product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Akt (pan) (C67E7) Rabbit mAb (Biotinylated)
catalog :
5373
clonality :
monoclonal
host :
rabbit
conjugate :
biotin
clone name :
C67E7
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry - frozen section
citations: 58
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 9
E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Selfridge J, Wilkins H, E L, Carl S, Koppel S, Funk E, et al. Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure. J Bioenerg Biomembr. 2015;47:1-11 pubmed publisher
  • western blot; mouse; 1:1000
E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-2583 pubmed publisher
Nakakido M, Deng Z, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN. Neoplasia. 2015;17:367-73 pubmed publisher
Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, et al. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochem Pharmacol. 2015;95:16-27 pubmed publisher
Rohrbach T, Jarboe J, Anderson J, Trummell H, Hicks P, Weaver A, et al. Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Int J Oncol. 2015;46:1079-88 pubmed publisher
Kuboki Y, Shimizu K, Hatori T, Yamamoto M, Shibata N, Shiratori K, et al. Molecular biomarkers for progression of intraductal papillary mucinous neoplasm of the pancreas. Pancreas. 2015;44:227-35 pubmed publisher
Aoyama A, Katayama R, Oh hara T, Sato S, Okuno Y, Fujita N. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance. Mol Cancer Ther. 2014;13:2978-90 pubmed publisher
Bao M, Zhang Y, Lou X, Cheng Y, Zhou H. Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries. PLoS ONE. 2014;9:e106540 pubmed publisher
Katayama R, Friboulet L, Koike S, Lockerman E, Khan T, Gainor J, et al. Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib. Clin Cancer Res. 2014;20:5686-96 pubmed publisher
Trucco L, Andreoli V, Núñez N, Maccioni M, Bocco J. Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. FASEB J. 2014;28:5262-76 pubmed publisher
Wang Q, Wang H, Zhang Y, Zhang Y, Xiao W. Activation of uPAR is required for cigarette smoke extract-induced epithelial-mesenchymal transition in lung epithelial cells. Oncol Res. 2013;21:295-305 pubmed publisher
Zhang X, Yang B, Wang J, Mo X, Zhang J, Hua Z. FADD is essential for glucose uptake and survival of thymocytes. Biochem Biophys Res Commun. 2014;451:202-7 pubmed publisher
Shimabukuro J, Yamaoka A, Murata K, Kotani E, Hirano T, Nakajima Y, et al. 3D co-cultures of keratinocytes and melanocytes and cytoprotective effects on keratinocytes against reactive oxygen species by insect virus-derived protein microcrystals. Mater Sci Eng C Mater Biol Appl. 2014;42:64-9 pubmed publisher
Hauser J, Lindner R. Coalescence of B cell receptor and invariant chain MHC II in a raft-like membrane domain. J Leukoc Biol. 2014;96:843-55 pubmed publisher
Gronnier C, Bruyère E, Lahdaoui F, Jonckheere N, Perrais M, Leteurtre E, et al. The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. Biochim Biophys Acta. 2014;1843:2432-7 pubmed publisher
Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, et al. CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE. 2014;9:e101137 pubmed publisher
Takagi S, Takemoto A, Takami M, Oh hara T, Fujita N. Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis. Cancer Sci. 2014;105:983-8 pubmed publisher
Algars A, Avoranta T, Osterlund P, Lintunen M, Sundström J, Jokilehto T, et al. Heterogeneous EGFR gene copy number increase is common in colorectal cancer and defines response to anti-EGFR therapy. PLoS ONE. 2014;9:e99590 pubmed publisher
Fuke Y, Hishinuma M, Namikawa M, Oishi Y, Matsuzaki T. Wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human breast cancer by possible involvement of the NF-?B pathways. Nutr Cancer. 2014;66:879-87 pubmed publisher
Kim H, Abd Elmageed Z, Davis C, El Bahrawy A, Naura A, Ekaidi I, et al. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37. Mol Med. 2014;20:270-9 pubmed publisher
Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. Reprint of "GPR30 mediates estrogen rapid signaling and neuroprotection". Mol Cell Endocrinol. 2014;389:92-8 pubmed publisher
Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, et al. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med. 2014;3:734-44 pubmed publisher
Bao M, Zhang Y, Lou X, Xiao Y, Cheng Y, Zhou H. Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. Can J Physiol Pharmacol. 2014;92:299-306 pubmed publisher
Cheng X, Li Y, Tan J, Sun B, Xiao Y, Fang X, et al. CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition. Cancer Lett. 2014;348:77-87 pubmed publisher
Medina E, Oberheu K, Polusani S, Ortega V, Velagaleti G, Oyajobi B. PKA/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells. Leukemia. 2014;28:2080-9 pubmed publisher
Schmid C, Streicher J, Meltzer H, Bohn L. Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a ?arrestin2-independent activation of Akt. Neuropsychopharmacology. 2014;39:1902-13 pubmed publisher
Xiao W, Feng Y, Holst J, Hartmann B, Yang H, Teitelbaum D. Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. FASEB J. 2014;28:2073-87 pubmed publisher
Ghosh A, Lu G, Su G, McEvoy B, Sadiq O, DiMusto P, et al. Phosphorylation of AKT and abdominal aortic aneurysm formation. Am J Pathol. 2014;184:148-58 pubmed publisher
Miura H, Matsuda M, Aoki K. Development of a FRET biosensor with high specificity for Akt. Cell Struct Funct. 2014;39:9-20 pubmed
El Gazzar A, Cai X, Reeves R, Dai Z, Caballero Benítez A, McDonald D, et al. Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells. Oncogene. 2014;33:4932-40 pubmed publisher
Mukhopadhyay C, Zhao X, Maroni D, Band V, Naramura M. Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. PLoS ONE. 2013;8:e75907 pubmed publisher
Kota V, Dhople V, Fullbright G, Smythe N, Szulc Z, Bielawska A, et al. 2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells. J Proteome Res. 2013;12:4366-75 pubmed publisher
Lorenzato A, Biolatti M, Delogu G, Capobianco G, Farace C, Dessole S, et al. AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells. Exp Cell Res. 2013;319:2627-36 pubmed publisher
Liao R, Jung J, Tchaicha J, Wilkerson M, Sivachenko A, Beauchamp E, et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 2013;73:5195-205 pubmed publisher
Guo F, Ma Y, Kadegowda A, Betters J, Xie P, Liu G, et al. Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res. 2013;54:2109-20 pubmed publisher
Fujiki K, Inamura H, Matsuoka M. Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium. Arch Toxicol. 2013;87:2119-27 pubmed publisher
Sadighi Akha A, Theriot C, Erb Downward J, McDermott A, Falkowski N, Tyra H, et al. Acute infection of mice with Clostridium difficile leads to eIF2? phosphorylation and pro-survival signalling as part of the mucosal inflammatory response. Immunology. 2013;140:111-22 pubmed publisher
Nakles R, Kallakury B, Furth P. The PPAR? agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency. Am J Pathol. 2013;182:1976-85 pubmed publisher
de Jong A, Maass A, Oberdorf Maass S, de Boer R, van Gilst W, Van Gelder I. Cyclical stretch induces structural changes in atrial myocytes. J Cell Mol Med. 2013;17:743-53 pubmed publisher
Wu S, Ju G, Du T, Zhu Y, Liu G. Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo. PLoS ONE. 2013;8:e61366 pubmed publisher
Goyal P, Brünnert D, Ehrhardt J, Bredow M, Piccenini S, Zygmunt M. Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. Mol Hum Reprod. 2013;19:528-38 pubmed publisher
Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed publisher
Benhenda S, Ducroux A, Rivi re L, Sobhian B, Ward M, Dion S, et al. Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription. J Virol. 2013;87:4360-71 pubmed publisher
Cervelli V, Scioli M, Gentile P, Doldo E, Bonanno E, Spagnoli L, et al. Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance. Stem Cells Transl Med. 2012;1:206-20 pubmed publisher
Wu A, Dalvi P, Lu X, Yang M, Riddick D, Matthews J, et al. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol Pharmacol. 2013;83:377-88 pubmed publisher
Asai J, Takenaka H, Hirakawa S, Sakabe J, Hagura A, Kishimoto S, et al. Topical simvastatin accelerates wound healing in diabetes by enhancing angiogenesis and lymphangiogenesis. Am J Pathol. 2012;181:2217-24 pubmed publisher
Tsujimoto I, Yoshida A, Yoneda Kato N, Kato J. Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells. FEBS Lett. 2012;586:4326-31 pubmed publisher
Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, Tanaka K, Miyata T, et al. Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement Altern Med. 2012;12:188 pubmed publisher
Fujita M, Tohji C, Honda Y, Yamamoto Y, Nakamura T, Yagami T, et al. Cytotoxicity of 15-deoxy-?(12,14)-prostaglandin J(2) through PPAR?-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. Int J Med Sci. 2012;9:555-66 pubmed
Cheng L, Lin Z, Shu R, Liu D, Zhang X, Liu B, et al. Analogous effects of recombinant human full-length amelogenin expressed by Pichia pastoris yeast and enamel matrix derivative in vitro. Cell Prolif. 2012;45:456-65 pubmed publisher
Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, et al. Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model. Mol Cancer. 2012;11:46 pubmed publisher
Almansour N, Pirogova E, Coloe P, Cosic I, Istivan T. A bioactive peptide analogue for myxoma virus protein with a targeted cytotoxicity for human skin cancer in vitro. J Biomed Sci. 2012;19:65 pubmed publisher
Sharma N, Kumar V, Everingham S, Mali R, Kapur R, Zeng L, et al. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012;32:2653-63 pubmed publisher
Mundra J, Terskiy A, Howells R. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther. 2012;342:273-87 pubmed publisher
Zhang S, Zhou X, Lang R, Guo F. RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS ONE. 2012;7:e33773 pubmed publisher
Jonckheere N, Skrypek N, Merlin J, Dessein A, Dumont P, Leteurtre E, et al. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PLoS ONE. 2012;7:e32232 pubmed publisher
Wen Q, Zhou L, Zhou C, Zhou M, Luo W, Ma L. Change in hepatocyte growth factor concentration promote mesenchymal stem cell-mediated osteogenic regeneration. J Cell Mol Med. 2012;16:1260-73 pubmed publisher
product information
SKU :
5373S
Product-Name :
Akt (pan) (C67E7) Rabbit mAb (Biotinylated)
Size :
100 ul
Price-(USD) :
291 USD
Species-x-Reactivity :
H, M, R, Mk, Dm, (Pg)
Applications :
Western blot
Product-Category :
PI3K / Akt Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
60
Host :
Rabbit
Target :
Akt1/Akt2/Akt3
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.