| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; human; loading ...; fig 8j
- western blot; mouse; loading ...; fig s4a
| Li X, Wu Y, Zhao J, Wang H, Tan J, Yang M, et al. Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus. Theranostics. 2020;10:2675-2695 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5b
| Chen Z, Zhang J, Xue H, Qian M, Guo X, Gao X, et al. Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition. Integr Cancer Ther. 2020;19:1534735419900927 pubmed publisher |
- western blot; human; loading ...; fig 8b
| Tian S, Peng P, Li J, Deng H, Zhan N, Zeng Z, et al. SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway. Aging (Albany NY). 2020;12:3574-3593 pubmed publisher |
- western blot; human; loading ...; fig 5e
| Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4c
| Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 6e
| Zeng S, Bai J, Jiang H, Zhu J, Fu C, He M, et al. Treatment With Liraglutide Exerts Neuroprotection After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway. Front Cell Neurosci. 2019;13:585 pubmed publisher |
- western blot; mouse; 187 ng/ml; loading ...; fig 4c
| Choi J, Zhong X, McAlpine W, Liao T, Zhang D, Fang B, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019;364: pubmed publisher |
- western blot; human; loading ...; fig 1c
| Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, et al. AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. Nat Cell Biol. 2019;21:226-237 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5c
| Ding Y, Li N, Dong B, Guo W, Wei H, Chen Q, et al. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest. 2019;129:759-773 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 8b
| Zhu H, Zhang L, Wu Y, Dong B, Guo W, Wang M, et al. T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. elife. 2018;7: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5a
| Nie S, Tan Y, Zhang Z, Chen G, Xiong J, Hu D, et al. Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities. Front Aging Neurosci. 2018;10:303 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4h
| Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed publisher |
- western blot; mouse; loading ...; fig 3c
| Wang X, Li Q, Liu C, Hall P, Jiang J, Katchis C, et al. Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration. Cell Rep. 2018;24:2540-2552.e6 pubmed publisher |
- western blot; human; loading ...; fig 1d
| Zheng C, Wang J, Lin M, Zhang P, Liu L, Lin J, et al. CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer. J Exp Clin Cancer Res. 2018;37:59 pubmed publisher |
- western blot; mouse; loading ...; fig s3f
| Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher |
- western blot; mouse; fig 4b
| Markussen L, Winther S, Wicksteed B, Hansen J. GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep. 2018;8:3469 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1c
| Xue C, Hong L, Lin J, Yao X, Wu D, Lin X, et al. β-Elemene inhibits the proliferation of primary human airway granulation fibroblasts by down-regulating canonical Wnt/β-catenin pathway. Biosci Rep. 2018;38: pubmed publisher |
- western blot; human; loading ...; fig s2
| Shuang W, Hou L, Zhu Y, Li Q, Hu W. Mcl-1 stabilization confers resistance to taxol in human gastric cancer. Oncotarget. 2017;8:82981-82990 pubmed publisher |
- immunohistochemistry; fruit fly ; fig s2
| Romero Pozuelo J, Demetriades C, Schroeder P, Teleman A. CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc. Dev Cell. 2017;42:376-387.e5 pubmed publisher |
- western blot; mouse; loading ...; fig 2h
| Akiel M, Guo C, Li X, Rajasekaran D, Mendoza R, Robertson C, et al. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer Res. 2017;77:4014-4025 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Suresh S, Chavalmane A, Dj V, Yarreiphang H, Rai S, Paul A, et al. A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity. Autophagy. 2017;13:1221-1234 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4c
| Wang X, Chen H, Tian R, Zhang Y, Drutskaya M, Wang C, et al. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nat Commun. 2017;8:14091 pubmed publisher |
- western blot; mouse; fig 3b
| CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed publisher |
- immunocytochemistry; human; loading ...; fig s1
| Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher |
- western blot; mouse; loading ...; fig 12A
| Shen C, Zhou J, Wang X, Yu X, Liang C, Liu B, et al. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway. EBioMedicine. 2017;16:238-250 pubmed publisher |
- western blot; mouse; fig 1a
| Zheng B, Wang J, Tang L, Tan C, Zhao Z, Xiao Y, et al. Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro. Int J Biol Sci. 2017;13:110-121 pubmed publisher |
- western blot; human; loading ...; fig 4i
| Chen Y, Li C, Xie H, Fan Y, Yang Z, Ma J, et al. Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K→︀AKT→︀GSK3β→︀AM signaling. Oncogene. 2017;36:2879-2888 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 9d
| Hussain R, Macklin W. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017;37:397-412 pubmed publisher |
- western blot; dogs; 1:1000; loading ...; fig 7b
| Wetzel F, Mittag S, Cano Cortina M, Wagner T, Kramer O, Niedenthal R, et al. SUMOylation regulates the intracellular fate of ZO-2. Cell Mol Life Sci. 2017;74:373-392 pubmed publisher |
- immunocytochemistry; mouse; 1:100; loading ...; fig s8d
- western blot; mouse; 1:2000; loading ...; fig s8f
| Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed |
- western blot; human; loading ...; fig 5a
| Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed publisher |
- western blot; human; fig 6a
| Xing H, Lim Y, Chong J, Lee J, Aarsland D, Ballard C, et al. Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with ?-amyloid burden and synaptic deficits in Lewy body dementias. Mol Brain. 2016;9:84 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 8e
| Olianas M, Dedoni S, Onali P. LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells. J Pharmacol Exp Ther. 2016;359:340-353 pubmed |
- western blot; human; fig 5
| Weikel K, Cacicedo J, Ruderman N, Ido Y. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016;36: pubmed publisher |
- western blot; mouse; loading ...; fig 6b
| Chelko S, Asimaki A, Andersen P, Bedja D, Amat Alarcon N, Demazumder D, et al. Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016;1: pubmed publisher |
- western blot; human; fig 6
| Bie Q, Sun C, Gong A, Li C, Su Z, Zheng D, et al. Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer. Sci Rep. 2016;6:25447 pubmed publisher |
- western blot; mouse; 1:500; fig 3c
| Li N, Liu S, Zhang H, Deng Z, Zhao H, Zhao Q, et al. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles. Int J Mol Sci. 2016;17: pubmed publisher |
- western blot; human; loading ...; fig 3c
| Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, et al. Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation. Biochim Biophys Acta. 2016;1863:1106-18 pubmed publisher |
- western blot; human; fig 4
| Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed publisher |
- western blot; mouse; fig 3
| da Rocha A, Pereira B, Pauli J, Cintra D, De Souza C, Ropelle E, et al. Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. PLoS ONE. 2015;10:e0140020 pubmed publisher |
- western blot; human; loading ...; fig 5e
| Salim H, Zong D, Hååg P, Novak M, Mörk B, Lewensohn R, et al. DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines. BMC Cancer. 2015;15:628 pubmed publisher |
- western blot; mouse; 1:1000; fig s3
| Plescher M, Teleman A, Demetriades C. TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1. Sci Rep. 2015;5:13828 pubmed publisher |
- western blot; human; fig 1
| Chiang K, Chen H, Hsu S, Pang J, Wang S, Hsu J, et al. PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Des Devel Ther. 2015;9:4631-8 pubmed publisher |
- western blot; human; fig 3
| Reis C, Chen P, Srinivasan S, Aguet F, Mettlen M, Schmid S. Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis. EMBO J. 2015;34:2132-46 pubmed publisher |
- western blot; human; fig 5
| Shi C, Zhang M, Tong M, Yang L, Pang L, Chen L, et al. miR-148a is Associated with Obesity and Modulates Adipocyte Differentiation of Mesenchymal Stem Cells through Wnt Signaling. Sci Rep. 2015;5:9930 pubmed publisher |
| Moreira J, Wohlwend M, Alves M, Wisløff U, Bye A. A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med. 2015;13:76 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Hossini A, Megges M, Prigione A, Lichtner B, Toliat M, Wruck W, et al. Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. BMC Genomics. 2015;16:84 pubmed publisher |
- western blot; mouse; 1:1000; fig 4a
| Zheng T, Yang X, Wu D, Xing S, Bian F, Li W, et al. Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway. Br J Pharmacol. 2015;172:3284-301 pubmed publisher |
| Williams J, Ni H, Haynes A, Manley S, Li Y, Jaeschke H, et al. Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice. J Biol Chem. 2015;290:10934-46 pubmed publisher |
| Manley S, Ni H, Williams J, Kong B, DiTacchio L, Guo G, et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol. 2014;2:991-1002 pubmed publisher |
- western blot; human; fig 6
| Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher |
| McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-? response and ROR?t localization. Eur J Immunol. 2014;44:1137-42 pubmed publisher |
- western blot; human; fig 6
| BENTLEY C, Jurinka S, Kljavin N, Vartanian S, Ramani S, Gonzalez L, et al. A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation. Biochem J. 2013;452:313-20 pubmed publisher |
| Chopra S, Jenney A, Palmer A, Niepel M, Chung M, Mills C, et al. Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells. Cell Syst. 2019;: pubmed publisher |
| Ligorio M, Sil S, Malagon Lopez J, Nieman L, Misale S, Di Pilato M, et al. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019;: pubmed publisher |
| Lun X, Szklarczyk D, Gábor A, Dobberstein N, Zanotelli V, Saez Rodriguez J, et al. Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. Mol Cell. 2019;74:1086-1102.e5 pubmed publisher |
| Götzel K, Chemnitzer O, Maurer L, Dietrich A, Eichfeld U, Lyros O, et al. In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett's sequence. BMC Gastroenterol. 2019;19:38 pubmed publisher |
| Liu B, Yang H, Pilarsky C, Weber G. The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer. Int J Mol Sci. 2018;19: pubmed publisher |
| Wang Y, Wong C, Yan M, Li L, Liu T, Or P, et al. Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Cancer Lett. 2018;429:54-65 pubmed publisher |
| Venkataramani V, Küffer S, Cheung K, Jiang X, Trumper L, Wulf G, et al. CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas. Clin Cancer Res. 2018;24:460-473 pubmed publisher |
| Hadjadj D, Kim S, Denecker T, Ben Driss L, Cadoret J, Maric C, et al. A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas. Aging (Albany NY). 2017;9:2695-2716 pubmed publisher |
| Zhang Y, Yin B, Shu B, Liu Z, Ding H, Jia C. Differential expression of microRNA let-7b-5p regulates burn-induced hyperglycemia. Oncotarget. 2017;8:72886-72892 pubmed publisher |
| Wang Y, Fu D, Su J, Chen Y, Qi C, Sun Y, et al. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells. Sci Rep. 2017;7:999 pubmed publisher |
| Ohtsuka H, Iguchi T, Hayashi M, Kaneda M, Iida K, Shimonaka M, et al. SDF-1?/CXCR4 Signaling in Lipid Rafts Induces Platelet Aggregation via PI3 Kinase-Dependent Akt Phosphorylation. PLoS ONE. 2017;12:e0169609 pubmed publisher |
| Montoya A, Amaya C, Belmont A, Diab N, Trevino R, Villanueva G, et al. Use of non-selective β-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget. 2017;8:6446-6460 pubmed publisher |
| Guo J, Yang L, Qiao Y, Liu Z. Glycogen synthase kinase?3? is required for epithelial?mesenchymal transition and barrier dysfunction in mouse podocytes under high glucose conditions. Mol Med Rep. 2016;14:4091-4098 pubmed publisher |
| Kotoh J, Sasaki D, Matsumoto K, Maeda A. Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. J Vet Med Sci. 2016;78:1683-1691 pubmed |
| Zhang M, Yin H, Wang W, Li J, Wang X. Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest. Acta Pharmacol Sin. 2016;37:1190-8 pubmed publisher |
| Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, et al. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget. 2016;7:45414-45428 pubmed publisher |
| Mukherji A, Kobiita A, Chambon P. Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours. Proc Natl Acad Sci U S A. 2015;112:E6683-90 pubmed publisher |
| Guidotti S, Minguzzi M, Platano D, Cattini L, Trisolino G, Mariani E, et al. Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients. PLoS ONE. 2015;10:e0143865 pubmed publisher |
| Zuckermann A, La Ragione R, Baines D, Williams R. Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model. Br J Pharmacol. 2015;172:5306-17 pubmed publisher |
| Otsuka R, Harada N, Aoki S, Shirai K, Nishitsuji K, Nozaki A, et al. C-terminal region of GADD34 regulates eIF2α dephosphorylation and cell proliferation in CHO-K1 cells. Cell Stress Chaperones. 2016;21:29-40 pubmed publisher |
| Sidrauski C, Tsai J, Kampmann M, Hearn B, Vedantham P, Jaishankar P, et al. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. elife. 2015;4:e07314 pubmed publisher |
| Schulz E, Klampfl P, Holzapfel S, Janecke A, Ulz P, Renner W, et al. Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X. Nat Commun. 2014;5:5191 pubmed publisher |
| Wilson S, Moutal A, Melemedjian O, Wang Y, Ju W, François Moutal L, et al. The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Front Cell Neurosci. 2014;8:196 pubmed publisher |
| Mudireddy S, Abdul A, Gorjala P, Gary R. Beryllium is an inhibitor of cellular GSK-3? that is 1,000-fold more potent than lithium. Biometals. 2014;27:1203-16 pubmed publisher |
| Grassilli E, Ianzano L, Bonomo S, Missaglia C, Cerrito M, Giovannoni R, et al. GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. PLoS ONE. 2014;9:e100947 pubmed publisher |
| Masvekar R, El Hage N, Hauser K, Knapp P. Morphine enhances HIV-1SF162-mediated neuron death and delays recovery of injured neurites. PLoS ONE. 2014;9:e100196 pubmed publisher |
| Deng H, Zhang X, Wang M, Zheng H, Liu L, Wang Z. ER-?36-mediated rapid estrogen signaling positively regulates ER-positive breast cancer stem/progenitor cells. PLoS ONE. 2014;9:e88034 pubmed publisher |
| Fedorchenko O, Stiefelhagen M, Peer Zada A, Barthel R, Mayer P, Eckei L, et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood. 2013;121:4126-36 pubmed publisher |
| Ikushima Y, Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, et al. Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. Blood. 2013;121:1995-2007 pubmed publisher |
| Mirlashari M, Randen I, Kjeldsen Kragh J. Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway. Leuk Res. 2012;36:499-508 pubmed publisher |
