EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb (Biotinylated) | Cell Signaling Technology 5354 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb (Biotinylated)

catalog :

5354

clonality :

monoclonal

host :

rabbit

conjugate :

biotin

clone name :

43B2

reactivity :

human

application :

western blot

more info or order :

Cell Signaling Technology product webpage

citations: 22

Reference
Baldi L, Mengoli M, Bisagni A, Banzi M, Boni C, Rossi G. Concomitant EGFR mutation and ALK rearrangement in lung adenocarcinoma is more frequent than expected: report of a case and review of the literature with demonstration of genes alteration into the same tumor cells. Lung Cancer. 2014;86:291-5 pubmed publisher
Houang M, Sioson L, Clarkson A, Watson N, Farzin M, Toon C, et al. EGFR mutation specific immunohistochemistry is a useful adjunct which helps to identify false negative mutation testing in lung cancer. Pathology. 2014;46:501-8 pubmed publisher
Wang X, Wang G, Hao Y, Xu Y, Zhang L. A comparison of ARMS and mutation specific IHC for common activating EGFR mutations analysis in small biopsy and cytology specimens of advanced non small cell lung cancer. Int J Clin Exp Pathol. 2014;7:4310-6 pubmed
Bondgaard A, Høgdall E, Mellemgaard A, Skov B. High specificity but low sensitivity of mutation-specific antibodies against EGFR mutations in non-small-cell lung cancer. Mod Pathol. 2014;27:1590-8 pubmed publisher
Secq V, Villeret J, Fina F, Carmassi M, Carcopino X, Garcia S, et al. Triple negative breast carcinoma EGFR amplification is not associated with EGFR, Kras or ALK mutations. Br J Cancer. 2014;110:1045-52 pubmed publisher
Soma S, Tsuta K, Takano T, Hatanaka Y, Yoshida A, Suzuki K, et al. Intratumoral distribution of EGFR-amplified and EGFR-mutated cells in pulmonary adenocarcinoma. Pathol Res Pract. 2014;210:155-60 pubmed publisher
Kawahara A, Taira T, Abe H, Watari K, Murakami Y, Fukumitsu C, et al. Fixation effect of SurePath preservative fluids using epidermal growth factor receptor mutation-specific antibodies for immunocytochemistry. Cancer Cytopathol. 2014;122:145-52 pubmed publisher
Ho H, Chang F, Ma H, Liao L, Chuang Y, Chang Chien Y, et al. Molecular diagnostic algorithm for epidermal growth factor receptor mutation detection in Asian lung adenocarcinomas: comprehensive analyses of 445 Taiwanese patients with immunohistochemistry, PCR-direct sequencing and Scorpion/ARMS methods. Respirology. 2013;18:1261-70 pubmed publisher
Uramoto H, Yamada S, Tanaka F. Angiogenesis of lung cancer utilizes existing blood vessels rather than developing new vessels using signals from carcinogenesis. Anticancer Res. 2013;33:1913-6 pubmed
Wang Y, Jiang C, Guan J, Yang G, Yue J, Chen H, et al. Molecular alterations of EGFR in small intestinal adenocarcinoma. Int J Colorectal Dis. 2013;28:1329-35 pubmed publisher
Jiang G, Fan C, Zhang X, Dong Q, Wang L, Liu Y, et al. Ascertaining an appropriate diagnostic algorithm using EGFR mutation-specific antibodies to detect EGFR status in non-small-cell lung cancer. PLoS ONE. 2013;8:e59183 pubmed publisher
Fan X, Liu B, Xu H, Yu B, Shi S, Zhang J, et al. Immunostaining with EGFR mutation-specific antibodies: a reliable screening method for lung adenocarcinomas harboring EGFR mutation in biopsy and resection samples. Hum Pathol. 2013;44:1499-507 pubmed publisher
Shiozawa T, Ishii G, Goto K, Nagai K, Mimaki S, Ono S, et al. Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung. Pathol Int. 2013;63:77-84 pubmed publisher
Kim L, Kim K, Yoon Y, Ryu J, Choi S, Park I, et al. Clinicopathologic and molecular characteristics of lung adenocarcinoma arising in young patients. J Korean Med Sci. 2012;27:1027-36 pubmed publisher
Angulo B, Conde E, Suarez Gauthier A, Plaza C, Martinez R, Redondo P, et al. A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry. PLoS ONE. 2012;7:e43842 pubmed publisher
Kawahara A, Taira T, Azuma K, Tominaga M, Hattori S, Kawahara M, et al. A diagnostic algorithm using EGFR mutation-specific antibodies for rapid response EGFR-TKI treatment in patients with non-small cell lung cancer. Lung Cancer. 2012;78:39-44 pubmed publisher
Tabara K, Kanda R, Sonoda K, Kubo T, Murakami Y, Kawahara A, et al. Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. PLoS ONE. 2012;7:e41017 pubmed publisher
Shimamura T, Perera S, Foley K, Sang J, Rodig S, Inoue T, et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res. 2012;18:4973-85 pubmed publisher
Ambrosini Spaltro A, Campanini N, Bortesi B, Azzoni C, Naldi N, Ampollini L, et al. EGFR mutation-specific antibodies in pulmonary adenocarcinoma: a comparison with DNA direct sequencing. Appl Immunohistochem Mol Morphol. 2012;20:356-62 pubmed publisher
Tsai T, Wu S, Chang Y, Wu C, Tsai M, Wei P, et al. Effusion immunocytochemistry as an alternative approach for the selection of first-line targeted therapy in advanced lung adenocarcinoma. J Thorac Oncol. 2012;7:993-1000 pubmed publisher
Sakuma Y, Yamazaki Y, Nakamura Y, Yoshihara M, Matsukuma S, Nakayama H, et al. WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. Lab Invest. 2012;92:371-83 pubmed publisher
Azuma K, Okamoto I, Kawahara A, Taira T, Nakashima K, Hattori S, et al. Association of the expression of mutant epidermal growth factor receptor protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatment. J Thorac Oncol. 2012;7:122-7 pubmed publisher

product information

SKU :

5354S

Product-Name :

EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb (Biotinylated)

Size :

100 ul

Price-(USD) :

291 USD

Species-x-Reactivity :

Applications :

Western blot

Product-Category :

RTK

Shipping-Temp :

COLD

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

175

Host :

Rabbit

Target :

EGFR (Leu858Arg) mutation

Primary-Protein :

EGFR

Alt-Names :

EGFR,ERBB,ERBB1,Epidermal growth factor receptor,HER1,PIG61,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian),mENA

more info or order :

Cell Signaling Technology product webpage