product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Rb (Ser780) (D59B7) Rabbit mAb
catalog :
8180
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
D59B7
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2d
Zhang Y, He L, Huang L, Yao S, Lin N, Li P, et al. Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway. Clin Transl Med. 2021;11:e503 pubmed publisher
  • western blot; human; loading ...; fig 2f, 2g
Zhang Y, Ma Y, Wu G, Xie M, Luo C, Huang X, et al. SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression. Cell Death Discov. 2021;7:192 pubmed publisher
  • western blot; human; fig 6a
Nagamura Y, Miyazaki M, Nagano Y, Yuki M, Fukami K, Yanagihara K, et al. PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification. Oncogenesis. 2021;10:25 pubmed publisher
  • western blot; mouse; loading ...; fig 4e
Qiao F, Law H, Krieger K, Clement E, Xiao Y, Buckley S, et al. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Biol Open. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 3e
Rossi F, Legnini I, Megiorni F, Colantoni A, Santini T, Morlando M, et al. Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. Oncogene. 2019;38:3843-3854 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig e3b
Sharifnia T, Wawer M, Chen T, Huang Q, Weir B, Sizemore A, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nat Med. 2019;25:292-300 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira N, et al. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018;553:91-95 pubmed publisher
  • western blot; human; loading ...; fig 2b
Paculova H, Kramara J, Simečková S, Fedr R, Soucek K, Hylse O, et al. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumour Biol. 2017;39:1010428317727479 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 5j, 5l
Chong I, Aronson L, Bryant H, Gulati A, Campbell J, Elliott R, et al. Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer. Gut. 2018;67:1780-1792 pubmed publisher
  • western blot; human; loading ...; fig 2
Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher
  • western blot; human; 1:1500; loading ...; fig 4c
Luo X, Peng J, Su L, Wang D, Yu Y. Fangchinoline inhibits the proliferation of SPC-A-1 lung cancer cells by blocking cell cycle progression. Exp Ther Med. 2016;11:613-618 pubmed
  • western blot; human; fig 7
Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed publisher
Lei J, Shao J, Zhang J, IGLESIA M, Chan D, Cao J, et al. Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Rep. 2018;24:1434-1444.e7 pubmed publisher
Yang C, Li Z, Bhatt T, Dickler M, Giri D, Scaltriti M, et al. Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence. Oncogene. 2017;36:2255-2264 pubmed publisher
Barton K, Misuraca K, Cordero F, Dobrikova E, Min H, Gromeier M, et al. PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. PLoS ONE. 2013;8:e77639 pubmed publisher
product information
SKU :
8180S
Product-Name :
Phospho-Rb (Ser780) (D59B7) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunoprecipitation
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
110
Host :
Rabbit
Target :
Rb (Ser780) phosphate
Primary-Protein :
Rb
Alt-Names :
OSRC,RB1,Rb,Retinoblastoma-associated protein,p105-Rb,pRb,pp110,retinoblastoma 1,retinoblastoma suspectibility protein
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.