product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
ASCT2 (D7C12) Rabbit mAb
catalog :
8057
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
D7C12
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
Cell Signaling Technology product webpage
citations: 8
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2c
Jensen H, Potempa M, Gotthardt D, Lanier L. Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells. J Immunol. 2017;199:1967-1972 pubmed publisher
  • western blot; human; loading ...; fig 3a
White M, Lin C, Rajapakshe K, Dong J, Shi Y, Tsouko E, et al. Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer. Mol Cancer Res. 2017;15:1017-1028 pubmed publisher
  • western blot; human; loading ...; fig 4a
Sontakke P, Koczula K, Jaques J, Wierenga A, Brouwers Vos A, Pruis M, et al. Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation. PLoS ONE. 2016;11:e0153226 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 2g, 2h
van Geldermalsen M, Wang Q, Nagarajah R, Marshall A, Thoeng A, Gao D, et al. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene. 2016;35:3201-8 pubmed publisher
Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, et al. LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. Nature. 2019;569:275-279 pubmed publisher
Bröer A, Fairweather S, Broer S. Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets. Front Pharmacol. 2018;9:785 pubmed publisher
Yang Z, Follett J, Kerr M, Clairfeuille T, Chandra M, Collins B, et al. Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2. J Biol Chem. 2018;293:6802-6811 pubmed publisher
Tao X, Lu Y, Qiu S, Wang Y, Qin J, Fan Z. AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis. Cancer Lett. 2017;408:33-42 pubmed publisher
product information
SKU :
8057S
Product-Name :
ASCT2 (D7C12) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, Mk
Applications :
Flow cytometry
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
49, 75
Host :
Rabbit
Target :
ASCT2
Primary-Protein :
SLC1A5
Alt-Names :
AAAT,ASCT2,ATB(0),ATBO,Baboon M7 virus receptor,FLJ31068,M7V1,M7VS1,Neutral amino acid transporter B(0),R16,RD114 virus receptor,RD114/simian type D retrovirus receptor,RDR,RDRC,SLC1A5,Sodium-dependent neutral amino acid transporter type 2,Solute carrier family 1 member 5,neutral amino acid transporter B,solute carrier family 1 (neutral amino acid transporter), member 5
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.