| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig s6c
| Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Luo H, Jing B, Xia Y, Zhang Y, Hu M, Cai H, et al. WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia. Cancer Cell Int. 2019;19:56 pubmed publisher |
- immunoprecipitation; mouse; 1:1000; loading ...; fig 5c
| Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s3g
| Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher |
- western blot; mouse; 1:200; loading ...; fig 6e
| Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, et al. UBXN3B positively regulates STING-mediated antiviral immune responses. Nat Commun. 2018;9:2329 pubmed publisher |
- western blot; human; loading ...; fig s6u
| Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin F, et al. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Sci Adv. 2018;4:eaar2824 pubmed publisher |
- western blot; human; loading ...; fig ev3c
| Zaffagnini G, Savova A, Danieli A, Romanov J, Tremel S, Ebner M, et al. p62 filaments capture and present ubiquitinated cargos for autophagy. EMBO J. 2018;37: pubmed publisher |
- western blot; human; fig 5c
| Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher |
- western blot; human; loading ...; fig e9d
| Ashkenazi A, Bento C, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, et al. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. 2017;545:108-111 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher |
- western blot; Drosophila melanogaster; loading ...; fig 4e
| Vonk J, Yeshaw W, Pinto F, Faber A, Lahaye L, Kanon B, et al. Drosophila Vps13 Is Required for Protein Homeostasis in the Brain. PLoS ONE. 2017;12:e0170106 pubmed publisher |
- western blot; human; loading ...; fig s7b
| Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher |
- western blot; human; fig 1
| Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher |
- western blot; mouse; loading ...
| Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed publisher |
- immunoprecipitation; human; loading ...; fig s6a, s6b
| Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher |
- western blot; human; fig 3b
| Hochrainer K, Pejanovic N, Olaseun V, Zhang S, Iadecola C, Anrather J. The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res. 2015;43:9889-904 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher |
- western blot; human; fig 3
| Mahanic C, Budhavarapu V, Graves J, Li G, Lin W. Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37. J Biol Chem. 2015;290:26508-22 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Zhao J, Molitor T, Langston J, Nichols R. LRRK2 dephosphorylation increases its ubiquitination. Biochem J. 2015;469:107-20 pubmed publisher |
- western blot; malaria parasite P. falciparum; fig 2
| Mbengue A, Bhattacharjee S, Pandharkar T, Liu H, Estiu G, Stahelin R, et al. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature. 2015;520:683-7 pubmed publisher |
- western blot; mouse; fig 7
| Yazlovitskaya E, Tseng H, Viquez O, Tu T, Mernaugh G, McKee K, et al. Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell. 2015;26:1857-74 pubmed publisher |
- western blot; rat; loading ...; fig s4
| Widagdo J, Chai Y, Ridder M, Chau Y, Johnson R, Sah P, et al. Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation. Cell Rep. 2015;10:783-795 pubmed publisher |
- western blot; mouse; 1:1000
| Kanayama M, Inoue M, Danzaki K, Hammer G, He Y, Shinohara M. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun. 2015;6:5779 pubmed publisher |
- western blot; mouse; 1:1,000
| Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy. J Biol Chem. 2014;289:33131-6 pubmed publisher |
- western blot; mouse; fig 4
| Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014;33:2581-96 pubmed publisher |
- western blot; human; fig 3, 4, 5
| Kobayashi T, Masoumi K, Massoumi R. Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells. Oncogene. 2015;34:2251-60 pubmed publisher |
| Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014;322:43-50 pubmed publisher |
| Wu H, Shi L, Zhang Y, Peng X, Zheng T, Li Y, et al. Ubiquitination Is Essential for Avibirnavirus Replication by Supporting VP1 Polymerase Activity. J Virol. 2019;93: pubmed publisher |
| Liu J, Yuan Y, Xu J, Xiao K, Xu Y, Guo T, et al. β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling. Front Immunol. 2018;9:2930 pubmed publisher |
| Conte C, Griffis E, Hickson I, Pérez Oliva A. USP45 and Spindly are part of the same complex implicated in cell migration. Sci Rep. 2018;8:14375 pubmed publisher |
| Robeson A, Lindblom K, Wojton J, Kornbluth S, Matsuura K. Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators. EMBO J. 2018;37: pubmed publisher |
| Bhattacharjee S, Bose P, Patel K, Roy S, Gain C, Gowda H, et al. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis. 2018;9:605 pubmed publisher |
| Liu Q, Zhang S, Chen G, Zhou H. E3 ubiquitin ligase Nedd4 inhibits AP-1 activity and TNF-α production through targeting p38α for polyubiquitination and subsequent degradation. Sci Rep. 2017;7:4521 pubmed publisher |
| Jiang L, Xiong J, Zhan J, Yuan F, Tang M, Zhang C, et al. Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis. J Biol Chem. 2017;292:13296-13311 pubmed publisher |
| Hooper C, Jackson S, Coughlin E, Coon J, Miyamoto S. Covalent modification of the NF-κB essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro. J Biol Chem. 2014;289:33161-74 pubmed publisher |
| Liu N, Li X, Huang H, Zhao C, Liao S, Yang C, et al. Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth. Oncotarget. 2014;5:5453-71 pubmed |
| Blessing N, Brockman A, Chadee D. The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3. Mol Cell Biol. 2014;34:3132-43 pubmed publisher |
| Chen C, Meng Y, Wang L, Wang H, Tian C, Pang G, et al. Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the I?Ba/NF-?B and MKP1/ERK/STAT1 pathways. Immunology. 2014;142:307-19 pubmed publisher |
| Zhang J, Ma W, Tian S, Fan Z, Ma X, Yang X, et al. RanBPM interacts with T?RI, TRAF6 and curbs TGF induced nuclear accumulation of T?RI. Cell Signal. 2014;26:162-72 pubmed publisher |
