product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Bmi1 (D20B7) XP® Rabbit mAb
catalog :
6964
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D20B7
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 6a, 6b
Maroni G, Bassal M, Krishnan I, Fhu C, Savova V, Zilionis R, et al. Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. Commun Biol. 2021;4:370 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1c
  • western blot; human; 1:1000; loading ...; fig 2a, 2b
Shields C, Potlapalli S, Cuya Smith S, Chappell S, Chen D, Martinez D, et al. Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target. Mol Oncol. 2021;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Li W, Zhang N, Jin C, Long M, Rajabi H, Yasumizu Y, et al. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020;5: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3a
Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, et al. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature. 2020;578:296-300 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Zhan Y, Li R, Feng C, Li X, Huang S, Wang L, et al. Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2. Biomed Pharmacother. 2020;121:109602 pubmed publisher
  • western blot; human; loading ...; fig 5a
Wang Z, Feng X, Molinolo A, Martin D, Vitale Cross L, Nohata N, et al. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 5a
Chen X, Hu L, Yang H, Ma H, Ye K, Zhao C, et al. DHHC protein family targets different subsets of glioma stem cells in specific niches. J Exp Clin Cancer Res. 2019;38:25 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8a
Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1f
Lee J, Yu K, Kim H, Kang I, Kim J, Lee B, et al. BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1. Aging (Albany NY). 2016;8:1670-89 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Mansouri S, Singh S, Alamsahebpour A, Burrell K, Li M, Karabork M, et al. DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma. Oncotarget. 2016;7:56431-56446 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5a
  • immunoprecipitation; human; loading ...; fig 3d
  • western blot; human; loading ...; fig 3d
Zheng G, Li N, Jia X, Peng C, Luo L, Deng Y, et al. MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer. J Mol Med (Berl). 2016;94:1129-1141 pubmed
  • western blot; human; 1:1000; fig 4
Oliva C, Markert T, Gillespie G, Griguer C. Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas. Oncotarget. 2015;6:4330-44 pubmed
  • western blot; human
Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, et al. Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis. Biochem Biophys Res Commun. 2015;458:470-475 pubmed publisher
  • chromatin immunoprecipitation; rat; fig 3
Koo J, Mazei Robison M, LaPlant Q, Egervári G, Braunscheidel K, Adank D, et al. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci. 2015;18:415-22 pubmed publisher
  • chromatin immunoprecipitation; human; 1:100
  • immunoprecipitation; human; 1:1000
  • western blot; human; 1:1000
Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed publisher
Hata T, Rajabi H, Takahashi H, Yasumizu Y, Li W, Jin C, et al. MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells. Cancer Res. 2019;79:5711-5722 pubmed publisher
Kahn S, Wang X, Nitta R, Gholamin S, Theruvath J, Hutter G, et al. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018;9:4121 pubmed publisher
Zhang Z, Bu X, Chen H, Wang Q, Sha W. Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin. Int J Mol Med. 2016;38:1199-207 pubmed publisher
Trino S, Iacobucci I, Erriquez D, Laurenzana I, De Luca L, Ferrari A, et al. Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients. Oncotarget. 2016;7:12951-61 pubmed publisher
Shahi M, York D, Gandour Edwards R, Withers S, Holt R, Rebhun R. BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance. PLoS ONE. 2015;10:e0131006 pubmed publisher
Shibuya K, Okada M, Suzuki S, Seino M, Seino S, Takeda H, et al. Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells. Oncotarget. 2015;6:651-61 pubmed
Tu K, Li C, Zheng X, Yang W, Yao Y, Liu Q. Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. Oncol Rep. 2014;32:1571-7 pubmed publisher
product information
SKU :
6964P
Product-Name :
Bmi1 (D20B7) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, Mk
Applications :
Chromatin Immunoprecipitation
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
41, 43
Host :
Rabbit
Target :
BMI1
Primary-Protein :
BMI1
Alt-Names :
B lymphoma Mo-MLV insertion region 1 homolog,BMI1,BMI1 polycomb ring finger oncogene,MGC12685,PCGF4,Polycomb complex protein BMI-1,Polycomb group RING finger protein 4,RING finger protein 51,RNF51,flvi-2/bmi-1,murine leukemia viral (bmi-1) oncogene homolog,oncogene BMI-1,polycomb group protein Bmi1,polycomb group ring finger 4
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.