| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig 6a
| Zhang H, Ben Zablah Y, Liu A, Lee D, Zhang H, Meng Y, et al. Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice. Mol Brain. 2021;14:121 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7e
| Qiao Y, Jin T, Guan S, Cheng S, Wen S, Zeng H, et al. Long non-coding RNA Lnc-408 promotes invasion and metastasis of breast cancer cell by regulating LIMK1. Oncogene. 2021;40:4198-4213 pubmed publisher |
- western blot; mouse; 1:10,000; loading ...; fig s3-2b
| Renteria R, Cazares C, Baltz E, Schreiner D, Yalcinbas E, Steinkellner T, et al. Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure. elife. 2021;10: pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 1b
| Märklin M, Fuchs A, Tandler C, Heitmann J, Salih H, Kauer J, et al. Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia. Front Immunol. 2020;11:1995 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5
| Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4s2h
| Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed publisher |
- western blot; human; 1:10,000; loading ...
| Sharifnia T, Wawer M, Chen T, Huang Q, Weir B, Sizemore A, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nat Med. 2019;25:292-300 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5e
| Chiang A, Fowler S, Savjani R, Hilsenbeck S, Wallace C, Cirrito J, et al. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018;215:1349-1364 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4j
| Nardone G, Oliver De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, et al. YAP regulates cell mechanics by controlling focal adhesion assembly. Nat Commun. 2017;8:15321 pubmed publisher |
- western blot; mouse; 1:50; fig 5b
| Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann B, et al. Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol. 2017;216:1567-1577 pubmed publisher |
- western blot; mouse; loading ...; fig 5b
| Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3g
| Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, et al. Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. J Biol Chem. 2017;292:1438-1448 pubmed publisher |
- flow cytometry; human; loading ...; fig 4c
| Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed |
- western blot; human; 1:1000; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 8c
- western blot; mouse; 1:1000; loading ...; fig 9a
| Kumar A, Paeger L, Kosmas K, Kloppenburg P, Noegel A, Peche V. Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2. Front Cell Neurosci. 2016;10:180 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 2e
- western blot; human; 1:700; loading ...; fig 3c
| Gao J, Fu S, Zeng Z, Li F, Niu Q, Jing D, et al. Cyclic stretch promotes osteogenesis-related gene expression in osteoblast-like cells through a cofilin-associated mechanism. Mol Med Rep. 2016;14:218-24 pubmed publisher |
- western blot; human; fig 7
| Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher |
- western blot; human; fig s2
| Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei F, et al. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016;6:23372 pubmed publisher |
- western blot; mouse; 1:2000; fig 1
| Liu A, Zhou Z, Dang R, Zhu Y, Qi J, He G, et al. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. J Cell Biol. 2016;212:449-63 pubmed publisher |
- western blot; mouse; fig 3
| Lu K, Tounsi A, Shridhar N, Küblbeck G, Klevenz A, Prokosch S, et al. Dickkopf-3 Contributes to the Regulation of Anti-Tumor Immune Responses by Mesenchymal Stem Cells. Front Immunol. 2015;6:645 pubmed publisher |
- western blot; human; fig 4
| Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher |
- western blot; human; fig s2
| Hong N, Qi A, Weaver A. PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions. J Cell Biol. 2015;210:753-69 pubmed publisher |
- western blot; human; fig s4
| Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva Salcedo E, et al. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS ONE. 2015;10:e0130540 pubmed publisher |
- immunoprecipitation; human; fig 6
- immunocytochemistry; human; fig 6
- western blot; human; fig 6
| Dugina V, Khromova N, Rybko V, Blizniukov O, Shagieva G, Chaponnier C, et al. Tumor promotion by γ and suppression by β non-muscle actin isoforms. Oncotarget. 2015;6:14556-71 pubmed |
- western blot; mouse; loading ...; fig 3a
| Woo J, Zhao X, Khan H, Penn C, Wang X, Joly Amado A, et al. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death Differ. 2015;22:921-34 pubmed publisher |
- western blot; rat; 1:1000
| Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed publisher |
- western blot; mouse; 1:1000
| Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed publisher |
- chromatin immunoprecipitation; human
| Madak Erdogan Z, Ventrella R, Petry L, Katzenellenbogen B. Novel roles for ERK5 and cofilin as critical mediators linking ER?-driven transcription, actin reorganization, and invasiveness in breast cancer. Mol Cancer Res. 2014;12:714-27 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:400
- immunocytochemistry; human; 1:1000; fig 4
- western blot; human; 1:1000
| Polachini G, Sobral L, Mercante A, Paes Leme A, Xavier F, Henrique T, et al. Proteomic approaches identify members of cofilin pathway involved in oral tumorigenesis. PLoS ONE. 2012;7:e50517 pubmed publisher |
| Zhang L, Wang L, Hiremath U, Bisoyi H, Nair G, Yelamaggad C, et al. Dynamic Orthogonal Switching of a Thermoresponsive Self-Organized Helical Superstructure. Adv Mater. 2017;29: pubmed publisher |
| Valderrama C, Clark A, Urano F, Unanue E, Carrero J. Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice. Eur J Immunol. 2017;47:830-840 pubmed publisher |
| Ang W, Church A, Kulis M, Choi H, Burks A, Abraham S. Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. J Clin Invest. 2016;126:4103-4118 pubmed publisher |
| Sengelaub C, Navrazhina K, Ross J, Halberg N, Tavazoie S. PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling. EMBO J. 2016;35:62-76 pubmed publisher |
| Tominaga N, Kosaka N, Ono M, Katsuda T, Yoshioka Y, Tamura K, et al. Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat Commun. 2015;6:6716 pubmed publisher |
| Speranza L, Giuliano T, Volpicelli F, De Stefano M, Lombardi L, Chambery A, et al. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Front Behav Neurosci. 2015;9:62 pubmed publisher |
| Li C, Lun W, Zhao X, Lei S, Guo Y, Ma J, et al. Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm. 2015;2015:434692 pubmed publisher |
| Garcia Manero G, Khoury H, Jabbour E, Lancet J, Winski S, Cable L, et al. A phase I study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes. Clin Cancer Res. 2015;21:985-94 pubmed publisher |
| Gaumann A, Drexler H, Lang S, Stoeltzing O, Diermeier Daucher S, Buchdunger E, et al. The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®). Int J Oncol. 2014;45:2267-77 pubmed publisher |
| Liu J, Lin X, Yang X, Zhou L, He S, Zhuang S, et al. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res. 2014;42:12041-51 pubmed publisher |
| MartÃnez Neri P, López Rincón G, Mancilla Jiménez R, Del Toro Arreola S, Muñoz Valle J, Fafutis Morris M, et al. Prolactin modulates cytokine production induced by culture filtrate proteins of M. bovis through different signaling mechanisms in THP1 cells. Cytokine. 2015;71:38-44 pubmed publisher |
| Yu G, Lee Y, Cheng C, Wu C, Song J, Gallick G, et al. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res. 2015;13:348-57 pubmed publisher |
| Bielig H, Lautz K, Braun P, Menning M, Machuy N, Brügmann C, et al. The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling. PLoS Pathog. 2014;10:e1004351 pubmed publisher |
| Jacob S, Foster A, Yemelin A, Thines E. Histidine kinases mediate differentiation, stress response, and pathogenicity in Magnaporthe oryzae. Microbiologyopen. 2014;3:668-87 pubmed publisher |
| Crocetti J, Silva O, Humphries L, Tibbs M, Miceli M. Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells. J Immunol. 2014;193:2651-60 pubmed publisher |
| Kimura T, Kobayashi S, Hanihara Tatsuzawa F, Sayama A, Maruyama T, Muta T. Responses of macrophages to the danger signals released from necrotic cells. Int Immunol. 2014;26:697-704 pubmed publisher |
| Birner P, Berghoff A, Dinhof C, Pirker C, Capper D, Schoppmann S, et al. MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases. Arch Dermatol Res. 2014;306:873-84 pubmed publisher |
| Wang C, Li G, Shi Y, Zhang X, Li J, Wang Z, et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons. J Physiol Biochem. 2014;70:735-47 pubmed publisher |
| Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R. TGF-?-activated kinase 1 (TAK1) signaling regulates TGF-?-induced WNT-5A expression in airway smooth muscle cells via Sp1 and ?-catenin. PLoS ONE. 2014;9:e94801 pubmed publisher |
| Wang C, Zhang L, Li G, Shi Y, Li J, Zhang X, et al. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res. 2014;92:944-54 pubmed publisher |
| Cai W, Liang L, Wang L, Han J, Zhu X, Han H, et al. Inhibition of Notch signaling leads to increased intracellular ROS by up-regulating Nox4 expression in primary HUVECs. Cell Immunol. 2014;287:129-35 pubmed publisher |
| Wang C, Li J, Zhang L, Zhang X, Yu S, Liang X, et al. Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-?B signal pathway. Neurochem Int. 2013;63:741-9 pubmed publisher |
| Nomura J, Busso N, Ives A, Tsujimoto S, Tamura M, So A, et al. Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK. PLoS ONE. 2013;8:e75527 pubmed publisher |
| Liu G, Bi Y, Wang R, Shen B, Zhang Y, Yang H, et al. Kinase AKT1 negatively controls neutrophil recruitment and function in mice. J Immunol. 2013;191:2680-90 pubmed publisher |
| Feige E, Yacov N, Salem Y, Levi I, Mendel I, Propheta Meiran O, et al. Inhibition of monocyte chemotaxis by VB-201, a small molecule lecinoxoid, hinders atherosclerosis development in ApoE?/? mice. Atherosclerosis. 2013;229:430-9 pubmed publisher |
| Ammann J, Cooke A, Trowsdale J. Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol. 2013;190:5030-6 pubmed publisher |
| Aguilera Montilla N, Chamorro S, Nieto C, Sanchez Cabo F, Dopazo A, Fernández Salguero P, et al. Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells. Blood. 2013;121:e108-17 pubmed publisher |
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| Yamada J, Jinno S. Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis. J Comp Neurol. 2013;521:1184-201 pubmed publisher |
| Stavniichuk R, Shevalye H, Hirooka H, Nadler J, Obrosova I. Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. Biochem Pharmacol. 2012;83:932-40 pubmed publisher |
| Kogai T, Liu Y, Mody K, Shamsian D, Brent G. Regulation of sodium iodide symporter gene expression by Rac1/p38? mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. J Biol Chem. 2012;287:3292-300 pubmed publisher |
