product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
BACE (D10E5) Rabbit mAb
catalog :
5606S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
hamsters, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/DilutionReference
  • immunohistochemistry - frozen section; mouse; fig 5d
  • western blot (knockout validation); mouse; fig 5a
  • western blot; human; fig 2b
  • immunoprecipitation; human; fig 2b
  • immunoprecipitation; mouse; fig 1b
Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
  • immunoprecipitation; mouse
Kizuka Y, Nakano M, Kitazume S, Saito T, Saido T, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016;473:21-30 pubmed publisher
  • western blot; mouse; 1:2000; fig 2
Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed publisher
  • western blot; hamsters; fig 11a
  • western blot; mouse; fig 11a
Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  • western blot; human; 1:1000; fig 2
  • western blot; mouse; 1:1000; fig 2
  • immunocytochemistry; human; 1:250; fig 6
Kurkinen K, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, et al. SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016;129:2224-38 pubmed publisher
  • immunohistochemistry; mouse; 1:400
  • immunocytochemistry; mouse; 1:500
Li H, Ruberu K, Muñoz S, Jenner A, Spiro A, Zhao H, et al. Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. Neurobiol Aging. 2015;36:1820-33 pubmed publisher
  • western blot; mouse; fig 2a
Parsi S, Smith P, Goupil C, Dorval V, Hébert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed publisher
  • western blot; mouse; 1:250; fig 4
Hou X, Adeosun S, Zhang Q, Barlow B, Brents M, Zheng B, et al. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease. Front Aging Neurosci. 2015;7:207 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Tan M, Yu J, Jiang T, Zhu X, Guan H, Tan L. IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J Alzheimers Dis. 2014;38:633-46 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher
Prasad H, Rao R. The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease. J Biol Chem. 2015;290:5311-27 pubmed publisher
Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, et al. Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer's disease mouse model. J Neurosci. 2013;33:8423-41 pubmed publisher
Tan J, Li Q, Ciccotosto G, Crouch P, Culvenor J, White A, et al. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein. PLoS ONE. 2013;8:e61246 pubmed publisher
Walker K, Kang E, Whalen M, Shen Y, Tesco G. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 2012;32:10423-37 pubmed publisher
Giusti-Rodriguez P, Gao J, Graff J, Rei D, Soda T, Tsai L. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1). J Neurosci. 2011;31:15751-6 pubmed publisher
product information
SKU :
5606S
Product-Name :
BACE (D10E5) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R
Applications :
Immunoprecipitation
Product-Category :
Neuroscience
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
70
Host :
Rabbit
Target :
BACE1
Primary-Protein :
BACE
Alt-Names :
APP beta-secretase,ASP2,Asp 2,Aspartyl protease 2,BACE,BACE1,Beta-secretase 1,Beta-site APP cleaving enzyme 1,Beta-site amyloid precursor protein cleaving enzyme 1,FLJ90568,HSPC104,KIAA1149,Memapsin-2,Membrane-associated aspartic protease 2,beta-site APP-cleaving enzyme 1,beta-site amyloid beta A4 precursor protein-cleaving enzyme,transmembrane aspartic proteinase Asp2
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.