product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
TRAF6 (D21G3) Rabbit mAb
catalog :
8028
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D21G3
reactivity :
human, mouse
application :
western blot, immunoprecipitation
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3g
Zheng H, Xu W, Zhou W, Yang R, Chen P, Liu T, et al. Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination. Cell Death Dis. 2021;12:497 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e
Guo G, Gao M, Gao X, Zhu B, Huang J, Luo K, et al. SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal Transduct Target Ther. 2021;6:119 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2e
Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, et al. HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma. Theranostics. 2020;10:10434-10447 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3e
Li H, Lan J, Wang G, Guo K, Han C, Li X, et al. KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation. J Exp Clin Cancer Res. 2020;39:12 pubmed publisher
  • western blot; human; loading ...; fig 5a
Ginster S, Bardet M, Unterreiner A, Malinverni C, Renner F, Lam S, et al. Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation. PLoS ONE. 2017;12:e0169026 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3e
Lu W, Liu S, Li B, Xie Y, Izban M, Ballard B, et al. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene. 2017;36:1364-1373 pubmed publisher
  • western blot; human; loading ...; fig 6c
Hedl M, Yan J, Abraham C. IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Rep. 2016;16:2442-55 pubmed publisher
  • western blot; human; 1:800; fig 4
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, et al. The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1. Sci Rep. 2016;6:27597 pubmed publisher
  • western blot; human
Schmidt T, Schmid Burgk J, Hornung V. Synthesis of an arrayed sgRNA library targeting the human genome. Sci Rep. 2015;5:14987 pubmed publisher
  • western blot; human; 1:1000; fig 4
Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, et al. SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget. 2015;6:771-88 pubmed
Dong D, Zhou H, Na S, Niedra R, Peng Y, Wang H, et al. GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. PLoS ONE. 2018;13:e0205303 pubmed publisher
Sharma N, Verma R, Kumawat K, Basu A, Singh S. miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells. J Neuroinflammation. 2015;12:30 pubmed publisher
Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum. 2013;65:2996-3006 pubmed publisher
Endale M, Park S, Kim S, Kim S, Yang Y, Cho J, et al. Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-?B-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology. 2013;218:1452-67 pubmed publisher
Hulsmans M, Van Dooren E, Mathieu C, Holvoet P. Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin. PLoS ONE. 2012;7:e32794 pubmed publisher
product information
SKU :
8028S
Product-Name :
TRAF6 (D21G3) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, Mk
Applications :
Immunoprecipitation
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
60
Host :
Rabbit
Target :
TRAF6
Primary-Protein :
TRAF6
Alt-Names :
E3 ubiquitin-protein ligase TRAF6,Interleukin-1 signal transducer,MGC:3310,RING finger protein 85,RNF85,TNF receptor-associated factor 6,TRAF6
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.