Smad2 (D43B4) XP® Rabbit mAb | Cell Signaling Technology 5339 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Smad2 (D43B4) XP® Rabbit mAb

catalog :

5339

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

D43B4

reactivity :

guinea pig, human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, proximity ligation assay

more info or order :

Cell Signaling Technology product webpage

citations: 96

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 6d western blot; human; loading ...; fig 6a	Jacquet M, Hervouet E, Baudu T, Herfs M, Parratte C, Feugeas J, et al. GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback. Biology (Basel). 2021;10: pubmed publisher
western blot; bovine; 1:1000; loading ...; fig 3a	Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s5a	Arnold F, Mahaddalkar P, Kraus J, Zhong X, Bergmann W, Srinivasan D, et al. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration. Adv Sci (Weinh). 2021;8:2100626 pubmed publisher
western blot; human; 1:2000; loading ...; fig 5f	Pang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, et al. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Front Cell Dev Biol. 2021;9:706143 pubmed publisher
western blot; human; 1:1000; fig 5e	Bruce J, To K, Lui V, Chung G, Chan Y, Tsang C, et al. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nat Commun. 2021;12:4193 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6e	Niu B, Liu J, Lv B, Lin J, Li X, Wu C, et al. Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun. 2021;12:2809 pubmed publisher
western blot; human; loading ...; fig 5d	Sun X, He Z, Guo L, Wang C, Lin C, Ye L, et al. ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer. J Exp Clin Cancer Res. 2021;40:149 pubmed publisher
western blot; rat; 1:1000; fig 6e	Meng K, Cai H, Cai S, Hong Y, Zhang X. Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats. Front Cell Dev Biol. 2021;9:644160 pubmed publisher
western blot; human; 1:1000; loading ...; fig 1c	Nishad R, Mukhi D, Singh A, Motrapu M, Chintala K, Tammineni P, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12:342 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6c	Kushioka J, Kaito T, Okada R, Ishiguro H, Bal Z, Kodama J, et al. A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone. Bone Res. 2020;8:41 pubmed publisher
western blot; human; loading ...; fig s2	Shoemaker L, McCormick A, Allen B, Chang S. Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. Clin Transl Med. 2020;10:e99 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7a	Huang W, Yu D, Wang M, Han Y, Lin J, Wei D, et al. ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma. Cell Prolif. 2020;53:e12836 pubmed publisher
western blot; mouse; loading ...; fig 6a	Chakrabarti M, Al Sammarraie N, Gebere M, Bhattacharya A, Chopra S, Johnson J, et al. Transforming Growth Factor Beta3 is Required for Cardiovascular Development. J Cardiovasc Dev Dis. 2020;7: pubmed publisher
western blot; human; 1:100; loading ...; fig 5c	Wang X, Lu Q, Fei X, Zhao Y, Shi B, Li C, et al. Expression and Prognostic Value of Id-4 in Patients with Esophageal Squamous Cell Carcinoma. Onco Targets Ther. 2020;13:1225-1234 pubmed publisher
western blot; human; loading ...; fig 6f	Wang H, Chen Z, Wang S, Gao X, Qian M, Qiu W, et al. TGFβ1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-κB signalling pathway in human gliomas. Mol Oncol. 2020;14:407-425 pubmed publisher
immunohistochemistry; mouse; 1:50; loading ...; fig 2b western blot; mouse; 1:1000; loading ...; fig 2d	van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
western blot; mouse; 1:500; fig 6a	Cibi D, Mia M, Guna Shekeran S, Yun L, Sandireddy R, Gupta P, et al. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. elife. 2019;8: pubmed publisher
western blot; mouse; loading ...; fig 6i	Rajderkar S, Mann J, Panaretos C, Yumoto K, Li H, Mishina Y, et al. Trim33 is required for appropriate development of pre-cardiogenic mesoderm. Dev Biol. 2019;450:101-114 pubmed publisher
western blot; human; 1:2500; loading ...; fig 3b	Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed publisher
western blot; mouse; loading ...; fig 4c	Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y, et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. EBioMedicine. 2019;40:43-55 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5a	Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed publisher
western blot; mouse; loading ...; fig 5a	Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4g	Wang M, Tang C, Xing R, Liu X, Han X, Liu Y, et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry. 2018;: pubmed publisher
western blot; rat; loading ...; fig 4i	Bitar M, Nader J, Al Ali W, Al Madhoun A, Arefanian H, Al Mulla F. Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452 pubmed publisher
western blot; mouse; 1:500; loading ...; fig s2	Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
western blot; mouse; fig 3a	Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk U, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018;9:1352 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 5a	Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed publisher
western blot; human; loading ...; fig 2e	Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
western blot; mouse; 1:1000; fig 6b	Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
western blot; mouse; loading ...; fig 1c	Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 8c	Chatterjee A, Kosmacek E, Oberley Deegan R. MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway. Radiat Res. 2017;187:367-381 pubmed publisher
western blot; human; loading ...; fig 5a	Melchionna R, Iapicca P, Di Modugno F, Trono P, Sperduti I, Fassan M, et al. The pattern of hMENA isoforms is regulated by TGF-?1 in pancreatic cancer and may predict patient outcome. Oncoimmunology. 2016;5:e1221556 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6b	Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, et al. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017;8:14105 pubmed publisher
western blot; mouse; loading ...; fig 4e	Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed publisher
western blot; mouse; loading ...; fig 5b	Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6a	Yang J, Savvatis K, Kang J, Fan P, Zhong H, Schwartz K, et al. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. Nat Commun. 2016;7:13710 pubmed publisher
western blot; human; loading ...; fig 2c	Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7d	Zhu L, Gómez Durán A, Saretzki G, Jin S, Tilgner K, Melguizo Sanchís D, et al. The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol. 2016;215:187-202 pubmed
chromatin immunoprecipitation; mouse; loading ...; fig 5b	Wang W, Song B, Anbarchian T, Shirazyan A, Sadik J, Lyons K. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016;12:e1006352 pubmed publisher
western blot; mouse; loading ...; fig s2a	Yang P, Schmit B, Fu C, Desart K, Oh S, Berceli S, et al. Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events. Sci Rep. 2016;6:35444 pubmed publisher
western blot; human; loading ...; fig 4d	VanOudenhove J, Medina R, Ghule P, Lian J, Stein J, Zaidi S, et al. Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling. Stem Cell Reports. 2016;7:884-896 pubmed publisher
western blot; mouse; loading ...; fig 6b western blot; rat; fig 6h	Barallobre Barreiro J, Gupta S, Zoccarato A, Kitazume Taneike R, Fava M, Yin X, et al. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016;134:817-32 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3d	Kim D, Chang M, Yoon C, Middeldorp J, Martinez O, Byeon S, et al. Epstein-Barr virus BARF1-induced NFÎºB/miR-146a/SMAD4 alterations in stomach cancer cells. Oncotarget. 2016;7:82213-82227 pubmed publisher
western blot; rat; loading ...; fig 3d	Kang L, Zhang D, Ma C, Zhang J, Jia K, Liu J, et al. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Sci Rep. 2016;6:27460 pubmed publisher
western blot; human; 1:1000; loading ...	Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom D, Zairis S, et al. Clonal evolution of glioblastoma under therapy. Nat Genet. 2016;48:768-76 pubmed publisher
western blot; human; fig 2	Lin S, Wang B, Lin C, Chien P, Wu Y, Ko J, et al. Chidamide alleviates TGF-?-induced epithelial-mesenchymal transition in lung cancer cell lines. Mol Biol Rep. 2016;43:687-95 pubmed publisher
western blot; mouse; fig 3	Garrel G, Racine C, L hôte D, Denoyelle C, Guigon C, di Clemente N, et al. Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty. Sci Rep. 2016;6:23790 pubmed publisher
western blot; human; 1:800; fig 4	Bassey Archibong B, Kwiecien J, Milosavljevic S, Hallett R, Rayner L, Erb M, et al. Kaiso depletion attenuates transforming growth factor-? signaling and metastatic activity of triple-negative breast cancer cells. Oncogenesis. 2016;5:e208 pubmed publisher
western blot; mouse	Hwang S, Jang S, Kim M, Kim L, Kim B, Kim H, et al. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nat Commun. 2016;7:10789 pubmed publisher
western blot; mouse; 1:1000; fig 2	del RÃo C, Navarrete C, Collado J, Bellido M, GÃ³mez CaÃ±as M, Pazos M, et al. The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-Î³ and CB2 pathways. Sci Rep. 2016;6:21703 pubmed publisher
western blot; human; fig 5	Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-Î² signalling. Oncogene. 2016;35:4388-98 pubmed publisher
western blot; mouse; 1:2500; fig 6	Das R, Xu S, Nguyen T, Quan X, Choi S, Kim S, et al. Transforming Growth Factor Î²1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. J Biol Chem. 2015;290:30830-42 pubmed publisher
western blot; mouse; 1:1000; fig 2	Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed publisher
western blot; mouse; 1:1000; fig 1	Zhao Y, Londono P, Cao Y, Sharpe E, Proenza C, O Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015;6:8243 pubmed publisher
proximity ligation assay; mouse; fig s12 chromatin immunoprecipitation; mouse; 1:50; fig s15	Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher
western blot; mouse; fig 1	Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, et al. JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J. 2015;34:2162-81 pubmed publisher
western blot; human; fig 5	Zhao L, Liu S, Che X, Hou K, Ma Y, Li C, et al. Bufalin inhibits TGF-Î²-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-Î² receptors. Int J Mol Med. 2015;36:645-52 pubmed publisher
western blot; human; fig 1	Li L, Qi L, Liang Z, Song W, Liu Y, Wang Y, et al. Transforming growth factor-Î²1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells. Int J Mol Med. 2015;36:113-22 pubmed publisher
western blot; human; fig 5	Min K, Liggett J, Silva G, Wu W, Wang R, Shen R, et al. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Oncogene. 2016;35:377-88 pubmed publisher
western blot; mouse	PerdigÃ£o Henriques R, Petrocca F, Altschuler G, Thomas M, Le M, Tan S, et al. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes. Oncogene. 2016;35:158-72 pubmed publisher
western blot; mouse; 1:500	Tapia O, Fong L, Huber M, Young S, Gerace L. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS ONE. 2015;10:e0116196 pubmed publisher
western blot; human	Perna F, Vu L, Themeli M, Kriks S, Hoya Arias R, Khanin R, et al. The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. Stem Cell Reports. 2015;4:658-69 pubmed publisher
western blot; human; fig 3	Rao R, Dhele N, Cheemadan S, Ketkar A, Jayandharan G, Palakodeti D, et al. Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming. Sci Rep. 2015;5:8229 pubmed publisher
western blot; human; 1:1000	Aykul S, Ni W, Mutatu W, Martinez Hackert E. Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes. PLoS ONE. 2015;10:e0114954 pubmed publisher
western blot; human; loading ...; fig 2c	Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, et al. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Clin Sci (Lond). 2015;128:761-74 pubmed publisher
western blot; mouse; loading ...; fig S1a	Gu A, Zhang S, Wang Y, Xiong H, Curtis T, Wan Y. A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor Î² receptor signaling. Immunity. 2015;42:68-79 pubmed publisher
immunocytochemistry; human; 1:100	Ehnert S, Freude T, Ihle C, Mayer L, Braun B, Graeser J, et al. Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation - description of a novel in vitro model. Exp Cell Res. 2015;332:247-58 pubmed publisher
western blot; human; loading ...; fig s3g	Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, et al. Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nat Commun. 2014;5:5780 pubmed publisher
western blot; rat; 1:1000	Scholze A, Foo L, Mulinyawe S, Barres B. BMP signaling in astrocytes downregulates EGFR to modulate survival and maturation. PLoS ONE. 2014;9:e110668 pubmed publisher
western blot; rat	Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G, et al. Hepatocyte growth factor regulates the TGF-?1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med. 2014;34:381-90 pubmed publisher
western blot; rat	Beaudoin M, Snook L, Arkell A, Stefanson A, Wan Z, Simpson J, et al. Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats. Obesity (Silver Spring). 2014;22:1632-42 pubmed publisher
immunocytochemistry; human; 1:50; tbl 1 western blot; human	Kondo M, Yamaoka K, Sonomoto K, Fukuyo S, Oshita K, Okada Y, et al. IL-17 inhibits chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE. 2013;8:e79463 pubmed publisher
western blot; mouse; 1:1000; fig 7	Das R, Xu S, Quan X, Nguyen T, Kong I, Chung C, et al. Upregulation of mitochondrial Nox4 mediates TGF-?-induced apoptosis in cultured mouse podocytes. Am J Physiol Renal Physiol. 2014;306:F155-67 pubmed publisher
western blot; rat; 1:1000	Mitchell K, Shah J, Tsytsikova L, Campbell A, Affram K, Symes A. LPS antagonism of TGF-? signaling results in prolonged survival and activation of rat primary microglia. J Neurochem. 2014;129:155-68 pubmed publisher
western blot; mouse; 1:1000	Gillette M, Bray K, Blumenthaler A, Vargo Gogola T. P190B RhoGAP overexpression in the developing mammary epithelium induces TGF?-dependent fibroblast activation. PLoS ONE. 2013;8:e65105 pubmed publisher
chromatin immunoprecipitation; human	Sakaki Yumoto M, Liu J, Ramalho Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013;288:18546-60 pubmed publisher
western blot; rat	Lessard S, Rivas D, Alves Wagner A, Hirshman M, Gallagher I, Constantin Teodosiu D, et al. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes. 2013;62:2717-27 pubmed publisher
western blot; guinea pig	Eckhouse S, Akerman A, Logdon C, Oelsen J, O Quinn E, Nadeau E, et al. Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: relationship to interstitial microRNA dynamics and myocardial function. J Thorac Cardiovasc Surg. 2013;145:267-275, 277.e1-4; discussion 275-7 pubmed publisher
	Hernandez I, Chissey A, Guibourdenche J, Atasoy R, Coumoul X, Fournier T, et al. Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways. Antioxidants (Basel). 2021;10: pubmed publisher
	Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, et al. The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 2021;54:308-323.e6 pubmed publisher
	Ravindran S, Pasha M, Agouni A, Munusamy S. Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury. Biomolecules. 2019;9: pubmed publisher
	Paw M, Wnuk D, Kądziołka D, Sęk A, Lasota S, Czyz J, et al. Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization. Int J Mol Sci. 2018;19: pubmed publisher
	Qin Y, Garrison B, Ma W, Wang R, Jiang A, Li J, et al. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Cell. 2018;174:156-171.e16 pubmed publisher
	Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, et al. Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding. Biomed Res Int. 2018;2018:3293584 pubmed publisher
	Strasen J, Sarma U, Jentsch M, Bohn S, Sheng C, Horbelt D, et al. Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels. Mol Syst Biol. 2018;14:e7733 pubmed publisher
	Duhachek Muggy S, Bhat K, Vlashi E, Pajonk F. Growth Differentiation Factor 11 does not Mitigate the Lethal Effects of Total-Abdominal Irradiation. Radiat Res. 2017;188:469-475 pubmed publisher
	Junk D, Bryson B, Smigiel J, Parameswaran N, Bartel C, Jackson M. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Oncogene. 2017;36:4001-4013 pubmed publisher
	Xiang S, Zeng Y, Xiong B, Qin Y, Huang X, Jiang Y, et al. Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells. J Inflamm (Lond). 2016;13:19 pubmed publisher
	Li C, Wang Q, Li J, Hu M, Shi S, Li Z, et al. Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFÎ²1/Smad signaling pathway. Int J Nanomedicine. 2016;11:373-86 pubmed publisher
	Maier A, Peille A, Vuaroqueaux V, Lahn M. Anti-tumor activity of the TGF-Î² receptor kinase inhibitor galunisertib (LY2157299 monohydrate) in patient-derived tumor xenografts. Cell Oncol (Dordr). 2015;38:131-44 pubmed publisher
	Liu Y, Liu X, Hao W, Decker Y, Schomburg R, FÃ¼lÃ¶p L, et al. IKKÎ² deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J Neurosci. 2014;34:12982-99 pubmed publisher
	Chen Y, Hsiao P, Weng C, Kuo K, Kuo T, Wu D, et al. SMAD4 loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells. BMC Cancer. 2014;14:181 pubmed publisher
	Chen D, Wang W, Qin J, Wang M, Murugesan S, Nadkarni D, et al. Identification of the ZAK-MKK4-JNK-TGF? signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ. Curr Cancer Drug Targets. 2013;13:651-60 pubmed
	Miles D, Wakeling S, Stringer J, Van Den Bergen J, Wilhelm D, Sinclair A, et al. Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS ONE. 2013;8:e54606 pubmed publisher
	Chen H, Ko J, Wong V, Hyytiäinen M, Keski Oja J, Chua D, et al. LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. Cancer Lett. 2012;325:89-98 pubmed publisher
	Michael D, Salter R, Ramji D. TGF-? inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2. Biochim Biophys Acta. 2012;1822:1608-16 pubmed publisher

product information

SKU :

5339S

Product-Name :

Smad2 (D43B4) XP® Rabbit mAb

Size :

100 ul

Price-(USD) :

260 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Chromatin Immunoprecipitation

Product-Category :

Developmental Biology

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

Smad2

Primary-Protein :

Smad2

Alt-Names :

JV18,JV18-1,MAD homolog 2,MAD, mothers against decapentaplegic homolog 2,MADH2,MADR2,MGC22139,MGC34440,Mad protein homolog,Mad-related protein 2,Mothers against DPP homolog 2,Mothers against decapentaplegic homolog 2,SMAD 2,SMAD family member 2,SMAD, mothers against DPP homolog 2,SMAD2,Sma- and Mad-related protein 2,hMAD-2,hSMAD2,mother against DPP homolog 2

more info or order :

Cell Signaling Technology product webpage