contributes to Neutrophilic Asthma in an IL-17A-Dependent Manner and Is Suppressed by IL-37. Allergy Asthma Immunol Res. 2022;14:505-527 pubmed publisher
  • western blot; human
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, et al. T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer. J Immunother Cancer. 2022;10: pubmed publisher
  • western blot; mouse; loading ...; fig 8g, 8h
Liu J, Lai X, Yu R, Ding H, Bai H, Yang Z, et al. Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity. PLoS Pathog. 2022;18:e1010873 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Shi H, Yin Z, Koronyo Y, Fuchs D, Sheyn J, Davis M, et al. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia. Acta Neuropathol Commun. 2022;10:136 pubmed publisher
  • western blot; human; 1:1000; fig 7a
Chen L, Song Z, Cao X, Fan M, Zhou Y, Zhang G. Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor. elife. 2022;11: pubmed publisher
  • western blot; human; loading ...; fig 4c
Yu L, Guo Q, Luo Z, Wang Y, Weng J, Chen Y, et al. TXN inhibitor impedes radioresistance of colorectal cancer cells with decreased ALDH1L2 expression via TXN/NF-κB signaling pathway. Br J Cancer. 2022;127:637-648 pubmed publisher
  • western blot; human; loading ...; fig 4g
Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, et al. Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy. Cell Rep. 2022;39:110796 pubmed publisher
  • flow cytometry; mouse; 1:500; loading ...; fig 1a
Lopes N, Boucherit N, Santamaria J, Provin N, Charaix J, Ferrier P, et al. Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages. elife. 2022;11: pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Zheng W, Feng Y, Zeng Z, Ye M, Wang M, Liu X, et al. Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis. J Neuroinflammation. 2022;19:52 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5f
  • western blot; mouse; 1:2000; loading ...; fig 7d
Wang X, Xiong J, Zhou D, Zhang S, Wang L, Tian Q, et al. TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. J Biol Chem. 2022;298:101611 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2c
Zhao L, Li Y, Xu T, Lv Q, Bi X, Liu X, et al. Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ1 signaling pathway in diabetic atherosclerosis. Mol Med. 2022;28:4 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 5e
Yang C, Wang W, Deng P, Li C, Zhao L, Gao H. Fibroblast Growth Factor 21 Modulates Microglial Polarization That Attenuates Neurodegeneration in Mice and Cellular Models of Parkinson's Disease. Front Aging Neurosci. 2021;13:778527 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 2f, 3e
Sato K, Sato T, Ohno Oishi M, Ozawa M, Maekawa S, Shiga Y, et al. CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice. Exp Eye Res. 2021;213:108826 pubmed publisher
  • western blot; rat; loading ...
Hu S, Liu D, Li C, Xu Y, Hu K, Cui L, et al. Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NF-κB signaling pathway. Sci Rep. 2021;11:18824 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Ho T, Yeh S, Chen S, Tsao Y. Integrin αv and Vitronectin Prime Macrophage-Related Inflammation and Contribute the Development of Dry Eye Disease. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; loading ...; fig 3b
  • immunohistochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 1e
Xu X, Lei Y, Chen L, Zhou H, Liu H, Jiang J, et al. Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J Exp Clin Cancer Res. 2021;40:253 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2g, 4a
Zhan C, Sun Y, Pan J, Chen L, Yuan T. Effect of the Notch4/Dll4 signaling pathway in early gestational intrauterine infection on lung development. Exp Ther Med. 2021;22:972 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5a
Jiao L, Eickhoff R, Egners A, Jumpertz S, Roth J, Erdem M, et al. Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. J Pathol. 2021;255:270-284 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Yang W, Lu X, Zhang T, Han W, Li J, He W, et al. TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling. Bone Res. 2021;9:33 pubmed publisher
  • western blot; human; loading ...; fig 6f
Berthelet J, Wimmer V, Whitfield H, Serrano A, Boudier T, Mangiola S, et al. The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile. Sci Adv. 2021;7: pubmed publisher
  • western blot; human; fig s3-1n
Jeong D, Kim H, Kim H, Kang M, Jung H, Oh Y, et al. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. elife. 2021;10: pubmed publisher
  • western blot; rat; loading ...; fig 3c
Wu Y, Zhang J, Li C, Hu H, Qin B, Wang T, et al. The Activation of ROS/NF-κB/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition. Oxid Med Cell Longev. 2021;2021:8836355 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig s25a
  • immunocytochemistry; mouse; 1:200; loading ...; fig s25a
Li J, Pan L, Pembroke W, Rexach J, Godoy M, Condro M, et al. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021;12:3958 pubmed publisher
  • western blot; human; 1:1000; fig 9b
Liu Y, Bao S, Guo W, Liu W. Bone mesenchymal stem cell derived exosomes alleviate high phosphorus-induced calcification of vascular smooth muscle cells through the NONHSAT 084969.2/NF-κB axis. Aging (Albany NY). 2021;13:16749-16762 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4e
Shani O, Raz Y, Monteran L, Scharff Y, Levi Galibov O, Megides O, et al. Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. elife. 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig 2g
Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, et al. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep. 2021;35:109272 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 4a
Frottin F, Pérez Berlanga M, Hartl F, Hipp M. Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model. elife. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 7g
Zhang X, Song L, Li L, Zhu B, Huo L, Hu Z, et al. Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy. Signal Transduct Target Ther. 2021;6:235 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Zhang H, Li X, Wang J, Cheng Q, Shang Y, Wang G. Baicalin relieves Mycoplasma pneumoniae infection‑induced lung injury through regulating microRNA‑221 to inhibit the TLR4/NF‑κB signaling pathway. Mol Med Rep. 2021;24: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3e
Xu X, Huang X, Zhang L, Huang X, Qin Z, Hua F. Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway. BMC Nephrol. 2021;22:218 pubmed publisher
  • western blot; mouse; loading ...; fig 2a, 4c
Liu Y, Zienkiewicz J, Boyd K, Smith T, Xu Z, Hawiger J. Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles. Sci Rep. 2021;11:11907 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Jiang D, Zhang J, Lin S, Wang Y, Chen Y, Fan J. Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet. Front Cell Dev Biol. 2021;9:628143 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:800; loading ...; fig s12a
  • western blot; mouse; 1:1000; loading ...; fig 1d
Atcha H, Jairaman A, Holt J, Meli V, Nagalla R, Veerasubramanian P, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021;12:3256 pubmed publisher
  • immunocytochemistry; mouse; 1:300; fig 7d
Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  • western blot; human; loading ...; fig 7e
Ma X, Zhao T, Yan H, Guo K, Liu Z, Wei L, et al. Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma. Cell Death Dis. 2021;12:544 pubmed publisher
  • western blot; human; loading ...; fig 3c
Leon K, Buj R, Lesko E, Dahl E, Chen C, Tangudu N, et al. DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. J Cell Biol. 2021;220: pubmed publisher
  • western blot; mouse; loading ...; fig 4i
Polavaram N, Dutta S, Islam R, Bag A, Roy S, Poitz D, et al. Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases. Bone Res. 2021;9:24 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3f
Li Q, Liu M, Sun Y, Jin T, Zhu P, Wan X, et al. SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress. J Exp Clin Cancer Res. 2021;40:168 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Lindfors S, Polianskyte Prause Z, Bouslama R, Lehtonen E, Mannerla M, Nisen H, et al. Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo. Diabetologia. 2021;64:1866-1879 pubmed publisher
  • western blot; mouse; loading ...; fig 5h
Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, et al. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. J Nutr Biochem. 2021;95:108761 pubmed publisher
  • immunocytochemistry; rat; 1:50; loading ...; fig 5c
  • western blot; rat; 1:1000; loading ...; fig 5a
Huang P, Bai L, Liu L, Fu J, Wu K, Liu H, et al. Redd1 knockdown prevents doxorubicin-induced cardiac senescence. Aging (Albany NY). 2021;13:13788-13806 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10b
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Ye S, Su L, Shan P, Ye B, Wu S, Liang G, et al. LCZ696 Attenuated Doxorubicin-Induced Chronic Cardiomyopathy Through the TLR2-MyD88 Complex Formation. Front Cell Dev Biol. 2021;9:654051 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7p
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, et al. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biol. 2021;43:101979 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4b
Huo Y, Selenica P, Mahdi A, Pareja F, Kyker Snowman K, Chen Y, et al. Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development. NPJ Breast Cancer. 2021;7:45 pubmed publisher
  • western blot; mouse; loading ...; fig 3g
He S, Lu Y, Guo Y, Li S, Lu X, Shao S, et al. Krüppel-Like Factor 15 Modulates CXCL1/CXCR2 Signaling-Mediated Inflammatory Response Contributing to Angiotensin II-Induced Cardiac Remodeling. Front Cell Dev Biol. 2021;9:644954 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:400; loading ...; fig 6c
  • immunohistochemistry; rat; loading ...; fig 5f
  • western blot; rat; 1:1000; loading ...; fig 6a
Xu H, Wang Y, Luo Y. OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats. Mol Med. 2021;27:37 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5
Hao X, Qiu Y, Cao L, Yang X, Zhou D, Liu J, et al. Over-Expression of Centromere Protein U Participates in the Malignant Neoplastic Progression of Breast Cancer. Front Oncol. 2021;11:615427 pubmed publisher
  • western blot; mouse; loading ...; fig s2
Brea R, Valdecantos P, Rada P, Alen R, García Monzón C, Bosca L, et al. Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. Aging (Albany NY). 2021;13:7800-7827 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6g
Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher
  • western blot; mouse; loading ...
Liu X, Jiang J, Liao Y, Tang I, Zheng E, Qiu W, et al. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. Adv Sci (Weinh). 2021;8:2002147 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c, 8c
Fang Y, Jiang Q, Li S, Zhu H, Xu R, Song N, et al. Opposing functions of β-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3. Cell Death Differ. 2021;28:1822-1836 pubmed publisher
  • chromatin immunoprecipitation; human; 1:100; loading ...; fig 4d
Mao F, Lv Y, Hao C, Teng Y, Liu Y, Cheng P, et al. Helicobacter pylori-Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense. Cell Mol Gastroenterol Hepatol. 2021;12:395-425 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d, 4i
Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, et al. RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming. Nat Commun. 2021;12:1394 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 3b
Matsuzawa F, Kamachi H, Mizukami T, Einama T, Kawamata F, Fujii Y, et al. Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells. BMC Cancer. 2021;21:200 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Zhang W, Wang L, Sun X, Liu X, Xiao Y, Zhang J, et al. Toll-like receptor 5-mediated signaling enhances liver regeneration in mice. Mil Med Res. 2021;8:16 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zhang Y, Liu J, Wang X, Zhang J, Xie C. Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury. Aging (Albany NY). 2021;13:6752-6764 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...
Sela Y, Li J, Kuri P, Merrell A, Li N, Lengner C, et al. Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation. elife. 2021;10: pubmed publisher
  • western blot; mouse; fig 7a
Li B, Yin J, Chang J, Zhang J, Wang Y, Huang H, et al. Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction. J Endocrinol. 2021;249:1-18 pubmed publisher
  • western blot; human; loading ...; fig 4d, 4e
Shen D, Tian L, Yang F, Li J, Li X, Yao Y, et al. ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development. Cell Death Discov. 2021;7:21 pubmed publisher
  • western blot; mouse; loading ...; fig 3i
Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, et al. ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth. Cancer Res. 2021;81:174-186 pubmed publisher
  • western blot; human; fig 6h
  • western blot; mouse; loading ...; fig 2g
Chen S, Zhang H, Li J, Shi J, Tang H, Zhang Y, et al. Tripartite Motif-Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β-Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation. Hepatology. 2021;73:738-758 pubmed publisher
  • western blot; chicken; loading ...; fig 6a
Chou P, Chen Y, Chung T, Walzem R, Lai L, Chen S. Supplemental 25-hydroxycholecalciferol Alleviates Inflammation and Cardiac Fibrosis in Hens. Int J Mol Sci. 2020;21: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Hu Q, Lu Y, Hu F, He S, Xu X, Niu Y, et al. Resistant dextrin reduces obesity and attenuates adipose tissue inflammation in high-fat diet-fed mice. Int J Med Sci. 2020;17:2611-2621 pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Wang T, Gao Y, Yue R, Wang X, Shi Y, Xu J, et al. Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF-κB/NLRP3 Axis. Evid Based Complement Alternat Med. 2020;2020:2735714 pubmed publisher
  • western blot; mouse; loading ...; fig 6
Kim Y, Oh S, Ahn J, Yook J, Kim C, Park S, et al. The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia. Int J Mol Sci. 2020;21: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, et al. HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma. Theranostics. 2020;10:10434-10447 pubmed publisher
  • western blot; rat; 1:3000; loading ...; fig 6a
Chen Y, Chen H, Fan H, Tung Y, Kuo C, Tu M, et al. Anti-Inflammatory, Antioxidant, and Antifibrotic Effects of Kefir Peptides on Salt-Induced Renal Vascular Damage and Dysfunction in Aged Stroke-Prone Spontaneously Hypertensive Rats. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, et al. Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis. Front Immunol. 2020;11:1598 pubmed publisher
  • western blot; human; loading ...; fig 2a
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6e
Wang W, Wang H, Xiang L, Ni T, Jin F, Deng J, et al. DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer. Oncol Rep. 2020;44:77-90 pubmed publisher
  • western blot; mouse; loading ...; fig s6c
Han C, Kang I, Harten I, Gebe J, Chan C, Omer M, et al. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020;31:107818 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10a
Lechertier T, Reynolds L, Kim H, Pedrosa A, Gómez Escudero J, Muñoz Félix J, et al. Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nat Commun. 2020;11:2810 pubmed publisher
  • western blot; mouse; loading ...; fig 8c
Xiong L, Zhao K, Cao Y, Guo H, Pan J, Yang X, et al. Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency. PLoS Biol. 2020;18:e3000731 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Du T, Yan Z, Zhu S, Chen G, Wang L, Ye Z, et al. QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism. Cell Death Dis. 2020;11:330 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3f
Deng M, Tam J, Wang L, Liang K, Li S, Zhang L, et al. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun. 2020;11:2193 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
An J, Kerns K, Ouellette A, Robinson L, Morris H, Kaczorowski C, et al. Rapamycin rejuvenates oral health in aging mice. elife. 2020;9: pubmed publisher
  • flow cytometry; human; 1:100; loading ...; fig 2a
Wong S, Lenzini S, Cooper M, Mooney D, Shin J. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci Adv. 2020;6:eaaw0158 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3b
Ruscetti M, Morris J, Mezzadra R, Russell J, Leibold J, Romesser P, et al. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Cell. 2020;181:424-441.e21 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2c
  • immunocytochemistry; human; 1:300; loading ...; fig 1f
  • western blot; human; 1:1000; loading ...; fig 1g, 1h, 2e
Szymura S, Bernal G, Wu L, Zhang Z, Crawley C, Voce D, et al. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy. BMC Biol. 2020;18:32 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4b, s12b
von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
  • western blot; domestic rabbit; 1:1000; loading ...; fig 3b
Qian B, Huang H, Cheng M, Qin T, Chen T, Zhao J. Mechanism of HMGB1-RAGE in Kawasaki disease with coronary artery injury. Eur J Med Res. 2020;25:8 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 5c
Yan S, Ding H, Peng J, Wang X, Pang C, Wei J, et al. Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro. Biosci Rep. 2020;40: pubmed publisher
  • western blot; mouse; loading ...; fig 4g
Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig s3a
Chen F, Jiang G, Liu H, Li Z, Pei Y, Wang H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. Bone Res. 2020;8:10 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2i, 5h
Yang H, Wang L, Zang C, Wang Y, Shang J, Zhang Z, et al. Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson's Disease Models. Front Neurosci. 2020;14:45 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 5k
  • western blot; human; loading ...; fig 5e
Wang S, Qi Y, Gao X, Qiu W, Liu Q, Guo X, et al. Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma. Cell Death Dis. 2020;11:168 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2
Ahmed C, ILDEFONSO C, Johnson H, Lewin A. A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis. PLoS ONE. 2020;15:e0227524 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Wan G, An Y, Tao J, Wang Y, Zhou Q, Yang R, et al. MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway. Biosci Rep. 2020;40: pubmed publisher
  • western blot; human; loading ...; fig 8b
Tian S, Peng P, Li J, Deng H, Zhan N, Zeng Z, et al. SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway. Aging (Albany NY). 2020;12:3574-3593 pubmed publisher
  • western blot; human; fig 1b
Chandrasekaran B, Dahiya N, Tyagi A, Kolluru V, Saran U, Baby B, et al. Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. 2020;9:23 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3c
Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900 pubmed publisher
  • western blot; mouse; loading ...; fig 3f
Guo X, Kolpakov M, Hooshdaran B, Schappell W, Wang T, Eguchi S, et al. Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload. JACC Basic Transl Sci. 2020;5:69-83 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 2a
  • western blot; human; 1:1000; loading ...; fig 3b
Potilinski M, Ortiz G, Salica J, Lopez E, Fernández Acquier M, Chuluyan E, et al. Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy. PLoS ONE. 2020;15:e0228895 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
  • western blot; human; loading ...; fig 6c
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6l
Pakarinen E, Danilova T, Voikar V, Chmielarz P, Piepponen P, Airavaara M, et al. MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. Eneuro. 2020;7: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Meng X, Zhao Y, Han B, Zha C, Zhang Y, Li Z, et al. Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways. Nat Commun. 2020;11:594 pubmed publisher
  • western blot; human; fig 7g
Nixon C, Mavigner M, Sampey G, Brooks A, Spagnuolo R, Irlbeck D, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020;578:160-165 pubmed publisher
  • western blot; human; loading ...; fig 1a
Lohard S, Bourgeois N, Maillet L, Gautier F, Fétiveau A, Lasla H, et al. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nat Commun. 2020;11:259 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2b
Li Y, Xu S, Xu Q, Chen Y. Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-κB signalling pathway. Artif Cells Nanomed Biotechnol. 2020;48:452-462 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200; loading ...; fig 1a
Vargas Caraveo A, Sayd A, Robledo Montaña J, Caso J, Madrigal J, Garcia Bueno B, et al. Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs. J Neuroinflammation. 2020;17:6 pubmed publisher
  • immunocytochemistry; human; fig 2e
  • western blot; human; fig 2a
Jia Z, Huang Y, Ji X, Sun J, Fu G. Ticagrelor and clopidogrel suppress NF-κB signaling pathway to alleviate LPS-induced dysfunction in vein endothelial cells. BMC Cardiovasc Disord. 2019;19:318 pubmed publisher
  • western blot; human; loading ...; fig 4g
Wang H, Chen Z, Wang S, Gao X, Qian M, Qiu W, et al. TGFβ1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-κB signalling pathway in human gliomas. Mol Oncol. 2020;14:407-425 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 4c
Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 7d
  • western blot; mouse; 1:1000; loading ...; fig 7a
Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y. Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function. Front Pharmacol. 2019;10:1354 pubmed publisher
  • immunocytochemistry; mouse; 1:400; loading ...; fig s3c
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig e6e, e6f
Lalaoui N, Boyden S, Oda H, Wood G, Stone D, Chau D, et al. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020;577:103-108 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:200; loading ...; fig 4d
  • immunocytochemistry; mouse; 1:200; loading ...; fig s4b
  • western blot; mouse; 1:1000; loading ...; fig 4a
Wu Y, Chen K, Xing G, Li L, Ma B, Hu Z, et al. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Sci Adv. 2019;5:eaax7525 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5g
  • western blot; human; loading ...; fig 4c
  • western blot; African green monkey; loading ...; fig 5h
Lee C, Aizawa K, Jiang J, Kung S, Jain R. JLP-centrosome is essential for the microtubule-mediated nucleocytoplasmic transport induced by extracellular stimuli. Sci Adv. 2019;5:eaav0318 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1e, 2c
Li Z, Wang H, Zeng Q, Yan J, Hu Y, Li H, et al. p65/miR-23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma. Cancer Med. 2020;9:711-723 pubmed publisher
  • western blot; mouse; loading ...; fig 2a, 2e
Thirugnanam K, Cossette S, Lu Q, Chowdhury S, Harmann L, Gupta A, et al. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. J Am Heart Assoc. 2019;8:e012792 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7a
Xia Y, Xue M, Wang Y, Huang Z, Huang C. Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord. J Pain Res. 2019;12:2851-2863 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4g
Eyre R, Alferez D, Santiago Gómez A, Spence K, McConnell J, Hart C, et al. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019;10:5016 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s6
Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, et al. The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis. Oncogene. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig e6j
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Wang P, Qi X, Xu G, Liu J, Guo J, Li X, et al. CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. Aging (Albany NY). 2019;11:7402-7415 pubmed publisher
  • western blot; human; loading ...; fig 2d
Managò A, Audrito V, Mazzola F, Sorci L, Gaudino F, Gizzi K, et al. Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation. Nat Commun. 2019;10:4116 pubmed publisher
  • western blot; mouse; loading ...; fig 10b
Zhou C, Sun X, Hu Y, Song J, Dong S, Kong D, et al. Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease. Aging (Albany NY). 2019;11:7257-7273 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Xiao W, Wang L, Howard J, Kolhe R, Rojiani A, Rojiani M. TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC. Cancers (Basel). 2019;11: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Zhang R, Liu Y, Chen Y, Li Q, Marshall C, Wu T, et al. Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption. CNS Neurosci Ther. 2020;26:228-239 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 6b
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 6a, 6b
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R. A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation. Mediators Inflamm. 2019;2019:8709583 pubmed publisher
  • western blot; human; loading ...; fig 5a, 5b
Kong L, Wu Z, Zhao Y, Lu X, Shi H, Liu S, et al. Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression. Biosci Rep. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 3d
  • western blot; pigs ; fig 1h
Liu Y, Li R, Chen X, Zhi Y, Deng R, Zhou E, et al. Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway. MBio. 2019;10: pubmed publisher
  • western blot; human; loading ...; fig 5b
Zhang H, Wang J, Wang Y, Gao C, Gu Y, Huang J, et al. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats. Oxid Med Cell Longev. 2019;2019:2853534 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 6g
  • western blot; mouse; 1:1000; loading ...; fig 6c
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, et al. Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. Nat Commun. 2019;10:1801 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f
Walens A, DiMarco A, Lupo R, Kroger B, Damrauer J, Alvarez J. CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5h
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6
Wang P, Liu X, Kong C, Liu X, Teng Z, Ma Y, et al. Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament. Int J Mol Med. 2019;43:2005-2014 pubmed publisher
  • western blot; rat; loading ...; fig s1
Hlavac N, VandeVord P. Astrocyte Mechano-Activation by High-Rate Overpressure Involves Alterations in Structural and Junctional Proteins. Front Neurol. 2019;10:99 pubmed publisher
  • western blot; human; loading ...; fig 2f
Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a, 3c, s3d
Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6d
Wu W, Zhang W, Choi M, Zhao J, Gao P, Xue M, et al. Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation. Redox Biol. 2019;22:101137 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Beug S, Cheung H, Sanda T, St Jean M, Beauregard C, Mamady H, et al. The transcription factor SP3 drives TNF-α expression in response to Smac mimetics. Sci Signal. 2019;12: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Fan Y, Yang L, Wei Q, Ding Y, Tang Z, Tan P, et al. Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells. Asian J Androl. 2019;21:393-399 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3a
  • western blot; human; loading ...; fig 3b
Zhang J, Wang D, Wang L, Wang S, Roden A, Zhao H, et al. Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2019;316:L487-L497 pubmed publisher
  • western blot; human; loading ...; fig s8c
Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 6c
  • immunocytochemistry; human; 1:100; loading ...; fig 3f
  • western blot; human; loading ...; fig 3a, 3b
Lou C, Lu H, Ma Z, Liu C, Zhang Y. Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway. Biomed Pharmacother. 2019;109:563-572 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3g, 4c
Zhang X, Zhang M, Wang C. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Biochem Biophys Res Commun. 2018;506:137-144 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Yin J, Wang Y, Chang J, Li B, Zhang J, Liu Y, et al. Apelin inhibited epithelial-mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i. Cell Death Dis. 2018;9:1031 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3a
Pan H, Palekar R, Hou K, Bacon J, Yan H, Springer L, et al. Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice. Int J Nanomedicine. 2018;13:5187-5205 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Chorzalska A, Morgan J, Ahsan N, Treaba D, Olszewski A, Petersen M, et al. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018;: pubmed publisher
  • western blot; human; loading ...; fig 6d
Lee S, North K, Kim E, Jang E, Obeng E, Lu S, et al. Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations. Cancer Cell. 2018;34:225-241.e8 pubmed publisher
  • western blot; human; loading ...; fig 4b
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018;361:290-295 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4a
Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, et al. αv Integrins regulate germinal center B cell responses through noncanonical autophagy. J Clin Invest. 2018;128:4163-4178 pubmed publisher
  • western blot; human; loading ...; fig 2b
Dai L, Del Valle L, Miley W, Whitby D, Ochoa A, Flemington E, et al. Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene. 2018;37:4534-4545 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 8b
Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, et al. Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. Sci Rep. 2018;8:5927 pubmed publisher
  • western blot; human; loading ...; fig s4a
Cuomo F, Coppola A, Botti C, Maione C, Forte A, Scisciola L, et al. Pro-inflammatory cytokines activate hypoxia-inducible factor 3? via epigenetic changes in mesenchymal stromal/stem cells. Sci Rep. 2018;8:5842 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Kornberg M, Bhargava P, Kim P, Putluri V, Snowman A, Putluri N, et al. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018;360:449-453 pubmed publisher
  • western blot; human; fig 1a
Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo R, et al. The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Cell Death Dis. 2018;9:374 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 4f
Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed publisher
  • western blot; mouse; 1:1000
Sun J, Wang Z, Wang X. Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice. Organogenesis. 2018;14:13-24 pubmed publisher
  • western blot; human; loading ...; fig 4j
  • western blot; mouse; fig 5f
Zhang H, Song Y, Yang H, Liu Z, Gao L, Liang X, et al. Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018;37:2456-2468 pubmed publisher
  • western blot; human; loading ...; fig 7c
Bogdan D, Falcone J, Kanjiya M, Park S, Carbonetti G, Studholme K, et al. Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. J Biol Chem. 2018;293:5295-5306 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5m
Jung Y, Cackowski F, Yumoto K, Decker A, Wang J, Kim J, et al. CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes. Cancer Res. 2018;78:2026-2039 pubmed publisher
  • western blot; human; fig 5h
Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
  • western blot; human; 1:1000; fig 3h
Xu S, Zhou Z, Li H, Liu Z, Pan X, Wang F, et al. BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis. J Cell Sci. 2018;131: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3c
Ehrnström B, Beckwith K, Yurchenko M, Moen S, Kojen J, Lentini G, et al. Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Front Immunol. 2017;8:1243 pubmed publisher
  • western blot; human; fig 1c
Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher
  • western blot; mouse; loading ...; fig 7e
Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Yang Y, Yang S, Guo J, Cui Y, Tang B, Li X, et al. Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17. J Neurosci. 2017;37:9101-9115 pubmed publisher
  • immunocytochemistry; mouse; fig 7a
  • western blot; mouse; fig 7b
Naik S, Padhi A, Ganguli G, Sengupta S, Pati S, Das D, et al. Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway. Infect Immun. 2017;85: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 3c
Franz S, Rennert P, Woznik M, Grützke J, Lüdde A, Arriero Pais E, et al. Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes. J Virol. 2017;91: pubmed publisher
  • western blot; mouse; loading ...; fig 4f
Akiel M, Guo C, Li X, Rajasekaran D, Mendoza R, Robertson C, et al. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer Res. 2017;77:4014-4025 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s13a
Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, et al. The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nat Commun. 2017;8:15426 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Aroor A, Habibi J, Kandikattu H, Garro Kacher M, Barron B, Chen D, et al. Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice. Cardiovasc Diabetol. 2017;16:61 pubmed publisher
  • western blot; human; loading ...; fig 2a, 2c, 2d
Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Yan X, Zhu Z, Xu S, Yang L, Liao X, Zheng M, et al. MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways. Sci Rep. 2017;7:45915 pubmed publisher
  • western blot; mouse; 1:500; fig 7b
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed publisher
  • immunocytochemistry; mouse; fig 5f
McFarland A, Luo S, Ahmed Qadri F, Zuck M, Thayer E, Goo Y, et al. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. Immunity. 2017;46:433-445 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 2d
  • western blot; human; loading ...; fig 2d
Zhang C, Jiang H, Wang P, Liu H, Sun X. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017;7:44708 pubmed publisher
  • western blot; human; loading ...; fig 1b
Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4e
Jin Z, Liang F, Yang J, Mei W. hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer. PLoS Genet. 2017;13:e1006672 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 2f
Matsumoto Y, LaRose J, Kent O, Lim M, Changoor A, Zhang L, et al. RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. J Clin Invest. 2017;127:1303-1315 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Song Y, Lai L, Chong Z, He J, Zhang Y, Xue Y, et al. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses. Nat Commun. 2017;8:14654 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
  • western blot; human; 1:1000; loading ...; fig 4a; 4b; 4e
Ju H, Ying H, Tian T, Ling J, Fu J, Lu Y, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017;8:14437 pubmed publisher
  • western blot; human; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 5b
Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
  • flow cytometry; mouse; fig 2d
  • western blot; mouse; fig 5a
Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher
  • western blot; human; loading ...; fig 2b
  • western blot; mouse; loading ...; fig 2a, 3a
Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
  • immunocytochemistry; rat; 1:500; loading ...; fig 5a
König H, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, et al. NF-κB regulates neuronal ankyrin-G via a negative feedback loop. Sci Rep. 2017;7:42006 pubmed publisher
  • immunocytochemistry; mouse; 1:400; loading ...; fig 5c
  • western blot; mouse; loading ...; fig 5b
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig S17A
Li C, Bi Y, Li Y, Yang H, Yu Q, Wang J, et al. Dendritic cell MST1 inhibits Th17 differentiation. Nat Commun. 2017;8:14275 pubmed publisher
  • western blot; human; loading ...; fig 4b
Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
  • western blot; human; fig 4e
Indrakusuma I, Romacho T, Eckel J. Protease-Activated Receptor 2 Promotes Pro-Atherogenic Effects through Transactivation of the VEGF Receptor 2 in Human Vascular Smooth Muscle Cells. Front Pharmacol. 2016;7:497 pubmed publisher
  • western blot; human; loading ...; fig 7g
Cianciola N, Chung S, Manor D, Carlin C. Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. J Virol. 2017;91: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5h
Oller J, Méndez Barbero N, Ruiz E, Villahoz S, Renard M, Canelas L, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017;23:200-212 pubmed publisher
  • western blot; human; loading ...; fig 7a
Zhang W, Kang M, Zhang T, Li B, Liao X, Wang R. Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Shahriari K, Shen F, Worrede Mahdi A, Liu Q, Gong Y, Garcia F, et al. Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Oncogene. 2017;36:2846-2856 pubmed publisher
  • immunocytochemistry; mouse; fig 3c
Wang R, Zhang Y, Xu L, Lin Y, Yang X, Bai L, et al. Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice. Sci Rep. 2016;6:36790 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6e
Ballmann C, Denney T, Beyers R, Quindry T, Romero M, Amin R, et al. Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice. Am J Physiol Heart Circ Physiol. 2017;312:H128-H140 pubmed publisher
  • western blot; mouse; loading ...; fig s3h
Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s5e
Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, et al. Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. Am J Physiol Heart Circ Physiol. 2016;311:H1485-H1497 pubmed publisher
  • western blot; human; loading ...; fig 3
Jiang Y, Zeng Y, Huang X, Qin Y, Luo W, Xiang S, et al. Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1023-L1035 pubmed publisher
  • other; mouse; 1:200; loading ...; fig 4
  • western blot; mouse; 1:1000; loading ...; fig 3a
Zhou Z, Tang Y, Jin X, Chen C, Lu Y, Liu L, et al. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression. J Diabetes Res. 2016;2016:4847812 pubmed
  • western blot; mouse; 1:2000; loading ...; fig 9a
He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  • immunocytochemistry; human; loading ...; fig 3b
Ding S, Mooney N, Li B, Kelly M, Feng N, Loktev A, et al. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016;12:e1005929 pubmed publisher
  • western blot; mouse; loading ...; fig 4
Figueroa González G, García Castillo V, Coronel Hernández J, López Urrutia E, León Cabrera S, Arias Romero L, et al. Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer. J Cancer. 2016;7:1632-1644 pubmed
  • western blot; human; loading ...; fig 4a
Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed
  • western blot; human; loading ...; fig 5b
Sikora M, Jacobsen B, Levine K, Chen J, Davidson N, Lee A, et al. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016;18:92 pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Kaneda M, Messer K, Ralainirina N, Li H, Leem C, Gorjestani S, et al. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016;539:437-442 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s8d
Hirai Yuki A, Hensley L, McGivern D, Gonzalez Lopez O, Das A, Feng H, et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016;353:1541-1545 pubmed
  • western blot; rat; loading ...; fig 6f
Alomar F, Singh J, Jang H, Rozanzki G, Shao C, Padanilam B, et al. Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats. Br J Pharmacol. 2016;173:3307-3326 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Ando Y, Oku T, Tsuji T. Platelet Supernatant Suppresses LPS-Induced Nitric Oxide Production from Macrophages Accompanied by Inhibition of NF-?B Signaling and Increased Arginase-1 Expression. PLoS ONE. 2016;11:e0162208 pubmed publisher
  • western blot; human; loading ...; fig 4b
de Jong M, Liu Z, Chen D, Alto N. Shigella flexneri suppresses NF-?B activation by inhibiting linear ubiquitin chain ligation. Nat Microbiol. 2016;1:16084 pubmed publisher
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; mouse; fig 6
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Wang W, Jiang M, Liu S, Zhang S, Liu W, Ma Y, et al. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci U S A. 2016;113:9581-6 pubmed publisher
  • western blot; human; fig 6
Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 5
  • western blot; rat; 1:1000; loading ...; fig 8a
Ta M, Schwensen K, Liuwantara D, Huso D, Watnick T, Rangan G. Constitutive renal Rel/nuclear factor-?B expression in Lewis polycystic kidney disease rats. World J Nephrol. 2016;5:339-57 pubmed publisher
  • western blot; human; loading ...; fig 4a
Ciaraldi T, Ryan A, Mudaliar S, Henry R. Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes. PLoS ONE. 2016;11:e0158209 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Zhu L, Luo T, Xu X, Guo Y, Zhao X, Wang T, et al. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. J Exp Med. 2016;213:1555-70 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4e
Ge X, Huang S, Gao H, Han Z, Chen F, Zhang S, et al. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain Res. 2016;1650:31-40 pubmed publisher
  • western blot; human; loading ...; fig 3b
Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-?B pathway in a transcription-independent manner. Nucleic Acids Res. 2016;44:7331-49 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8a
Xiang N, Liu J, Liao Y, Huang Y, Wu Z, Bai Z, et al. Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway. Sci Rep. 2016;6:27583 pubmed publisher
  • western blot; mouse; 1:1000; fig 5b
Yan X, Cen Y, Wang Q. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated I?B expression. Sci Rep. 2016;6:28915 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, et al. Activation of STING requires palmitoylation at the Golgi. Nat Commun. 2016;7:11932 pubmed publisher
  • western blot; human; loading ...; fig 5a
Li Y, Liu C, Su T, Cheng H, Jeng Y, Lin H, et al. Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model. Oncotarget. 2016;7:47173-47185 pubmed publisher
  • western blot; mouse; fig 4
Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher
  • western blot; mouse; loading ...; fig 2h
Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher
  • western blot; human; fig 2a
Hendrayani S, Al Harbi B, Al Ansari M, Silva G, Aboussekhra A. The inflammatory/cancer-related IL-6/STAT3/NF-?B positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts. Oncotarget. 2016;7:41974-41985 pubmed publisher
  • western blot; human; 1:1000; fig 3
Lu Z, Chen W, Li Y, Li L, Zhang H, Pang Y, et al. TNF-? enhances vascular cell adhesion molecule-1 expression in human bone marrow mesenchymal stem cells via the NF-?B, ERK and JNK signaling pathways. Mol Med Rep. 2016;14:643-8 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:120; fig 6
Kobayashi E, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7:11624 pubmed publisher
  • western blot; rat; fig 8
Zhu Y, Ramos da Silva S, He M, Liang Q, Lu C, Feng P, et al. An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog. 2016;12:e1005648 pubmed publisher
  • western blot; human; loading ...; fig 3c
Park S, Yi H, Suh N, Park Y, Koh J, Jeong S, et al. Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-?B. Oncotarget. 2016;7:39796-39808 pubmed publisher
  • western blot; rat; 1:2000
Wang Y, Li J, Ji G, Zhai K, Wang H, Liu X. The Involvement of Ca(2+) Signal Pathways in Distal Colonic Myocytes in a Rat Model of Dextran Sulfate Sodium-induced Colitis. Chin Med J (Engl). 2016;129:1185-92 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 4f
  • western blot; mouse; loading ...; fig 4i
Rothhammer V, Mascanfroni I, Bunse L, Takenaka M, Kenison J, Mayo L, et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016;22:586-97 pubmed publisher
  • western blot; human; fig 9e
  • western blot; bovine; loading ...; fig 9f
Ishizuka S, Askew E, Ishizuka N, Knudson C, Knudson W. 4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition. J Biol Chem. 2016;291:12087-104 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5c
Wang X, Wang N, Li H, Liu M, Cao F, Yu X, et al. Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. Int J Mol Sci. 2016;17:577 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
  • western blot; mouse; 1:500; fig 4
Chen G, Luo Y, Eriksson D, Meng X, Qian C, Bauerle T, et al. High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6. Oncotarget. 2016;7:26653-69 pubmed publisher
  • western blot; mouse; loading ...; fig 5e
Damle S, Martin R, Cross J, Conrad D. Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis. Mucosal Immunol. 2017;10:205-214 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s10
  • western blot; human; 1:1000; loading ...; fig 6e
Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Xu W, Huang M, Zhang Y, Li H, Zheng H, Yu L, et al. Extracts of Bauhinia championii (Benth.) Benth. attenuate the in?ammatory response in a rat model of collagen-induced arthritis. Mol Med Rep. 2016;13:4167-74 pubmed publisher
  • immunocytochemistry; mouse; 1:250; loading ...; fig 5a
  • western blot; mouse; 1:2500; loading ...; fig 4b
Leus N, van der Wouden P, van den Bosch T, Hooghiemstra W, Ourailidou M, Kistemaker L, et al. HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Biochem Pharmacol. 2016;108:58-74 pubmed publisher
  • western blot; human; 1:1000; fig 2a
Ranjan K, Pathak C. FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016;6:22787 pubmed publisher
  • western blot; rat; 1:1000; fig 2
Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, et al. Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice. Arthritis Res Ther. 2016;18:62 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 1f
van der Heijden M, Zimberlin C, Nicholson A, Colak S, Kemp R, Meijer S, et al. Bcl-2 is a critical mediator of intestinal transformation. Nat Commun. 2016;7:10916 pubmed publisher
  • western blot; mouse; loading ...; fig s1d-e
Wang G, Liu X, Gaertig M, Li S, Li X. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A. 2016;113:3359-64 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Nagase M, Kurihara H, Aiba A, Young M, Sakai T. Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS ONE. 2016;11:e0150886 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Naik E, Dixit V. Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity. J Immunol. 2016;196:3438-51 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1c
Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, et al. Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation. Biochim Biophys Acta. 2016;1863:1106-18 pubmed publisher
  • western blot; mouse; fig 4b
Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed A, Chen X, et al. Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway. Proc Natl Acad Sci U S A. 2016;113:1871-6 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 3
  • western blot; mouse; 1:1000; fig 3
Kishi N, MacDonald J, Ye J, Molyneaux B, Azim E, Macklis J. Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice. Nat Commun. 2016;7:10520 pubmed publisher
  • western blot; human; 1:1000; fig 5
Evans M, Sauer S, Nath S, Robinson T, Morse M, Devi G. X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity. Cell Death Dis. 2016;7:e2073 pubmed publisher
  • western blot; mouse; fig 5
Ding X, Pan L, Wang Y, Xu Q. Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice. Int J Mol Med. 2016;37:703-15 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Lin A, Jahrling J, Zhang W, Derosa N, Bakshi V, Romero P, et al. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab. 2017;37:217-226 pubmed
  • western blot; human; 1:1000; fig 6i
Roth Flach R, Skoura A, Matevossian A, Danai L, Zheng W, Cortes C, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015;6:8995 pubmed publisher
  • western blot; mouse; fig 5
Gao Q, Liu Y, Wu Y, Zhao Q, Wang L, Gao S, et al. IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB. Int J Mol Med. 2016;37:347-58 pubmed publisher
  • western blot; human; fig 2d
Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher
  • western blot; human; fig 4
Lee J, Park K, Han D, Bang N, Kim D, Na H, et al. PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. PLoS ONE. 2015;10:e0142624 pubmed publisher
  • western blot; human; 1:1000; fig 3
  • immunocytochemistry; mouse; 1:100; fig s1
Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015;6:8755 pubmed publisher
  • western blot; human; fig 3
Qin W, Li C, Zheng W, Guo Q, Zhang Y, Kang M, et al. Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget. 2015;6:39839-54 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s4a
Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed publisher
  • immunocytochemistry; mouse; 1:400; fig 6c
Bugajev V, Hálová I, Dráberová L, Bambousková M, Potůčková L, Draberova H, et al. Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells. Cell Mol Life Sci. 2016;73:1265-85 pubmed publisher
  • western blot; human; fig s10d
Shain A, Garrido M, Botton T, Talevich E, Yeh I, Sanborn J, et al. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015;47:1194-9 pubmed publisher
  • western blot; mouse
Qu D, Weygant N, May R, Chandrakesan P, Madhoun M, Ali N, et al. Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PLoS ONE. 2015;10:e0134212 pubmed publisher
  • western blot; mouse
Álvaro Bartolomé M, García Sevilla J. The neuroplastic index p-FADD/FADD and phosphoprotein PEA-15, interacting at GABAA receptor, are upregulated in brain cortex during midazolam-induced hypnosis in mice. Eur Neuropsychopharmacol. 2015;25:2131-44 pubmed publisher
  • immunocytochemistry; mouse; 1:400; fig s5
  • western blot; mouse; 1:1000; fig 1
  • immunohistochemistry - paraffin section; human; 1:400; fig 7
Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  • ChIP-Seq; human; 1:1000; fig 4d
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 2b
Nagaraja A, Dorniak P, Sadaoui N, Kang Y, Lin T, Armaiz Pena G, et al. Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene. 2016;35:2390-7 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6d
Sibbesen N, Kopp K, Litvinov I, Jønson L, Willerslev Olsen A, Fredholm S, et al. Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma. Oncotarget. 2015;6:20555-69 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:400; fig s4
Binder Gallimidi A, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein A, et al. Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6:22613-23 pubmed
  • immunocytochemistry; human; fig 2
Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, et al. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015;6:7652 pubmed publisher
  • flow cytometry; mouse; fig 6
Jin X, Yao T, Zhou Z, Zhu J, Zhang S, Hu W, et al. Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway. Biomed Res Int. 2015;2015:732450 pubmed publisher
  • western blot; rat; 1:1000
Tang H, Hua F, Wang J, Yousuf S, Atif F, Sayeed I, et al. Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury. Brain Inj. 2015;29:1165-1174 pubmed publisher
  • western blot; mouse
Keller B, García Sevilla J. Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:54-62 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 8
Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J. Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection. J Biol Chem. 2015;290:17306-20 pubmed publisher
  • western blot; human
Greenfeld H, Takasaki K, Walsh M, Ersing I, Bernhardt K, Ma Y, et al. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015;11:e1004890 pubmed publisher
  • western blot; human
Willy J, Young S, Stevens J, Masuoka H, Wek R. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell. 2015;26:2190-204 pubmed publisher
  • western blot; human; fig 3
  • western blot; mouse; fig 3
Fei F, Joo E, Tarighat S, Schiffer I, Paz H, Fabbri M, et al. B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3. Oncotarget. 2015;6:11378-94 pubmed
  • western blot; human; fig 2
Ohashi M, Holthaus A, Calderwood M, Lai C, Krastins B, Sarracino D, et al. The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. PLoS Pathog. 2015;11:e1004822 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5
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  • chromatin immunoprecipitation; human; 1:100; loading ...; fig 5c
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product information
SKU :
8242P
Product-Name :
NF-κB p65 (D14E12) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Dg
Applications :
Chromatin Immunoprecipitation
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
65
Host :
Rabbit
Target :
NFkB-p65
Primary-Protein :
NFkB-p65
Alt-Names :
MGC131774,NFKB3,Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3,RELA,TF65,Transcription factor p65,p65,v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)),v-rel reticuloendotheliosis viral oncogene homolog A (avian),v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.