product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
DR5 (D4E9) XP® Rabbit mAb
catalog :
8074
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
D4E9
reactivity :
human, rat
application :
western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 7
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 9e
  • immunocytochemistry; human; 1:200; loading ...; fig 2f
Iurlaro R, Püschel F, León Annicchiarico C, O Connor H, Martin S, Palou Gramón D, et al. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 2a
Zhao L, Zhang B. Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. Sci Rep. 2017;7:44735 pubmed publisher
  • western blot; human; fig 3a
Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
  • western blot; human; loading ...; fig 2a
Park S, Jwa E, Shin S, Ju E, Park I, Pak J, et al. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. Int J Biochem Cell Biol. 2017;83:47-55 pubmed publisher
  • western blot; rat
  • immunocytochemistry; human
Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher
Lewis A, Valley C, Peery S, Brummel B, Braun A, Karim C, et al. Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function. J Mol Biol. 2016;428:4843-4855 pubmed publisher
Woo S, Min K, Seo B, Kwon T. YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-?B-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells. Oncotarget. 2016;7:61520-61532 pubmed publisher
product information
SKU :
8074P
Product-Name :
DR5 (D4E9) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
40, 48
Host :
Rabbit
Target :
DR5,Trail-R2
Primary-Protein :
TRAIL-R2
Alt-Names :
DR5,KILLER,TNFRSF10B,TRAILR2,TRICK2,ZTNFR9,tumor necrosis factor receptor superfamily, member 10b
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.