KEAP1 (D6B12) Rabbit mAb | Cell Signaling Technology 8047 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

KEAP1 (D6B12) Rabbit mAb

catalog :

8047

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

D6B12

reactivity :

human, mouse, rat, bovine

application :

western blot, immunocytochemistry, western blot knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; fig 6a	Strous E, Vanhoudt A, Smolenaars A, van Schaik G, Schouten M, de Pater H, et al. Observational Study on Variation of Longitudinal Platelet Counts in Calves over the First 14 Days of Life and Reference Intervals from Cross-Sectional Platelet and Leukocyte Counts in Dairy Calves up to Two Months of Age. Animals (Basel). 2021;11: pubmed publisher
western blot knockout validation; human; fig 6a	Xi Y, Jing Z, Wei W, Chun Z, Quan Q, Qing Z, et al. Inhibitory effect of sodium butyrate on colorectal cancer cells and construction of the related molecular network. BMC Cancer. 2021;21:127 pubmed publisher
western blot knockout validation; human; fig 6a	Huang D, Dai C, Li S, Li X. Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury. Aging (Albany NY). 2021;13:11010-11025 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 8b	Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y. Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function. Front Pharmacol. 2019;10:1354 pubmed publisher
western blot; human; loading ...; fig s2k	Sanghvi V, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, et al. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell. 2019;178:807-819.e21 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3i	Li C, Liu Q, Xie L. Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress. Biochem Biophys Res Commun. 2018;507:22-29 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2f, 2h	Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher
western blot; human; loading ...; fig 1A; 1B	Cheng L, Li K, Yi N, Li X, Wang F, Xue B, et al. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. Oncotarget. 2017;8:13186-13194 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2f	Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher
western blot; rat; fig 3	Ashino T, Yamamoto M, Numazawa S. Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep. 2016;6:26291 pubmed publisher
western blot; human; fig 2a	Kabaria S, Choi D, Chaudhuri A, Jain M, Li H, Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic Biol Med. 2015;89:548-56 pubmed publisher
western blot; mouse; fig 6a	Tomasovic A, Kurrle N, SÃ¼rÃ¼n D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor Î² (PdgfrÎ²) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher
western blot; rat; 1:1000	Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, Banerjee S. Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS ONE. 2014;9:e94228 pubmed publisher
	Castiglione G, Xu Z, Zhou L, Duh E. Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. Nat Commun. 2020;11:2476 pubmed publisher
	Zou Y, Palte M, Deik A, Li H, Eaton J, Wang W, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10:1617 pubmed publisher
	Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle N, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017;32:824-839.e8 pubmed publisher
	Wang Y, Okazaki Y, Shi L, Kohda H, Tanaka M, Taki K, et al. Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis. Cancer Sci. 2016;107:250-7 pubmed publisher
	Xing H, Cai Y, Wang X, Wang L, Li P, Wang G, et al. The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3Î² Inactivation. PLoS ONE. 2015;10:e0145183 pubmed publisher
	Orimoto A, Suzuki T, Ueno A, Kawai T, Nakamura H, Kanamori T. Effect of 2-hydroxyethyl methacrylate on antioxidant responsive element-mediated transcription: a possible indication of its cytotoxicity. PLoS ONE. 2013;8:e58907 pubmed publisher

product information

SKU :

8047S

Product-Name :

KEAP1 (D6B12) Rabbit mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M, R, (Mk, B, Pg)

Applications :

Immunofluorescence (Immunocytochemistry)

Product-Category :

Ubiquitin and Ubiquitin-like proteins

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

60-64

Host :

Rabbit

Target :

KEAP1

Primary-Protein :

KEAP1

Alt-Names :

Cytosolic inhibitor of Nrf2,INRF2,KEAP1,KIAA0132,KLHL19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454

more info or order :

Cell Signaling Technology product webpage