| Published Application/Species/Sample/Dilution | Reference |
|---|
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; human; loading ...; fig 7f
| Ruan H, Ma Y, Torres S, Zhang B, Feriod C, Heck R, et al. Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes Dev. 2017;31:1655-1665 pubmed publisher |
- western blot; rat; loading ...; fig 1a
- western blot; mouse; loading ...; fig 1b
| Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano A, Monfregola J, et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 2017;127:3717-3729 pubmed publisher |
- western blot; human; loading ...; fig 3c
| Møller A, Kampmann U, Hedegaard J, Thorsen K, Nordentoft I, Vendelbo M, et al. Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes. Sci Rep. 2017;7:43775 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Wolfson R, Chantranupong L, Wyant G, Gu X, Orozco J, Shen K, et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017;543:438-442 pubmed publisher |
- western blot; human; loading ...; fig 7f
| Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch A, Muller S, et al. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. elife. 2017;6: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3d
| Cooper H, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin K, et al. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017;26:1432-1443 pubmed publisher |
- western blot; human; loading ...
| Ruf S, Heberle A, Langelaar Makkinje M, Gelino S, Wilkinson D, Gerbeth C, et al. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy. 2017;13:486-505 pubmed publisher |
- western blot; human; fig 2f
| Cramer S, Saha A, Liu J, Tadi S, Tiziani S, Yan W, et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med. 2017;23:120-127 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Li D, Xie B, Wu X, Li J, Ding Y, Wen X, et al. Late-stage inhibition of autophagy enhances calreticulin surface exposure. Oncotarget. 2016;7:80842-80854 pubmed publisher |
- western blot; mouse; loading ...; fig 6h
- western blot; human; 1:150; loading ...; fig s3c
| Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, et al. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Sci Adv. 2016;2:e1601167 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Pan H, Zhong X, Lee S. Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. BMC Biochem. 2016;17:14 pubmed publisher |
- western blot; mouse; fig 2
| Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li J, et al. Activation of mTORC1 is essential for ?-adrenergic stimulation of adipose browning. J Clin Invest. 2016;126:1704-16 pubmed publisher |
- western blot; human; 1:1000; fig s3
| Liu X, Xiao Z, Han L, Zhang J, Lee S, Wang W, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18:431-42 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Button R, Vincent J, Strang C, Luo S. Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget. 2016;7:5157-75 pubmed publisher |
- western blot; mouse; fig 6
| Cherepkova M, Sineva G, Pospelov V. Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway. Cell Death Dis. 2016;7:e2050 pubmed publisher |
- western blot; rat; fig s3
| Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher |
- western blot; mouse; 1:500; fig 2
| Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, et al. Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med. 2015;7:1403-17 pubmed publisher |
- western blot; rat; 1:1000; fig 3e
| Zhang J, Tripathi D, Jing J, Alexander A, Kim J, Powell R, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259-1269 pubmed publisher |
- western blot; mouse; fig 3a
- western blot; human; fig 3a
| Munson M, Allen G, Toth R, Campbell D, Lucocq J, Ganley I. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 2015;34:2272-90 pubmed publisher |
- western blot; human; 1:1000
| Li C, Siragy H. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab. 2015;309:E302-10 pubmed publisher |
- western blot; mouse; fig 4
| Feng D, Youn D, Zhao X, Gao Y, Quinn W, Xiaoli A, et al. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS ONE. 2015;10:e0126240 pubmed publisher |
- western blot; human; 1:1000; fig 1,2,3,4,5,6,7
| Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Medina D, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, et al. Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB. Nat Cell Biol. 2015;17:288-99 pubmed |
- western blot; human; fig 4
| Rebsamen M, Pochini L, Stasyk T, de Araújo M, Galluccio M, Kandasamy R, et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015;519:477-81 pubmed publisher |
- western blot; mouse
- western blot; rat
| Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher |
- immunocytochemistry; mouse; 1:100
| Bandyopadhyay U, Nagy M, Fenton W, Horwich A. Absence of lipofuscin in motor neurons of SOD1-linked ALS mice. Proc Natl Acad Sci U S A. 2014;111:11055-60 pubmed publisher |
- western blot; human; fig 4
| Chin R, Fu X, Pai M, Vergnes L, Hwang H, Deng G, et al. The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397-401 pubmed publisher |
- western blot; mouse; fig 6
| Watanabe T, Takemura G, Kanamori H, Goto K, Tsujimoto A, Okada H, et al. Restriction of food intake prevents postinfarction heart failure by enhancing autophagy in the surviving cardiomyocytes. Am J Pathol. 2014;184:1384-94 pubmed publisher |
| Nwadike C, Williamson L, Gallagher L, Guan J, Chan E. AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Mol Cell Biol. 2018;38: pubmed publisher |
| Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, et al. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy. 2018;14:336-346 pubmed publisher |
| Dite T, Ling N, Scott J, Hoque A, Galic S, Parker B, et al. The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs. Nat Commun. 2017;8:571 pubmed publisher |
| Kitaoka Y, Takeda K, Tamura Y, Fujimaki S, Takemasa T, Hatta H. Nrf2 deficiency does not affect denervation-induced alterations in mitochondrial fission and fusion proteins in skeletal muscle. Physiol Rep. 2016;4: pubmed publisher |
| Manzoni C, Mamais A, Roosen D, Dihanich S, Soutar M, Plun Favreau H, et al. mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Sci Rep. 2016;6:35106 pubmed publisher |
| Fan X, Tian C, Wang H, Xu Y, Ren K, Zhang B, et al. Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection. Sci Rep. 2015;5:14728 pubmed publisher |
| Mimouna S, Bazin M, Mograbi B, Darfeuille Michaud A, Brest P, Hofman P, et al. HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC). Autophagy. 2014;10:2333-45 pubmed publisher |
| Guan B, Krokowski D, Majumder M, Schmotzer C, Kimball S, Merrick W, et al. Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2?. J Biol Chem. 2014;289:12593-611 pubmed publisher |
