| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; loading ...; fig 2e
| Abe H, Satoh J, Shirasaka Y, Kogure A, Kato H, Ito S, et al. Priming Phosphorylation of TANK-Binding Kinase 1 by IκB Kinase β Is Essential in Toll-Like Receptor 3/4 Signaling. Mol Cell Biol. 2020;40: pubmed publisher |
- immunocytochemistry; human; 1:250; fig 2
- western blot; human; 1:2000; fig 5
- immunocytochemistry knockout validation; mouse; 1:250; fig 1f
- western blot; mouse; 1:2000; fig 5
| Pourcelot M, Zemirli N, Silva da Costa L, Loyant R, Garcin D, Vitour D, et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. BMC Biol. 2016;14:69 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2d
| Zhang Q, Xiu B, Zhang L, Chen M, Chi W, Li L, et al. Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization. J Immunother Cancer. 2022;10: pubmed publisher |
- western blot; mouse; loading ...; fig 1b, 4g
| Zang N, Cui C, Guo X, Song J, Hu H, Yang M, et al. cGAS-STING activation contributes to podocyte injury in diabetic kidney disease. iScience. 2022;25:105145 pubmed publisher |
- western blot; mouse; loading ...; fig 3b
- western blot; human; loading ...; fig 5f
| Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, et al. T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer. J Immunother Cancer. 2022;10: pubmed publisher |
- western blot; mouse; fig 5e
| Zhao X, Hu S, Zeng L, Liu X, Song Y, Zhang Y, et al. Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation. iScience. 2022;25:104690 pubmed publisher |
- western blot; human; loading ...; fig 2k
| Tan H, Yong Y, Xue Y, Liu H, Furihata T, Shankar E, et al. cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model. iScience. 2022;25:104404 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2b
| Taniguchi H, Caeser R, Chavan S, Zhan Y, Chow A, Manoj P, et al. WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC. Cell Rep. 2022;39:110814 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4e, 4f
| Li C, Shen Q, Zhang P, Wang T, Liu W, Li R, et al. Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells. J Exp Clin Cancer Res. 2021;40:315 pubmed publisher |
- western blot; pigs ; loading ...; fig 1i
| Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, et al. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathog. 2021;17:e1009940 pubmed publisher |
- western blot; human; loading ...; fig 1d
| Proctor M, Gonzalez Cruz J, Daignault Mill S, Veitch M, Zeng B, Ehmann A, et al. Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers (Basel). 2021;13: pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig s3a, s3b
| Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep. 2021;36:109412 pubmed publisher |
- western blot; mouse; loading ...; fig 5g
| Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, et al. Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury. Cell Death Dis. 2021;12:673 pubmed publisher |
- western blot; mouse; loading ...; fig 2g
| Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, et al. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep. 2021;35:109272 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Wu W, Qu Y, Yu S, Wang S, Yin Y, Liu Q, et al. Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity. MBio. 2021;12:e0100521 pubmed publisher |
- western blot; human; 1:1000; fig 3e
| Kulkarni N, O Neill A, Dokoshi T, Luo E, Wong G, Gallo R. Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors. J Biol Chem. 2021;297:100828 pubmed publisher |
- western blot; mouse; loading ...; fig 5h
| Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, et al. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. J Nutr Biochem. 2021;95:108761 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 7a
| Jang S, Economides K, Moniz R, Sia C, Lewis N, McCoy C, et al. ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance. Commun Biol. 2021;4:497 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Hung C, Lombardo P, Malik N, Brun S, Hellberg K, Van Nostrand J, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021;7: pubmed publisher |
- western blot; human; 1:2000
| Lopacinski A, Sweatt A, Smolko C, Gray Gaillard E, Borgman C, Shah M, et al. Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Cell Syst. 2021;12:304-323.e13 pubmed publisher |
- western blot; mouse; loading ...; fig 3f, 6e
| Yu Z, Li X, Yang M, Huang J, Fang Q, Jia J, et al. TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO. Signal Transduct Target Ther. 2021;6:90 pubmed publisher |
- western blot; human; 1:2000; fig s3b
| Zhou R, Wu Q, Wang M, Irani S, Li X, Zhang Q, et al. The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. PLoS Biol. 2021;19:e3001122 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1e
| Hou P, Jia P, Yang K, Li Z, Tian T, Lin Y, et al. An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
- western blot; mouse; loading ...; fig 3h
| Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, et al. ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth. Cancer Res. 2021;81:174-186 pubmed publisher |
- western blot; mouse; loading ...; fig s7a
| Zhang D, Liu C, Li H, Jiao J. Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors. Adv Sci (Weinh). 2020;7:2002117 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
| Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, et al. Reactive oxygen species oxidize STING and suppress interferon production. elife. 2020;9: pubmed publisher |
- western blot; human; loading ...; fig 4c
| Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, et al. Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. J Cell Biol. 2020;219: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 8b
| Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 2020;11:2488 pubmed publisher |
- western blot; human; loading ...; fig s1a
| Blanco Melo D, Nilsson Payant B, Liu W, Uhl S, Hoagland D, Møller R, et al. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell. 2020;181:1036-1045.e9 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 3f
- western blot; human; 1:2000; loading ...; fig 2c
| Deng M, Tam J, Wang L, Liang K, Li S, Zhang L, et al. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun. 2020;11:2193 pubmed publisher |
- western blot; mouse; 1:1000; loading ...
| Wu Y, Chou T, Young L, Hsieh F, Pan H, Mo S, et al. Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation. Cell Death Dis. 2020;11:305 pubmed publisher |
- western blot; human; loading ...; fig 3c
| Nixon C, Mavigner M, Sampey G, Brooks A, Spagnuolo R, Irlbeck D, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020;578:160-165 pubmed publisher |
- other; mouse; 1:400; loading ...; fig 5
| Budzik J, Swaney D, Jimenez Morales D, Johnson J, Garelis N, Repasy T, et al. Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages. elife. 2020;9: pubmed publisher |
- western blot; human; loading ...; fig 4a
| Cai H, Yan L, Liu N, Xu M, Cai H. IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway. Biomed Pharmacother. 2020;123:109790 pubmed publisher |
- proximity ligation assay; human; 1:1000; loading ...; fig 3a
| Luteijn R, Zaver S, Gowen B, Wyman S, Garelis N, Onia L, et al. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019;573:434-438 pubmed publisher |
- western blot; human; loading ...
| Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, et al. Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS Pathog. 2019;15:e1008002 pubmed publisher |
- western blot; human; loading ...; fig 2f
| Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, et al. NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1. J Immunol. 2019;: pubmed publisher |
- western blot; human; loading ...; fig 2c
| Zhang W, Wang G, Xu Z, Tu H, Hu F, Dai J, et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019;: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1b
| Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell S, et al. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature. 2019;: pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig 9d
- western blot; mouse; 1:1000; loading ...; fig 9a
| Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, et al. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging (Albany NY). 2019;11:2457-2476 pubmed publisher |
- western blot; human; loading ...; fig 5f
| Liu C, Li X, Nan F, Jiang S, Gao X, Guo S, et al. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell. 2019;177:865-880.e21 pubmed publisher |
- immunocytochemistry; mouse; 1:100; loading ...; fig 2e
- western blot; mouse; loading ...; fig 2a, s2e
| Tan Y, Kagan J. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019;: pubmed publisher |
- western blot; human; loading ...; fig 5d
| Dai J, Huang Y, He X, Zhao M, Wang X, Liu Z, et al. Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Cell. 2019;: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a, 3c, s3d
| Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher |
- western blot; mouse; loading ...; fig 6c
| Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 1p, 5g, 6f
- western blot; human; 1:500; loading ...; fig 2d, 2l
| Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, et al. STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun. 2018;9:5226 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Mohamud Y, Qu J, Xue Y, Liu H, Deng H, Luo H. CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation. Cell Death Differ. 2019;26:1062-1076 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Qi D, Hu L, Jiao T, Zhang T, Tong X, Ye X. Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity. J Virol. 2018;92: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s4a
| Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher |
- immunocytochemistry; mouse; fig 7e
| Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 4b
| Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, et al. UBXN3B positively regulates STING-mediated antiviral immune responses. Nat Commun. 2018;9:2329 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1b
- western blot; human; 1:1000; loading ...; fig 1a
| Lork M, Kreike M, Staal J, Beyaert R. Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKK?/TBK1 as a Case Study. Front Cell Dev Biol. 2018;6:40 pubmed publisher |
- western blot; human; loading ...; fig 3
| Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher |
- western blot; mouse; fig 2j
| Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher |
- western blot; human; loading ...; fig 5b
| Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 6e
- western blot; human; 1:1000; loading ...; fig 6a
| Goodwin J, Dowdle W, Dejesus R, Wang Z, Bergman P, Kobylarz M, et al. Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9. Cell Rep. 2017;20:2341-2356 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Luecke S, Holleufer A, Christensen M, Jønsson K, Boni G, Sørensen L, et al. cGAS is activated by DNA in a length-dependent manner. EMBO Rep. 2017;18:1707-1715 pubmed publisher |
- western blot; human; fig 4
| Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Bhattacharya S, Srinivasan K, Abdisalaam S, Su F, Raj P, Dozmorov I, et al. RAD51 interconnects between DNA replication, DNA repair and immunity. Nucleic Acids Res. 2017;45:4590-4605 pubmed publisher |
- immunocytochemistry; human; loading ...; fig s1
| Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7b
| Almine J, O Hare C, Dunphy G, Haga I, Naik R, Atrih A, et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun. 2017;8:14392 pubmed publisher |
- western blot; mouse; fig 3b
- western blot; human; loading ...; fig 2b
| Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher |
- western blot; human; loading ...; fig 2d
| Jønsson K, Laustsen A, Krapp C, Skipper K, Thavachelvam K, Hotter D, et al. IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun. 2017;8:14391 pubmed publisher |
- immunoprecipitation; mouse; loading ...; fig 4
- western blot; mouse; loading ...; fig 2A
- western blot; human; loading ...; fig 5A
| Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Lin T, Cheng C, Su H, Huang N, Chen J, Kang H, et al. Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus. Front Immunol. 2016;7:440 pubmed |
- western blot; human; loading ...; fig 7c
| Zhang X, Zheng Z, Liu X, Shu B, Mao P, Bai B, et al. Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway. J Neuroinflammation. 2016;13:209 pubmed publisher |
- western blot; mouse; fig 4c
| Kim J, Weeratunga P, Kim M, Nikapitiya C, Lee B, Uddin M, et al. Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med. 2016;16:265 pubmed publisher |
- other; African green monkey; 1:50; fig 1
- immunocytochemistry; African green monkey; 1:100; fig 1
- western blot; African green monkey; 1:1000; fig 1
- immunocytochemistry; mouse; 1:100; fig s4
- western blot; mouse; 1:1000; fig 3
| Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, et al. Activation of STING requires palmitoylation at the Golgi. Nat Commun. 2016;7:11932 pubmed publisher |
- western blot; mouse; fig 1a
| Anghelina D, Lam E, Falck Pedersen E. Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. J Virol. 2016;90:5915-27 pubmed publisher |
- western blot; human; fig 3
| Richter B, Sliter D, Herhaus L, Stolz A, Wang C, Beli P, et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016;113:4039-44 pubmed publisher |
- western blot; human; fig 4
| Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-? regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher |
- western blot; human; loading ...; fig 2e
| Qin Y, Liu Q, Tian S, Xie W, Cui J, Wang R. TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3? to TBK1. Cell Res. 2016;26:613-28 pubmed publisher |
- western blot; human; fig s2
| Zhang G, Chan B, Samarina N, Abere B, Weidner Glunde M, Buch A, et al. Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci U S A. 2016;113:E1034-43 pubmed publisher |
- immunocytochemistry; human; fig 1
- western blot; human; 1:1000; fig 1
| Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun. 2015;6:10072 pubmed publisher |
| Sirohi K, Kumari A, Radha V, Swarup G. A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. PLoS ONE. 2015;10:e0138289 pubmed publisher |
- western blot; mouse; fig 4
- western blot; human; fig 4
| Khan K, Dô F, Marineau A, Doyon P, Clément J, Woodgett J, et al. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed publisher |
- western blot; mouse; fig 1
| Malik N, Vollmer S, Nanda S, López Pelaéz M, Prescott A, Gray N, et al. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. Biochem J. 2015;468:363-72 pubmed publisher |
- western blot; mouse; fig 4
- western blot; human; fig 4
| Majumdar T, Chattopadhyay S, Ozhegov E, Dhar J, Goswami R, Sen G, et al. Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLoS Pathog. 2015;11:e1004779 pubmed publisher |
- western blot; human; fig 2
| Kemp M, Lindsey Boltz L, Sancar A. UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1). J Biol Chem. 2015;290:12184-94 pubmed publisher |
- western blot; mouse; fig 4
| West A, Khoury Hanold W, Staron M, Tal M, Pineda C, Lang S, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520:553-7 pubmed publisher |
- immunoprecipitation; human
- immunocytochemistry; human
- western blot; human
- immunoprecipitation; mouse
- immunocytochemistry; mouse
- western blot; mouse
| Ro S, Semple I, Park H, Park H, Park H, Kim M, et al. Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014;281:3816-27 pubmed publisher |
| Alshebremi M, Tomchuck S, Myers J, Kingsley D, Eid S, Abiff M, et al. Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation. J Immunother Cancer. 2023;11: pubmed publisher |
| Jeremiah N, Ferran H, Antoniadou K, De Azevedo K, Nikolic J, Maurin M, et al. RELA tunes innate-like interferon I/III responses in human T cells. J Exp Med. 2023;220: pubmed publisher |
| Zhou J, Sarkar M, Okamura K, Harris J, Gudjonsson J, Fitzgerald K. Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Proc Natl Acad Sci U S A. 2023;120:e2213777120 pubmed publisher |
| Tabtieng T, Lent R, Kaku M, Monago Sanchez A, Gaglia M. Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi's Sarcoma-Associated Herpesvirus Infection. MBio. 2022;13:e0244622 pubmed publisher |
| Steiner A, Hrovat Schaale K, Prigione I, Yu C, Laohamonthonkul P, Harapas C, et al. Deficiency in coatomer complex I causes aberrant activation of STING signalling. Nat Commun. 2022;13:2321 pubmed publisher |
| Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, et al. m6A modifications regulate intestinal immunity and rotavirus infection. elife. 2022;11: pubmed publisher |
| Huang L, Xu W, Liu H, Xue M, Liu X, Zhang K, et al. African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1. J Immunol. 2021;207:2754-2769 pubmed publisher |
| Fermaintt C, Takahashi Ruiz L, Liang H, Mooberry S, Risinger A. Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA. Mol Pharmacol. 2021;100:309-318 pubmed publisher |
| Li S, Shao Q, Zhu Y, Ji X, Luo J, Xu Y, et al. Porcine RIG-I and MDA5 Signaling CARD Domains Exert Similar Antiviral Function Against Different Viruses. Front Microbiol. 2021;12:677634 pubmed publisher |
| Li S, Yang J, Zhu Y, Wang H, Ji X, Luo J, et al. Analysis of Porcine RIG-I Like Receptors Revealed the Positive Regulation of RIG-I and MDA5 by LGP2. Front Immunol. 2021;12:609543 pubmed publisher |
| Kim J, Cho E, Mun S, Kim S, Kim S, Kim D, et al. Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis. Biomedicines. 2021;9: pubmed publisher |
| Beel S, Kolloch L, Apken L, Jürgens L, Bolle A, Sudhof N, et al. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Nat Commun. 2020;11:3409 pubmed publisher |
| Zhou C, Chen X, Planells Cases R, Chu J, Wang L, Cao L, et al. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020;52:767-781.e6 pubmed publisher |
| Xu X, Kalac M, Markson M, Chan M, Brody J, Bhagat G, et al. Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL). Cell Death Dis. 2020;11:94 pubmed publisher |
| Zhang H, Christensen C, Dries R, Oser M, Deng J, Diskin B, et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2019;: pubmed publisher |
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