product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
SQSTM1/p62 Antibody
catalog :
5114S
quantity :
100 ul
price :
235 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 37
Published Application/Species/DilutionReference
  • western blot; rat; 1:1000; fig 3
Lesmana R, Sinha R, Singh B, Zhou J, Ohba K, Wu Y, et al. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology. 2016;157:23-38 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
Krishnan V, White Z, McMahon C, Hodgetts S, Fitzgerald M, Shavlakadze T, et al. A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice. J Neuropathol Exp Neurol. 2016;75:464-78 pubmed publisher
  • western blot; mouse; fig 3
Hamlin A, Basford J, Jaeschke A, Hui D. Low density lipoprotein receptor-related protein-1 deficiency exacerbates palmitate-induced steatosis and toxicity in hepatocytes. J Biol Chem. 2016;: pubmed
  • western blot; rat; 1:1000; fig 2
Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Walter C, Clemens L, Müller A, Fallier-Becker P, Proikas-Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher
  • western blot; human; fig 3
Kim M, Sandford E, Gatica D, Qiu Y, Liu X, Zheng Y, et al. Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. elife. 2016;5: pubmed publisher
  • western blot; mouse; fig 1
Liu L, Zheng L, Zou P, Brooke J, Smith C, Long Y, et al. FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes. Cell Cycle. 2016;:1-9 pubmed
  • western blot; human; fig 2
Xue H, Yuan G, Guo X, Liu Q, Zhang J, Gao X, et al. A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway. Autophagy. 2016;12:1129-52 pubmed publisher
  • western blot; human; fig 3
Jung S, Li C, Duan J, Lee S, Kim K, Park Y, et al. TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition. Oncotarget. 2015;6:29060-75 pubmed publisher
  • western blot; rat; 1:1000; fig 1
Wang L, Hao H, Wang J, Wang X, Zhang S, Du Y, et al. Decreased autophagy: a major factor for cardiomyocyte death induced by β1-adrenoceptor autoantibodies. Cell Death Dis. 2015;6:e1862 pubmed publisher
  • western blot; mouse; fig 3e
Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
  • western blot; human
Singh K, Lovren F, Pan Y, Quan A, Ramadan A, Matkar P, et al. The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem. 2015;290:2547-59 pubmed publisher
  • western blot; mouse
Fukui K, Ferris H, Kahn C. Effect of cholesterol reduction on receptor signaling in neurons. J Biol Chem. 2015;290:26383-92 pubmed publisher
  • western blot; rat
Opperman C, Sishi B. Tumor necrosis factor alpha stimulates p62 accumulation and enhances proteasome activity independently of ROS. Cell Biol Toxicol. 2015;31:83-94 pubmed publisher
  • western blot; human; 1:1000; fig 8
Wu H, Jiang Z, Ding P, Shao L, Liu R. Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells. Sci Rep. 2015;5:12291 pubmed publisher
  • western blot; human
Yang H, Ma Y, Zhou Y, Xu L, Chen X, Ding W, et al. Autophagy contributes to the enrichment and survival of colorectal cancer stem cells under oxaliplatin treatment. Cancer Lett. 2015;361:128-36 pubmed publisher
  • western blot; mouse; 1:500; fig 5
Ferreira J, Soares A, Ramalho J, Pereira P, Girao H. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Sci Rep. 2015;5:10210 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Qiao S, Dennis M, Song X, Vadysirisack D, Salunke D, Nash Z, et al. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015;6:7014 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6
  • western blot; mouse; fig 3
Zhang W, Hou J, Wang X, Jiang R, Yin Y, Ji J, et al. PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis. Oncotarget. 2015;6:9420-33 pubmed
  • western blot; mouse; 1:1000
Kanayama M, Inoue M, Danzaki K, Hammer G, He Y, Shinohara M. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun. 2015;6:5779 pubmed publisher
  • western blot; human
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher
  • immunoprecipitation; human
  • immunoprecipitation; mouse
  • western blot; human
  • western blot; mouse
  • immunocytochemistry; human
  • immunocytochemistry; mouse
Ro S, Semple I, Park H, Park H, Park H, Kim M, et al. Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 2014;281:3816-27 pubmed publisher
  • western blot; mouse; 1:500
Datta K, Suman S, Fornace A. Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine. Int J Biochem Cell Biol. 2014;57:167-76 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4
  • western blot; mouse; fig 4
Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, et al. Atg7 is required for acrosome biogenesis during spermatogenesis in mice. Cell Res. 2014;24:852-69 pubmed publisher
  • western blot; human; 1:1000
Chen M, Yi L, Jin X, Liang X, Zhou Y, Zhang T, et al. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy. 2013;9:2033-45 pubmed publisher
  • western blot; mouse; 1:1000
Baldo B, Soylu R, Petersen A. Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction. PLoS ONE. 2013;8:e83050 pubmed publisher
Ranjan A, Srivastava S. Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 2016;6:26165 pubmed publisher
Choi M, Kim H, Ham M, Choi D, Lee T, Shin D. Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes. Sci Rep. 2016;6:28476 pubmed publisher
Chung K, Jeong E, Park H, An H, Yu S. Mediation of Autophagic Cell Death by Type 3 Ryanodine Receptor (RyR3) in Adult Hippocampal Neural Stem Cells. Front Cell Neurosci. 2016;10:116 pubmed publisher
Pawar K, Hanisch C, Palma Vera S, Einspanier R, Sharbati S. Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagy. Sci Rep. 2016;6:19416 pubmed publisher
Liang S, Figtree G, Aiqun M, Ping Z. GAPDH-knockdown reduce rotenone-induced H9C2 cells death via autophagy and anti-oxidative stress pathway. Toxicol Lett. 2015;234:162-71 pubmed publisher
Holczer M, Márton M, Kurucz A, Banhegyi G, Kapuy O. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. Biomed Res Int. 2015;2015:319589 pubmed publisher
Shen C, Wang C, Fan F, Yang Z, Cao Q, Liu X, et al. Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway. Biochim Biophys Acta. 2015;1852:310-8 pubmed publisher
Li X, Zeng Z, Li Q, Xu Q, Xie J, Hao H, et al. Inhibition of microRNA-497 ameliorates anoxia/reoxygenation injury in cardiomyocytes by suppressing cell apoptosis and enhancing autophagy. Oncotarget. 2015;6:18829-44 pubmed
Ringer L, Sirajuddin P, Tricoli L, Waye S, Choudhry M, Parasido E, et al. The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells. Oncotarget. 2014;5:10678-91 pubmed
Ye L, Yu J, Liang Y, Zeng J, Huang R, Liao S. Beclin 1 knockdown retards re-endothelialization and exacerbates neointimal formation via a crosstalk between autophagy and apoptosis. Atherosclerosis. 2014;237:146-54 pubmed publisher
Kapuy O, Vinod P, Bánhegyi G. mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress - An experimental and modeling study. FEBS Open Bio. 2014;4:704-13 pubmed publisher
product information
SKU :
5114S
Product-Name :
SQSTM1/p62 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Western blot
Product-Category :
Autophagy
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
60
Host :
Rabbit
Target :
SQSTM1
Primary-Protein :
SQSTM1
Alt-Names :
A170,EBI3-associated protein of 60 kDa,EBI3-associated protein p60,EBIAP,ORCA,OSIL,PDB3,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,SQSTM,SQSTM1,Sequestosome-1,Ubiquitin-binding protein p62,ZIP3,oxidative stress induced like,p60,p62,p62B,phosphotyrosine independent ligand for the Lck SH2 domain p62,sequestosome 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.