| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig s1a
| Barão S, Gärtner A, Leyva DÃaz E, Demyanenko G, Munck S, Vanhoutvin T, et al. Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse. Cell Rep. 2015;12:1367-76 pubmed publisher |
- western blot knockout validation; mouse; fig 5a
- immunohistochemistry - frozen section; mouse; fig 5d
- immunoprecipitation; mouse; fig 1b
- immunoprecipitation; human; fig 2b
- western blot; human; fig 2b
| Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 4a
- western blot; human; 1:1000; loading ...; fig 4b
| Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher |
- western blot; mouse; loading ...; fig 3e
| Pan R, Ma J, Kong X, Wang X, Li S, Qi X, et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 2019;5:eaau6328 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s3b
| Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Huang M, Qi W, Fang S, Jiang P, Yang C, Mo Y, et al. Pigment Epithelium-Derived Factor Plays a Role in Alzheimer's Disease by Negatively Regulating Aβ42. Neurotherapeutics. 2018;15:728-741 pubmed publisher |
- western blot; human; loading ...; fig 1f
| Xu S, Nigam S, Brodin L. Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein. Neurodegener Dis. 2018;18:26-37 pubmed publisher |
- western blot; human; loading ...; fig 3b
| Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher |
- western blot; rat; 1:1500; loading ...; fig 6a
- western blot; human; 1:1500; loading ...; fig 5b
| Roberts H, Schneider B, Brown D. α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP. PLoS ONE. 2017;12:e0171925 pubmed publisher |
- western blot; hamsters; loading ...; fig 8a
| Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher |
- western blot; human; fig 4
| Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, et al. Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Sci Rep. 2016;6:34505 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 8
- western blot; mouse; 1:1000; loading ...; fig ev4b
| Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
- immunocytochemistry; human; 1:250; fig 6
- western blot; human; 1:1000; fig 2
| Kurkinen K, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, et al. SEPT8 modulates ?-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016;129:2224-38 pubmed publisher |
- western blot; mouse; 1:2000; fig 2
| Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed publisher |
- western blot; hamsters; fig 11a
- western blot; mouse; fig 11a
| Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher |
- immunohistochemistry; mouse; fig 7
| Yuan P, Grutzendler J. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016;36:632-41 pubmed publisher |
- western blot; mouse; 1:250; fig 4
| Hou X, Adeosun S, Zhang Q, Barlow B, Brents M, Zheng B, et al. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease. Front Aging Neurosci. 2015;7:207 pubmed publisher |
- immunoprecipitation; mouse
- immunocytochemistry; mouse
- western blot; mouse
| Kizuka Y, Nakano M, Kitazume S, Saito T, Saido T, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016;473:21-30 pubmed publisher |
- western blot; mouse; fig 2a
| Parsi S, Smith P, Goupil C, Dorval V, Hébert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 4c
- western blot; mouse; 1:1000; loading ...; fig 4a
| Bhatt D, Puig K, Gorr M, Wold L, Combs C. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS ONE. 2015;10:e0127102 pubmed publisher |
- immunocytochemistry; mouse; 1:500
- immunohistochemistry; mouse; 1:400
| Li H, Ruberu K, Muñoz S, Jenner A, Spiro A, Zhao H, et al. Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. Neurobiol Aging. 2015;36:1820-33 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:500
| Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher |
- western blot; mouse; 1:1000; fig 3
| Tan M, Yu J, Jiang T, Zhu X, Guan H, Tan L. IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J Alzheimers Dis. 2014;38:633-46 pubmed publisher |
| Lundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed publisher |
| Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher |
| Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al. Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ. Alzheimers Res Ther. 2019;11:97 pubmed publisher |
| Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher |
| Boscher E, Husson T, Quenez O, Laquerriere A, Marguet F, Cassinari K, et al. Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer's Disease. J Alzheimers Dis. 2019;68:1243-1255 pubmed publisher |
| Voytyuk I, Mueller S, Herber J, Snellinx A, Moechars D, Van Loo G, et al. BACE2 distribution in major brain cell types and identification of novel substrates. Life Sci Alliance. 2018;1:e201800026 pubmed publisher |
| Sadleir K, Popovic J, Vassar R. ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease. J Biol Chem. 2018;293:18434-18443 pubmed publisher |
| Chatila Z, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram M, et al. BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice. Eneuro. 2018;5: pubmed publisher |
| Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, et al. BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS ONE. 2018;13:e0200344 pubmed publisher |
| Rao C, Farooqui M, Zhang Y, Asch A, Yamada H. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018;:e12797 pubmed publisher |
| van Nieuwenhove E, Garcia Perez J, Helsen C, Rodriguez P, van Schouwenburg P, Dooley J, et al. A kindred with Mutant IKAROS and autoimmunity. J Allergy Clin Immunol. 2018;: pubmed publisher |
| Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, et al. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018;8:1329 pubmed publisher |
| Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, et al. BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology. Acta Neuropathol. 2018;135:695-710 pubmed publisher |
| Sun M, Zhang H. Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiol Aging. 2017;60:129-140 pubmed publisher |
| Serrano Pozo A, Sánchez GarcÃa M, Heras GarvÃn A, March DÃaz R, Navarro V, Vizuete M, et al. Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo. PLoS ONE. 2017;12:e0170345 pubmed publisher |
| Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed publisher |
| Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W. Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons. Mol Brain. 2015;8:73 pubmed publisher |
| Prasad H, Rao R. The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease. J Biol Chem. 2015;290:5311-27 pubmed publisher |
| Cheret C, Willem M, Fricker F, Wende H, Wulf Goldenberg A, Tahirovic S, et al. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO J. 2013;32:2015-28 pubmed publisher |
| Tan J, Li Q, Ciccotosto G, Crouch P, Culvenor J, White A, et al. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein. PLoS ONE. 2013;8:e61246 pubmed publisher |
| Walker K, Kang E, Whalen M, Shen Y, Tesco G. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 2012;32:10423-37 pubmed publisher |
| Giusti Rodríguez P, Gao J, Graff J, Rei D, Soda T, Tsai L. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of ?-secretase (BACE1). J Neurosci. 2011;31:15751-6 pubmed publisher |
