product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Cleaved PARP (Asp214) (D64E10) XP® Rabbit mAb
catalog :
5625S
quantity :
100 ul
price :
301 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 33
Published Application/Species/DilutionReference
  • western blot; human; 1:1000; fig 3
Li Q, Guo Y, Chen F, Liu J, Jin P. Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing. Exp Ther Med. 2016;12:45-50 pubmed
  • western blot; human; fig 1
  • immunocytochemistry; human; fig 1
  • immunohistochemistry; human; fig 1
Andersen A, Flinck M, Oernbo E, Pedersen N, Viuff B, Pedersen S. Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment. Mol Cancer. 2016;15:45 pubmed publisher
  • western blot; human; fig 2
Peng H, Cheng Y, Hsu Y, Wu G, Kuo C, Liou J, et al. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0158440 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 4
Chen N, Uddin B, Voit R, Schiebel E. Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc Natl Acad Sci U S A. 2016;113:990-5 pubmed publisher
  • western blot; human; 1:1000; fig s5
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich M, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529:216-20 pubmed publisher
  • western blot; human; fig 2
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, et al. Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. Oncotarget. 2016;7:1717-31 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; fig 5
Lian Y, Yuan J, Cui Q, Feng Q, Xu M, Bei J, et al. Upregulation of KLHDC4 Predicts a Poor Prognosis in Human Nasopharyngeal Carcinoma. PLoS ONE. 2016;11:e0152820 pubmed publisher
  • western blot; human; 1:1000; fig 5
Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed publisher
  • western blot; human
Wang Y, Han A, Chen E, Singh R, Chichester C, Moore R, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol. 2015;46:1924-34 pubmed publisher
  • western blot; human; fig f4
Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed
  • western blot; human; fig 8c
Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
  • western blot; human; 1:1000; fig 6
Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher
  • western blot; human
Jeong H, Gil N, Lee H, Cho S, Kim K, Chun K, et al. Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression. J Cell Biochem. 2015;116:1602-12 pubmed publisher
  • western blot; human; fig 5
Hamacher-Brady A, Brady N. Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation. J Biol Chem. 2015;290:22005-18 pubmed publisher
  • western blot; human; fig 1
Voets E, Marsman J, Demmers J, Beijersbergen R, Wolthuis R. The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Sci Rep. 2015;5:14798 pubmed publisher
  • western blot; human
Girotti M, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015;27:85-96 pubmed publisher
  • western blot; human; fig 6
Otani K, Dong Y, Li X, Lu J, Zhang N, Xu L, et al. Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer. J Pathol. 2014;234:302-15 pubmed publisher
  • western blot; human
George S, Vishwamitra D, Manshouri R, Shi P, Amin H. The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014;5:5750-63 pubmed
  • western blot; human
Cheng Y, Holloway M, Nguyen K, McCauley D, Landesman Y, Kauffman M, et al. XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer. Mol Cancer Ther. 2014;13:675-86 pubmed publisher
  • western blot; human
Kemp M, Gaddameedhi S, Choi J, Hu J, Sancar A. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem. 2014;289:26574-83 pubmed publisher
  • western blot; human
Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher
  • western blot; human; 1:500
Snyder A, Dulin-Smith A, Houston R, Durban A, Brisbin B, Oostra T, et al. Expression pattern of id proteins in medulloblastoma. Pathol Oncol Res. 2013;19:437-46 pubmed publisher
  • western blot; human
Lin Y, Richards F, Krippendorff B, Bramhall J, Harrington J, Bapiro T, et al. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer. 2012;107:1692-701 pubmed publisher
Robl B, Botter S, Pellegrini G, Neklyudova O, Fuchs B. Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model. J Exp Clin Cancer Res. 2016;35:113 pubmed publisher
Chang H, Wang H, Chen C, Hung T, Hou M, Yuan S, et al. 5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells. Molecules. 2014;19:3149-59 pubmed publisher
Yen Y, Farooqi A, Li K, Butt G, Tang J, Wu C, et al. Methanolic extracts of Solieria robusta inhibits proliferation of oral cancer Ca9-22 cells via apoptosis and oxidative stress. Molecules. 2014;19:18721-32 pubmed publisher
Kolokoltsova O, Grant A, Huang C, Smith J, Poussard A, Tian B, et al. RIG-I enhanced interferon independent apoptosis upon Junin virus infection. PLoS ONE. 2014;9:e99610 pubmed publisher
He P, Kuhara H, Tachibana I, Jin Y, Takeda Y, Tetsumoto S, et al. Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9. FEBS Open Bio. 2013;3:225-30 pubmed publisher
Akazawa Y, Isomoto H, Matsushima K, Kanda T, Minami H, Yamaghchi N, et al. Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis. PLoS ONE. 2013;8:e82322 pubmed publisher
Tomioka H, Mukohara T, Kataoka Y, Ekyalongo R, Funakoshi Y, Imai Y, et al. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. Int J Oncol. 2012;41:551-8 pubmed publisher
Pedeboscq S, Rey C, Petit M, Harpey C, De Giorgi F, Ichas F, et al. Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. PLoS ONE. 2012;7:e36811 pubmed publisher
Robaszkiewicz A, Erdélyi K, Kovacs K, Kovacs I, Bai P, Rajnavolgyi E, et al. Hydrogen peroxide-induced poly(ADP-ribosyl)ation regulates osteogenic differentiation-associated cell death. Free Radic Biol Med. 2012;53:1552-64 pubmed publisher
Patel R, Forinash K, Pireddu R, Sun Y, Sun N, Martin M, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012;72:5025-34 pubmed publisher
product information
SKU :
5625S
Product-Name :
Cleaved PARP (Asp214) (D64E10) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
301 USD
Species-x-Reactivity :
H, Mk
Applications :
Flow cytometry
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
89
Host :
Rabbit
Target :
PARP1 (Asp214, 89 kD) cleaved
Primary-Protein :
PARP1
Alt-Names :
ADP-ribosyltransferase (NAD+,ADP-ribosyltransferase NAD(+),ADPRT,ADPRT 1,ADPRT1,NAD(+) ADP-ribosyltransferase 1,PARP,PARP-1,PARP1,PPOL,Poly [ADP-ribose] polymerase 1,Poly[ADP-ribose] synthase 1,pADPRT-1,poly (ADP-ribose) polymerase 1,poly (ADP-ribose) polymerase family, member 1,poly (ADP-ribose) polymerase),poly(ADP-ribose) polymerase,poly(ADP-ribose) synthetase,poly(ADP-ribosyl)transferase
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.