product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Atg16L1 (D6D5) Rabbit mAb
catalog :
8089
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D6D5
reactivity :
human, mouse, rat, pigs
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, western blot knockout validation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 2c
  • western blot knockout validation; human; 1:1000; loading ...; fig 2b, 2d
Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig 4b
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig s6a
Jacquin E, Leclerc Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Autophagy. 2017;13:854-867 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Prins M, Giugliano F, van Roest M, van de Graaf S, Koelink P, Wildenberg M. Thiopurines correct the effects of autophagy impairment on intestinal healing - a potential role for ARHGAP18/RhoA. Dis Model Mech. 2021;14: pubmed publisher
  • western blot; human; loading ...; fig 4a
Dahou H, Minati M, Jacquemin P, Assi M. Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig 4e
Li X, Huang K, Liu X, Ruan H, Ma L, Liang J, et al. Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway. Front Pharmacol. 2021;12:639574 pubmed publisher
  • western blot; human; loading ...; fig 2c
Hung C, Lombardo P, Malik N, Brun S, Hellberg K, Van Nostrand J, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021;7: pubmed publisher
  • western blot; human; loading ...; fig 1b
Kim D, Park J, Choi H, Kim C, Bae E, Ma S, et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD. Cell Death Dis. 2021;12:320 pubmed publisher
  • flow cytometry; human; loading ...
Sun R, Hedl M, Abraham C. TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. Cell Mol Gastroenterol Hepatol. 2021;11:249-272 pubmed publisher
  • western blot; mouse; 1:2000; loading ...
Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, et al. Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat Commun. 2020;11:4150 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1b
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Zhao X, Nedvetsky P, Stanchi F, Vion A, Popp O, Zühlke K, et al. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 7b
Jimenez Orgaz A, Kvainickas A, Nägele H, Denner J, Eimer S, Dengjel J, et al. Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy. EMBO J. 2018;37:235-254 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Bansal M, Moharir S, Sailasree S, Sirohi K, Sudhakar C, Sarathi D, et al. Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein. J Biol Chem. 2018;293:132-147 pubmed publisher
  • western blot; mouse; loading ...; fig s3j
Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher
  • western blot; human; loading ...; fig 3
Bartusch C, Döring T, Prange R. Rab33B Controls Hepatitis B Virus Assembly by Regulating Core Membrane Association and Nucleocapsid Processing. Viruses. 2017;9: pubmed publisher
  • western blot; human; fig 5
Zhang Q, Gao M, Zhang Y, Song Y, Cheng H, Zhou R. The germline-enriched Ppp1r36 promotes autophagy. Sci Rep. 2016;6:24609 pubmed publisher
  • immunocytochemistry; human; fig 3
  • western blot; human; fig s2
Corcelle Termeau E, Vindeløv S, Hämälistö S, Mograbi B, Keldsbo A, Bräsen J, et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy. 2016;12:833-49 pubmed publisher
  • western blot; mouse; fig 5
  • immunoprecipitation; pigs ; fig 7
  • western blot; pigs ; fig 7
Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Autophagy. 2015;11:1081-98 pubmed publisher
Mimouna S, Bazin M, Mograbi B, Darfeuille Michaud A, Brest P, Hofman P, et al. HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC). Autophagy. 2014;10:2333-45 pubmed publisher
Puri C, Renna M, Bento C, Moreau K, Rubinsztein D. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 2013;154:1285-99 pubmed publisher
Ouyang D, Xu L, He X, Zhang Y, Zeng L, Cai J, et al. Autophagy is differentially induced in prostate cancer LNCaP, DU145 and PC-3 cells via distinct splicing profiles of ATG5. Autophagy. 2013;9:20-32 pubmed publisher
product information
SKU :
8089S
Product-Name :
Atg16L1 (D6D5) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, (Mk)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Autophagy
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
66, 68
Host :
Rabbit
Target :
ATG16L1
Primary-Protein :
ATG16
Alt-Names :
A16L1,APG16 autophagy 16-like,APG16-like 1,APG16L,APG16L beta,ATG16,ATG16 autophagy related 16-like 1 (S. cerevisiae),ATG16 autophagy related 16-like protein 1,ATG16L,ATG16L1,Autophagy-related protein 16-1,FLJ00045,FLJ10035,FLJ10828,FLJ22677,IBD10,WD repeat domain 30,WDR30
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.