Notch3 (D11B8) Rabbit mAb | Cell Signaling Technology 5276 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Notch3 (D11B8) Rabbit mAb

catalog :

5276

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

D11B8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Cell Signaling Technology product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 7c, 7g	Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, et al. The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription. Nat Commun. 2019;10:2071 pubmed publisher
immunocytochemistry; human; 1:100; loading ...; fig s3d western blot; human; 1:1000; loading ...; fig s3c	Bhardwaj A, Yang Y, Ueberheide B, Smith S. Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation. Nat Commun. 2017;8:2214 pubmed publisher
immunohistochemistry; human; 1:1000; fig 2e western blot; human; 1:1000; fig 2a	Frank S, Berger P, Ljungman M, Miranti C. Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC. J Cell Sci. 2017;130:1952-1964 pubmed publisher
western blot; human; 1:1000; fig 4a immunohistochemistry - paraffin section; rat; 1:800; loading ...; fig 6h	Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 3b	Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed
western blot; human; fig 6d	Zhang P, He D, Chen Z, Pan Q, Du F, Zang X, et al. Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer. Biochem Pharmacol. 2016;118:18-30 pubmed publisher
western blot; human; 1:1000; fig 3b	Hanna J, Garcia M, Go J, Finkelstein D, Kodali K, Pagala V, et al. PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma. Cell Death Dis. 2016;7:e2256 pubmed publisher
western blot; human; fig 2	Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, et al. NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0154112 pubmed publisher
western blot; human; 1:1000	Gomi K, Arbelaez V, Crystal R, Walters M. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS ONE. 2015;10:e0116507 pubmed publisher
western blot; human; fig 1	Dong X, Lin Q, Aihara A, Li Y, Huang C, Chung W, et al. Aspartate Î²-Hydroxylase expression promotes a malignant pancreatic cellular phenotype. Oncotarget. 2015;6:1231-48 pubmed
western blot; human	So J, Lin J, Wahler J, Liby K, Sporn M, Suh N. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS ONE. 2014;9:e107616 pubmed publisher
immunoprecipitation; human western blot; human	Arasada R, Amann J, Rahman M, Huppert S, Carbone D. EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling. Cancer Res. 2014;74:5572-84 pubmed publisher
	Arasada R, Shilo K, Yamada T, Zhang J, Yano S, Ghanem R, et al. Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC. Nat Commun. 2018;9:3198 pubmed publisher
	Pedros C, Canonigo Balancio A, Kong K, Altman A. Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity. JCI Insight. 2017;2: pubmed publisher
	Li C, Song G, Zhang S, Wang E, Cui Z. Wnt3a increases the metastatic potential of non-small cell lung cancer cells in vitro in part via its upregulation of Notch3. Oncol Rep. 2015;33:1207-14 pubmed publisher
	Li C, Zhang S, Lu Y, Zhang Y, Wang E, Cui Z. The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. PLoS ONE. 2013;8:e84659 pubmed publisher
	Mezquita B, Mezquita J, Barrot C, Carvajal S, Pau M, Mezquita P, et al. A truncated-Flt1 isoform of breast cancer cells is upregulated by Notch and downregulated by retinoic acid. J Cell Biochem. 2014;115:52-61 pubmed publisher
	Tikka S, Ng Y, Di Maio G, Mykkänen K, Siitonen M, Lepikhova T, et al. CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells. J Cereb Blood Flow Metab. 2012;32:2171-80 pubmed publisher

product information

SKU :

5276S

Product-Name :

Notch3 (D11B8) Rabbit mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

Applications :

Immunoprecipitation

Product-Category :

Developmental Biology

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

90, 270

Host :

Rabbit

Target :

Notch3

Primary-Protein :

NOTCH3

Alt-Names :

CADASIL,CASIL,NOTC3,NOTCH3,Neurogenic locus notch homolog protein 3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain,Notch homolog 3 (Drosophila)

more info or order :

Cell Signaling Technology product webpage