| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockdown validation); human; fig 5
| Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed publisher |
- western blot; human; fig 1
| Hernando H, Gelato K, Lesche R, Beckmann G, Koehr S, Otto S, et al. EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes. Mol Cancer Ther. 2016;15:287-98 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Li J, Zhang S, Hu Q, Zhang K, Jin J, Zheng X, et al. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells. Sci Rep. 2016;6:26971 pubmed publisher |
| Fan H, Zhang H, Pascuzzi P, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016;35:715-26 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 6a
| Zha L, Li F, Wu R, Artinian L, Rehder V, Yu L, et al. The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation. J Biol Chem. 2015;290:25151-63 pubmed publisher |
- western blot; human
- immunoprecipitation; human
- immunocytochemistry; human
| Wan J, Zhan J, Li S, Ma J, Xu W, Liu C, et al. PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression. Nucleic Acids Res. 2015;43:3591-604 pubmed publisher |
- western blot; human; 1:200; fig 1
- immunohistochemistry; mouse; fig s4
| Fillmore C, Xu C, Desai P, Berry J, Rowbotham S, Lin Y, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature. 2015;520:239-42 pubmed publisher |
| Poirier J, Gardner E, Connis N, Moreira A, de Stanchina E, Hann C, et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene. 2015;34:5869-78 pubmed publisher |
- western blot; rat; 1:1000; fig s4
- immunohistochemistry; rat; 1:1000; fig 3
| Koo J, Mazei-Robison M, LaPlant Q, Egervári G, Braunscheidel K, Adank D, et al. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci. 2015;18:415-22 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
- immunoprecipitation; human; fig 3
- western blot; human; fig s3
| Nishioka C, Ikezoe T, Yang J, Yokoyama A. Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells. PLoS ONE. 2015;10:e0125017 pubmed publisher |
- immunocytochemistry; human; fig s3
- western blot; human; fig 2
| Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed publisher |
- chromatin immunoprecipitation; zebrafish ; 1:100
| Tien C, Jones A, Wang H, Gerigk M, Nozell S, Chang C. Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development. Development. 2015;142:722-31 pubmed publisher |
- chromatin immunoprecipitation; mouse
| Shpargel K, Starmer J, Yee D, Pohlers M, Magnuson T. KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet. 2014;10:e1004507 pubmed publisher |
- western blot; human; fig 4a
| Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir J, et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014;516:116-20 pubmed publisher |
- western blot; human; 1:1000; fig s7b
| Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014;20:1394-6 pubmed publisher |
- immunohistochemistry - paraffin section; human
- western blot; human
| Svedlund J, Barazeghi E, Stalberg P, Hellman P, Akerstrom G, Björklund P, et al. The histone methyltransferase EZH2, an oncogene common to benign and malignant parathyroid tumors. Endocr Relat Cancer. 2014;21:231-9 pubmed publisher |
- chromatin immunoprecipitation; human; 1:100
- immunoprecipitation; human; 1:1000
- western blot; human; 1:1000
| Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:300
| Karoopongse E, Yeung C, Byon J, Ramakrishnan A, Holman Z, Jiang P, et al. The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy. PLoS ONE. 2014;9:e107817 pubmed publisher |
- western blot; human; 1:1000
| Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed publisher |
- chromatin immunoprecipitation; mouse
| Lu F, Liu Y, Jiang L, Yamaguchi S, Zhang Y. Role of Tet proteins in enhancer activity and telomere elongation. Genes Dev. 2014;28:2103-19 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Corvetta D, Chayka O, Gherardi S, D'Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher |
| Deaton A, Gómez-Rodríguez M, Mieczkowski J, Tolstorukov M, Kundu S, Sadreyev R, et al. Enhancer regions show high histone H3.3 turnover that changes during differentiation. elife. 2016;5: pubmed publisher |
| Matsuda Y, Kobayashi-Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep. 2015;5:7701 pubmed publisher |
| Bae W, Kang K, Yu J, Yoo K, Factor V, Kaji K, et al. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. FASEB J. 2015;29:1653-62 pubmed publisher |
| Popovic R, Martinez-Garcia E, Giannopoulou E, Zhang Q, Zhang Q, Ezponda T, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet. 2014;10:e1004566 pubmed publisher |
| Hayashi A, Morikawa T, Kawai T, Kume H, Ishikawa S, Homma Y, et al. Clinicopathological and prognostic significance of EZH2 expression in upper urinary tract carcinoma. Virchows Arch. 2014;464:463-71 pubmed publisher |
| Chattergoon M, Latanich R, Quinn J, Winter M, Buckheit R, Blankson J, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10:e1004082 pubmed publisher |
| Blackledge N, Farcas A, Kondo T, King H, McGouran J, Hanssen L, et al. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell. 2014;157:1445-59 pubmed publisher |
| Jia N, Li Q, Tao X, Wang J, Hua K, Feng W. Enhancer of zeste homolog 2 is involved in the proliferation of endometrial carcinoma. Oncol Lett. 2014;8:2049-2054 pubmed |
| Sun N, Ye C, Zhao Q, Zhang Q, Xu C, Wang S, et al. Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS ONE. 2014;9:e100340 pubmed publisher |
| Forthun R, SenGupta T, Skjeldam H, Lindvall J, McCormack E, Gjertsen B, et al. Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLoS ONE. 2012;7:e48992 pubmed publisher |
| Li G, Warden C, Zou Z, Neman J, Krueger J, Jain A, et al. Altered expression of polycomb group genes in glioblastoma multiforme. PLoS ONE. 2013;8:e80970 pubmed publisher |
