| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; loading ...; fig s6b
| Singh A, Khare P, Obaid A, Conlon K, Basrur V, Depinho R, et al. SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018;9:4515 pubmed publisher |
- western blot; human; loading ...; fig 1g
| Song K, Kim J, Lee Y, Bae H, Lee H, Woo S, et al. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance. J Clin Invest. 2018;128:4098-4114 pubmed publisher |
- western blot; human; loading ...; fig s6c
| Alam M, Gaida M, Debnath S, Tagad H, Miller Jenkins L, Appella E, et al. Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. PLoS Biol. 2018;16:e2004111 pubmed publisher |
- immunoprecipitation; human; loading ...; fig 3a
- western blot; human; loading ...; fig 1b
| Tikhanovich I, Zhao J, Bridges B, Kumer S, Roberts B, Weinman S. Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300. J Biol Chem. 2017;292:13333-13344 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7c
| Yi J, Paranjape S, Walker M, Choudhury R, Wolter J, Fragola G, et al. The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/?-catenin pathway by inhibiting the proteasome. J Biol Chem. 2017;292:12503-12515 pubmed publisher |
- immunohistochemistry - frozen section; human; loading ...; fig 7b
| Almeida L, Neto M, Sousa L, Tannous M, Curti C, Leopoldino A. SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. Oncotarget. 2017;8:26802-26818 pubmed publisher |
- western blot; human; loading ...; fig 6c
| Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, et al. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017;127:2235-2248 pubmed publisher |
- chromatin immunoprecipitation; rat; loading ...; fig 2d
- immunohistochemistry; rat; 1:200; loading ...; fig 2c
- western blot; rat; 1:1000; loading ...; fig 2a
| Tao C, Hsu W, Ma Y, Cheng S, Lee E. Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ. 2017;24:597-614 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 4a
| Gilbert J, Man H. The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and ?-Catenin Signaling. Eneuro. 2016;3: pubmed |
- western blot; human; loading ...; fig 5d
| Bao M, Wang Y, Liu Y, Shi P, Lu H, Sha W, et al. NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells. J Exp Med. 2016;213:2383-2398 pubmed |
- immunoprecipitation; human; fig 5a
- western blot; human; fig 2b
| Kehrli K, Phelps M, Lazarchuk P, Chen E, Monnat R, Sidorova J. Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest. J Biol Chem. 2016;291:24487-24503 pubmed |
- western blot; human; fig 1b
| Ramakrishnan S, Ku S, Ciamporcero E, Miles K, Attwood K, Chintala S, et al. HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. BMC Cancer. 2016;16:617 pubmed publisher |
- western blot; human; loading ...; fig 6c
| Gay G, Braun L, Brenier Pinchart M, Vollaire J, Josserand V, Bertini R, et al. Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-?-mediated host defenses. J Exp Med. 2016;213:1779-98 pubmed publisher |
- western blot; human; 1:1000; fig 5e,7b
| Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 6d
| Yard B, Adams D, Chie E, Tamayo P, Battaglia J, Gopal P, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nat Commun. 2016;7:11428 pubmed publisher |
- western blot; human; fig 7
| Chaudhary S, Madhukrishna B, Adhya A, Keshari S, Mishra S. Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip). Oncogenesis. 2016;5:e219 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1b
| Leus N, van der Wouden P, van den Bosch T, Hooghiemstra W, Ourailidou M, Kistemaker L, et al. HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Biochem Pharmacol. 2016;108:58-74 pubmed publisher |
- RNA immunoprecipitation; human; fig 3
- western blot; human; fig s3
| G Hendrickson D, Kelley D, Tenen D, BERNSTEIN B, Rinn J. Widespread RNA binding by chromatin-associated proteins. Genome Biol. 2016;17:28 pubmed publisher |
- western blot; mouse; loading ...; fig 2c
| Paladino D, Yue P, Furuya H, Acoba J, Rosser C, Turkson J. A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget. 2016;7:7253-67 pubmed publisher |
- western blot; human; 1:1000; fig 6a
| Huang R, Langdon S, Tse M, Mullen P, Um I, Faratian D, et al. The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer. Oncotarget. 2016;7:4695-711 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 6
| Akhade V, Dighe S, Kataruka S, Rao M. Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells. Nucleic Acids Res. 2016;44:387-401 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 3
| Vishwakarma B, Nguyen N, Makishima H, Hosono N, Gudmundsson K, Negi V, et al. Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development. Leukemia. 2016;30:200-8 pubmed publisher |
| Duvall Noelle N, Karwandyar A, Richmond A, Raman D. LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Oncogene. 2016;35:1122-33 pubmed publisher |
- western blot; mouse; 1:500; fig 5
| Eisses J, Criscimanna A, Dionise Z, Orabi A, Javed T, Sarwar S, et al. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185:3304-15 pubmed publisher |
- western blot; human; 1:1000; fig s5
| Su S, Zhao Q, He C, Huang D, Liu J, Chen F, et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015;6:8523 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed publisher |
- chromatin immunoprecipitation; rat; fig 6
- western blot; rat; 1:1000; fig 8
| Formisano L, Guida N, Valsecchi V, Cantile M, Cuomo O, Vinciguerra A, et al. Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism. J Neurosci. 2015;35:7332-48 pubmed publisher |
- western blot; mouse; fig 1d
| Watanabe M, Takahashi H, Saeki Y, Ozaki T, Itoh S, Suzuki M, et al. The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ. elife. 2015;4:e05615 pubmed publisher |
- western blot; mouse; 1:2000; fig 5c
| Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, et al. Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. EMBO Mol Med. 2015;7:240-58 pubmed publisher |
| Blakeslee W, Wysoczynski C, Fritz K, Nyborg J, Churchill M, McKinsey T. Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism. Cell Signal. 2014;26:2912-20 pubmed publisher |
- western blot; human; fig 6
| Bots M, Verbrugge I, Martin B, Salmon J, Ghisi M, Baker A, et al. Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. 2014;123:1341-52 pubmed publisher |
- western blot; mouse; 1:1000
| Medford H, Porter K, Marsh S. Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2013;305:H114-23 pubmed publisher |
| Wobser M, Weber A, Glunz A, Tauch S, Seitz K, Butelmann T, et al. Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells. J Hematol Oncol. 2019;12:30 pubmed publisher |
| Laporte A, Barrott J, Yao R, Poulin N, Brodin B, Jones K, et al. HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma. PLoS ONE. 2017;12:e0169407 pubmed publisher |
| Rajarajacholan U, Thalappilly S, Riabowol K. ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization. Nucleic Acids Res. 2017;45:1776-1792 pubmed publisher |
| Witt A, Lee C, Lee T, Azzam D, Wang B, Caslini C, et al. Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. Oncogene. 2017;36:1707-1720 pubmed publisher |
| Deng Z, Liu X, Jin J, Xu H, Gao Q, Wang Y, et al. Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. Int J Biol Sci. 2016;12:1298-1308 pubmed |
| Khalil H, Langdon S, Goltsov A, Soininen T, Harrison D, Bown J, et al. A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells. Oncotarget. 2016;7:75874-75901 pubmed publisher |
| Shi G, Yoshida Y, Yuki K, Nishimura T, Kawata Y, Kawashima M, et al. Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity. Oncotarget. 2016;7:82158-82169 pubmed publisher |
| Subburaju S, Coleman A, Ruzicka W, Benes F. Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. Transl Psychiatry. 2016;6:e723 pubmed publisher |
| Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, et al. Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1. Sci Rep. 2015;5:16355 pubmed publisher |
| Grasso C, Tang Y, Truffaux N, Berlow N, Liu L, Debily M, et al. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med. 2015;21:555-9 pubmed publisher |
| Li L, Xue A, Li B, Shen Y, Li Y, Luo C, et al. JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI. Breast Cancer Res. 2014;16:R56 pubmed publisher |
| Wang X, Wang C, Wang J, Zhao S, Zhang K, Wang J, et al. Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-?B, MAPKs and Akt signaling pathways. Neuropharmacology. 2014;79:642-56 pubmed publisher |
| Potluri V, Noothi S, Vallabhapurapu S, Yoon S, Driscoll J, Lawrie C, et al. Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. PLoS ONE. 2013;8:e66121 pubmed publisher |
| Cox E, Marsh S. Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart. Cardiovasc Diabetol. 2013;12:101 pubmed publisher |
| Cai Y, Cui W, Chen W, Wei P, Chi Y, Zhang P, et al. The effects of a histone deacetylase inhibitor on biological behavior of diffuse large B-cell lymphoma cell lines and insights into the underlying mechanisms. Cancer Cell Int. 2013;13:57 pubmed publisher |
| Nicholson T, Singh A, Su H, Hevi S, Wang J, Bajko J, et al. A hypomorphic lsd1 allele results in heart development defects in mice. PLoS ONE. 2013;8:e60913 pubmed publisher |
| Li M, Riddle S, Frid M, El Kasmi K, McKinsey T, Sokol R, et al. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol. 2011;187:2711-22 pubmed publisher |
