Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb | Cell Signaling Technology 6943 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb

catalog :

6943

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

D49G4

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Cell Signaling Technology product webpage

citations: 91

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 10a	Li K, Wu R, Zhou M, Tong H, Luo K. Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system. Sci Adv. 2021;7:eabg7265 pubmed publisher
western blot; human; loading ...; fig 2c	Moon S, Lee H, Kim S, Hong J, Chun S, Lee H, et al. Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells. BMC Cancer. 2021;21:931 pubmed publisher
western blot; human; loading ...; fig 4a	Ha T, Choi Y, Noh H, Cha S, Kim J, Park S. Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons. Mol Brain. 2021;14:122 pubmed publisher
western blot; human; 1:500; loading ...; fig 3a	Shelton W, Thomas S, Alexander H, Thomes C, Conway D, Dubash A. Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion. Sci Rep. 2021;11:13295 pubmed publisher
western blot; mouse; loading ...; fig 2a	Kashima D, Kawahara M. Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers. Sci Rep. 2021;11:11758 pubmed publisher
western blot; human; 1:1000; loading ...; fig 4a	Brandel A, Aigal S, Lagies S, Schlimpert M, Meléndez A, Xu M, et al. The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa. Cell Mol Life Sci. 2021;78:3637-3656 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s4b	Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3i	Lechertier T, Reynolds L, Kim H, Pedrosa A, Gómez Escudero J, Muñoz Félix J, et al. Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nat Commun. 2020;11:2810 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2e	Alajati A, D Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, et al. CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo. J Clin Invest. 2020;130:2435-2450 pubmed publisher
western blot; human; 1:1000; fig 4f	Steins A, van Mackelenbergh M, van der Zalm A, Klaassen R, Serrels B, Goris S, et al. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. EMBO Rep. 2020;21:e48780 pubmed publisher
western blot; mouse; 1:500; loading ...; fig s4a	Cheung E, DeNicola G, Nixon C, Blyth K, Labuschagne C, Tuveson D, et al. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020;37:168-182.e4 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4d	Liu T, Han S, Dai Q, Zheng J, Liu C, Li S, et al. IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway. Front Immunol. 2019;10:2952 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6b, 6c	Reed M, Luissint A, Azcutia V, Fan S, O Leary M, Quirós M, et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019;10:5004 pubmed publisher
immunocytochemistry; human; loading ...; fig s4f	Laufer J, Hauser M, Kindinger I, Purvanov V, Pauli A, Legler D. Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation. Cell Rep. 2019;29:995-1009.e6 pubmed publisher
western blot; human; loading ...; fig 3b	Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed publisher
western blot; human; loading ...; fig 5a	Fenwick C, Loredo Varela J, Joo V, Pellaton C, Farina A, Rajah N, et al. Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. J Exp Med. 2019;: pubmed publisher
western blot; human; loading ...; fig e10b	Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, et al. Time-resolved protein activation by proximal decaging in living systems. Nature. 2019;569:509-513 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 8b western blot; human; 1:2000; loading ...; fig 8a	Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, et al. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019;: pubmed publisher
western blot; human; 1:1000; fig 3c	DeLalio L, Billaud M, Ruddiman C, Johnstone S, Butcher J, Wolpe A, et al. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. J Biol Chem. 2019;294:6940-6956 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2g	Salazar S, Cox T, Lee S, Brody A, Chyung A, Haas L, et al. Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss. J Neurosci. 2019;39:758-772 pubmed publisher
western blot; human; loading ...; fig 1b	Fan P, Narzisi G, Jayaprakash A, Venturini E, Robine N, Smibert P, et al. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. Proc Natl Acad Sci U S A. 2018;115:E6030-E6038 pubmed publisher
western blot; human; loading ...; fig 4d	Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, et al. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. Nat Commun. 2018;9:1523 pubmed publisher
western blot; human; 1:1000; fig 3a	Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed publisher
western blot; human; loading ...; fig 3a	Han B, Zhou B, Qu Y, Gao B, Xu Y, Chung S, et al. FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer. Oncogene. 2018;37:1399-1408 pubmed publisher
western blot; human; loading ...; fig 1a	Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
western blot; human; 1:500; loading ...; fig 8f	Shi Y, Ping Y, Zhou W, He Z, Chen C, Bian B, et al. Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth. Nat Commun. 2017;8:15080 pubmed publisher
immunocytochemistry; human; loading ...; fig 6h western blot; human; loading ...; fig 6k	Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, et al. Nuclear Shp2 directs normal embryo implantation via facilitating the ERÎ± tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017;114:4816-4821 pubmed publisher
western blot; human; fig 5b	Soni D, Regmi S, Wang D, Debroy A, Zhao Y, Vogel S, et al. Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions. Am J Physiol Lung Cell Mol Physiol. 2017;312:L1003-L1017 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2b	Mon N, Senga T, Ito S. Interleukin-1? activates focal adhesion kinase and Src to induce matrix metalloproteinase-9 production and invasion of MCF-7 breast cancer cells. Oncol Lett. 2017;13:955-960 pubmed publisher
western blot; human; loading ...; fig 6d	Hu M, Azeloglu E, Ron A, Tran Ba K, Calizo R, Tavassoly I, et al. A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction. Sci Rep. 2017;7:43934 pubmed publisher
western blot; human; 1:200; loading ...; fig 3a	Basu R, Wu S, Kopchick J. Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways. Oncotarget. 2017;8:21579-21598 pubmed publisher
western blot; human; loading ...; fig s8a western blot; mouse; fig s8a	Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, et al. Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia. 2017;31:1502-1512 pubmed publisher
western blot; human; loading ...; fig 2b	Ma K, Fu W, Tang M, Zhang C, Hou T, Li R, et al. PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment. Autophagy. 2017;13:579-591 pubmed publisher
western blot; human; 1:1000; fig 5b	Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
western blot; mouse; loading ...; fig 2a	Tian X, Ye M, Cao Y, Wang C. Losartan Improves Palmitate-Induced Insulin Resistance in 3T3-L1 Adipocytes Through Upregulation of Src Phosphorylation. Exp Clin Endocrinol Diabetes. 2017;125:136-140 pubmed publisher
western blot; mouse; loading ...; fig 5e	Mukhopadhyay C, Triplett A, Bargar T, HECKMAN C, Wagner K, Naramura M. Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation. Proc Natl Acad Sci U S A. 2016;113:E8228-E8237 pubmed publisher
western blot; human; loading ...; fig 5c	Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, et al. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget. 2016;7:86011-86025 pubmed publisher
western blot; human; loading ...; fig 1d	Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016;126:4527-4536 pubmed publisher
western blot; mouse; loading ...; fig 2c	Kishi T, Mayanagi T, Iwabuchi S, Akasaka T, Sobue K. Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity. Oncotarget. 2016;7:72113-72130 pubmed publisher
western blot; human; 1:200; fig st1	Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
western blot; mouse; fig 5e	Girola N, Matsuo A, Figueiredo C, Massaoka M, Farias C, Arruda D, et al. The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor. Peptides. 2016;85:1-15 pubmed publisher
western blot; human; 1:1000; fig 5	Liu M, Feng L, Sun P, Liu W, Wu W, Jiang B, et al. A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice. PLoS ONE. 2016;11:e0159789 pubmed publisher
western blot; human; loading ...; fig 1c	Monica V, Lo Iacono M, Bracco E, Busso S, di Blasio L, Primo L, et al. Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines. Oncotarget. 2016;7:76577-76589 pubmed publisher
western blot; human; fig 1	Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
western blot; human; fig 5	Jeong A, Han S, Lee S, Su Park J, Lu Y, Yu S, et al. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway. Sci Rep. 2016;6:27391 pubmed publisher
western blot; human; 1:1000; fig 2	Barretta M, Spano D, D Ambrosio C, Cervigni R, Scaloni A, Corda D, et al. Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2. Nat Commun. 2016;7:11727 pubmed publisher
western blot; human; 1:1000; fig 1	Su L, Li X, Wu X, Hui B, Han S, Gao J, et al. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Sci Rep. 2016;6:26023 pubmed publisher
western blot; human; fig 7	Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed publisher
western blot; human; fig 2	Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, et al. Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget. 2016;7:24483-94 pubmed publisher
western blot; human; fig 4	Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne P, Kim E, et al. Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma. Oncotarget. 2016;7:24018-26 pubmed publisher
western blot; rat; fig 5	Weilinger N, Lohman A, Rakai B, Ma E, Bialecki J, Maslieieva V, et al. Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nat Neurosci. 2016;19:432-42 pubmed publisher
western blot; rat; 1:1000; fig 6	Grindheim A, Hollås H, Raddum A, Saraste J, Vedeler A. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. J Cell Sci. 2016;129:314-28 pubmed publisher
western blot; human; loading ...; fig 2g	Shrivastava A, Prasad A, Kuzontkoski P, Yu J, Groopman J. Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements. Sci Rep. 2015;5:16833 pubmed publisher
western blot; human; 1:1000; fig 6	Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, et al. Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 2016;107:84-94 pubmed publisher
western blot; human; 1:1000; loading ...; fig 11	Sugiyama S, Yoshino Y, Kuriyama S, Inoue M, Komine K, Otsuka K, et al. A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization. Anticancer Agents Med Chem. 2016;16:633-47 pubmed
immunocytochemistry; rat; 1:100; fig 5 western blot; rat; 1:1000; fig 2	Fiore V, Strane P, Bryksin A, White E, Hagood J, Barker T. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015;211:173-90 pubmed publisher
western blot; human; 1:500; loading ...; fig 6a	Gu Y, Li H, Zhao L, Zhao S, He W, Rui L, et al. GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinoma. Oncotarget. 2015;6:33658-74 pubmed publisher
western blot; mouse; fig 3b	Chiang C, Uzoma I, Lane D, MemiÅ¡eviÄ‡ V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher
western blot; mouse; 1:1000	Tang Y, Ye M, Du Y, Qiu X, Lv X, Yang W, et al. EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus. Neuroscience. 2015;304:109-21 pubmed publisher
western blot; human; fig 4	Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed
western blot; mouse; 1:1000	Major J, Salih M, Tuana B. Interplay between the E2F pathway and Î²-adrenergic signaling in the pathological hypertrophic response of myocardium. J Mol Cell Cardiol. 2015;84:179-90 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 7c	Barosso I, Zucchetti A, Miszczuk G, Boaglio A, Taborda D, Roma M, et al. EGFR participates downstream of ERÎ± in estradiol-17Î²-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets. Arch Toxicol. 2016;90:891-903 pubmed publisher
western blot; human	Coon B, Baeyens N, Han J, Budatha M, Ross T, Fang J, et al. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. J Cell Biol. 2015;208:975-86 pubmed publisher
western blot; human; fig 1a western blot; mouse; fig 2b	Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
western blot; human	Girotti M, Lopes F, Preece N, Niculescu Duvaz D, Zambon A, Davies L, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015;27:85-96 pubmed publisher
western blot; human	Hong Y, Kim J, Pectasides E, Fox C, Hong S, Ma Q, et al. Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models. PLoS ONE. 2014;9:e109440 pubmed publisher
immunohistochemistry - frozen section; mouse western blot; mouse	Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, et al. An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 2014;52:897-906 pubmed publisher
western blot; human; fig 6	Menhofer M, Bartel D, Liebl J, Kubisch R, Busse J, Wagner E, et al. In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor. Cardiovasc Res. 2014;104:303-14 pubmed publisher
western blot; human	Guo W, Liu R, Bhardwaj G, Yang J, Changou C, Ma A, et al. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014;5:e1409 pubmed publisher
western blot; human	Tao W, Leng X, Chakraborty S, Ma H, Arlinghaus R. c-Abl activates janus kinase 2 in normal hematopoietic cells. J Biol Chem. 2014;289:21463-72 pubmed publisher
western blot; mouse	Lee M, Smith S, Murray S, Pham L, Minoo P, Nielsen H. Dihydrotestosterone potentiates EGF-induced ERK activation by inducing SRC in fetal lung fibroblasts. Am J Respir Cell Mol Biol. 2014;51:114-24 pubmed publisher
western blot; human	Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X, et al. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. 2014;50:1013-24 pubmed publisher
western blot; human; 1:500 western blot; rat; 1:500	Yang W, Wang X, Duan C, Lu L, Yang H. Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex. Neurochem Int. 2013;63:180-94 pubmed publisher
	Hikita T, Miyata M, Watanabe R, Oneyama C. In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter. Sci Rep. 2020;10:16616 pubmed publisher
	Ethaeb A, Mohammad M, Madkhali Y, Featherby S, Maraveyas A, Greenman J, et al. Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling. Apoptosis. 2020;25:29-41 pubmed publisher
	Balaji Ragunathrao V, Anwar M, Akhter M, Chavez A, Mao D, Natarajan V, et al. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling. Cell Rep. 2019;29:3472-3487.e4 pubmed publisher
	Sim W, Iyengar P, Lama D, Lui S, Ng H, Haviv Shapira L, et al. c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression. Nat Commun. 2019;10:4349 pubmed publisher
	Klomp J, Shaaya M, Matsche J, Rebiai R, Aaron J, Collins K, et al. Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem Biol. 2019;: pubmed publisher
	Doronzo G, Astanina E, Cora D, Chiabotto G, Comunanza V, Noghero A, et al. TFEB controls vascular development by regulating the proliferation of endothelial cells. EMBO J. 2019;38: pubmed publisher
	Masannat J, Purayil H, Zhang Y, Russin M, Mahmud I, Kim W, et al. Î²Arrestin2 Mediates Renal Cell Carcinoma Tumor Growth. Sci Rep. 2018;8:4879 pubmed publisher
	Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig P, et al. The target landscape of clinical kinase drugs. Science. 2017;358: pubmed publisher
	Obata Y, Horikawa K, Takahashi T, Akieda Y, Tsujimoto M, Fletcher J, et al. Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors. Oncogene. 2017;36:3661-3672 pubmed publisher
	LAW M, Ferreira R, Davis B, Higgins P, Kim J, Castellano R, et al. CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment. Breast Cancer Res. 2016;18:80 pubmed publisher
	Li Y, Zhong G, Sun W, Zhao C, Zhang P, Song J, et al. CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity. Sci Rep. 2015;5:16124 pubmed publisher
	Huynh F, Jones F. MicroRNA-7 inhibits multiple oncogenic pathways to suppress HER2Î”16 mediated breast tumorigenesis and reverse trastuzumab resistance. PLoS ONE. 2014;9:e114419 pubmed publisher
	Akin D, Wang S, Habibzadegah Tari P, Law B, Ostrov D, Li M, et al. A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy. 2014;10:2021-35 pubmed publisher
	Kong Q, Hua H, Cui A, Shao T, Song P, Jiang Y. SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK. Int J Mol Sci. 2014;15:16246-56 pubmed publisher
	Komiya E, Ohnuma K, Yamazaki H, Hatano R, Iwata S, Okamoto T, et al. CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells. Biochem Biophys Res Commun. 2014;447:609-15 pubmed publisher
	McKinley E, Liu H, McDonald W, Luo W, Zhao P, Coffey R, et al. Global phosphotyrosine proteomics identifies PKC? as a marker of responsiveness to Src inhibition in colorectal cancer. PLoS ONE. 2013;8:e80207 pubmed publisher
	Yoo S, Freisinger C, Lebert D, Huttenlocher A. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. J Cell Biol. 2012;199:225-34 pubmed publisher
	Kumari S, Vardhana S, Cammer M, Curado S, Santos L, Sheetz M, et al. T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse. Front Immunol. 2012;3:230 pubmed publisher

product information

SKU :

6943P

Product-Name :

Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb

Size :

40 ul

Price-(USD) :

123 USD

Species-x-Reactivity :

H, M, R

Applications :

Immunoprecipitation

Product-Category :

MAP Kinase Signaling

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

Fyn (Tyr420) phosphate/Hck (Tyr411) phosphate/Lck (Tyr394) phosphate/Lyn (Tyr397) phosphate/Src (Tyr419) phosphate/Yes (Tyr426) phosphate

more info or order :

Cell Signaling Technology product webpage