| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; loading ...; fig 4e
| Bao Y, Oguz G, Lee W, Lee P, Ghosh K, Li J, et al. EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Nat Commun. 2020;11:5878 pubmed publisher |
- immunohistochemistry knockout validation; mouse; loading ...; fig 2a
| Du X, Chen Y, Zhang Q, Lin J, Yu Y, Pan Z, et al. Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13B. J Bone Miner Res. 2020;35:956-965 pubmed publisher |
- western blot knockout validation; mouse; fig 1c
| Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, et al. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med. 2016;213:1459-77 pubmed publisher |
- western blot; mouse; loading ...; fig s1a
| Wei Y, Chen J, Xu X, Li F, Wu K, Jiang Y, et al. Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity-Related Properties. Adv Sci (Weinh). 2021;8:2004319 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Morel K, Sheahan A, Burkhart D, Baca S, Boufaied N, Liu Y, et al. EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Nat Cancer. 2021;2:444-456 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 5f
- western blot; human; loading ...; fig 3d
| Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s5c
| Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed publisher |
- ChIP-Seq; human; 1:50; loading ...; fig 3a
- immunoprecipitation; human; 1:500; fig 1d, 1e
- western blot; human; 1:1000; loading ...; fig 1b
| Jain P, Ballaré C, Blanco E, Vizan P, Di Croce L. PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. elife. 2020;9: pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1a, 1b, 1c, 1d
| Hoffmann F, Niebel D, Aymans P, Ferring Schmitt S, Dietrich D, Landsberg J. H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade. Clin Epigenetics. 2020;12:24 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1f
| Enomoto T, Aoki M, Hamasaki M, Abe H, Nonaka M, Inoue T, et al. Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis. Neurol Med Chir (Tokyo). 2020;60:136-146 pubmed publisher |
- chromatin immunoprecipitation; human; 1:100; loading ...; fig 4h
- immunoprecipitation; human; 1:300; loading ...; fig 6e
- western blot; human; 1:1000; loading ...; fig 4c
| Zhang L, Tian S, Pei M, Zhao M, Wang L, Jiang Y, et al. Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer. Oncol Rep. 2019;42:2655-2669 pubmed publisher |
- immunoprecipitation; human; loading ...; fig s1c
- western blot; human; 1:1000; loading ...; fig s1b
| Piunti A, Smith E, Morgan M, Ugarenko M, Khaltyan N, Helmin K, et al. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 2019;5:eaax2887 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 4c
- immunocytochemistry; human; 1:200; loading ...; fig 3s3a, 3s3b, 3s3c
- western blot; human; 1:1000; loading ...; fig 3d
| Azkanaz M, Rodríguez López A, de Boer B, Huiting W, Angrand P, Vellenga E, et al. Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock. elife. 2019;8: pubmed publisher |
- western blot; human; loading ...; fig 4i
| Fan M, Zou Y, He P, Zhang S, Sun X, Li C. Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis. Biosci Rep. 2019;: pubmed publisher |
- mass cytometry; human; loading ...; fig 3a
| Wagner J, Rapsomaniki M, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, et al. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell. 2019;177:1330-1345.e18 pubmed publisher |
- immunohistochemistry; human; 1:100; loading ...; fig 2a
- western blot; human; 1:1000; loading ...; fig 1f
| Lima Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, et al. Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nat Commun. 2019;10:1436 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Wang Z, Feng X, Molinolo A, Martin D, Vitale Cross L, Nohata N, et al. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019;: pubmed publisher |
- immunocytochemistry; human; loading ...; fig 5a
- western blot; human; loading ...; fig 5b
| Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, et al. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Sci Adv. 2019;5:eaau7887 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s2
| Chakraborty A, Laukka T, Myllykoski M, Ringel A, Booker M, Tolstorukov M, et al. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019;363:1217-1222 pubmed publisher |
- western blot; human; loading ...; fig s1c
| Meisenberg C, Pinder S, Hopkins S, Wooller S, Benstead Hume G, Pearl F, et al. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol Cell. 2019;73:212-223.e7 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 1h
- western blot; mouse; loading ...; fig 1a
| Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M. The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2. J Biol Chem. 2018;293:18031-18039 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig 5b
- flow cytometry; mouse; loading ...; fig 5a
| Casey A, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. J Cell Biol. 2018;217:2951-2974 pubmed publisher |
- flow cytometry; mouse; loading ...; fig s3b
| Rothberg J, Maganti H, Jrade H, Porter C, Palidwor G, Cafariello C, et al. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Cell Discov. 2018;4:21 pubmed publisher |
- immunocytochemistry; human; fig 3f
- western blot; human; 1:1000; loading ...; fig 3a
| Le Duff M, Gouju J, Jonchère B, Guillon J, Toutain B, Boissard A, et al. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis. 2018;9:199 pubmed publisher |
- western blot; mouse; loading ...; fig s15a
| Wang P, Xu J, Wang Y, Cao X. An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism. Science. 2017;358:1051-1055 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4a
| Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed publisher |
- immunoprecipitation; human; loading ...; fig 1b
- immunocytochemistry; human; 0.005 mg/ml; loading ...; fig 1c
- western blot; human; loading ...; fig 2b
| Jin Y, Huo B, Fu X, Hao T, Zhang Y, Guo Y, et al. LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes. Biomed Pharmacother. 2017;88:728-737 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Gonzalez M, Martin E, Anwar T, Arellano Garcia C, Medhora N, Lama A, et al. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep. 2017;18:1215-1228 pubmed publisher |
- western blot; mouse; loading ...; fig 4e
| Lyroni K, Patsalos A, Daskalaki M, Doxaki C, Soennichsen B, Helms M, et al. Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. J Immunol. 2017;198:1297-1307 pubmed publisher |
- immunoprecipitation; human; loading ...; fig 3a
- western blot; human; 1:1000; loading ...; fig 1e
| Göllner S, Oellerich T, Agrawal Singh S, Schenk T, Klein H, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69-78 pubmed publisher |
- immunoprecipitation; mouse; fig s6
- western blot; mouse; 1:1000; fig s3
| Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova T, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50
- western blot; human; 1:1000; loading ...; fig 3a
- immunohistochemistry - paraffin section; mouse; 1:50
- western blot; mouse; 1:1000; loading ...; fig 1a
| Lu W, Liu S, Li B, Xie Y, Izban M, Ballard B, et al. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene. 2017;36:1364-1373 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 2a
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1c
- western blot; mouse; 1:500; fig 1d
| Xiao X, Senavirathna L, Gou X, Huang C, Liang Y, Liu L. EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis. Physiol Rep. 2016;4: pubmed publisher |
- western blot; human; fig 6
| Nelson D, Jaber Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016;17:158 pubmed publisher |
- western blot; human; 1:1000; fig 2b,4b,7b
| Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Li J, Zhang S, Hu Q, Zhang K, Jin J, Zheng X, et al. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells. Sci Rep. 2016;6:26971 pubmed publisher |
- western blot; human; loading ...; fig 1e
| Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed publisher |
- western blot; human; fig 1
| Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed publisher |
- western blot; mouse; fig 8a
| Minnich M, Tagoh H, Bönelt P, Axelsson E, Fischer M, Cebolla B, et al. Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation. Nat Immunol. 2016;17:331-43 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:2000; fig 7
- western blot; human; 1:2000; loading ...; fig 3e
| Sengupta D, Byrum S, Avaritt N, Davis L, Shields B, Mahmoud F, et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016;15:765-75 pubmed publisher |
- western blot; human; fig 1
| Hernando H, Gelato K, Lesche R, Beckmann G, Koehr S, Otto S, et al. EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes. Mol Cancer Ther. 2016;15:287-98 pubmed publisher |
- immunohistochemistry; rat; fig 2
- western blot; rat; fig 1
| Laumet G, Garriga J, Chen S, Zhang Y, Li D, Smith T, et al. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015;18:1746-55 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Maleszewska M, Vanchin B, Harmsen M, Krenning G. The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence. Angiogenesis. 2016;19:9-24 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 6a
| Zha L, Li F, Wu R, Artinian L, Rehder V, Yu L, et al. The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation. J Biol Chem. 2015;290:25151-63 pubmed publisher |
- western blot; human; loading ...; fig st2
| Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed publisher |
- western blot; mouse; fig 1a
- immunocytochemistry; human; 1:200
| Khan M, Walters L, Li Q, Thomas D, Miller J, Zhang Q, et al. Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma. Lab Invest. 2015;95:1278-90 pubmed publisher |
- immunocytochemistry; mouse; fig 4
| McCleland M, Soukup T, Liu S, Esensten J, De Sousa E Melo F, Yaylaoglu M, et al. Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. J Pathol. 2015;237:508-19 pubmed publisher |
- western blot; human; loading ...; fig 7a
| Kotomura N, Harada N, Ishihara S. The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. PLoS ONE. 2015;10:e0128282 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
- immunoprecipitation; human; fig 3
- western blot; human; fig s3
| Nishioka C, Ikezoe T, Yang J, Yokoyama A. Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells. PLoS ONE. 2015;10:e0125017 pubmed publisher |
| Fan H, Zhang H, Pascuzzi P, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016;35:715-26 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6g
| Zhang P, Yang X, Ma X, Ingram D, Lazar A, Torres K, et al. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Mol Cancer. 2015;14:55 pubmed publisher |
- immunoprecipitation; human
- immunocytochemistry; human
- western blot; human
| Wan J, Zhan J, Li S, Ma J, Xu W, Liu C, et al. PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression. Nucleic Acids Res. 2015;43:3591-604 pubmed publisher |
- immunocytochemistry; human; fig s3
- western blot; human; fig 2
| Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed publisher |
| Poirier J, Gardner E, Connis N, Moreira A, de Stanchina E, Hann C, et al. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene. 2015;34:5869-78 pubmed publisher |
- immunohistochemistry; rat; 1:1000; fig 3
- western blot; rat; 1:1000; fig s4
| Koo J, Mazei Robison M, LaPlant Q, Egervári G, Braunscheidel K, Adank D, et al. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci. 2015;18:415-22 pubmed publisher |
- immunohistochemistry; mouse; fig s4
- western blot; human; 1:200; fig 1
| Fillmore C, Xu C, Desai P, Berry J, Rowbotham S, Lin Y, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature. 2015;520:239-42 pubmed publisher |
- chromatin immunoprecipitation; zebrafish ; 1:100
| Tien C, Jones A, Wang H, Gerigk M, Nozell S, Chang C. Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development. Development. 2015;142:722-31 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3
| Matsuda Y, Kobayashi Ishihara M, Fujikawa D, Ishida T, Watanabe T, Yamagishi M. Epigenetic heterogeneity in HIV-1 latency establishment. Sci Rep. 2015;5:7701 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 3
- immunoprecipitation; mouse; fig 3
| Wurm S, Zhang J, Guinea Viniegra J, GarcÃa F, Muñoz J, Bakiri L, et al. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015;29:144-56 pubmed publisher |
- western blot; human; 1:1000
| Naganuma K, Hatta M, Ikebe T, Yamazaki J. Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma. BMC Cancer. 2014;14:988 pubmed publisher |
- western blot; human; fig 4a
| Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir J, et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014;516:116-20 pubmed publisher |
- western blot; human; 1:1000; fig s7b
| Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014;20:1394-6 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:300
| Karoopongse E, Yeung C, Byon J, Ramakrishnan A, Holman Z, Jiang P, et al. The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy. PLoS ONE. 2014;9:e107817 pubmed publisher |
- chromatin immunoprecipitation; mouse
| Lu F, Liu Y, Jiang L, Yamaguchi S, Zhang Y. Role of Tet proteins in enhancer activity and telomere elongation. Genes Dev. 2014;28:2103-19 pubmed publisher |
- chromatin immunoprecipitation; mouse
| Shpargel K, Starmer J, Yee D, Pohlers M, Magnuson T. KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet. 2014;10:e1004507 pubmed publisher |
- RNA immunoprecipitation; human; loading ...; fig 4a
| Sun N, Ye C, Zhao Q, Zhang Q, Xu C, Wang S, et al. Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS ONE. 2014;9:e100340 pubmed publisher |
- chromatin immunoprecipitation; human; 1:100
- immunoprecipitation; human; 1:1000
- western blot; human; 1:1000
| Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, et al. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1
| Hayashi A, Morikawa T, Kawai T, Kume H, Ishikawa S, Homma Y, et al. Clinicopathological and prognostic significance of EZH2 expression in upper urinary tract carcinoma. Virchows Arch. 2014;464:463-71 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher |
| Park S, Fong K, Kim J, Wang F, Lu X, Lee Y, et al. Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer. Sci Adv. 2021;7: pubmed publisher |
| Huang S, Fantini D, Merrill B, Bagchi S, Guzman G, Raychaudhuri P. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Cancer Res. 2017;77:6562-6575 pubmed publisher |
| Vaz M, Hwang S, Kagiampakis I, Phallen J, Patil A, O Hagan H, et al. Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations. Cancer Cell. 2017;32:360-376.e6 pubmed publisher |
| Hanssen L, Kassouf M, Oudelaar A, Biggs D, Preece C, Downes D, et al. Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nat Cell Biol. 2017;19:952-961 pubmed publisher |
| Jung H, Byun H, Jee B, Min S, Jeoun U, Lee Y, et al. The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence. J Biol Chem. 2017;292:3729-3739 pubmed publisher |
| Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley S, et al. EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis. Oncotarget. 2017;8:13509-13520 pubmed publisher |
| Wang X, Sehgal L, Jain N, Khashab T, Mathur R, Samaniego F. LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2. J Transl Med. 2016;14:346 pubmed publisher |
| Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher |
| Deaton A, Gómez Rodríguez M, Mieczkowski J, Tolstorukov M, Kundu S, Sadreyev R, et al. Enhancer regions show high histone H3.3 turnover that changes during differentiation. elife. 2016;5: pubmed publisher |
| Bitler B, Aird K, Garipov A, Li H, Amatangelo M, Kossenkov A, et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015;21:231-8 pubmed publisher |
| Bae W, Kang K, Yu J, Yoo K, Factor V, Kaji K, et al. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. FASEB J. 2015;29:1653-62 pubmed publisher |
| Jia N, Li Q, Tao X, Wang J, Hua K, Feng W. Enhancer of zeste homolog 2 is involved in the proliferation of endometrial carcinoma. Oncol Lett. 2014;8:2049-2054 pubmed |
| Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada C, Lin M, et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet. 2014;46:1227-32 pubmed publisher |
| Popovic R, Martinez Garcia E, Giannopoulou E, Zhang Q, Zhang Q, Ezponda T, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet. 2014;10:e1004566 pubmed publisher |
| Wolfe A, Singh K, Zhong Y, Drewe P, Rajasekhar V, Sanghvi V, et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014;513:65-70 pubmed publisher |
| Blackledge N, Farcas A, Kondo T, King H, McGouran J, Hanssen L, et al. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell. 2014;157:1445-59 pubmed publisher |
| Girard N, Bazille C, Lhuissier E, Benateau H, Llombart Bosch A, Boumediene K, et al. 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells. PLoS ONE. 2014;9:e98176 pubmed publisher |
| Chattergoon M, Latanich R, Quinn J, Winter M, Buckheit R, Blankson J, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10:e1004082 pubmed publisher |
| Svedlund J, Barazeghi E, Stalberg P, Hellman P, Akerstrom G, Björklund P, et al. The histone methyltransferase EZH2, an oncogene common to benign and malignant parathyroid tumors. Endocr Relat Cancer. 2014;21:231-9 pubmed publisher |
| Li G, Warden C, Zou Z, Neman J, Krueger J, Jain A, et al. Altered expression of polycomb group genes in glioblastoma multiforme. PLoS ONE. 2013;8:e80970 pubmed publisher |
| Forthun R, SenGupta T, Skjeldam H, Lindvall J, McCormack E, Gjertsen B, et al. Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLoS ONE. 2012;7:e48992 pubmed publisher |
